The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
A model of the cell-autonomous mammalian circadian clock
Open accessAbstract
Circadian timekeeping by intracellular molecular clocks is evident widely in prokaryotes and eukaryotes. The clockworks are driven by autoregulatory feedback loops that lead to oscillating levels of components whose maxima are in fixed phase relationships with one another. These phase relationships are the key metric characterizing the operation of the clocks. In this study, we built a mathematical model from the regulatory structure of the intracellular circadian clock in mice and identified its parameters using an iterative evolutionary strategy, with minimum cost achieved through conformance to phase separations seen in cell-autonomous oscillators. The model was evaluated against the experimentally observed cell-autonomous circadian phenotypes of gene knockouts, particularly retention of rhythmicity and changes in expression level of molecular clock components. These tests reveal excellent de novo predictive ability of the model. Furthermore, sensitivity analysis shows that these knockout phenotypes are robust to parameter perturbation.
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Cites
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
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Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms
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Interacting molecular loops in the mammalian circadian clock
Shearman, L. P., Sriram, S., Weaver, D. R., Maywood, E. S., Chaves, I., Zheng, B., Kume, K., Lee, C. C., van der, G. T. J., Horst, et al. (2000) · Science · doi:10.1126/science.288.5468.1013 · Cited by 1,367
Mammalian circadian biology: elucidating genome-wide levels of temporal organization
Lowrey, P. L., & Takahashi, J. S. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.175925 · Cited by 976
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Transcriptional oscillation of canonical clock genes in mouse peripheral tissues
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Cited by
Control principles of complex systems
Liu, Y.-Y., & Barabási, A.-L. (2016) · Reviews of Modern Physics · doi:10.1103/revmodphys.88.035006 · Cited by 654
Herzog, E. D., Hermanstyne, T., Smyllie, N. J., & Hastings, M. H. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a027706 · Cited by 266
Evolution of circadian rhythms: from bacteria to human
Bhadra, U., Thakkar, N., Das, P., & Pal Bhadra, M. (2017) · Sleep Medicine · doi:10.1016/j.sleep.2017.04.008 · Cited by 167
Circadian rhythms and the HPA axis: A systems view
Androulakis, I. P. (2021) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1518 · Cited by 55
Metadata
- Authors
- Mirsky, H. P., Liu, A. C., Welsh, D. K., Kay, S. A., & Doyle, F. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-07-07
- Volume
- 106
- Issue
- 27
- Pages
- 11107-11112
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2014654814
- Cited by
- 196
- References
- 8
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- green
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- Mirsky, H. P., Liu, A. C., Welsh, D. K., Kay, S. A., & Doyle, F. J. (2009). A model of the cell-autonomous mammalian circadian clock. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0904837106
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
