The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
XIAP mediates NOD signaling via interaction with RIP2
Open accessAbstract
NOD1 and NOD2 are members of the NOD-like receptor (NLR) protein family that are involved in sensing the presence of pathogens and are a component of the innate immune system. Upon activation by specific bacterial peptides derived from peptidoglycans, NODs interact via a CARD-CARD interaction with the receptor-interacting protein kinase RIP2, an inducer of NF-κB activation. In this report, we show that NOD signaling is dependent on XIAP, a member of the inhibitor of apoptosis protein (IAP) family. Cells deficient in XIAP exhibit a marked reduction in NF-κB activation induced by microbial NOD ligands and by over-expression of NOD1 or NOD2. Moreover, we show that XIAP interacts with RIP2 via its BIR2 domain, which could be disrupted by XIAP antagonists SMAC and SMAC-mimicking compounds. Both NOD1 and NOD2 associated with XIAP in a RIP2-dependent manner, providing evidence that XIAP associates with the NOD signalosome. Taken together, our data suggest a role for XIAP in regulating innate immune responses by interacting with NOD1 and NOD2 through interaction with RIP2.
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Cites
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X-linked IAP is a direct inhibitor of cell-death proteases
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Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan
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“Festjens N, Vanden Berghe T, Cornelis S, Vandenabeele P (2007) RIP1, a kinase on the crossroads of a cell’s decision to live or die.”
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IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer
Gyrd-Hansen, M., & Meier, P. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2889 · Cited by 790
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Philpott, D. J., Sorbara, M. T., Robertson, S. J., Croitoru, K., & Girardin, S. E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3565 · Cited by 668
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Metadata
- Authors
- Krieg, A., Correa, R. G., Garrison, J. B., Le Negrate, G., Welsh, K., Huang, Z., Knoefel, W. T., & Reed, J. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-08-25
- Volume
- 106
- Issue
- 34
- Pages
- 14524-14529
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2168030198
- Cited by
- 286
- References
- 44
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Krieg, A., Correa, R. G., Garrison, J. B., Le Negrate, G., Welsh, K., Huang, Z., Knoefel, W. T., & Reed, J. C. (2009). XIAP mediates NOD signaling via interaction with RIP2. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0907131106
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