Tracking footprints of artificial selection in the dog genome
Open accessAbstract
The size, shape, and behavior of the modern domesticated dog has been sculpted by artificial selection for at least 14,000 years. The genetic substrates of selective breeding, however, remain largely unknown. Here, we describe a genome-wide scan for selection in 275 dogs from 10 phenotypically diverse breeds that were genotyped for over 21,000 autosomal SNPs. We identified 155 genomic regions that possess strong signatures of recent selection and contain candidate genes for phenotypes that vary most conspicuously among breeds, including size, coat color and texture, behavior, skeletal morphology, and physiology. In addition, we demonstrate a significant association between HAS2 and skin wrinkling in the Shar-Pei, and provide evidence that regulatory evolution has played a prominent role in the phenotypic diversification of modern dog breeds. Our results provide a first-generation map of selection in the dog, illustrate how such maps can rapidly inform the genetic basis of canine phenotypic variation, and provide a framework for delineating the mechanistic basis of how artificial selection promotes rapid and pronounced phenotypic evolution.
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Selective breeding has influenced the genes associated with behaviour.
“Selective breeding has also influenced the genes associated with behaviour [140], and the degree of selection has also impacted behaviour [141].”
From Ethical Concerns about Fashionable Dog Breeding (2024) · cites this paper as [140]
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- Authors
- Akey, J. M., Ruhe, A. L., Akey, D. T., Wong, A. K., Connelly, C. F., Madeoy, J., Nicholas, T. J., & Neff, M. W.
- Affiliations
- University of Washington (US)
- University of California, Davis (US)
- Translational Genomics Research Institute (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-01-11
- Volume
- 107
- Issue
- 3
- Pages
- 1160-1165
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2824266
- OpenAlex
- W2134440374
- Cited by
- 350
- References
- 3
- Citations by year
- 2026: 15 · 2025: 15 · 2024: 33 · 2023: 17 · 2022: 19 · 2021: 23 · 2020: 18 · 2019: 21 · 2018: 18 · 2017: 21 · 2016: 23 · 2015: 25 · 2014: 25 · 2013: 25 · 2012: 20
- FWCI
- 13.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM076036)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- selective breeding, dogs, dog breeds, candidate genes, HAS2, skin wrinkling, Shar-Pei, regulatory evolution, phenotypic diversification, body size, coat color, skeletal morphology
- MeSH terms
- Animals, Dogs, Phenotype, Selection, Genetic, Species Specificity, Genome, Polymorphism, Single Nucleotide
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