The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
“Control” laboratory rodents are metabolically morbid: Why it matters
Open accessAbstract
Failure to recognize that many standard control rats and mice used in biomedical research are sedentary, obese, glucose intolerant, and on a trajectory to premature death may confound data interpretation and outcomes of human studies. Fundamental aspects of cellular physiology, vulnerability to oxidative stress, inflammation, and associated diseases are among the many biological processes affected by dietary energy intake and exercise. Although overfed sedentary rodents may be reasonable models for the study of obesity in humans, treatments shown to be efficacious in these animal models may prove ineffective or exhibit novel side effects in active, normal-weight subjects.
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“The efficacy of drugs is affected by physical fitness/activity status (104, 328) in addition to genetic disposition.”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [328]
Citations
Cites
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Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Inflammation and insulin resistance
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
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Cited by
Sorted by citations
Lack of Exercise Is a Major Cause of Chronic Diseases
Booth, F. W., Roberts, C. K., & Laye, M. J. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110025 · Cited by 2,575
Fasting: molecular mechanisms and clinical applications
Longo, V. D., & Mattson, M. P. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.008 · Cited by 1,425
Self-citationImpact of intermittent fasting on health and disease processes
Mattson, M. P., Longo, V. D., & Harvie, M. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.10.005 · Cited by 1,187
Self-citationImpact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Mattison, J. A., Roth, G. S., Beasley, T. M., Tilmont, E. M., Handy, A. M., Herbert, R. L., Longo, D. L., Allison, D. B., Young, J. E., Bryant, M., et al. (2012) · Nature · doi:10.1038/nature11432 · Cited by 1,145
Animal models of obesity and diabetes mellitus
Kleinert, M., Clemmensen, C., Hofmann, S. M., Moore, M. C., Renner, S., Woods, S. C., Huypens, P., Beckers, J., de Angelis, M. H., Schürmann, A., et al. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.161 · Cited by 893
Metadata
- Authors
- Martin, B., Ji, S., Maudsley, S., & Mattson, M. P.
- Affiliations
- National Institute on Aging (US)
- National Institutes of Health (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-03
- Volume
- 107
- Issue
- 14
- Pages
- 6127-6133
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2852022
- OpenAlex
- W2081308389
- Cited by
- 354
- References
- 109
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 22 · 2023: 14 · 2022: 20 · 2021: 17 · 2020: 19 · 2019: 35 · 2018: 19 · 2017: 18 · 2016: 20 · 2015: 18 · 2014: 35 · 2013: 19 · 2012: 36
- FWCI
- 23.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- laboratory rodents, sedentary behavior, obesity, impaired glucose tolerance, metabolic disorders, oxidative stress, inflammation, physical activity, energy intake, animal models of human disease, premature mortality
- MeSH terms
- Animals, Body Weight, Obesity, Morbid, Physical Conditioning, Animal, Models, Animal, Caloric Restriction, Mice, Rats
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