The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Basal epithelial stem cells are efficient targets for prostate cancer initiation
Open accessAbstract
Prevailing theories suggest that luminal cells are the origin of prostate cancer because it is histologically defined by basal cell loss and malignant luminal cell expansion. We introduced a series of genetic alterations into prospectively identified populations of murine basal/stem and luminal cells in an in vivo prostate regeneration assay. Stromal induction of FGF signaling, increased expression of the ETS family transcription factor ERG1, and constitutive activation of PI3K signaling were evaluated. Combination of activated PI3K signaling and heightened androgen receptor signaling, which is associated with disease progression to androgen independence, was also performed. Even though luminal cells fail to respond, basal/stem cells demonstrate efficient capacity for cancer initiation and can produce luminal-like disease characteristic of human prostate cancer in multiple models. This finding provides evidence in support of basal epithelial stem cells as one target cell for prostate cancer initiation and demonstrates the propensity of primitive cells for tumorigenesis.
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Cites
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“(3) used this approach to demonstrate that BCR-ABL can induce myeloid disease in mice when introduced into HSC but not more committed progenitors, while other fusion oncogenes can initiate disease from both stem cells and progenitors (4, 5).”
MethodA luminal epithelial stem cell that is a cell of origin for prostate cancer
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Cited by
Visvader, J. E. (2011) · Nature · doi:10.1038/nature09781 · Cited by 1,449
The translational landscape of mTOR signalling steers cancer initiation and metastasis
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Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling
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Identification of a Cell of Origin for Human Prostate Cancer
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Self-citationPC3 is a cell line characteristic of prostatic small cell carcinoma
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Self-citation
Metadata
- Authors
- Lawson, D. A., Zong, Y., Memarzadeh, S., Xin, L., Huang, J., & Witte, O. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-01-25
- Volume
- 107
- Issue
- 6
- Pages
- 2610-2615
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2039015433
- Cited by
- 275
- References
- 35
- FWCI
- 30.99
- Type
- journal article
- Language
- en
- Open access
- green
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