CoChat
Sign Up
Cited by 327Muscle Physiology and DisordersMuscle metabolism and nutritionNeurogenetic and Muscular Disorders Research

The DOI matches its Crossref record; 56 of the 57 references it cites were found in a registry or an index.

Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detraining

Open access
Bruusgaard, J. C., Johansen, I. B., Egner, I. M., Rana, Z. A., Gundersen, K.·2010·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0913935107PMC PMC2930527
Open this paper in CoChat — free account

Abstract

Effects of previous strength training can be long-lived, even after prolonged subsequent inactivity, and retraining is facilitated by a previous training episode. Traditionally, such "muscle memory" has been attributed to neural factors in the absence of any identified local memory mechanism in the muscle tissue. We have used in vivo imaging techniques to study live myonuclei belonging to distinct muscle fibers and observe that new myonuclei are added before any major increase in size during overload. The old and newly acquired nuclei are retained during severe atrophy caused by subsequent denervation lasting for a considerable period of the animal's lifespan. The myonuclei seem to be protected from the high apoptotic activity found in inactive muscle tissue. A hypertrophy episode leading to a lasting elevated number of myonuclei retarded disuse atrophy, and the nuclei could serve as a cell biological substrate for such memory. Because the ability to create myonuclei is impaired in the elderly, individuals may benefit from strength training at an early age, and because anabolic steroids facilitate more myonuclei, nuclear permanency may also have implications for exclusion periods after a doping offense.

Overview

Integrity signals

Registry

Crossref · 10.1073/pnas.0913935107

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 57 references

Research works printed but not linked: 10

  1. E Strassburger, Ûber die Wirkungssphäre der kerne und die zellgrösse. Histologische Beiträge 5, 97–124 (1893).
  2. 10.1017/S1464793100005595 · DOI · Paper page
  3. RS O’Connor, GK Pavlath, In response to Point:Counterpoint: Satellite cell addition is/is not obligatory for skeletal muscle hypertrophy. J Appl Physiol 103, 1102 (2007).
  4. 10.1152/japplphysiol.00101.2007a · DOI
  5. 10.1152/japplphysiol.00466.2007 · DOI
  6. 10.1152/japplphysiol.00466.2007 · DOI
  7. FW Booth, In response to Point:Counterpoint: Satellite cell addition is/is not obligatory for skeletal muscle hypertrophy. J Appl Physiol 103, 1105, (lett). (2007).
  8. F Kadi, In response to Point:Counterpoint: Satellite cell addition is/is not obligatory for skeletal muscle hypertrophy. J Appl Physiol 103, 1105, (lett). (2007).
  9. SC Bodine, In response to Point:Counterpoint: Satellite cell addition is/is not obligatory for skeletal muscle hypertrophy. J Appl Physiol 103, 1105–1106, (lett). (2007).
  10. DA Lowe, In response to Point:Counterpoint: Satellite cell addition is/is not obligatory for skeletal muscle hypertrophy. J Appl Physiol 103, 1106, (lett). (2007).

Cited by

Sorted by citations

Items 101–200 of 325

Related

See all

Metadata

Authors
Bruusgaard, J. C., Johansen, I. B., Egner, I. M., Rana, Z. A., & Gundersen, K.
Affiliations
University of Oslo (NO)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2010-08-16
Volume
107
Issue
34
Pages
15111-15116
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0913935107
PMC
PMC2930527
OpenAlex
W2057868246
Cited by
327
References
57
Citations by year
2026: 11 · 2025: 21 · 2024: 14 · 2023: 22 · 2022: 25 · 2021: 43 · 2020: 27 · 2019: 22 · 2018: 18 · 2017: 13 · 2016: 26 · 2015: 15 · 2014: 20 · 2013: 17 · 2012: 17
FWCI
6.52
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Norges Forskningsråd (rcn-foriss-191730, rcn-foriss-182717)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Genetics (clinical) › Neurogenetic and Muscular Disorders Research
Keywords
myonuclei, muscle hypertrophy, detraining, muscle memory, resistance training, denervation atrophy, disuse atrophy, apoptosis, myonuclear domain, aging, anabolic steroids
MeSH terms
Animals, Cell Nucleus, Female, Humans, Hypertrophy, Male, Models, Biological, Muscle Denervation, Muscular Atrophy, Physical Conditioning, Animal, Rats, Wistar, Apoptosis, Muscle Fibers, Skeletal, Models, Animal, Mice, Rats, Resistance Training

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review