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Cited by 327Muscle Physiology and DisordersMuscle metabolism and nutritionNeurogenetic and Muscular Disorders Research

The DOI matches its Crossref record; 56 of the 57 references it cites were found in a registry or an index.

Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detraining

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Bruusgaard, J. C., Johansen, I. B., Egner, I. M., Rana, Z. A., Gundersen, K.·2010·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0913935107PMC PMC2930527
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Abstract

Effects of previous strength training can be long-lived, even after prolonged subsequent inactivity, and retraining is facilitated by a previous training episode. Traditionally, such "muscle memory" has been attributed to neural factors in the absence of any identified local memory mechanism in the muscle tissue. We have used in vivo imaging techniques to study live myonuclei belonging to distinct muscle fibers and observe that new myonuclei are added before any major increase in size during overload. The old and newly acquired nuclei are retained during severe atrophy caused by subsequent denervation lasting for a considerable period of the animal's lifespan. The myonuclei seem to be protected from the high apoptotic activity found in inactive muscle tissue. A hypertrophy episode leading to a lasting elevated number of myonuclei retarded disuse atrophy, and the nuclei could serve as a cell biological substrate for such memory. Because the ability to create myonuclei is impaired in the elderly, individuals may benefit from strength training at an early age, and because anabolic steroids facilitate more myonuclei, nuclear permanency may also have implications for exclusion periods after a doping offense.

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Research works printed but not linked: 10

  1. E Strassburger, Ûber die Wirkungssphäre der kerne und die zellgrösse. Histologische Beiträge 5, 97–124 (1893).
  2. 10.1017/S1464793100005595 · DOI · Paper page
  3. RS O’Connor, GK Pavlath, In response to Point:Counterpoint: Satellite cell addition is/is not obligatory for skeletal muscle hypertrophy. J Appl Physiol 103, 1102 (2007).
  4. 10.1152/japplphysiol.00101.2007a · DOI
  5. 10.1152/japplphysiol.00466.2007 · DOI
  6. 10.1152/japplphysiol.00466.2007 · DOI
  7. FW Booth, In response to Point:Counterpoint: Satellite cell addition is/is not obligatory for skeletal muscle hypertrophy. J Appl Physiol 103, 1105, (lett). (2007).
  8. F Kadi, In response to Point:Counterpoint: Satellite cell addition is/is not obligatory for skeletal muscle hypertrophy. J Appl Physiol 103, 1105, (lett). (2007).
  9. SC Bodine, In response to Point:Counterpoint: Satellite cell addition is/is not obligatory for skeletal muscle hypertrophy. J Appl Physiol 103, 1105–1106, (lett). (2007).
  10. DA Lowe, In response to Point:Counterpoint: Satellite cell addition is/is not obligatory for skeletal muscle hypertrophy. J Appl Physiol 103, 1106, (lett). (2007).

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Metadata

Authors
Bruusgaard, J. C., Johansen, I. B., Egner, I. M., Rana, Z. A., & Gundersen, K.
Affiliations
University of Oslo (NO)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2010-08-16
Volume
107
Issue
34
Pages
15111-15116
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0913935107
PMC
PMC2930527
OpenAlex
W2057868246
Cited by
327
References
57
Citations by year
2026: 11 · 2025: 21 · 2024: 14 · 2023: 22 · 2022: 25 · 2021: 43 · 2020: 27 · 2019: 22 · 2018: 18 · 2017: 13 · 2016: 26 · 2015: 15 · 2014: 20 · 2013: 17 · 2012: 17
FWCI
6.52
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Norges Forskningsråd (rcn-foriss-191730, rcn-foriss-182717)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Genetics (clinical) › Neurogenetic and Muscular Disorders Research
Keywords
myonuclei, muscle hypertrophy, detraining, muscle memory, resistance training, denervation atrophy, disuse atrophy, apoptosis, myonuclear domain, aging, anabolic steroids
MeSH terms
Animals, Cell Nucleus, Female, Humans, Hypertrophy, Male, Models, Biological, Muscle Denervation, Muscular Atrophy, Physical Conditioning, Animal, Rats, Wistar, Apoptosis, Muscle Fibers, Skeletal, Models, Animal, Mice, Rats, Resistance Training

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