Cited by 250Circadian rhythm and melatoninDNA Repair MechanismsMetal complexes synthesis and properties

The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.

Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase

Open access

Kang, Tae-Hong, Lindsey-Boltz, Laura A., Reardon, Joyce T., Sancar, Aziz·2010·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0915085107PMC PMC2841896

Open this paper in CoChat — free account

Abstract

Cisplatin is one of the most commonly used anticancer drugs. It kills cancer cells by damaging their DNA, and hence cellular DNA repair capacity is an important determinant of its efficacy. Here, we investigated the repair of cisplatin-induced DNA damage in mouse liver and testis tissue extracts prepared at regular intervals over the course of a day. We find that the XPA protein, which plays an essential role in repair of cisplatin damage by nucleotide excision repair, exhibits circadian oscillation in the liver but not in testis. Consequently, removal of cisplatin adducts in liver extracts, but not in testis extracts, exhibits a circadian pattern with zenith at ∼5 pm and nadir at ∼5 am. Furthermore, we find that the circadian oscillation of XPA is achieved both by regulation of transcription by the core circadian clock proteins including cryptochrome and by regulation at the posttranslational level by the HERC2 ubiquitin ligase. These findings may be used as a guide for timing of cisplatin chemotherapy.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.0915085107

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The resurgence of platinum-based cancer chemotherapy
Kèlland, L. R. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2167 · Cited by 4,733
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317
Self-citation
REPLICATION PROTEIN A: A Heterotrimeric, Single-Stranded DNA-Binding Protein Required for Eukaryotic DNA Metabolism
Wold, M. S. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.61 · Cited by 1,445
Direct Cellular Responses to Platinum-Induced DNA Damage
Jung, Y., & Lippard, S. J. (2007) · Chemical Reviews · doi:10.1021/cr068207j · Cited by 1,412
DNA excision repair
Sancar, A. (1996) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.65.070196.000355 · Cited by 1,131
Self-citation
Physiological functions of the HECT family of ubiquitin ligases
Rotin, D., & Kumar, S. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2690 · Cited by 1,105
Transcription-coupled DNA repair: two decades of progress and surprises
Hanawalt, P. C., & Spivak, G. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2549 · Cited by 1,081
Differential regulation of mammalian Period genes and circadian rhythmicity by cryptochromes 1 and 2
Vitaterna, M. H., Selby, C. P., Todo, T., Niwa, H., Thompson, C., Fruechte, E. M., Hitomi, K., Thresher, R. J., Ishikawa, T., Miyazaki, J., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12114 · Cited by 690
Self-citation
Circadian Rhythms: Mechanisms and Therapeutic Implications
Levi, F., & Schibler, U. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105208 · Cited by 645

Flagged first, then by citations

Show all 50 references

1 of the 50 references couldn’t be matched to a known paper.

Sorted by citations

Items 101–200 of 248

The conserved molting/circadian rhythm regulator NHR-23/NR1F1 serves as an essential co-regulator of C. elegans spermatogenesis
Ragle, J. M., Aita, A. L., Morrison, K. N., Martínez-Méndez, R., Saeger, H. N., Ashley, G. E., Johnson, L. C., Schubert, K., Shakes, D. C., & Ward, J. D. (2020) · Development · doi:10.1242/dev.193862 · Cited by 28
Nucleotide excision repair efficiency in quiescent human fibroblasts is modulated by circadian clock
Bee, L., Marini, S., Pontarin, G., Ferraro, P., Costa, R., Albrecht, U., & Celotti, L. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv081 · Cited by 27
UV-Induced Nuclear Import of XPA Is Mediated by Importin-α4 in An ATR-Dependent Manner
Li, Z., Musich, P. R., Cartwright, B. M., Wang, H., & Zou, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068297 · Cited by 26
Turning a water and oil insoluble cisplatin derivative into a nanoparticle formulation for cancer therapy
Guo, S., Wang, Y., Miao, L., Xu, Z., Lin, C.-H. M., & Huang, L. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.05.045 · Cited by 26
NDR1 modulates the UV-induced DNA-damage checkpoint and nucleotide excision repair
Park, J., Choi, J. Y., Yi, J. M., Chung, J. W., Leem, S., Koh, S. S., & Kang, T. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.04.071 · Cited by 25
Self-citation
ARNTL2 is an indicator of poor prognosis, promotes epithelial-to-mesenchymal transition and inhibits ferroptosis in lung adenocarcinoma
Zhang, H., Shan, G., Jin, X., Yu, X., Bi, G., Feng, M., Wang, H., Lin, M., Zhan, C., Wang, Q., et al. (2022) · Translational Oncology · doi:10.1016/j.tranon.2022.101562 · Cited by 24
Enhanced nucleotide excision repair capacity in lung cancer cells by preconditioning with DNA-damaging agents
Choi, J. Y., Park, J., Yi, J. M., Leem, S., & Kang, T. (2015) · Oncotarget · doi:10.18632/oncotarget.4610 · Cited by 25
Self-citation
Sex-dependent correlation between survival and expression of genes related to the circadian oscillator in patients with colorectal cancer
Hasakova, K., Vician, M., Reis, R. D. F., Zeman, M., & Herichová, I. (2018) · Chronobiology International · doi:10.1080/07420528.2018.1488722 · Cited by 27
Circadian Rhythm of NER and ATR Pathways
Kang, T. (2021) · Biomolecules · doi:10.3390/biom11050715 · Cited by 24
Self-citation
The Influence of Circadian Rhythms on DNA Damage Repair in Skin Photoaging
Su, Z. G., Hu, Q., Li, X., Wang, Z., & Xie, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252010926 · Cited by 26
RNF8 and RNF168 but not HERC2 are required for DNA damage-induced ubiquitylation in chicken DT40 cells
Oestergaard, V. H., Pentzold, C., Pedersen, R. T., Iosif, S., Alpi, A. F., Bekker‐Jensen, S., Mailand, N., & Lisby, M. (2012) · DNA repair · doi:10.1016/j.dnarep.2012.08.005 · Cited by 23
Novel loss-of-function mutation in HERC2 is associated with severe developmental delay and paediatric lethality
Elpidorou, M., Best, S. K., Poulter, J. A., Hartill, V. L., Hobson, E., Sheridan, E. G., & Johnson, C. A. (2020) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2020-106873 · Cited by 23
Estradiol differently affects melanin synthesis of malignant and normal melanocytes: a relationship with clock and clock-controlled genes
Poletini, M. O., de Assis, L. V. M., Moraes, M. N., & Castrucci, A. M. D. L. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2781-3 · Cited by 22
NEURL4 regulates the transcriptional activity of tumor suppressor protein p53 by modulating its oligomerization
Cubillos‐Rojas, M., Schneider, T., Bartrons, R., Ventura, F., & Rosa, J. L. (2017) · Oncotarget · doi:10.18632/oncotarget.18699 · Cited by 22
HERC2 regulates RPA2 by mediating ATR-induced Ser33 phosphorylation and ubiquitin-dependent degradation
Lai, Y., Zhu, M., Wu, W., Rokutanda, N., Togashi, Y., Liang, W., & Ohta, T. (2019) · Scientific Reports · doi:10.1038/s41598-019-50812-x · Cited by 21
How and Why the Circadian Clock Regulates Proliferation of Adult Epithelial Stem Cells
D, B. A. M., Duan, J., & Karri, S. S. (2023) · Stem Cells · doi:10.1093/stmcls/sxad013 · Cited by 24
Differential DNA damage responses in p53 proficient and deficient cells: cisplatin-induced nuclear import of XPA is independent of ATR checkpoint in p53-deficient lung cancer cells.
(2011) · PubMed Central · Cited by 21
The role of HERC2 and RNF8 ubiquitin E3 ligases in the promotion of translesion DNA synthesis in the chicken DT40 cell line
Mohiuddin, M., Kobayashi, S., Keka, I. S., Guilbaud, G., Sale, J. E., Narita, T., Abdel-Aziz, H. I., Wang, X., Ogawa, S., Sasanuma, H., et al. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.02.002 · Cited by 21
Cancer, hear my battle CRY
Chan, A. B., & Lamia, K. A. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12658 · Cited by 22
Exploiting the Circadian Clock for Improved Cancer Therapy: Perspective From a Cell Biologist
Kuo, T. T., & Ladurner, A. G. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01210 · Cited by 20
Running for time: circadian rhythms and melanoma
Markova-Car, E., Jurišić, D., Ilić, N., & Pavelić, S. K. (2014) · Tumor Biology · doi:10.1007/s13277-014-1904-2 · Cited by 20
Circadian Dysrhythmias, Physiological Aberrations, and the Link to Skin Cancer
Gutiérrez, D., & Arbesman, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050621 · Cited by 21
Heat shock antagonizes UVA-induced responses in murine melanocytes and melanoma cells: an unexpected interaction
de Assis, L. V. M., Moraes, M. N., & Castrucci, A. M. D. L. (2017) · Photochemical & Photobiological Sciences · doi:10.1039/c6pp00330c · Cited by 20
Exploring the Roles of HERC2 and the NEDD4L HECT E3 Ubiquitin Ligase Subfamily in p53 Signaling and the DNA Damage Response
Mathieu, N. A., Levin, R. H., & Spratt, D. E. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.659049 · Cited by 22
Molecular crosstalk between circadian clock and cancer and therapeutic implications
Qu, M. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1143001 · Cited by 19
14-3-3σ confers cisplatin resistance in esophageal squamous cell carcinoma cells via regulating DNA repair molecules
Lai, K., Chan, K. T., Choi, M. Y., Wang, H. K., Fung, Y. M. E., Lam, H. Y., Tan, W., Tung, L. N., Tong, D. K. H., Sun, R. W., et al. (2015) · Tumor Biology · doi:10.1007/s13277-015-4018-6 · Cited by 19
Sleep duration and cancer risk: time to use a “sleep-years” index?
Erren, T. C. (2012) · Cancer Causes & Control · doi:10.1007/s10552-012-0027-6 · Cited by 20
Time‐dependent changes in proliferation, DNA damage and clock gene expression in hepatocellular carcinoma and healthy liver of a transgenic mouse model
Hassan, S. A., Schmithals, C., von Harten, M., Piiper, A., Korf, H., & von Gall, C. (2020) · International Journal of Cancer · doi:10.1002/ijc.33228 · Cited by 19
Epigenetic Regulation of Nucleotide Excision Repair
Li, W., Jones, K., Burke, T. J., Hossain, M. A., & Lariscy, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.847051 · Cited by 17
Potential Role of the Circadian Clock in the Regulation of Cancer Stem Cells and Cancer Therapy
Lee, Y., & Tanggono, A. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214181 · Cited by 18
Retracted : MicroRNA‐21 antisense oligonucleotide improves the sensitivity of A375 human melanoma cell to Cisplatin: An in vitro study
Zhang, H., Si, L., Zeng, A., Long, F., Zheng, Q., Zhao, R., & Bai, M. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26455 · Cited by 17
Retracted
Exploring the role of circadian clock gene and association with cancer pathophysiology
Keshvari, M., Nejadtaghi, M., Hosseini-Beheshti, F., Rastqar, A., & Patel, N. (2019) · Chronobiology International · doi:10.1080/07420528.2019.1681440 · Cited by 17
Interaction of metal complexes with nucleic acids
Suntharalingam, K., & Vilar, R. (2011) · Annual Reports Section A (Inorganic Chemistry) · doi:10.1039/c1ic90027g · Cited by 17
NOT THAT RIGID MIDGETS AND NOT SO FLEXIBLE GIANTS: ON THE ABUNDANCE AND ROLES OF INTRINSIC DISORDER IN SHORT AND LONG PROTEINS
Howell, M., Green, R. J., Killeen, A., WEDDERBURN, L., Picascio, V., Rabionet, A., Peng, Z., Larina, M., Xue, B., Kurgan, L., et al. (2012) · Journal of Biological Systems · doi:10.1142/s0218339012400086 · Cited by 17
Circadian clocks and tumor biology: What is to learn from human skin biopsies?
Lengyel, Z., Battyáni, Z., Szekeres, G., CSERNUS, V. J., & Nagy, A. D. (2013) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2013.03.033 · Cited by 16
Circadian disruption and cisplatin chronotherapy for mammary carcinoma
Koritala, B. S. C., Porter, K. I., Sarkar, S., & Gaddameedhi, S. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.115863 · Cited by 16
Pharmacological Approaches to Hearing Loss
Cederroth, C. R., Dyhrfjeld‐Johnsen, J., & Canlon, B. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.124.001195 · Cited by 18
The Need for Antiepileptic Drug Chronotherapy to Treat Selected Childhood Epilepsy Syndromes and Avert the Harmful Consequences of Drug Resistance
Manganaro, S., Loddenkemper, T., & Rotenberg, A. (2017) · Journal of Central Nervous System Disease · doi:10.1177/1179573516685883 · Cited by 16
The expression of clock genes cry1 and cry2 in human colorectal cancer and tumor adjacent tissues correlates differently dependent on tumor location
Hasakova, K., Vician, M., Reis, R. D. F., Zeman, M., & Herichová, I. (2018) · Neoplasma · doi:10.4149/neo_2018_180122n47 · Cited by 16
Cisplatin's dual-effect on the circadian clock triggers proliferation and apoptosis
Sadiq, Z., Varghese, E., & Büsselberg, D. (2020) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2020.100054 · Cited by 16
Structural and Sequence Similarities of Hydra Xeroderma Pigmentosum A Protein to Human Homolog Suggest Early Evolution and Conservation
Barve, A., Ghaskadbi, S., & Ghaskadbi, S. (2013) · BioMed Research International · doi:10.1155/2013/854745 · Cited by 15
Post-translational Modifications of Nucleotide Excision Repair Proteins and Their Role in the DNA Repair
Rechkunova, N. I., Maltseva, E. A., & Lavrik, O. I. (2019) · Biochemistry (Moscow) · doi:10.1134/s0006297919090037 · Cited by 15
Pharmacological inhibition of cryptochrome and REV-ERB promotes DNA repair and cell cycle arrest in cisplatin-treated human cells
Anabtawi, N., Cvammen, W., & Kemp, M. G. (2021) · Scientific Reports · doi:10.1038/s41598-021-97603-x · Cited by 20
TCRP1 contributes to cisplatin resistance by preventing Pol β degradation in lung cancer cells
Liu, X., Wang, C., Gu, Y., Zhang, Z., Zheng, G., & He, Z. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2217-x · Cited by 14
Multitissue Circadian Proteome Atlas of WT and Per1−/−/Per2−/− Mice
Qian, L., Gu, Y., Zhai, Q., Xue, Z., Liu, Y., Li, S., Zeng, Y., Sun, R., Zhang, Q., Cai, X., et al. (2023) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2023.100675 · Cited by 15
HERC2 inactivation abrogates nucleolar localization of RecQ helicases BLM and WRN
Zhu, M., Wu, W., Togashi, Y., Liang, W., Miyoshi, Y., & Ohta, T. (2021) · Scientific Reports · doi:10.1038/s41598-020-79715-y · Cited by 14
The role of circadian gene CLOCK in cancer
Rashed, N., Liu, W., Zhou, X., Bode, A. M., & Luo, X. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2024.119782 · Cited by 12
The Downregulation of Both Giant HERCs, HERC1 and HERC2, Is an Unambiguous Feature of Chronic Myeloid Leukemia, and HERC1 Levels Are Associated with Leukemic Cell Differentiation
Ali, M. S., Magnati, S., Panuzzo, C., Cilloni, D., Saglio, G. N., Pergolizzi, B., & Bracco, E. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11020324 · Cited by 12
The XPA Protein—Life under Precise Control
Krasikova, Y. S., Lavrik, O. I., & Rechkunova, N. I. (2022) · Cells · doi:10.3390/cells11233723 · Cited by 12
Clock in radiation oncology clinics: cost-free modality to alleviate treatment-related toxicity
Ali, Y. F., Hong, Z., Liu, N., & Zhou, G. (2022) · Cancer Biology & Therapy · doi:10.1080/15384047.2022.2041953 · Cited by 13
Analysis of DNA-damage response to ionizing radiation in serum-shock synchronized human fibroblasts
Corrà, S., Salvadori, R., Bee, L., Barbieri, V., & Mognato, M. (2017) · Cell Biology and Toxicology · doi:10.1007/s10565-017-9394-9 · Cited by 13
DNA Repair Repertoire of the Enigmatic Hydra
Barve, A., Galande, A. A., Ghaskadbi, S., & Ghaskadbi, S. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.670695 · Cited by 11
Role of Type II Protein Arginine Methyltransferase 5 in the Regulation of Circadian Per1 Gene
Na, J., Lee, K., Kim, H.-G., Shin, J.-Y., Na, W., Jeong, H., Lee, J., Cho, S., Kim, W., & Ju, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048152 · Cited by 11
Circadian function in cancer: Regulating the DNA damage response
Ramsey, M. R., & Ellisen, L. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107319108 · Cited by 12
Trichosanthesï¿½kirilowii extract enhances repair of UVB radiation‑induced DNA damage by regulating BMAL1 and miR‑142‑3p in human keratinocytes
Joo, J., Hong, I., Kim, N., & Choi, E. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7932 · Cited by 11
Cross Talk between the Circadian Clock Proteins and TP53 in Cancer and Therapeutic Significance
Valafar, B., Zaravinos, A., & Bonavida, B. (2021) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.2022042860 · Cited by 11
The circadian clock, aging and its implications in cancer
Rezaeian, A.-H., Dang, F., & Wei, W. (2023) · Neoplasia · doi:10.1016/j.neo.2023.100904 · Cited by 10
The impact of training shifts in dancers’ chronotype and sleep patterns
Coirolo, N., Silva, A., & Tassino, B. (2020) · Sleep Science · doi:10.5935/1984-0063.20200010 · Cited by 10
Does evening sun increase the risk of skin cancer?
MITRA, S. P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116516108 · Cited by 11
Mechanismen der DNA‐Reparatur durch Photolyasen und Exzisionsnukleasen (Nobel‐Aufsatz)
Sancar, A. (2016) · Angewandte Chemie · doi:10.1002/ange.201601524 · Cited by 10
Self-citation
A diagnostic model for Parkinson’s disease based on circadian rhythm-related genes
Wang, L., Bao, Y., Duan, X., Li, H., Ding, H., Yu, F., Yang, J., Hu, Y., & Huang, D. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05424-z · Cited by 9
Perfluorooctane sulfonate induced ferritinophagy via detyrosinated alpha tubulin-TRIM21-HERC2-regulated NCOA4 degradation in hepatocytes
Feng, R., Hu, L., Yang, W., Liang, P., Li, Y., Tian, K., Wang, K., Qiu, T., Zhang, J., Sun, X., et al. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.126101 · Cited by 9
Therapeutic potential of ginsenosides in circadian rhythm-based skin disorders
Ha, H., Shin, H., Min, S., Sutopo, N. C., Yerkesh, K., Jung, E., Song, M., Cho, J. Y., & Lee, J. (2025) · Journal of Ginseng Research · doi:10.1016/j.jgr.2025.04.004 · Cited by 9
Circadian clock, cell cycle, and breast cancer: an updated review
Sultan, A., Parganiha, A., Sultan, T., Choudhary, V., & Pati, A. K. (2016) · Biological Rhythm Research · doi:10.1080/09291016.2016.1263011 · Cited by 9
Using genetics to predict patient response to platinum-based chemotherapy
Karachaliou, N., Moreno, M. D. L. L. G. G., Sosa, A. E., Santarpía, M., Lazzari, C., Capote, A. R., Massutí, B., & Rosell, R. (2017) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2017.1298969 · Cited by 9
Rhythms of risk: the intersection of clocks, cancer, and chronotherapy
Mello, R. M., Masri, S., & Lamia, K. A. (2026) · Journal of Clinical Investigation · doi:10.1172/jci198780 · Cited by 10
Establishment of a Microplate‐Formatted Cell‐Based Immunoassay for Rapid Analysis of Nucleotide Excision Repair Ability in Human Primary Cells
Nishinaga, M., Kurata, R., ONISHI, K., Kuriyama, K., Wakasugi, M., & Matsunaga, T. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01073.x · Cited by 8
Deregulation of the circadian clock constitutes a significant factor in tumorigenesis: a clockwork cancer. Part I: clocks and clocking machinery
Uth, K., & Sleigh, R. (2014) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2014.915155 · Cited by 8
Alcohol Effects on Colon Epithelium are Time‐Dependent
Bishehsari, F., Zhang, L., Voigt, R. M., Maltby, N., Semsarieh, B., ZORUB, E., Shaikh, M. W., Wilber, S., Armstrong, A., Mirbagheri, S., et al. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14141 · Cited by 8
Sunlight-Induced DNA Damage: Molecular Mechanisms and Photoprotection Strategies
Douki, T. (2016) · Springer eBooks · doi:10.1007/978-3-319-43157-4_3 · Cited by 8
Melatonin improves the vitrification of sheep morulae by modulating transcriptome
Ji, P., Liu, Y., Yan, L., Jia, Y., Zhao, M., Lv, D., Yao, Y., Ma, W., Yin, D., Liu, F., et al. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2023.1212047 · Cited by 7
Idarubicin combats abiraterone and enzalutamide resistance in prostate cells via targeting XPA protein
Zhang, Y., Wei, W., Li, C., Wang, S., Wang, S., Xiao, S., He, C., Qi, Z., Qi, Z., Li, B., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05490-5 · Cited by 8
Flavonoid Nobiletin Exhibits Differential Effects on Cell Viability in Keratinocytes Exposed to UVA versus UVB Radiation
Cvammen, W., & Kemp, M. G. (2022) · Photochemistry and Photobiology · doi:10.1111/php.13625 · Cited by 6
The REV‐ERB antagonist SR8278 modulates keratinocyte viability in response to UVA and UVB radiation
Cvammen, W., & Kemp, M. G. (2024) · Photochemistry and Photobiology · doi:10.1111/php.13930 · Cited by 6
Peptidomic analysis of blastocyst culture medium and the effect of peptide derived from blastocyst culture medium on blastocyst formation and viability
Ji, H., Shi, X., Wang, J., Cao, S., Ling, X., Zhang, J., Shen, R., & Zhao, C. L. (2019) · Molecular Reproduction and Development · doi:10.1002/mrd.23308 · Cited by 6
Efficacy and Safety of Systemic and Locoregional Cisplatin Chronotherapy in Rats with Ovarian Carcinoma
Kireeva, G. S., Александровна, Г. Е., Александрович, М. М., Osetnik, V. K., Круглов, С. С., Панченко, А. В., Dorofeeva, A. A., Тындык, М. Л., Федорос, Е. И., & Anisimov, V. N. (2021) · OncoTargets and Therapy · doi:10.2147/ott.s309285 · Cited by 6
Understanding the crosstalk of molecular factors and signaling pathways reveals novel biomarkers of cisplatin resistance in testicular germ cell tumors
Roška, J., & Jurkovičová, D. (2019) · Neoplasma · doi:10.4149/neo_2019_190318n244 · Cited by 5
Transcription factors, nucleotide excision repair, and cancer: A review of molecular interplay
Guneri-Sozeri, P. Y., & Adebalı, O. (2024) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2024.106724 · Cited by 6
Chronobiology in the wild: toolkit to study daily rhythms in free-living animals
Silvério, J. T., & Tachinardi, P. (2020) · Sleep Science · doi:10.5935/1984-0063.20200020 · Cited by 5
Fetal programming of adipose tissue function by gestational chronodisruption
Halabí, D., Ehrenfeld, P., Méndez, N., Hans, G. H. R., & Torres‐Farfan, C. (2020) · Sleep Science · doi:10.5935/1984-0063.20200014 · Cited by 8
Logic of the Temporal Compartmentalization of the Hepatic Metabolic Cycle
Zhu, B. (2022) · Physiology · doi:10.1152/physiol.00003.2022 · Cited by 4
Circadian control of cisplatin-DNA adduct repair and apoptosis in culture cells
Jeon, J., Lee, S.-G., Park, J., Lee, T.-H., & Kang, T. (2023) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2023.106454 · Cited by 4
Self-citation
Nucleotides and nucleic acids; oligo- and polynucleotides
Loakes, D. (2012) · Royal Society of Chemistry eBooks · doi:10.1039/9781849734875-00169 · Cited by 4
XPA is susceptible to proteolytic cleavage by cathepsin L during lysis of quiescent cells
Khan, S., Cvammen, W., Anabtawi, N., Choi, J., & Kemp, M. G. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103260 · Cited by 4
The ZZ domain of HERC2 is a receptor of arginylated substrates
Tencer, A. H., Liu, J., Zhu, J., Burkholder, N. T., Zhang, Y., Wu, W., Strahl, B. D., Ohta, T., & Kutateladze, T. G. (2022) · Scientific Reports · doi:10.1038/s41598-022-10119-w · Cited by 4
Electrocortical temporal complexity during wakefulness and sleep: an updated account
González, J., Cavelli, M., Mondino, A., Pascovich, C., Castro‐Zaballa, S., Rubido, N., & Torterolo, P. (2020) · Sleep Science · doi:10.5935/1984-0063.20200013 · Cited by 6
A PDZ scaffolding/ CaM ‐mediated pathway in Cryptochrome signaling
Bellanda, M., Damulewicz, M., Zambelli, B., Costanzi, E., Gregoris, F., Mammi, S., Tosatto, S. C. E., Costa, R., Minervini, G., & Mazzotta, G. M. (2024) · Protein Science · doi:10.1002/pro.4914 · Cited by 3
Sleep and maternal behavior in the postpartum rat after haloperidol and midazolam treatments
Peña, F., Rivas, M., González, J., Schwarzkopf, N., Torterolo, P., Ferreira, A., & Benedetto, L. (2020) · Sleep Science · doi:10.5935/1984-0063.20200019 · Cited by 4
Social modulation on daily variability in electric behavior
Gascue, V., da Silva, A. C. R., & Migliaro, A. (2020) · Sleep Science · doi:10.5935/1984-0063.20200012 · Cited by 6
Circadian Post-transcriptional Control of Metabolism
Green, C. B. (2016) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-319-27069-2_5 · Cited by 4
Circadian Rhythms, Physical and Mental Health
Hennion, V., & Étain, B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819641-0.00115-8 · Cited by 4
Targeting the Golgi apparatus enhances PD-L1 blockade and synergizes with oxaliplatin to improve immunotherapy efficacy
Li, H., Cui, C., Sun, C., Chen, Z., Gao, D., Yuan, P., Tian, S., Zhong, Q., Xu, F., Liang, X., et al. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111343 · Cited by 3
A tale of two cities: A tribute to Aziz Sancar's Nobel Prize in Chemistry for his molecular characterization of NER
Houten, B. V. (2016) · DNA repair · doi:10.1016/j.dnarep.2015.12.002 · Cited by 3
Introduction to Mammalian Circadian Clock System
Zhao, M., Lu, D., Chen, M., & Wu, B. (2020) · Springer eBooks · doi:10.1007/978-981-15-8807-5_1 · Cited by 4
Untitled work
(2013) · Digital Commons - East Tennessee State University (East Tennessee State University) · Cited by 3
Circadian rhythms and new options for novel anticancer therapies
Zmrzljak, U. P. (2015) · ChronoPhysiology and Therapy · doi:10.2147/cpt.s54541 · Cited by 3
Wavelengths and temporal effects on the response of mammalian cells to UV radiation: Limitations of action spectra illustrated by genotoxicity
Douki, T. (2021) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2021.112169 · Cited by 3
Biochemistry That Times the Day
Egli, M., & Johnson, C. H. (2014) · Biochemistry · doi:10.1021/bi5014968 · Cited by 3
Response to “XPA is primarily cytoplasmic but is transported into the nucleus upon UV damage”
Wood, R. D., Manandhar, M., Lowery, M. G., Boulware, K. S., Lin, K., & Lu, Y. (2018) · DNA repair · doi:10.1016/j.dnarep.2018.01.002 · Cited by 3
The Interplay Between Circadian Clocks and the Tumour Microenvironment in Breast Cancer
Finger, A., Ector, C., & Weaver, V. M. (2026) · Cancers · doi:10.3390/cancers18060925 · Cited by 2

Authors: Kang, T.-H., Lindsey-Boltz, L. A., Reardon, J. T., & Sancar, A.
Affiliations: University of North Carolina at Chapel Hill (US)
Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599
Corresponding author: Sancar, Aziz
ORCID: Kang, Tae-Hong
Sancar, Aziz
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2010-03-16
Volume: 107
Issue: 11
Pages: 4890-4895
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0915085107
PMC: PMC2841896
OpenAlex: W2164742545
Cited by: 250
References: 50
Citations by year: 2026: 13 · 2025: 5 · 2024: 11 · 2023: 13 · 2022: 14 · 2021: 16 · 2020: 33 · 2019: 17 · 2018: 14 · 2017: 15 · 2016: 19 · 2015: 12 · 2014: 16 · 2013: 15 · 2012: 16
FWCI: 7.43
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: University of Pittsburgh
National Institutes of Health (GM31082)
National Institute of General Medical Sciences (R01GM032833, R01GM031082, GM310.82, R37GM031082, GM32833)
National Institute of Environmental Health Sciences (P30ES010126)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
Keywords: circadian clock, XPA, nucleotide excision repair, cisplatin, DNA repair, cryptochrome, post-translational regulation, transcriptional regulation, liver, testis, chemotherapy timing, DNA adducts
MeSH terms: Animals, Biological Clocks, Cell Line, Circadian Rhythm, Cisplatin, DNA Damage, DNA Repair, Humans, Liver, Male, Protein Binding, Protein Processing, Post-Translational, RNA, Messenger, Testis, Time Factors, Tissue Extracts, Down-Regulation, DNA Adducts, Guanine Nucleotide Exchange Factors, Ubiquitin-Protein Ligases, Mice, Xeroderma Pigmentosum Group A Protein, Cryptochromes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks