The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Hybrid PET-optical imaging using targeted probes
Open accessAbstract
Fusion imaging of radionuclide-based molecular (PET) and structural data [x-ray computed tomography (CT)] has been firmly established. Here we show that optical measurements [fluorescence-mediated tomography (FMT)] show exquisite congruence to radionuclide measurements and that information can be seamlessly integrated and visualized. Using biocompatible nanoparticles as a generic platform (containing a 18 F isotope and a far red fluorochrome), we show good correlations between FMT and PET in probe concentration ( r 2 > 0.99) and spatial signal distribution ( r 2 > 0.85). Using a mouse model of cancer and different imaging probes to measure tumoral proteases, macrophage content and integrin expression simultaneously, we demonstrate the distinct tumoral locations of probes in multiple channels in vivo. The findings also suggest that FMT can serve as a surrogate modality for the screening and development of radionuclide-based imaging agents.
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Cites
Identification of splenic reservoir monocytes and their deployment to inflammatory sites
Swirski, F. K., Nahrendorf, M., Etzrodt, M., Wildgruber, M., Cortez-Retamozo, V., Panizzi, P., Figueiredo, J.-L., Kohler, R. H., Chudnovskiy, A., Waterman, P., et al. (2009) · Science · doi:10.1126/science.1175202 · Cited by 2,221
Self-citationDesign considerations for tumour-targeted nanoparticles
Choi, H. S., Liu, W., Liu, F., Nasr, K., Misra, P., Bawendi, M. G., & Frangioni, J. V. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2009.314 · Cited by 754
Biodegradable dendritic positron-emitting nanoprobes for the noninvasive imaging of angiogenesis
Almutairi, A., Rossin, R., Shokeen, M., Hagooly, A., Ananth, A., Capoccia, B., Guillaudeu, S., Abendschein, D., Anderson, C. J., Welch, M. J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811757106 · Cited by 235
Monocyte Subset Dynamics in Human Atherosclerosis Can Be Profiled with Magnetic Nano-Sensors
Wildgruber, M., Lee, H., Chudnovskiy, A., Yoon, T.-J., Etzrodt, M., Pittet, M. J., Nahrendorf, M., Croce, K., Libby, P., Weissleder, R., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005663 · Cited by 54
Self-citation
Cited by
Ernsting, M. J., Murakami, M., Roy, A., & Li, S.-D. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.09.013 · Cited by 1,012
Nanomedicine(s) under the Microscope
Duncan, R., & Gaspar, R. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200394t · Cited by 981
Therapeutic siRNA silencing in inflammatory monocytes in mice
Leuschner, F., Dutta, P., Gorbatov, R., Novobrantseva, T. I., Donahoe, J. S., Courties, G., Lee, K. M., Kim, J. I., Markmann, J. F., Marinelli, B., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1989 · Cited by 839
Self-citationThe role of myeloid cells in cancer therapies
Engblom, C., Pfirschke, C., & Pittet, M. J. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.54 · Cited by 788
Self-citationImaging macrophages with nanoparticles
Weissleder, R., Nahrendorf, M., & Pittet, M. J. (2014) · Nature Materials · doi:10.1038/nmat3780 · Cited by 809
Metadata
- Authors
- Nahrendorf, M., Keliher, E., Marinelli, B., Waterman, P., Feruglio, P. F., Fexon, L., Pivovarov, M., Swirski, F. K., Pittet, M. J., Vinegoni, C., & Weissleder, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-04-12
- Volume
- 107
- Issue
- 17
- Pages
- 7910-7915
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2106666760
- Cited by
- 222
- References
- 4
- FWCI
- 19.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Nahrendorf, M., Keliher, E., Marinelli, B., Waterman, P., Feruglio, P. F., Fexon, L., Pivovarov, M., Swirski, F. K., Pittet, M. J., Vinegoni, C., & Weissleder, R. (2010). Hybrid PET-optical imaging using targeted probes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0915163107
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