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Ancient origin of the integrin-mediated adhesion and signaling machinery

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Sebé-Pedrós, Arnau, Roger, Andrew J., Lang, Franz B., King, Nicole, Ruiz-Trillo, Iñaki·2010·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1002257107
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Abstract

The evolution of animals (metazoans) from their unicellular ancestors required the emergence of novel mechanisms for cell adhesion and cell–cell communication. One of the most important cell adhesion mechanisms for metazoan development is integrin-mediated adhesion and signaling. The integrin adhesion complex mediates critical interactions between cells and the extracellular matrix, modulating several aspects of cell physiology. To date this machinery has been considered strictly metazoan specific. Here we report the results of a comparative genomic analysis of the integrin adhesion machinery, using genomic data from several unicellular relatives of Metazoa and Fungi. Unexpectedly, we found that core components of the integrin adhesion complex are encoded in the genome of the apusozoan protist Amastigomonas sp., and therefore their origins predate the divergence of Opisthokonta, the clade that includes metazoans and fungi. Furthermore, our analyses suggest that key components of this apparatus have been lost independently in fungi and choanoflagellates. Our data highlight the fact that many of the key genes that had formerly been cited as crucial for metazoan origins have a much earlier origin. This underscores the importance of gene cooption in the unicellular-to-multicellular transition that led to the emergence of the Metazoa.

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Metadata

Authors
Sebé-Pedrós, A., Roger, A. J., Lang, F. B., King, N., & Ruiz-Trillo, I.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2010-05-17
Volume
107
Issue
22
Pages
10142-10147
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1002257107
OpenAlex
W2152824691
Cited by
254
References
7
FWCI
13.77
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Ancient origin of the integrin-mediated adhesion and signaling machinery. https://app.cochat.ai/papers/10.1073/pnas.1002257107
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Sebé-Pedrós, A., Roger, A. J., Lang, F. B., King, N., & Ruiz-Trillo, I. (2010). Ancient origin of the integrin-mediated adhesion and signaling machinery. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1002257107

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