The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
Open accessAbstract
Otto Warburg's theory on the origins of cancer postulates that tumor cells have defects in mitochondrial oxidative phosphorylation and therefore rely on high levels of aerobic glycolysis as the major source of ATP to fuel cellular proliferation (the Warburg effect). This is in contrast to normal cells, which primarily utilize oxidative phosphorylation for growth and survival. Here we report that the major function of glucose metabolism for Kras-induced anchorage-independent growth, a hallmark of transformed cells, is to support the pentose phosphate pathway. The major function of glycolytic ATP is to support growth under hypoxic conditions. Glutamine conversion into the tricarboxylic acid cycle intermediate alpha-ketoglutarate through glutaminase and alanine aminotransferase is essential for Kras-induced anchorage-independent growth. Mitochondrial metabolism allows for the generation of reactive oxygen species (ROS) which are required for Kras-induced anchorage-independent growth through regulation of the ERK MAPK signaling pathway. We show that the major source of ROS generation required for anchorage-independent growth is the Q o site of mitochondrial complex III. Furthermore, disruption of mitochondrial function by loss of the mitochondrial transcription factor A (TFAM) gene reduced tumorigenesis in an oncogenic Kras-driven mouse model of lung cancer. These results demonstrate that mitochondrial metabolism and mitochondrial ROS generation are essential for Kras-induced cell proliferation and tumorigenesis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Providing cells with αKG, oxaloacetate, or pyruvate is sufficient to rescue cancer cell proliferation in conditions of glutamine starvation, confirming that glutamine supports proliferation by replenishing depleted TCA cycle intermediates, a process termed anaplerosis (Altman et al., 2016; Weinberg et al., 2010; Yuneva et al., 2007).”
From Targeting Metabolism for Cancer Therapy (2017) · cites this paper as Weinberg et al., 2010
In the citing paper
“However, KRAS has also been shown to promote cancer cell growth by stimulating alanine aminotransferase activity, leading to high levels of α-ketoglutarate for the TCA cycle and mitochondrial ROS generation, which was required for mutant KRAS-driven tumorigenesis in a mouse model of lung cancer64.”
From The metabolic landscape of RAS-driven cancers from biology to therapy (2021) · cites this paper as [64]
In the citing paper
“A low level of reactive oxygen species (ROS) activates tumorigenic growth signaling; however, when the level exceeds the cellular redox capacity, ROS can damage macromolecules such as proteins, lipids and nucleotides55.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [55]
In the citing paper
“Correspondingly, in K-Ras mutant cells, the oxygen consumption rate and ATP generation are enhanced by glutamine, contributing to tumorigenesis55.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [55]
In the citing paper
“Notably, alanine levels were significantly decreased in Mpc knockdown cells, highlighting a role for mitochondrial pyruvate and mitochondrial alanine aminotransferase (ALT2) in mediating glutamine anaplerosis which was previously described in cancer cells (Weinberg et al., 2010).”
From Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier (2014) · cites this paper as Weinberg et al., 2010
In the citing paper
“Another study reported that mitochondrial ROS are necessary for the KRAS (Kirsten rat sarcoma virus)—induced anchored-independent growth of lung cancer.”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Weinberg et al. 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088
On Respiratory Impairment in Cancer Cells
Warburg, O. H. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,472
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06734 · Cited by 2,820
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622
Gao, P., Tchernyshyov, I., Chang, T.-C., Lee, Y.-S., Kita, K., Ochi, T., Zeller, K. I., De Marzo, A. M., Van Eyk, J. E., Mendell, J. T., et al. (2009) · Nature · doi:10.1038/nature07823 · Cited by 2,124
Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001
Hypoxia, HIF1 and glucose metabolism in the solid tumour
Denko, N. C. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2468 · Cited by 1,707
Fantin, V. R., St-Pierre, J., & Leder, P. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.04.023 · Cited by 1,635
Flagged first, then by citations
Cited by
Sorted by citations
Items 901–1,000 of 1,001
Cellular metabolism in pancreatic cancer as a tool for prognosis and treatment (Review)
Zuzčák, M., & Trnka, J. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5383 · Cited by 33
Xu, J., Zhu, K., Wang, Y., & Chen, J. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04447-7 · Cited by 32
Mitochondrial genome instability in colorectal adenoma and adenocarcinoma
de Araújo, L. F., Fonseca, A. S., Muys, B. R., Plaça, J. R., Bueno, R. D. B. E. L., Lorenzi, J. C. C., dos Santos, A. R. D., de Molfetta, G. A., Zanette, D. L., de Souza, J. E. S., et al. (2015) · Tumor Biology · doi:10.1007/s13277-015-3640-7 · Cited by 32
Jeong, S. H., Song, I. S., Kim, H. K., Lee, S. R., Song, S., Suh, H., Yoon, Y. G., Yoo, Y. H., Kim, N., Rhee, B. D., et al. (2012) · Molecules and Cells · doi:10.1007/s10059-012-0081-7 · Cited by 32
Tang, S., Yang, L., Tang, X., & Liu, M. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.07.028 · Cited by 33
Oxidative Stress Response Biomarkers of Ovarian Cancer Based on Single-Cell and Bulk RNA Sequencing
Zheng, M., Hu, Y., Liu, O., Li, S., Wang, Y., Li, X., Liu, J., Yang, Q. F., Li, X., & Lin, B. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/1261039 · Cited by 31
How the Disruption of Mitochondrial Redox Signalling Contributes to Ageing
Castejón‐Vega, B., Cordero, M. D., & Sanz, A. (2023) · Antioxidants · doi:10.3390/antiox12040831 · Cited by 32
Skildum, A. J., Dornfeld, K. J., & Wallace, K. B. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1268-2 · Cited by 32
Glutamine, Glucose and other Fuels for Cancer
Ruiz-Pérez, M. V., Sánchez‐Jiménez, F., Alonso, F. J., Segura, J., Márquez, J., & Medina, M. Á. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990482 · Cited by 31
Toxico‐Metabolomics of Engineered Nanomaterials: Progress and Challenges
Ahmad, F., Wang, X., & Li, W. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201904268 · Cited by 31
Kalyanaraman, B. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101665 · Cited by 31
Self-citationZheng, B., Wu, L., Ma, L., Liu, S., Li, L., Xie, W., & Li, X. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b13-00058 · Cited by 31
Reactive Oxygen Species and Oncoprotein Signaling-A Dangerous Liaison
Chong, S. J. F., Lai, J. X. H., Eu, J. Q., Bellot, G. L., & Pervaiz, S. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7441 · Cited by 30
Anderson, R. G., Pladna, K. M., Schramm, N. J., Wheeler, F. B., Kridel, S. J., & Pardee, T. S. (2023) · Cancers · doi:10.3390/cancers15020484 · Cited by 29
Beyond cell cycle regulation: The pleiotropic function of CDK4 in cancer
Ziegler, D. V., Parashar, K., & Fajas, L. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.12.002 · Cited by 32
Lee, H. M., Muhammad, N., Lieu, E. L., Cai, F., Mu, J., Ha, Y., Cao, G., Suchors, C., Joves, K., Chronis, C., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01066-z · Cited by 33
CRISPR-StAR enables high-resolution genetic screening in complex in vivo models
Uijttewaal, E. C. H., Lee, J., Sell, A. C., Botay, N., Vainorius, G., Novatchkova, M., Baar, J. C., Yang, J., Potzler, T., Leij, S., et al. (2024) · Nature Biotechnology · doi:10.1038/s41587-024-02512-9 · Cited by 35
Functional mitochondrial respiration is essential for glioblastoma tumour growth
Brisudová, P., Stojanovic, D., Novák, J., Nahácka, Z., Oliveira, G. L., Vaňátko, O., Dvorakova, S., Endaya, B., Truksa, J., Kubiskova, M., et al. (2025) · Oncogene · doi:10.1038/s41388-025-03429-6 · Cited by 29
Cancer metabolomics in basic science perspective
Kwon, H. N., Oh, S., Jin, X., An, Y., & Park, S. (2015) · Archives of Pharmacal Research · doi:10.1007/s12272-015-0552-4 · Cited by 32
Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation
Bettoun, A., Joffre, C., Zago, G., Surdez, D., Vallerand, D., Gündoğdu, R., Sharif, A. A. D., Gómez-Ferrer, M., Cascone, I., Meunier, B., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9875 · Cited by 31
Pseudo‑Ginsenoside Rh2 induces A549 cells apoptosis via the Ras/Raf/ERK/p53 pathway
Wang, Y., Xu, H., Lu, Z., Yu, X., Lv, C., Tian, Y., & Sui, D. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6067 · Cited by 30
Shang, Y., Zhang, F., Li, D., Li, C., Li, H., Jiang, Y., & Zhang, D. (2018) · Pathology - Research and Practice · doi:10.1016/j.prp.2018.08.012 · Cited by 30
Methionine supplementation stimulates mitochondrial respiration
Tripodi, F., Castoldi, A., Nicastro, R., Reghellin, V., Lombardi, L., Airoldi, C., Falletta, E., Maffioli, E., Scarcia, P., Palmieri, L., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.09.007 · Cited by 31
Aberrant mitochondrial function in ageing and cancer
Whitehall, J. C., & Greaves, L. C. (2019) · Biogerontology · doi:10.1007/s10522-019-09853-y · Cited by 34
Mitochondria-targeted compounds in the treatment of cancer
Kafkova, A., & Trnka, J. (2020) · Neoplasma · doi:10.4149/neo_2020_190725n671 · Cited by 30
Protective effects of curcumin on chemical and drug-induced cardiotoxicity: a review
Yarmohammadi, F., Hayes, A. W., & Karimi, G. (2021) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-021-02072-8 · Cited by 31
Pal, D., Rai, A., Checker, R., Patwardhan, R. S., Singh, B., Sharma, D., & Sandur, S. K. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108890 · Cited by 29
Daraei, H., Toolabian, K., Thompson, I. P., & Qiu, G. (2021) · Frontiers of Environmental Science & Engineering · doi:10.1007/s11783-021-1453-z · Cited by 30
Cancer Metabostemness and Metabolic Reprogramming via P2X7 Receptor
Rabelo, I. L. A., Arnaud-Sampaio, V. F., Adinolfi, E., Ulrich, H., & Lameu, C. (2021) · Cells · doi:10.3390/cells10071782 · Cited by 30
Ahn, J. S., Li, J., Chen, E., Kent, D. G., Park, H. J., & Green, A. R. (2015) · Oncogene · doi:10.1038/onc.2015.285 · Cited by 31
Wang, S., Wu, X., Bi, W., Xu, J., Hou, L., Li, G., Pan, Y., Zhang, H., Li, M., Du, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56444-2 · Cited by 29
Dai, H., Zhao, K., Zhao, Y., Jiang, K., Hang, Z., Huang, X., Luo, W., Nie, J., Qin, C., & Zhou, W. (2025) · BMC Urology · doi:10.1186/s12894-025-01914-4 · Cited by 29
Zhang, S., Yang, C., Yang, Z., Zhang, D., Ma, X., Mills, G. B., & Liu, Z. (2015) · Europe PMC (PubMed Central) · Cited by 29
RetractedTumour microenvironment on mitochondrial dynamics and chemoresistance in cancer
Han, Y., Cho, U., Kim, S., Park, I. S., Cho, J., Dhanasekaran, D. N., & Song, Y. S. (2018) · Free Radical Research · doi:10.1080/10715762.2018.1459594 · Cited by 28
Glucose Metabolites Exert Opposing Roles in Tumor Chemoresistance
Huang, C., Huang, C., Pai, Y.-C., Lin, B., Lee, T., Liang, P., & Yu, L. C. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01282 · Cited by 29
Cheng, G., Hardy, M., Zielonka, J., Weh, K. M., Zielonka, M., Boyle, K. A., AbuEid, M., McAllister, D. M., Bennett, B., Kresty, L. A., et al. (2020) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2020.100210 · Cited by 29
Self-citationAlrumaihi, F., Khan, M. A., Allemailem, K. S., Alsahli, M. A., Almatroudi, A., Younus, H., Alsuhaibani, S. A., Algahtani, M., & Khan, A. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s300025 · Cited by 33
Ge, C., Wang, Y., Feng, Y., Wang, S., Zhang, K., Xu, X., Zhang, Z., Zhao, Y., Wang, Y., Gao, L., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.06.015 · Cited by 29
Ravera, S., Bertola, N., Pasquale, C., Bruno, S., Benedicenti, S., Ferrando, S., Zekiy, A. O., Arany, P. R., & Amaroli, A. (2021) · Biomedicines · doi:10.3390/biomedicines9111717 · Cited by 29
Advances in metformin‑based metabolic therapy for non‑small cell lung cancer (Review)
Chen, N., Zhou, Y.-S., Wang, L.-C., & Huang, J. (2022) · Oncology Reports · doi:10.3892/or.2022.8266 · Cited by 29
Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability
Ghosh, J. C., Perego, M., Agarwal, E., Bertolini, I., Wang, Y., Goldman, A. R., Tang, H., Kossenkov, A. V., Landis, C. J., Languino, L. R., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2115624119 · Cited by 29
Organic Selenium induces ferroptosis in pancreatic cancer cells
Noè, R., Inglese, N., Romani, P., Serafini, T., Paoli, C., Calciolari, B., Fantuz, M., Zamborlin, A., Surdo, N. C., Spada, V., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102962 · Cited by 30
Liu, Z., Liu, J., Li, L., Nie, D., Tao, Q., Wu, J., Fan, J., Lin, C., Zhao, S., & Ju, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135236 · Cited by 29
Li, W., Li, X., Wang, W., Yi, M., Zhou, Y., Zheng, P., Xiong, W., Yang, J., Peng, S., McCarthy, J. B., et al. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.020 · Cited by 29
Friend or Foe? Mitochondria as a Pharmacological Target in Cancer Treatment
Dickerson, T., Jauregui, C. E., & Teng, Y. (2017) · Future Medicinal Chemistry · doi:10.4155/fmc-2017-0110 · Cited by 28
Chen, D., Sun, X., Zhang, X., & Cao, J. (2018) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22195 · Cited by 29
Rai, P., & Sobol, R. W. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.03.001 · Cited by 28
Contributing factors to the oxidation-induced mutational landscape in human cells
Cordero, C., Mehta, K. P. M., Weaver, T., Ling, J. A., Freudenthal, B., Cortez, D., & Roberts, S. A. (2024) · Nature Communications · doi:10.1038/s41467-024-55497-z · Cited by 36
Shi, Y.-L., Feng, S., Chen, W., Hua, Z.-C., Bian, J.-J., & Yin, W. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.547 · Cited by 28
Identification of a redox-modulatory interaction between selenoprotein W and 14-3-3 protein
Jeon, Y. H., Ko, K. Y., Lee, J. H., Park, K., Jang, J. K., & Kim, I. Y. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.10.006 · Cited by 28
Mieap-regulated mitochondrial quality control is frequently inactivated in human colorectal cancer
Kamino, H., Nakamura, Y., Tsuneki, M., Sano, H., Miyamoto, Y., Kitamura, N., Futamura, M., Kanai, Y., Taniguchi, H., Shida, D., et al. (2016) · Oncogenesis · doi:10.1038/oncsis.2015.43 · Cited by 30
Spotlight on the relevance of mtDNA in cancer
Cruz‐Bermúdez, A., Vicente-Blanco, R. J., González‐Vioque, E., Provencio, M., Fernández‐Moreno, M. Á., & Garesse, R. (2016) · Clinical & Translational Oncology · doi:10.1007/s12094-016-1561-6 · Cited by 29
Zhou, W.-X., Chen, C., Liu, X., Li, Y., Lin, Y., Wu, X.-T., Kong, L., & Luo, J. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112980 · Cited by 28
The ER-mitochondria Ca2+ signaling in cancer progression: Fueling the monster
Bustos, G., Ahumada-Castro, U., Silva-Pavez, E., Puebla, A., Lovy, A., & Cárdenas, C. (2021) · International review of cytology · doi:10.1016/bs.ircmb.2021.03.006 · Cited by 28
Emerging Roles of NDUFS8 Located in Mitochondrial Complex I in Different Diseases
Wang, S., Kang, Y., Wang, R., Deng, J., Yu, Y., Yu, J. J., & Wang, J. (2022) · Molecules · doi:10.3390/molecules27248754 · Cited by 28
Pheochromocytoma: Gasping for Air
Jochmanová, I., Zhuang, Z., & Pacák, K. (2015) · Hormones and Cancer · doi:10.1007/s12672-015-0231-4 · Cited by 30
Real-Time in Vivo Detection of H2O2 Using Hyperpolarized 13C-Thiourea
Wibowo, A., Park, J. M., Liu, S.-C., Khosla, C., & Spielman, D. M. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.7b00130 · Cited by 28
Doxycycline targets aldehyde dehydrogenase‑positive breast cancer stem cells
Lin, C.-C. A., Lo, M., Moody, R., Stevers, N. O., Tinsley, S. L., & Sun, D. (2018) · Oncology Reports · doi:10.3892/or.2018.6337 · Cited by 28
Wang, X., & Xiong, X. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s510972 · Cited by 28
Proteomic signatures associated with p53 mutational status in lung adenocarcinoma
Taguchi, A., Delgado, O., Çeliktaş, M., Katayama, H., Wang, H., Gazdar, A. F., & Hanash, S. (2014) · PROTEOMICS · doi:10.1002/pmic.201400378 · Cited by 28
Niu, Y., Pan, D., Shi, D., Bai, Q., Liu, H., & Yao, X. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145219 · Cited by 28
PKC epsilon is a Key Regulator of Mitochondrial Redox Homeostasis in Acute Myeloid Leukemia
Marcantonio, D. D., Martinez, E., Sidoli, S., Vadaketh, J., Nieborowska-Skorska, M., Gupta, A., Meadows, J., Ferraro, F., Masselli, E., Challen, G. A., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2684 · Cited by 20
The application of metabolomics in ovarian cancer management: a systematic review
Ahmed-Salim, Y., Galazis, N., Bracewell‐Milnes, T., Phelps, D. L., Jones, B. P., Chan, M. F., Muñoz-Gonzalez, M. D., Matsuzono, T., Smith, J. R., Yazbek, J., et al. (2020) · International Journal of Gynecological Cancer · doi:10.1136/ijgc-2020-001862 · Cited by 29
Subramanian, V., Rodemoyer, B., Shastri, V. M., Rasmussen, L. J., Desler, C., & Schmidt, K. H. (2021) · Scientific Reports · doi:10.1038/s41598-021-81075-0 · Cited by 26
Gal, K. L., Wiel, C., Ibrahim, M. X., Henricsson, M., Sayin, V. I., & Bergö, M. O. (2021) · Antioxidants · doi:10.3390/antiox10020163 · Cited by 26
Escaping KRAS: Gaining Autonomy and Resistance to KRAS Inhibition in KRAS Mutant Cancers
Adachi, Y., Kimura, R., Hirade, K., & Ebi, H. (2021) · Cancers · doi:10.3390/cancers13205081 · Cited by 28
Cáceres-Gutiérrez, R. E., Alfaro‐Mora, Y., Andonegui, M. A., Díaz‐Chávez, J., & Herrera, L. A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.751367 · Cited by 28
Mitochondrial metabolic determinants of multiple myeloma growth, survival, and therapy efficacy
Nair, R., Gupta, P., & Shanmugam, M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1000106 · Cited by 29
Hu, P., Song, W., Shan, Y., Du, M., Huang, M., Song, C., & Zhang, L. (2015) · Food & Function · doi:10.1039/c5fo00248f · Cited by 27
Somers, K., Wen, V. W., Middlemiss, S., Osborne, B., Forgham, H., Jung, M., Karsa, M., Clifton, M., Bongers, A., Gao, J., et al. (2019) · Oncogene · doi:10.1038/s41388-018-0666-5 · Cited by 28
Tian, J., Luo, J., Zeng, X., Ke, C., Wang, Y., Liu, Z., Li, L., Zhang, Y., Hu, Z., & Yang, C. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-008226 · Cited by 28
Puurand, M., Peet, N., Piirsoo, A., Peetsalu, M., Soplepmann, J., Sirotkina, M., Peetsalu, A., Hemminki, A., & Seppet, E. K. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1399-3 · Cited by 26
Yi, M., Yang, J., Li, W., Li, X., Xiong, W., McCarthy, J. B., Li, G., & Xiang, B. (2017) · Journal of Cancer · doi:10.7150/jca.17579 · Cited by 26
Chong, S. J. F., Lai, J. X. H., Qu, J., Hirpara, J. L., Kang, J., Swaminathan, K., Loh, T. K. S., Kumar, A., Vali, S., Abbasi, T., et al. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.05.009 · Cited by 26
Mitochondrial NOS1 suppresses apoptosis in colon cancer cells through increasing SIRT3 activity
Wang, Q., Ye, S., Chen, X., Xu, P., Li, K., Zeng, S., Huang, M., Gao, W., Chen, J., Zhang, Q., et al. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.05.114 · Cited by 26
Peroxynitrite promotes serine-62 phosphorylation-dependent stabilization of the oncoprotein c-Myc
Raman, D., Chong, S. J. F., Iskandar, K. B., Hirpara, J. L., & Pervaiz, S. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101587 · Cited by 25
DRP1 promotes lactate utilization in KRAS‐mutant non‐small‐cell lung cancer cells
Hu, M., Zhao, Y. C., Cao, Y., Tang, Q., Feng, Z., Ni, J., & Zhou, X. (2020) · Cancer Science · doi:10.1111/cas.14603 · Cited by 27
Metabolic synthetic lethality by targeting NOP56 and mTOR in KRAS-mutant lung cancer
Zhang, Y., Liang, S., Zhao, L., Yang, H., Marti, T. M., Hegedűs, B., Gao, Y., Zheng, B., Chen, C., Wang, W., et al. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02240-5 · Cited by 28
Li, R., Tao, M., Xu, T., Huang, Y., Zogona, D., Pan, S., Wu, T., & Xu, X. (2022) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.11808 · Cited by 25
Zhao, Y., Wang, Y., Miao, Z., Liu, Y., & Yang, Q. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08495-1 · Cited by 26
Critical roles and clinical perspectives of RNA methylation in cancer
Li, G., Yao, Q., Liu, P., Zhang, H., Liu, Y., Li, S., Shi, Y., Li, Z., & Zhu, W. (2024) · MedComm · doi:10.1002/mco2.559 · Cited by 29
Uncovering metabolism in rhabdomyosarcoma
Monti, E., & Fanzani, A. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1071746 · Cited by 26
Porporato, P. E., & Sonveaux, P. (2014) · Molecular & Cellular Oncology · doi:10.4161/23723548.2014.968043 · Cited by 26
Du, Y., Gu, X., Cheng, S., Li, L., Liu, H., Hu, L.-P., & Gao, F. (2015) · Tumor Biology · doi:10.1007/s13277-015-4431-x · Cited by 25
A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma
Yenugonda, V. M., Nomura, N., Kouznetsova, V. L., Tsigelny, I. F., Fogal, V., Nurmemmedov, E., Kesari, S., & Babić, I. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1312-7 · Cited by 31
Metabolic consequences of HIF silencing in a triple negative human breast cancer xenograft
Bharti, S. K., Mironchik, Y., Wildes, F. B., Penet, M., Goggins, E. S., Krishnamachary, B., & Bhujwalla, Z. M. (2018) · Oncotarget · doi:10.18632/oncotarget.24569 · Cited by 26
The molecular rationale for therapeutic targeting of glutamine metabolism in pulmonary hypertension
Bertero, T., Perk, D., & Chan, S. Y. (2019) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1615438 · Cited by 26
Zeng, T., Li, B., Shu, X., Pang, J., Wang, H., Cai, X., Liao, Y., Xiao, X., Chong, Y., Gong, J., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1183474 · Cited by 25
Solsona, B. G., Horn, H., Schmitt, A., Xu, W., Bucher, P., Heinrich, A., Kalmbach, S., Kreienkamp, N., Franke, M., Wimmers, F., et al. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023010964 · Cited by 26
Cheng, G., Hardy, M., Hillard, C. J., Feix, J. B., & Kalyanaraman, B. (2024) · Communications Biology · doi:10.1038/s42003-024-06330-2 · Cited by 29
Self-citationMetabolomics and cellular altered pathways in cancer biology: A review
Bhardwaj, J. K., Siwach, A., & Sachdeva, S. N. (2024) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23807 · Cited by 27
Cai, L., Hammond, N. G., Tasdogan, A., Alsamraae, M., Yang, C., Cameron, R. B., Quan, P., Solmonson, A., Gu, W., Pachnis, P., et al. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-1319 · Cited by 28
Oxidative and Glycolytic Metabolism: Their Reciprocal Regulation and Dysregulation in Cancer
Cordani, M., Rumio, C., Bontempi, G., Strippoli, R., & Marcucci, F. (2025) · Cells · doi:10.3390/cells14151177 · Cited by 28
The prognostic significance of wild-type isocitrate dehydrogenase 2 (IDH2) in breast cancer
Aljohani, A., Toss, M. S., Kurozumi, S., Joseph, C., Aleskandarany, M. A., Miligy, I. M., Ansari, R. E., Mongan, N. P., Ellis, I. O., Green, A. R., et al. (2019) · Breast Cancer Research and Treatment · doi:10.1007/s10549-019-05459-7 · Cited by 25
Shao, S. H., Qin, T., Qian, W., Yue, Y., Xiao, Y., Li, X., Zhang, D., Wang, Z., Ma, Q., & Lei, J. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15596 · Cited by 25
RetractedGarlapati, C., Joshi, S., Turaga, R. C., Mishra, M., Reid, M. D., Kapoor, S., Artinian, L. R., Rehder, V., & Aneja, R. (2021) · Theranostics · doi:10.7150/thno.62724 · Cited by 26
Tumour microenvironment in pheochromocytoma and paraganglioma
Martinelli, S., Amore, F., Canu, L., Maggi, M., & Rapizzi, E. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1137456 · Cited by 26
Hyperglycemia Promotes K-Ras-Induced Lung Tumorigenesis through BASCs Amplification
Micucci, C., Orciari, S., & Catalano, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105550 · Cited by 24
Mori, K., Uchida, T., Fukumura, M., Tamiya, S., Higurashi, M., Sakai, H., Ishikawa, F., & Shibanuma, M. (2016) · Cancer Science · doi:10.1111/cas.12953 · Cited by 26
Blecha, J., Novais, S. M., Rohlenová, K., Novotná, E., Lettlová, S., Schmitt, S., Zischka, H., Neužil, J., & Rohlena, J. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.07.033 · Cited by 25
Metadata
- Authors
- Weinberg, F., Hamanaka, R., Wheaton, W. W., Weinberg, S., Joseph, J., Lopez, M., Kalyanaraman, B., Mutlu, G. M., Budinger, G. R. S., & Chandel, N. S.
- Affiliations
- Northwestern University (US)
- Division of Pulmonary and Critical Care, Department of Medicine,
- Medical College of Wisconsin (US)
- Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, WI 53226
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-04-26
- Volume
- 107
- Issue
- 19
- Pages
- 8788-8793
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2889315
- OpenAlex
- W1982330633
- Cited by
- 1,742
- References
- 29
- Citations by year
- 2026: 63 · 2025: 100 · 2024: 124 · 2023: 122 · 2022: 149 · 2021: 154 · 2020: 137 · 2019: 138 · 2018: 111 · 2017: 108 · 2016: 100 · 2015: 113 · 2014: 89 · 2013: 77 · 2012: 77
- FWCI
- 23.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 BX000201)
- LUNGevity Foundation
- Respiratory Health Association of Metropolitan Chicago
- Respiratory Health Association
- National Institutes of Health
- National Heart, Lung, and Blood Institute (P01HL071643)
- National Cancer Institute (R01CA125112, R01CA152810, R01CA123067, CA125112, P30CA060553, T32CA070085, T32CA009560)
- National Institute of Environmental Health Sciences (ES 013995, ES015024, R01ES013995, R01ES015024)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- KRAS, mitochondrial metabolism, reactive oxygen species, pentose phosphate pathway, aerobic glycolysis, Warburg effect, anchorage-independent growth, glutaminase, alpha-ketoglutarate, TCA cycle, ERK signaling, mitochondrial complex III, TFAM, lung cancer, carcinogenesis, hypoxia
- MeSH terms
- Aerobiosis, Animals, Cell Adhesion, Cell Transformation, Neoplastic, Glutamine, Glycolysis, Humans, Lung Neoplasms, Mitochondria, Oxidative Phosphorylation, Pentose Phosphate Pathway, Electron Transport Complex III, Proto-Oncogene Proteins p21(ras), Reactive Oxygen Species, HCT116 Cells, Extracellular Signal-Regulated MAP Kinases, Cell Proliferation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
