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Proinflammatory T helper type 17 cells are effective B-cell helpers
Open accessAbstract
T helper type 17 (TH17) cells are highly proinflammatory effector T cells that are characterized by the production of high amounts of IL-17A, IL-17F, IL-21, and IL-22. Furthermore, TH17 cells have been associated with a number of autoimmune diseases. However, it is not clear whether TH17 cells can also serve as effective helper cells. Here we show that TH17 cells can function as B-cell helpers in that they not only induce a strong proliferative response of B cells in vitro but also trigger antibody production with class switch recombination in vivo. Transfer of TH17 cells into WT or T-cell receptor α–deficient mice, which lack endogenous T cells, induces a pronounced antibody response with preferential isotype class switching to IgG1, IgG2a, IgG2b, and IgG3, as well as the formation of germinal centers. Conversely, blockade of IL-17 signaling results in a significant reduction in both number and size of germinal centers. Whereas IL-21 is known to help B cells, IL-17 on its own drives B cells to undergo preferential isotype class switching to IgG2a and IgG3 subtypes. These observations provide insights into the unappreciated role of TH17 cells and their signature cytokines in mediating B-cell differentiation and class switch recombination.
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“multiple additional transcription factors were shown to be required for the expression of IL-17, including STAT3, IRF4, and BATF”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [19]
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Doreau, A., Bélot, A., Bastid, J., Riche, B., Trescol-Biémont, M.-C., Ranchin, B., Fabien, N., Cochat, P., Pouteil‐Noble, C., Trolliet, P., et al. (2009) · Nature Immunology · doi:10.1038/ni.1741 · Cited by 448
RetractedKorn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
Self-citationInterferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production
Snapper, C. M., & Paul, W. E. (1987) · Science · doi:10.1126/science.3107127 · Cited by 1,927
CD4 T cells: fates, functions, and faults
Zhu, J., & Paul, W. E. (2008) · Blood · doi:10.1182/blood-2008-05-078154 · Cited by 1,915
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
Korn, T., Bettelli, E., Gao, W., Awasthi, A., Jäger, A., Strom, T. B., Oukka, M., & Kuchroo, V. K. (2007) · Nature · doi:10.1038/nature05970 · Cited by 1,896
Self-citationJohnston, R. J., Poholek, A. C., DiToro, D., Yusuf, I., Eto, D., Barnett, B., Dent, A. L., Craft, J., & Crotty, S. (2009) · Science · doi:10.1126/science.1175870 · Cited by 1,626
Plasticity of CD4+ T Cell Lineage Differentiation
Zhou, L., Chong, M. M. W., & Littman, D. R. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.001 · Cited by 1,551
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J. J., Garrone, P., Garcia, E., Saeland, S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2593 · Cited by 1,526 · cited 1×
“So far, IL-17 has mainly been described as a potent proinflammatory cytokine that acts on fibroblasts, stromal, epithelial, and endothelial cells, and some monocytes to stimulate the secretion of other proinflammatory mediators, such as IL-1, IL-6, chemokine ligand CXCL8 (also known as IL-8), CXCL1, TNF-α, and granulo…”
BackgroundBcl6 mediates the development of T follicular helper cells
Nurieva, R. I., Chung, Y., Martinez, G. J., Yang, X. O., Tanaka, S., Matskevitch, T. D., Wang, Y.-H., & Dong, C. (2009) · Science · doi:10.1126/science.1176676 · Cited by 1,506
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Gaffen, S. L. (2009) · Nature reviews. Immunology · doi:10.1038/nri2586 · Cited by 1,475
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Li, G., Cao, H., & Hong, J. (2026) · Inflammation Research · doi:10.1007/s00011-026-02238-1 · Cited by 1
Bhat, A., Sosa, R. A., Terry, A. Q., Zheng, Y., Gjertson, D. W., Soltero, S., Maeda, K., Ha, M., Alfaro, J., Zhai, Y., et al. (2026) · American Journal of Transplantation · doi:10.1016/j.ajt.2026.04.022 · Cited by 1
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Mills, J.-L. S., Lepletier, A., Ozberk, V., Dooley, J., Kaden, J., Calcutt, A., Huo, Y., Hicks, A., Zaid, A., Good, M. F., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.10.566548
Tailoring Tfh Profiles Enhances Antibody Persistence to a Clade C HIV-1 Vaccine in Rhesus MacaquesPreprint
Verma, A., Hawes, C. E., Elizaldi, S. R., Smith, J. C., Rajasundaram, D., Pedersen, G. K., Shen, X., Williams, L. D., Tomaras, G. D., Kozlowski, P. A., et al. (2024) · eLife · doi:10.7554/elife.89395.2
Tailoring Tfh profiles enhances antibody persistence to a clade C HIV-1 vaccine in rhesus macaques
Verma, A., Hawes, C. E., Elizaldi, S. R., Smith, J. C., Rajasundaram, D., Pedersen, G. K., Shen, X., Williams, L. D., Tomaras, G. D., Kozlowski, P. A., et al. (2024) · eLife · doi:10.7554/elife.89395.3
龚, 珊. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.1441070
Metadata
- Authors
- Mitsdoerffer, M., Lee, Y., Jäger, A., Kim, H.-J., Korn, T., Kolls, J. K., Cantor, H., Bettelli, E., & Kuchroo, V. K.
- Affiliations
- Brigham and Women's Hospital (US)
- Dana-Farber Cancer Institute (US)
- Technical University of Munich (DE)
- Louisiana State University Health Sciences Center New Orleans (US)
- Benaroya Research Institute (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-07-26
- Volume
- 107
- Issue
- 32
- Pages
- 14292-14297
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2922571
- OpenAlex
- W2012706589
- Cited by
- 534
- References
- 36
- Citations by year
- 2026: 16 · 2025: 29 · 2024: 40 · 2023: 27 · 2022: 23 · 2021: 46 · 2020: 40 · 2019: 28 · 2018: 23 · 2017: 31 · 2016: 50 · 2015: 34 · 2014: 29 · 2013: 42 · 2012: 37
- FWCI
- 16.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Funders
- National Institutes of Health (5r01hl061271-15, 7r01hl079142-05)
- National Heart, Lung, and Blood Institute (R01-HL061271, R01-HL079142)
- National Institute of Allergy and Infectious Diseases (P01AI045757, P01AI056299)
- National Institute of Neurological Disorders and Stroke (P01NS038037, R37NS030843, R01NS035685, R01NS059996)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- B cell help, class switch recombination, IL-17, IL-21, germinal center, antibody isotype switching, B cell proliferation, B cell differentiation
- MeSH terms
- Animals, Antibody Formation, B-Lymphocytes, Cell Differentiation, T-Lymphocytes, Helper-Inducer, Immunoglobulin Isotypes, Inflammation, T-Lymphocytes, Immunoglobulin Class Switching, Interleukin-17, Cell Proliferation, Mice
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