Cited by 534T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisRheumatoid Arthritis Research and Therapies

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Proinflammatory T helper type 17 cells are effective B-cell helpers

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Mitsdoerffer, Meike, Lee, Youjin, Jäger, Anneli, Kim, Hye-Jung, Korn, Thomas, Kolls, Jay K., Cantor, Harvey, Bettelli, Estelle, Kuchroo, Vijay K.·2010·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1009234107PMC PMC2922571

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Abstract

T helper type 17 (TH17) cells are highly proinflammatory effector T cells that are characterized by the production of high amounts of IL-17A, IL-17F, IL-21, and IL-22. Furthermore, TH17 cells have been associated with a number of autoimmune diseases. However, it is not clear whether TH17 cells can also serve as effective helper cells. Here we show that TH17 cells can function as B-cell helpers in that they not only induce a strong proliferative response of B cells in vitro but also trigger antibody production with class switch recombination in vivo. Transfer of TH17 cells into WT or T-cell receptor α–deficient mice, which lack endogenous T cells, induces a pronounced antibody response with preferential isotype class switching to IgG1, IgG2a, IgG2b, and IgG3, as well as the formation of germinal centers. Conversely, blockade of IL-17 signaling results in a significant reduction in both number and size of germinal centers. Whereas IL-21 is known to help B cells, IL-17 on its own drives B cells to undergo preferential isotype class switching to IgG2a and IgG3 subtypes. These observations provide insights into the unappreciated role of TH17 cells and their signature cytokines in mediating B-cell differentiation and class switch recombination.

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1 retracted

Interleukin 17 acts in synergy with B cell–activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus
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Retracted
IL-17 and th17 cells
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Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation
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“So far, IL-17 has mainly been described as a potent proinflammatory cytokine that acts on fibroblasts, stromal, epithelial, and endothelial cells, and some monocytes to stimulate the secretion of other proinflammatory mediators, such as IL-1, IL-6, chemokine ligand CXCL8 (also known as IL-8), CXCL1, TNF-α, and granulo…”
Background
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Authors: Mitsdoerffer, M., Lee, Y., Jäger, A., Kim, H.-J., Korn, T., Kolls, J. K., Cantor, H., Bettelli, E., & Kuchroo, V. K.
Affiliations: Brigham and Women's Hospital (US)
Dana-Farber Cancer Institute (US)
Technical University of Munich (DE)
Louisiana State University Health Sciences Center New Orleans (US)
Benaroya Research Institute (US)
ORCID: Mitsdoerffer, Meike
Lee, Youjin
Kim, Hye-Jung
Korn, Thomas
Kolls, Jay K.
Cantor, Harvey
Bettelli, Estelle
Kuchroo, Vijay K.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2010-07-26
Volume: 107
Issue: 32
Pages: 14292-14297
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1009234107
PMC: PMC2922571
OpenAlex: W2012706589
Cited by: 534
References: 36
Citations by year: 2026: 16 · 2025: 29 · 2024: 40 · 2023: 27 · 2022: 23 · 2021: 46 · 2020: 40 · 2019: 28 · 2018: 23 · 2017: 31 · 2016: 50 · 2015: 34 · 2014: 29 · 2013: 42 · 2012: 37
FWCI: 16.19
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Funders: National Institutes of Health (5r01hl061271-15, 7r01hl079142-05)
National Heart, Lung, and Blood Institute (R01-HL061271, R01-HL079142)
National Institute of Allergy and Infectious Diseases (P01AI045757, P01AI056299)
National Institute of Neurological Disorders and Stroke (P01NS038037, R37NS030843, R01NS035685, R01NS059996)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords: B cell help, class switch recombination, IL-17, IL-21, germinal center, antibody isotype switching, B cell proliferation, B cell differentiation
MeSH terms: Animals, Antibody Formation, B-Lymphocytes, Cell Differentiation, T-Lymphocytes, Helper-Inducer, Immunoglobulin Isotypes, Inflammation, T-Lymphocytes, Immunoglobulin Class Switching, Interleukin-17, Cell Proliferation, Mice

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Proinflammatory T helper type 17 cells are effective B-cell helpers

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