The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors
Open accessAbstract
The direct and indirect pathways of the basal ganglia have been proposed to oppositely regulate locomotion and differentially contribute to pathological behaviors. Analysis of the distinct contributions of each pathway to behavior has been a challenge, however, due to the difficulty of selectively investigating the neurons comprising the two pathways using conventional techniques. Here we present two mouse models in which the function of striatonigral or striatopallidal neurons is selectively disrupted due to cell type–specific deletion of the striatal signaling protein dopamine- and cAMP-regulated phosphoprotein Mr 32kDa (DARPP-32). Using these mice, we found that the loss of DARPP-32 in striatonigral neurons decreased basal and cocaine-induced locomotion and abolished dyskinetic behaviors in response to the Parkinson's disease drug L-DOPA. Conversely, the loss of DARPP-32 in striatopallidal neurons produced a robust increase in locomotor activity and a strongly reduced cataleptic response to the antipsychotic drug haloperidol. These findings provide insight into the selective contributions of the direct and indirect pathways to striatal motor behaviors.
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Surmeier, D. J., Ding, J., Day, M., Wang, Z., & Shen, W. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.008 · Cited by 1,203
Self-citationMiyamoto, S., Duncan, G. E., Marx, C. E., & Lieberman, J. A. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001556 · Cited by 988 · cited 4×
“A common complication of the treatment of schizophrenia with first-generation antipsychotic drugs is the expression of extrapyramidal side effects, which can include catalepsy and drug-induced parkinsonism (5).”
BackgroundInfluentialA cellular mechanism of reward-related learning
Reynolds, J. N. J., Hyland, B. I., & Wickens, J. R. (2001) · Nature · doi:10.1038/35092560 · Cited by 879
Gong, R., Park, C. S., Abbassi, N. R., & Tang, S.-J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512524200 · Cited by 249 · cited 3×
“These mice were previously shown to express Cre selectively in striatonigral and striatopallidal neurons, respectively (12).”
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Self-citationRothwell, P. E., Fuccillo, M. V., Maxeiner, S., Hayton, S. J., Gokce, O., Lim, B. K., Fowler, S. C., Malenka, R. C., & Südhof, T. C. (2014) · Cell · doi:10.1016/j.cell.2014.04.045 · Cited by 477
Metadata
- Authors
- Bateup, H. S., Santini, E., Shen, W., Birnbaum, S., Valjent, E., Surmeier, D. J., Fisone, G., Nestler, E. J., & Greengard, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-08-03
- Volume
- 107
- Issue
- 33
- Pages
- 14845-14850
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2011736950
- Cited by
- 360
- References
- 4
- FWCI
- 12.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Bateup, H. S., Santini, E., Shen, W., Birnbaum, S., Valjent, E., Surmeier, D. J., Fisone, G., Nestler, E. J., & Greengard, P. (2010). Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1009874107
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
