The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Gravity-induced PIN transcytosis for polarization of auxin fluxes in gravity-sensing root cells
Open accessAbstract
Auxin is an essential plant-specific regulator of patterning processes that also controls directional growth of roots and shoots. In response to gravity stimulation, the PIN3 auxin transporter polarizes to the bottom side of gravity-sensing root cells, presumably redirecting the auxin flux toward the lower side of the root and triggering gravitropic bending. By combining live-cell imaging techniques with pharmacological and genetic approaches, we demonstrate that PIN3 polarization does not require secretion of de novo synthesized proteins or protein degradation, but instead involves rapid, transient stimulation of PIN endocytosis, presumably via a clathrin-dependent pathway. Moreover, gravity-induced PIN3 polarization requires the activity of the guanine nucleotide exchange factors for ARF GTPases (ARF-GEF) GNOM-dependent polar-targeting pathways and might involve endosome-based PIN3 translocation from one cell side to another. Our data suggest that gravity perception acts at several instances of PIN3 trafficking, ultimately leading to the polarization of PIN3, which presumably aligns auxin fluxes with gravity vector and mediates downstream root gravitropic response.
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Cites
Local, Efflux-Dependent Auxin Gradients as a Common Module for Plant Organ Formation
Benková, E., Michniewicz, M., Sauer, M., Teichmann, T., Seifertová, D., Jürgens, G., & Friml, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00924-3 · Cited by 2,633
Self-citationThe PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots
Blilou, I., Xu, J., Wildwater, M., Willemsen, V., Paponov, I., Friml, J., Heidstra, R., Aida, M., Palme, K., & Scheres, B. (2005) · Nature · doi:10.1038/nature03184 · Cited by 2,048
Self-citationEfflux-dependent auxin gradients establish the apical–basal axis of Arabidopsis
Friml, J., Vieten, A., Sauer, M., Weijers, D., Schwarz, H., Hamann, T., Offringa, R., & Jürgens, G. (2003) · Nature · doi:10.1038/nature02085 · Cited by 1,894
Self-citationRegulation of phyllotaxis by polar auxin transport
Reinhardt, D., Pesce, E.-R., Stieger, P., Mandel, T., Baltensperger, K., Bennett, M., Traas, J., Friml, J., & Kuhlemeier, C. (2003) · Nature · doi:10.1038/nature02081 · Cited by 1,523
Self-citationLateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis
Friml, J., Wiśniewska, J., Benková, E., Mendgen, K., & Palme, K. (2002) · Nature · doi:10.1038/415806a · Cited by 1,426
Self-citationAuxin: A Trigger for Change in Plant Development
Vanneste, S., & Friml, J. (2009) · Cell · doi:10.1016/j.cell.2009.03.001 · Cited by 1,302
Self-citationAuxin transport inhibitors block PIN1 cycling and vesicle trafficking
Geldner, N., Friml, J., Stierhof, Y.-D., Jürgens, G., & Palme, K. (2001) · Nature · doi:10.1038/35096571 · Cited by 1,241
Self-citationHeisler, M. G., Ohno, C., Das, P., Sieber, P., Reddy, G. V., Long, J. A., & Meyerowitz, E. M. (2005) · Current Biology · doi:10.1016/j.cub.2005.09.052 · Cited by 1,189
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PIN Proteins Perform a Rate-Limiting Function in Cellular Auxin Efflux
Petrášek, J., Mravec, J., Bouchard, R., Blakeslee, J. J., Abas, M., Seifertová, D., Wiśniewska, J., Tadele, Z., Kubeš, M., Čovanová, M., et al. (2006) · Science · doi:10.1126/science.1123542 · Cited by 921
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Cited by
PIN-Dependent Auxin Transport: Action, Regulation, and Evolution
Adamowski, M., & Friml, J. (2015) · The Plant Cell · doi:10.1105/tpc.114.134874 · Cited by 818
Self-citationDing, Z., Galván-Ampudia, C. S., Demarsy, E., Łangowski, Ł., Kleine-Vehn, J., Fan, Y., Morita, M. T., Tasaka, M., Fankhauser, C., Offringa, R., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2208 · Cited by 330
Self-citationVelasquez, S. M., Barbez, E., Kleine-Vehn, J., & Estevez, J. M. (2016) · Plant Physiology · doi:10.1104/pp.15.01863 · Cited by 132
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Metadata
- Authors
- Kleine-Vehn, J., Ding, Z., Jones, A. R., Tasaka, M., Morita, M. T., & Friml, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-12-06
- Volume
- 107
- Issue
- 51
- Pages
- 22344-22349
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2140375839
- Cited by
- 358
- References
- 35
- FWCI
- 26.19
- Type
- journal article
- Language
- en
- Open access
- green
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