Cited by 447Angiogenesis and VEGF in CancerBarrier Structure and Function StudiesAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF

Open access

Cao, Renhai, Brakenhielm, Ebba, Wahlestedt, Claes, Thyberg, Johan, Cao, Yihai·2001·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.101564798PMC PMC33478

Open this paper in CoChat — free account

Abstract

Most endocrine hormones are produced in tissues and organs with permeable microvessels that may provide an excess of hormones to be transported by the blood circulation to the distal target organ. Here, we investigate whether leptin, an endocrine hormone, induces the formation of vascular fenestrations and permeability, and we characterize its angiogenic property in the presence of other angiogenic factors. We provide evidence that leptin-induced new blood vessels are fenestrated. Under physiological conditions, capillary fenestrations are found in the leptin-producing adipose tissue in lean mice. In contrast, no vascular fenestrations were detected in the adipose tissue of leptin-deficient ob/ob mice. Thus, leptin plays a critical role in the maintenance and regulation of vascular fenestrations in the adipose tissue. Leptin induces a rapid vascular permeability response when administrated intradermally. Further, leptin synergistically stimulates angiogenesis with fibroblast growth factor (FGF)-2 and vascular endothelial growth factor (VEGF), the two most potent and commonly expressed angiogenic factors. These findings demonstrate that leptin has another new function—the increase of vascular permeability.

Integrity signals

Registry

Crossref · 10.1073/pnas.101564798

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid
Senger, D. R., Galli, S. J., Dvořàk, A. M., Perruzzi, C. A., Harvey, V. S., & Dvorak, H. F. (1983) · Science · doi:10.1126/science.6823562 · Cited by 3,969
Abnormal splicing of the leptin receptor in diabetic mice
Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature · doi:10.1038/379632a0 · Cited by 2,327
Biological Action of Leptin as an Angiogenic Factor
Sierra-Honigmann, M. R., Nath, A. K., Murakami, C., García‐Cardeña, G., Papapetropoulos, A., Sessa, W. C., Madge, L. A., Schechner, J. S., Schwabb, M. B., Polverini, P. J., et al. (1998) · Science · doi:10.1126/science.281.5383.1683 · Cited by 1,385
Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans
Masuzaki, H., Ogawa, Y., Sagawa, N., Hosoda, K., Matsumoto, T., Mise, H., Nishimura, H., Yoshimasa, Y., Tanaka, I., Mori, T., et al. (1997) · Nature Medicine · doi:10.1038/nm0997-1029 · Cited by 1,277
Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor
Roberts, W. G., & Palade, G. E. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.6.2369 · Cited by 1,039
Clinical applications of angiogenic growth factors and their inhibitors
Ferrara, N., & Alitalo, K. (1999) · Nature Medicine · doi:10.1038/70928 · Cited by 1,004
Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor
Bjørbæk, C., Uotani, S., da Silva, B., & Flier, J. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.32686 · Cited by 890
Vascular Permeability Factor/Vascular Endothelial Growth Factor and the Significance of Microvascular Hyperpermeability in Angiogenesis
Dvorak, H. F., Nagy, J. A., Feng, D., Brown, L. F., & Dvorak, A. M. (1999) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-642-59953-8_6 · Cited by 743
Leptin, the Product of Ob Gene, Promotes Angiogenesis
Bouloumié, A., Drexler, H. C. A., Lafontan, M., & Busse, R. (1998) · Circulation Research · doi:10.1161/01.res.83.10.1059 · Cited by 715

Show all 29 references

Research works printed but not linked: 4

H F Dvorak, J A Nagy, D Feng, L F Brown, A M Dvorak Curr Top Microbiol Immunol 237, 97–132 (1999).
B M Kenyon, E E Voest, C C Chen, E Flynn, J Folkman, R J D'Amato Invest Ophthalmol Visual Sci 37, 1625–1632 (1996).
E T Wei, J G Kiang, P Buchan, T W Smith J Pharmacol Exp Ther 238, 783–787 (1986).
H Yoshiji, S Kuriyama, D K Ways, J Yoshii, Y Miyamoto, M Kawata, Y Ikenaka, H Tsujinoue, T Nakatani, M Shibuya, H Fukui Cancer Res 59, 4413–4418 (1999).

Sorted by citations

Items 201–300 of 447

Effects of PPARγ agonists on the expression of leptin and vascular endothelial growth factor in breast cancer cells
Terrasi, M., Bazan, V., Caruso, S., Insalaco, L., Amodeo, V., Fanale, D., Corsini, L. R., Contaldo, C., Mercanti, A., Fiorio, E., et al. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24295 · Cited by 31
Brown and beige fat: the metabolic function, induction, and therapeutic potential
Qian, S., Huang, H., & Tang, Q. (2015) · Frontiers of Medicine · doi:10.1007/s11684-015-0382-2 · Cited by 33
Differential effects of MCP-1 and leptin on collateral flow and arteriogenesis
Schirmer, S. H., Buschmann, I. R., JOST, M., Hoefer, I. E., Grundmann, S., Andert, J.-P., Ulusans, S., Bode, C., Piek, J. J., & VANROYEN, N. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.06.022 · Cited by 31
Docosahexaenoic acid attenuates adipose tissue angiogenesis and insulin resistance in high fat diet‐fed middle‐aged mice via a sirt1‐dependent mechanism
Luo, X., Jia, R., Yao, Q., Xu, Y., Luo, Z., Luo, X., & Wang, N. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500714 · Cited by 30
Angiogenesis as a new target for cancer control
Harris, A. L. (2003) · European Journal of Cancer Supplements · doi:10.1016/s1359-6349(03)00007-7 · Cited by 30
Adipose-derived stem cells sustain prolonged angiogenesis through leptin secretion
Monache, S. D., Calgani, A., Sanità, P., Zazzeroni, F., Warschauer, E. G., Giuliani, A., Amicucci, G., & Angelucci, A. (2016) · Growth Factors · doi:10.1080/08977194.2016.1191481 · Cited by 30
Angiogenic content of microparticles in patients with diabetes and coronary artery disease predicts networks of endothelial dysfunction
Marei, I., Chidiac, O. M., Thomas, B., Pasquier, J., Dargham, S. R., Robay, A., Vakayil, M., Jameesh, M., Triggle, C. R., Rafii, A., et al. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01449-0 · Cited by 30
Leptin Promotes Angiogenesis via Pericyte STAT3 Pathway upon Intracerebral Hemorrhage
Cui, Q., Zhang, Y., Tian, N., Yang, J., Ya, D., Xiang, W., Zhou, Z., Jiang, Y., Deng, J., Yang, B., et al. (2022) · Cells · doi:10.3390/cells11172755 · Cited by 30
Effects of dietary fat on spontaneous metastasis of Lewis lung carcinoma in mice
Yan, L., & DeMars, L. C. S. (2010) · Clinical & Experimental Metastasis · doi:10.1007/s10585-010-9347-7 · Cited by 30
Metabolic syndrome and mammographic density: The Study of Women's Health Across the Nation
Conroy, S. M., Butler, L. M., Harvey, D. J., Gold, E. B., Sternfeld, B., Greendale, G. A., & Habel, L. A. (2010) · International Journal of Cancer · doi:10.1002/ijc.25790 · Cited by 30
In vivo delivery of cell-permeable antisense hypoxia-inducible factor 1α oligonucleotide to adipose tissue reduces adiposity in obese mice
Park, Y. S., David, A. E., Huang, Y., Park, J. B., He, H., Byun, Y., & Yang, V. C.-M. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.04.026 · Cited by 29
Leptin antagonism inhibits prostate cancer xenograft growth and progression
Philp, L., Rockstroh, A., Sadowski, M. C., Fard, A. T., Lehman, M., Tevž, G., Libério, M. S., Bidgood, C. L., Gunter, J. H., McPherson, S. J., et al. (2021) · Endocrine Related Cancer · doi:10.1530/erc-20-0405 · Cited by 29
Delayed leptin administration after stroke induces neurogenesis and angiogenesis
Avraham, Y., Dayan, M., Lasri, V., Vorobiev, L., Davidi, N., Chernoguz, D., Berry, E. M., & Leker, R. R. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.23147 · Cited by 29
Engineering of microscale vascularized fat that responds to perfusion with lipoactive hormones
Li, X., Xia, J., Nicolescu, C., Massidda, M. W., Ryan, T. J., & Tien, J. (2018) · Biofabrication · doi:10.1088/1758-5090/aae5fe · Cited by 28
Obesity and Inflammation: Colorectal Cancer Engines
Malhab, L. J. B., & Abdel‐Rahman, W. M. (2021) · Current Molecular Pharmacology · doi:10.2174/1874467214666210906122054 · Cited by 28
Leptin in the canine uterus and placenta: possible implications in pregnancy
Balogh, O., Staub, L. P., Gram, A., Boos, A., Kowalewski, M. P., & Reichler, I. M. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0003-6 · Cited by 28
Circulating levels of proinflammatory mediators as potential biomarkers of post-traumatic knee osteoarthritis development
Panina, S., Krolevets, I. V., Milyutina, N. P., Sagakyants, A. B., Корниенко, И. В., Ananyan, A. A., Zabrodin, M. A., Plotnikov, A. A., & Внуков, В. В. (2017) · Journal of Orthopaedics and Traumatology · doi:10.1007/s10195-017-0473-8 · Cited by 28
Quantitative and morphometric evaluation of the angiogenic effects of leptin
Talavera‐Adame, D., Xiong, Y., Zhao, T., Arias, A. E., Sierra-Honigmann, M. R., & Farkas, D. L. (2008) · Journal of Biomedical Optics · doi:10.1117/1.3028010 · Cited by 28
Leptin Induces Odontogenic Differentiation and Angiogenesis in Human Dental Pulp Cells via Activation of the Mitogen-activated Protein Kinase Signaling Pathway
Ngo, V. A., Jung, J., Koh, J., Oh, W., Hwang, Y., & Lee, B.-N. (2018) · Journal of Endodontics · doi:10.1016/j.joen.2017.11.018 · Cited by 27
Crosstalk Between Adipose and Lymphatics in Health and Disease
Westcott, G. P., & Rosen, E. D. (2021) · Endocrinology · doi:10.1210/endocr/bqab224 · Cited by 27
Fat Depot-Specific Differences in Angiogenic Growth Factor Gene Expression and Its Relation to Adipocyte Size in Cattle
Yamada, T., KAWAKAMI, S.-I., & NAKANISHI, N. (2010) · Journal of Veterinary Medical Science · doi:10.1292/jvms.10-0031 · Cited by 27
The effect of leptin on luteal angiogenic factors during the luteal phase of the estrous cycle in goats
Wiles, J. R., Katchko, R. A., Benavides, E. A., O’Gorman, C., Escudero, J. M., Keisler, D. H., Stanko, R. L., & Garcia, M. R. (2014) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2014.05.002 · Cited by 27
Effects of leptin on endothelial function with OB-Rb gene transfer in Zucker fatty rats
Jin, X.-Q., Fukuda, N., Su, J., Takagi, H., Lai, Y., Lin, Z., Kanmatsuse, K., Wang, Z.-W., & Unger, R. H. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00159-x · Cited by 27
Leptin serves as angiogenic/mitogenic factor in melanoma tumor growth
Amjadi, F., Mehdipoor, R., Zarkesh‐Esfahani, S. H., & Javanmard, S. H. (2016) · Advanced Biomedical Research · doi:10.4103/2277-9175.187005 · Cited by 26
From mice to men – mouse models in obesity research: What can we learn?
Scroyen, I., Hemmeryckx, B., & LIJNEN, H. R. (2013) · Thrombosis and Haemostasis · doi:10.1160/th12-11-0873 · Cited by 25
Effect of a 12-Month Exercise Intervention on Serum Biomarkers of Angiogenesis in Postmenopausal Women: A Randomized Controlled Trial
Duggan, C. R., Xiao, L., Wang, C., & McTiernan, A. (2014) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-13-1155 · Cited by 25
PLASMA OBTAINED DURING HUMAN ENDOTOXEMIA INCREASES ENDOTHELIAL ALBUMIN PERMEABILITY IN VITRO
van Eijk, L. T., Nooteboom, A., Hendriks, T., Sprong, T., Netea, M. G., Smits, P., van der Hoeven, J. G., & Pickkers, P. (2006) · Shock · doi:10.1097/01.shk.0000209527.35743.b0 · Cited by 25
In ovo administration of human recombinant leptin shows dose dependent angiogenic effect on chicken chorioallantoic membrane
Manjunathan, R., & Ragunathan, M. (2015) · Biological Research · doi:10.1186/s40659-015-0021-z · Cited by 24
Leptin receptor blockade reduces intrahepatic vascular resistance and portal pressure in an experimental model of rat liver cirrhosis
Delgado, M., Gracia‐Sancho, J., Marrone, G., Rodrı́guez-Vilarrupla, A., Deulofeu, R., Abraldeṣ, J. G., Bosch, J., & García‐Pagán, J. C. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00336.2012 · Cited by 24
Effect of Leptin on Odontoblastic Differentiation and Angiogenesis: An In Vivo Study
Choi, S.-H., Jang, J., Koh, J., Chang, H.-S., Hwang, Y., Hwang, I., Lee, B.-N., & Oh, W. (2019) · Journal of Endodontics · doi:10.1016/j.joen.2019.08.003 · Cited by 24
Different Transcriptional Control of Metabolism and Extracellular Matrix in Visceral and Subcutaneous Fat of Obese and Rimonabant Treated Mice
Poussin, C., Hall, D., Minehira, K., Galzin, A., Tarussio, D., & Thorens, B. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003385 · Cited by 24
Adiponectin and Leptin Exert Antagonizing Effects on HUVEC Tube Formation and Migration Modulating the Expression of CXCL1, VEGF, MMP-2 and MMP-9
Nigro, E., Mallardo, M., Polito, R., Scialò, F., Bianco, A., & Daniele, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147516 · Cited by 24
Identification of a novel leptin receptor duplicate in Atlantic salmon: Expression analyses in different life stages and in response to feeding status
Angotzi, A. R., Stefansson, S. O., Nilsen, T. O., Øvrebø, J. I., Andersson, E., Taranger, G. L., & Rønnestad, I. (2016) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2016.06.004 · Cited by 23
Cold Exposure Differentially Stimulates Angiogenesis in BAT and WAT of Mice: Implication in Adrenergic Activation
Luo, X. M., Jia, R., Luo, X., Wang, G., Zhang, Q., Qiao, H., Wang, N., & Yan, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000478680 · Cited by 25
Adrenomedullin and Leptin Levels in Diabetic Retinopathy and Retinal Diseases
Er, H., Doğanay, S., Özerol, E., & Yürekli, M. (2005) · Ophthalmologica · doi:10.1159/000083270 · Cited by 23
Peritoneal fluid and serum leptin concentrations in women with primary infertility
Gungor, T., Pektas, M. K., Karayalçın, R., & Mollamahmutoğlu, L. (2008) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-008-0744-y · Cited by 23
Association between hepatic angiogenesis and serum adipokine profile in non-obese chronic hepatitis C patients.
Kukla, M., Berdowska, A., Gabriel, A., Sawczyn, T., Mazur, W., Sobala‐Szczygieł, B., Grzonka, D., Zajęcki, W., Tomaszek, K., Bułdak, R. J., et al. (2011) · PubMed · Cited by 22
Adipose tissue, angiogenesis and angio-MIR under physiological and pathological conditions
Stefano, A. B. D., Massihnia, D., Grisafi, F., Castiglia, M., Toia, F., Montesano, L., Russo, A. D., Moschella, F., & Cordova, A. (2018) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2018.11.005 · Cited by 22
Angiogenesis in the New Zealand obese mouse model fed with high fat diet
Balwierz, A., Polus, A., Raźny, U., Wątor, Ł., Dyduch, G., Tomaszewska, R., Scherneck, S., Joost, H., & Dembinska-Kiec, A. (2009) · Lipids in Health and Disease · doi:10.1186/1476-511x-8-13 · Cited by 22
Obesity and leptin in breast cancer angiogenesis
Lagarde, C., Thapa, K., Cullen, N. M., Hawes, M. L., Salim, K., Benz, M. C., Dietrich, S. R., Burow, B. E., Bunnell, B. A., Martin, E. C., et al. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1465727 · Cited by 22
Human intestinal lipid storage through sequential meals reveals faster dinner appearance is associated with hyperlipidemia
Jácome-Sosa, M., Hu, Q., Manrique‐Acevedo, C., Phair, R. D., & Parks, E. J. (2021) · JCI Insight · doi:10.1172/jci.insight.148378 · Cited by 22
Obesity Impairs Enthesis Healing After Rotator Cuff Repair in a Rat Model
Bolam, S. M., Park, Y. E., Konar, S., Callon, K. E., Workman, J., Monk, A. P., Coleman, B., Cornish, J., Vickers, M. H., Munro, J. T., et al. (2021) · The American Journal of Sports Medicine · doi:10.1177/03635465211049219 · Cited by 21
Adiponectin induced placental cell apoptosis could be mediated via the ADIPOR1-receptor in pre-eclampsia with IUGR
Järvenpää, J., Vuoristo, J. T., Santaniemi, M., Ukkola, O. H., Savolainen, E., Jääskeläinen, M. M., Tapanainen, J. S., Kesäniemi, A., & Ryynänen, M. (2009) · Journal of Perinatal Medicine · doi:10.1515/jpm.2009.046 · Cited by 21
Effects of intraperitoneal vitamin E, melatonin and aprotinin on leptin expression in the guinea pig eye during experimental uveitis
Kükner, A., Çolakoğlu, N., Serin, D., Alagöz, G., Çelebi, S., & Kükner, A. Ş. (2005) · Acta Ophthalmologica Scandinavica · doi:10.1111/j.1600-0420.2005.00544.x · Cited by 21
Diabetic mouse models
Katsuda, Y., Ohta, T., Shinohara, M., Tong, B., & Yamada, T. (2013) · Open Journal of Animal Sciences · doi:10.4236/ojas.2013.34050 · Cited by 23
Modeling the Progression of Placental Transport from Early‐ to Late‐Stage Pregnancy by Tuning Trophoblast Differentiation and Vascularization
Kouthouridis, S., Sotra, A., Khan, Z., Alvarado, J., Raha, S., & Zhang, B. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301428 · Cited by 20
Fasting-dependent Vascular Permeability Enhancement in Brown Adipose Tissues Evidenced by Using Carbon Nanotubes as Fluorescent Probes
Yudasaka, M., Yomogida, Y., Zhang, M., Nakahara, M., Kobayashi, N., Tanaka, T., Okamatsu‐Ogura, Y., Saeki, K., & Kataura, H. (2018) · Scientific Reports · doi:10.1038/s41598-018-32758-8 · Cited by 19
Regulation of Obesity by Antiangiogenic Herbal Medicines
Shin, S. S., & Yoon, M. (2020) · Molecules · doi:10.3390/molecules25194549 · Cited by 21
Differential transendothelial transport of adiponectin complexes
Rutkowski, J. M., Halberg, N., Wang, Q. A., Holland, W. L., Xia, J. Y., & Scherer, P. E. (2014) · Cardiovascular Diabetology · doi:10.1186/1475-2840-13-47 · Cited by 22
Adipocyte-endothelial cell interplay in adipose tissue physiology
Chaurasiya, V., Haridas, P. A. N., & Olkkonen, V. M. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116081 · Cited by 20
Obesity drives depot-specific vascular remodeling in male white adipose tissue
Hasan, S. S., John, D., Rudnicki, M., AlZaim, I., Eberhard, D., Moll, I., Taylor, J., Klein, C., von Heesen, M., Conradi, L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60910-2 · Cited by 20
Association of plasma leptin levels and complexity of the culprit lesion in patients with unstable angina
Dubey, L., Zeng, H., Hashmi, S., Hongjie, W., & Tao, H. (2007) · International Journal of Cardiology · doi:10.1016/j.ijcard.2007.03.126 · Cited by 19
Correlations between circulating levels of adipokines and anti-angiogenic factors in women with BMI <30 and a late-onset preeclampsia
Eleuterio, N. M., Palei, A. C., Machado, J. D. S. R., Tanus-Santos, J. E., Cavalli, R. D. C., & Sandrim, V. C. (2013) · Hypertension in Pregnancy · doi:10.3109/10641955.2013.837174 · Cited by 19
Enhanced Angiogenesis in HUVECs Preconditioned with Media from Adipocytes Differentiated from Lipedema Adipose Stem Cells In Vitro
Al-Ghadban, S. I., Walczak, S. G., Isern, S. U., Martin, E. C., Herbst, K. L., & Bunnell, B. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713572 · Cited by 19
Gene expression of adipokines and adipokine receptors in the tumor microenvironment: associations of lower expression with more aggressive breast tumor features
Llanos, A. A. M., Yao, S., Singh, A., Aremu, J. B., Khiabanian, H., Lin, Y., Omene, C. O., Omilian, A. R., Khoury, T., Hong, C., et al. (2020) · Breast Cancer Research and Treatment · doi:10.1007/s10549-020-05972-0 · Cited by 18
Angiogenic biomarkers in children with congenital heart disease: possible implications
El-Melegy, N. T., & Mohamed, N. (2010) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/1824-7288-36-32 · Cited by 18
Hepatic leptin receptor expression can partially compensate for IL-6Rα deficiency in DEN-induced hepatocellular carcinoma
Mittenbühler, M. J., Sprenger, H.-G., Gruber, S., Wunderlich, C. M., Kern, L., Brüning, J. C., & Wunderlich, F. T. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.08.010 · Cited by 18
Angiogenesis–Browning Interplay Mediated by Asprosin-Knockout Contributes to Weight Loss in Mice with Obesity
Yin, T., Chen, S., Zeng, G., Yuan, W., Lu, Y., Zhang, Y., Huang, Q., Xiong, X., Xu, B., & Huang, Q. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416166 · Cited by 17
Terminal Arteriolar Network Structure/Function and Plasma Cytokine Levels in db/db and ob/ob Mouse Skeletal Muscle
Georgi, M. K., Vigilance, J., Dewar, A. M., & Frame, M. D. S. (2011) · Microcirculation · doi:10.1111/j.1549-8719.2011.00084.x · Cited by 16
Leptin ameliorates ischemic necrosis of the femoral head in rats with obesity induced by a high-fat diet
Zhou, L., Jang, K. Y., Moon, Y. J., Wagle, S., Kim, K. M., Lee, K. B., Park, B., & Kim, J. R. (2015) · Scientific Reports · doi:10.1038/srep09397 · Cited by 18
The angioregulatory phenotype of native human acute myelogenous leukemia cells: influence of karyotype, Flt3 abnormalities and differentiation status
Glenjen, N. I., Hovland, R., Wergeland, L., Wendelbo, Ø., Ernst, P., & Bruserud, Ø. (2003) · European Journal Of Haematology · doi:10.1034/j.1600-0609.2003.00130.x · Cited by 17
Beta cell specific probing with fluorescent exendin-4 is progressively reduced in type 2 diabetic mouse models
Lehtonen, J., Schäffer, L., Rasch, M. G., Hecksher‐Sørensen, J., & Ahnfelt‐Rønne, J. (2015) · Islets · doi:10.1080/19382014.2015.1137415 · Cited by 16
Leptin Promotes Glioblastoma
Lawrence, J. E., Cook, N., Rovin, R., & Winn, R. J. (2012) · Neurology Research International · doi:10.1155/2012/870807 · Cited by 17
Angiogenesis in refractory depression: A possible phenotypic target to avoid the blood brain barrier
Yamada, M. K. (2016) · Drug Discoveries & Therapeutics · doi:10.5582/ddt.2016.01003 · Cited by 16
Fat, obesity, and the endothelium
Yucel, N. D., & Arany, Z. P. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.09.003 · Cited by 15
Beneficial effects of metformin on mice female fertility after a high-fat diet intake
Velázquez, C., Herrero, Y., Bianchi, M. S., Cohen, D. J., Cuasnicu, P. S., Prost, K., Marinoni, R., Pascuali, N., Parborell, F., & Abramovich, D. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.111995 · Cited by 17
Pulmonary Vascular Congestion: A Mechanism for Distal Lung Unit Dysfunction in Obesity
Oppenheimer, B. W., Berger, K. I., Ali, S. M., Segal, L. N., Donnino, R. M., Katz, S. D., Parikh, M., & Goldring, R. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152769 · Cited by 16
Serum and Tissue Expression Levels of Leptin and Leptin Receptor Are Putative Markers of Specific Feline Mammary Carcinoma Subtypes
Gameiro, A., Nascimento, C., Urbano, A. C., Correia, J., & Ferreira, F. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.625147 · Cited by 18
Maternal serum, amniotic fluid and cord leptin levels at term: their correlations with fetal weight
Öktem, Ö., Dedeoğlu, N., Oymak, Y., Sezen, D., Köksal, L., Pekin, T., Gökaslan, H., & Kavak, Z. N. (2004) · Journal of Perinatal Medicine · doi:10.1515/jpm.2004.050 · Cited by 16
Leptin upregulates tissue factor expression in human breast cancer MCF-7 cells
Napoleone, E., Cutrone, A., Cugino, D., Latella, M. C., Zurlo, F., Iacoviello, L., de Gaetano, G., Donati, M. B., & Lorenzet, R. (2011) · Thrombosis Research · doi:10.1016/j.thromres.2011.07.037 · Cited by 16
Gene expression and protein distribution of leptin and its receptor in bovine oocytes and preattachment embryos produced in vitro
Madeja, Z. E., Warzych, E., Peippo, J., Lechniak, D., & Switonski, M. (2008) · animal · doi:10.1017/s1751731108003741 · Cited by 16
Phorbol esters induce PLVAP expression via VEGF and additional secreted molecules in MEK 1‐dependent and p38, JNK and PI 3K/Akt‐independent manner
Hamilton, B. J., Tse, D., & Stan, R. V. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13993 · Cited by 16
Weighing the Risk: effects of Obesity on the Mammary Gland and Breast Cancer Risk
Hillers‐Ziemer, L. E., & Arendt, L. M. (2020) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-020-09452-5 · Cited by 18
Heparinized Acellular Hydrogels for Magnetically Induced Wound Healing Applications
Pires, F., Silva, J. C., Ferreira, F. C., & Portugal, C. A. M. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c18877 · Cited by 15
The adipokine leptin modulates adventitial pericyte functions by autocrine and paracrine signalling
Riu, F., Slater, S. C., Jover, E., Rodríguez-Arabaolaza, I., Alvino, V. V., Avolio, E., Mangialardi, G., Cordaro, A., Satchell, S. C., Zebele, C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05868-y · Cited by 14
Immunohistochemical analysis of adipokine and adipokine receptor expression in the breast tumor microenvironment: associations of lower leptin receptor expression with estrogen receptor-negative status and triple-negative subtype
Llanos, A. A. M., Lin, Y., Chen, W., Yao, S., Norin, J., Chekmareva, M. A., Omene, C. O., Cong, L., Omilian, A. R., Khoury, T., et al. (2020) · Breast Cancer Research · doi:10.1186/s13058-020-1256-3 · Cited by 15
Leptin in Tumor Microenvironment
Angelucci, A., Clementi, L., & Alesse, E. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-43093-1_6 · Cited by 16
Leptin enhances endothelial cell differentiation and angiogenesis in murine embryonic stem cells
Kurtovic, S., Ng, T. T., Gupta, A., Arumugaswami, V., Chaiboonma, K. L., Aminzadeh, M. A., Makkar, R., Dafoe, D. C., & Talavera‐Adame, D. (2014) · Microvascular Research · doi:10.1016/j.mvr.2014.09.004 · Cited by 14
Bioinformatics methods in biomarkers of preeclampsia and associated potential drug applications
Peng, Y., Hong, H., Gao, N., Wan, A., & Ma, Y. (2022) · BMC Genomics · doi:10.1186/s12864-022-08937-3 · Cited by 14
Tumor microvasculature with endothelial fenestrations in VHL null clear cell renal cell carcinomas as a potent target of anti‐angiogenic therapy
Yamasaki, T., Kamba, T., Kanno, T., Inoue, T., Shibasaki, N., Arakaki, R., Yamada, T., Kondo, K., Kamoto, T., Nishiyama, H., et al. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02412.x · Cited by 16
Angiogenic Effect of Leptin in the Quail Chorioallantoic Membrane
Výboh, P., Zeman, M., Bilčı́k, B., Šárniková, B., & Košťál, Ľ. (2010) · Acta Veterinaria Brno · doi:10.2754/avb201079010013 · Cited by 14
The Links Between Obesity, Leptin, and Prostate Cancer
Chung, W. K., & Leibel, R. L. (2006) · The Cancer Journal · doi:10.1097/00130404-200605000-00004 · Cited by 14
Diabetes-associated dysregulated cytokines and cancer
Wu, Y., Dong, Y., Liu, Y., & Vadgama, J. V. (2016) · Integrative Cancer Science and Therapeutics · doi:10.15761/icst.1000173 · Cited by 13
INTRAVITREOUS LEPTIN CONCENTRATIONS IN PATIENTS WITH PROLIFERATIVE DIABETIC RETINOPATHY
Hernández, C., Lecube, A., Castellanos, J. M., Segura, R., Garat, M., García‐Arumí, J., & Simó, R. (2004) · Retina · doi:10.1097/00006982-200402000-00005 · Cited by 14
HDAC in obesity: A critical insight
Nijhawan, P., Behl, T., Khullar, G., Pal, G., Kandhwal, M., & Goyal, A. (2020) · Obesity Medicine · doi:10.1016/j.obmed.2020.100212 · Cited by 13
Tenomodulin gene and obesity-related phenotypes
Tolppanen, A., Kolehmainen, M., Pulkkinen, L., & Uusitupa, M. I. J. (2010) · Annals of Medicine · doi:10.3109/07853891003801123 · Cited by 13
Favorable effects of low-fat and low-carbohydrate dietary patterns on serum leptin, but not adiponectin, among overweight and obese premenopausal women: a randomized trial
Llanos, A. A. M., Krok, J. L., Peng, J., Pennell, M. L., Olivo‐Marston, S., Vitolins, M. Z., DeGraffinreid, C. R., & Paskett, E. D. (2014) · SpringerPlus · doi:10.1186/2193-1801-3-175 · Cited by 15
Transgenic overexpression of keratinocyte-specific VEGF and Ang1 in combination promotes wound healing under nondiabetic but not diabetic conditions.
Loyd, C. M., Diaconu, D., Fu, W., Adams, G. N., Brandt, E. N., Knutsen, D. A., Wolfram, J. A., McCormick, T. S., & Ward, N. L. (2012) · PubMed Central · Cited by 13
Stimulating angiogenesis mitigates the unloading-induced reduction in osteogenesis in early-stage bone repair in rats
Matsumoto, T., & Sato, S. (2015) · Physiological Reports · doi:10.14814/phy2.12335 · Cited by 13
Obesity, Diabetes and Metabolic Syndrome Impact on Tumor Angiogenesis
Incio, J., & Soares, R. (2013) · CRC Press eBooks · doi:10.1201/b14842-13 · Cited by 13
Endurance Exercise Mitigates Immunometabolic Adipose Tissue Disturbances in Cancer and Obesity
Neto, J. C. R., & Silveira, L. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249745 · Cited by 13
Metabolic syndrome in colorectal cancer liver metastasis: metabolic reprogramming and microenvironment crosstalk
Ma, Z., Wang, S., Liu, S., Yang, W., Hu, J., Lv, L., Qian, Y., & Lu, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1653442 · Cited by 17
Importance of insulin resistance to vascular repair and regeneration
Cubbon, R. M., Mercer, B. N., Sengupta, A., & Kearney, M. T. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.02.028 · Cited by 12
Matrix metalloproteinase inhibition affects adipose tissue mass in obese mice
Hul, M. V., Lupu, F., Dresselaers, T., Buyse, J. G., & LIJNEN, H. R. (2012) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2012.05714.x · Cited by 12
Embryonic adhesion is not affected by endometrial leptin receptor gene silencing
Cerveró, A., Domı́nguez, F., Horcajadas, J. A., Quiñonero, A., Pellicer, A., & Simón, C. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.12.028 · Cited by 12
Interplay between Hypoxia, Inflammation and Adipocyte Remodeling in the Metabolic Syndrome
Andrei, A. M., Berbecaru-Iovan, A., Din-Anghel, F. R. I., Stănciulescu, C. E., Berbecaru-Iovan, S., Baniţă, I. M., & Pisoschi, C. G. (2017) · InTech eBooks · doi:10.5772/65491 · Cited by 14
Subnormothermic short-term cultivation improves the vascularization capacity of adipose tissue-derived microvascular fragments
Laschke, M. W., Heß, A., Scheuer, C., Karschnia, P., & Menger, M. D. (2018) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2774 · Cited by 12
Low Doses of Ionizing Radiation Enhance the Angiogenic Potential of Adipocyte Conditioned Medium
Marques, F. G., Poli, E., Rino, J., Pinto, M. T., Diegues, I., Pina, F., & Santos, S. C. R. (2019) · Radiation Research · doi:10.1667/rr15438.1 · Cited by 12
Plasma 8-Isoprostane Concentrations and Adipogenic and Adipokine Gene Expression Patterns in Subcutaneous and Mesenteric Adipose Tissues of Fattening Wagyu Cattle
Yamada, T., HIGUCHI, M., & NAKANISHI, N. (2013) · Journal of Veterinary Medical Science · doi:10.1292/jvms.13-0071 · Cited by 11
Diphlorethohydroxycarmalol of Ishige okamurae and Caffeine Modified the Expression of Extracellular Fibrillars during Adipogenesis of Mouse Subcutaneous Adipose Derived Stem Cell
Jeon, Y., Song, S., Kim, H., & Cheon, Y. (2013) · Development & Reproduction · doi:10.12717/dr.2013.17.3.275 · Cited by 11

Authors: Cao, R., Brakenhielm, E., Wahlestedt, C., Thyberg, J., & Cao, Y.
Affiliations: Karolinska Institutet (SE)
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Center for Genomic Research, Department of Cell and Molecular Biology, Karolinska Institute, S-171 77 Stockholm, Sweden
ORCID: Wahlestedt, Claes
Cao, Yihai
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2001-05-08
Volume: 98
Issue: 11
Pages: 6390-6395
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.101564798
PMC: PMC33478
OpenAlex: W2111796479
Cited by: 446
References: 29
Citations by year: 2026: 5 · 2025: 10 · 2024: 7 · 2023: 12 · 2022: 22 · 2021: 17 · 2020: 19 · 2019: 19 · 2018: 14 · 2017: 23 · 2016: 17 · 2015: 17 · 2014: 18 · 2013: 40 · 2012: 24
FWCI: 6.17
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: leptin, vascular permeability, angiogenesis, FGF2, vascular endothelial growth factor, adipose tissue, ob/ob mice, hormone transport
MeSH terms: Adipose Tissue, Animals, Capillaries, Capillary Permeability, Cattle, Cell Division, Cells, Cultured, Cornea, Drug Synergism, Endothelium, Vascular, Female, Humans, Lymphokines, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Obese, Fibroblast Growth Factor 2, Endothelial Growth Factors, Corneal Neovascularization, Neovascularization, Physiologic, Leptin, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks