The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Magnetosome-like ferrimagnetic iron oxide nanocubes for highly sensitive MRI of single cells and transplanted pancreatic islets
Open accessAbstract
For ultrasensitive magnetic resonance imaging (MRI), magnetic nanoparticles with extremely high r2 relaxivity are strongly desired. Magnetosome-like nanoparticles were prepared by coating polyethylene glycol-phospholipid (PEG-phospholipid) onto ferrimagnetic iron oxide nanocubes (FIONs). FIONs exhibited a very high relaxivity (r2) of 324 mM -1 s -1 , allowing efficient labeling of various kinds of cells. The magnetic resonance (MR) imaging of single cells labeled with FIONs is demonstrated not only in vitro but also in vivo. Pancreatic islet grafts and their rejection could be imaged using FIONs on a 1.5 T clinical MRI scanner. The strong contrast effect of FIONs enabled MR imaging of transplanted islets in small rodents as well as in large animals. Therefore, we expect that MR imaging of pancreatic islet grafts using FIONs has the potentials for clinical applications. Furthermore, FIONs will enable highly sensitive noninvasive assessment after cell transplantation.
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Cited by
Lee, N., & Hyeon, T. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15248c · Cited by 995
Self-citationLee, N., Choi, S. H., & Hyeon, T. (2013) · Advanced Materials · doi:10.1002/adma.201300081 · Cited by 657
Self-citationOrganic Phase Syntheses of Magnetic Nanoparticles and Their Applications
Wu, L., Mendoza-Garcia, A., Li, Q., & Sun, S. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00687 · Cited by 601
Chemical Synthesis and Assembly of Uniformly Sized Iron Oxide Nanoparticles for Medical Applications
Ling, D., Lee, N., & Hyeon, T. (2015) · Accounts of Chemical Research · doi:10.1021/acs.accounts.5b00038 · Cited by 513
Self-citationJin, R., Lin, B., Li, D., & Ai, H. (2014) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.08.002 · Cited by 305
Metadata
- Authors
- Lee, N., Kim, H., Choi, S. H., Park, M., Kim, D., Kim, H.-C., Choi, Y., Lin, S., Kim, B. H., Jung, H. S., Kim, H., Park, K. S., Moon, W. K., & Hyeon, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-01-31
- Volume
- 108
- Issue
- 7
- Pages
- 2662-2667
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2084648630
- Cited by
- 200
- References
- 4
- FWCI
- 12.03
- Type
- journal article
- Language
- en
- Open access
- green
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- Lee, N., Kim, H., Choi, S. H., Park, M., Kim, D., Kim, H.-C., Choi, Y., Lin, S., Kim, B. H., Jung, H. S., Kim, H., Park, K. S., Moon, W. K., & Hyeon, T. (2011). Magnetosome-like ferrimagnetic iron oxide nanocubes for highly sensitive MRI of single cells and transplanted pancreatic islets. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1016409108
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