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Glucose metabolic dysregulation and oxidative stress in cholangiocarcinoma: molecular mechanisms, oncogenic drivers, and novel therapeutic targets

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Metabolic Remodeling in Bioenergetic Disorders and Cancer

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NDRG2 Inhibits Pyruvate Carboxylase-Mediated Anaplerosis and Combines with Glutamine Blockade To Inhibit The Growth of GliomaPreprint

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Hsa-miR-31-5p controls a metabolic switch in psoriatic keratinocytes that identifies therapeutic interventionPreprint

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Cancer Metabolism

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FBXW7 alleviates c-MYC repression of pyruvate carboxylase to support metabolic flexibilityPreprint

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TCA cycle rewiring underpins implantation and histone acetylation programmingPreprint

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Superfluous glutamine synthetase activity in Chinese Hamster Ovary cells selected under glutamine limitation is growth limiting in glutamine‐replete conditions and can be inhibited by serine

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Recent advances in small molecular inhibitors of pyruvate carboxylase for human diseases

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Targeting Metabolic Reprogramming: A New Frontier in Cancer Therapy

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Riboflavin-PLGA nanoparticles enhance the effectiveness of the pyruvate carboxylase inhibitor ZY-444 in targeting lipogenesis in colon and breast cancer

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A Narrative Review of the Role of Mitochondria in Cancer: From Metabolic Reprogramming to Therapeutic Targeting

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Metabolic Plasticity of IDH1- Mutant Glioma Cell Lines Is Responsible for Low Sensitivity to Glutaminase InhibitionPreprint

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Investigating Dysregulated Metabolic Pathways that Drive Cancer Pathogenicity

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The Epithelial To Mesenchymal Transition In Breast Cancer Induces Alterations In Metabolism

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Glioblastoma Multiforme Metabolism: Fuel to the Flame

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Energy metabolism of cancer: a suspected role of low Glutamine supply in the Warburg/Crabtree effects

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PREDICTORS AND PREMORBID CONDITIONS OF THE DEVELOPMENT OF FEMALE GENITAL CANCER, IN PARTICULAR ENDOMETRY CANCER AND BREAST CANCER

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Identification of MARCO and PCSK6 As Key Genes Promoting Hepatic Metastasis in Pancreatic Cancer via Bioinformatics AnalysisPreprint

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Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP productionPreprint

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Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP productionPreprint

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Assessing Pyruvate Carboxylase Flux as a Mechanistic Biological Marker in Fasting

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Supplementary Methods from Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma

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GLUD1 dictates muscle stem cell differentiation by controlling mitochondrial glutamate levelsPreprint

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Entendimento do papel de glutaminase 2 para a progressão tumoral

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Additional file 1 of Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis

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Affinity war: PSAT1 outcompetes the rest

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Inhibiting glioblastoma stem cells by targeting pyruvate carboxylase: A novel therapeutic strategy with both opportunities and challenges

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MPC2 Overexpression Drives Mitochondrial Oxidative Phosphorylation and Promotes Progression in Diffuse Large B-Cell Lymphoma

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Additional file 4 of Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

Ruiz‐Rodado, V., Lita, A., Dowdy, T., Celiku, O., Saldana, A. C., Wang, H., Yang, C. Z., Chari, R., Li, A., Zhang, W., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13126629

Additional file 2 of Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition

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Additional file 2 of Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

Ruiz‐Rodado, V., Lita, A., Dowdy, T., Celiku, O., Saldana, A. C., Wang, H., Yang, C. Z., Chari, R., Li, A., Zhang, W., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13126623

Additional file 1 of Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

Ruiz‐Rodado, V., Lita, A., Dowdy, T., Celiku, O., Saldana, A. C., Wang, H., Yang, C. Z., Chari, R., Li, A., Zhang, W., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13126620

Additional file 1 of Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition

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Additional file 6 of Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

Ruiz‐Rodado, V., Lita, A., Dowdy, T., Celiku, O., Saldana, A. C., Wang, H., Yang, C. Z., Chari, R., Li, A., Zhang, W., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13126635

Additional file 1 of 13C tracer analysis suggests extensive recycling of endogenous CO2 in vivo

Duan, L., Cooper, D. E., Scheidemantle, G. M., Locasale, J. W., Kirsch, D. G., & Liu, X. (2022) · Figshare · doi:10.6084/m9.figshare.20267682

Additional file 3 of Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

Ruiz‐Rodado, V., Lita, A., Dowdy, T., Celiku, O., Saldana, A. C., Wang, H., Yang, C. Z., Chari, R., Li, A., Zhang, W., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13126626

Additional file 5 of Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

Ruiz‐Rodado, V., Lita, A., Dowdy, T., Celiku, O., Saldana, A. C., Wang, H., Yang, C. Z., Chari, R., Li, A., Zhang, W., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13126632

Rôle du transporteur mitochondrial UCP2 dans la leucémie

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EVT-701 : targeting electron transport chain complex I as therapeutic approach in cancer

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Metabolic maintenance of breast cancer cells and metastases through E-cadherin/YAP–dependent pyruvate carboxylase expressionPreprint

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The metabolic escape: how tumor metabolic reprogramming drives drug resistance

Chen, Y., Wu, Z., Si, W., & Liu, X. (2026) · PeerJ · doi:10.7717/peerj.21400

Design, Synthesis, and Evaluation of Bibenzyl Analogues against Hepatocellular Carcinoma by Targeting Pyruvate Carboxylase

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Cysteine-mediated bortezomib resistance is governed by α-ketoacid availabilityPreprint

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Respiration-deficient cells require pyruvate carboxylase to suppress asparagine auxotrophy

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Early metabolic rewiring precedes arsenic-induced carcinogenesis in human lung epithelial cells

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Distinct Post-Exposure Metabolic States Following Pharmacological Perturbation of Mitochondrial Respiratory Complexes I–V in SH-SY5Y Cells: A Positional 13C-NMR Study

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BindingDB Entry 50013553: Discovery and optimization of withangulatin A derivatives as novel glutaminase 1 inhibitors for the treatment of triple-negative breast cancer.

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Respiratory stress unmasks asparagine vulnerability

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Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation

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NDRG2 inhibits pyruvate carboxylase-mediated anaplerosis and combines with glutamine blockade to inhibit the proliferation of glioma cells.

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Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer

Singleton, D. C., Dechaume, A.-L., Murray, P. M., Katt, W. P., Baguley, B. C., & Leung, E. Y. (2020) · BMC Cancer · doi:10.1186/s12885-020-06885-3 · Cited by 56

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