The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Reactive oxygen species are indispensable in ovulation
Open accessAbstract
Ovulation is stimulated by the preovulatory surge of the pituitary luteinizing hormone (LH). Because the ovulatory response is commonly identified with inflammation, we explored the involvement of reactive oxygen species (ROS) in this process. Our experiments show that administration of broad-range scavengers of oxidative species into the ovarian bursa of mice, hormonally induced to ovulate, significantly reduced the rate of ovulation. LH-induced cumulus mucification/expansion, a necessary requirement for ovulation, was prevented by antioxidants both in vivo and in an ex vivo system of isolated intact ovarian follicles. Along this line, H 2 O 2 fully mimicked the effect of LH, bringing about an extensive mucification/expansion of the follicle-enclosed cumulus–oocyte complexes. Impaired progesterone production was observed in isolated follicles incubated with LH in the presence of the antioxidant agents. Furthermore, LH-stimulated up-regulation of genes, the expression of which is crucial for ovulation, was substantially attenuated upon ROS ablation. This system was also used for demonstrating the role of ROS in phosphorylation and activation of the EGF receptor as well as its downstream effector, p42/44 MAPK. Together, our results provide evidence that ovarian production of ROS is an essential preovulatory signaling event, most probably transiently triggered by LH.
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Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.
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Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II
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MAPK3/1 (ERK1/2) in Ovarian Granulosa Cells Are Essential for Female Fertility
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Cited by
The effects of oxidative stress on female reproduction: a review
Agarwal, A., Aponte-Mellado, A., Premkumar, B. J., Shaman, A., & Gupta, S. (2012) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-10-49 · Cited by 1,637
A novel and compact review on the role of oxidative stress in female reproduction
Lu, J., Wang, Z., Cao, J., Chen, Y., & Dong, Y. (2018) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-018-0391-5 · Cited by 481
Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications
Da Broi, M. G., Giorgi, V. S. I., Wang, F., Keefe, D. L., Albertini, D., & Navarro, P. A. (2018) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-018-1143-3 · Cited by 312
Oxidative stress and the ageing endocrine system
Vitale, G., Salvioli, S., & Franceschi, C. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.29 · Cited by 270
The Role of Oxidative Stress and Antioxidant Balance in Pregnancy
Hussain, T., Murtaza, G., Metwally, E., Kalhoro, D. H., Kalhoro, M. S., Rahu, B. A., Sahito, R. G. A., Yin, Y., Yang, H., Chughtai, M. I., et al. (2021) · Mediators of Inflammation · doi:10.1155/2021/9962860 · Cited by 265
Metadata
- Authors
- Shkolnik, K., Tadmor, A., Ben-Dor, S., Nevo, N., Galiani, D., & Dekel, N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-01-10
- Volume
- 108
- Issue
- 4
- Pages
- 1462-1467
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2074002921
- Cited by
- 383
- References
- 52
- FWCI
- 14.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Shkolnik, K., Tadmor, A., Ben-Dor, S., Nevo, N., Galiani, D., & Dekel, N. (2011). Reactive oxygen species are indispensable in ovulation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1017213108
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