The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies
Open accessAbstract
Increased meiotic spindle abnormalities and aneuploidy in oocytes of women of advanced maternal ages lead to elevated rates of infertility, miscarriage, and trisomic conceptions. Despite the significance of the problem, strategies to sustain oocyte quality with age have remained elusive. Here we report that adult female mice maintained under 40% caloric restriction (CR) did not exhibit aging-related increases in oocyte aneuploidy, chromosomal misalignment on the metaphase plate, meiotic spindle abnormalities, or mitochondrial dysfunction (aggregation, impaired ATP production), all of which occurred in oocytes of age-matched ad libitum-fed controls. The effects of CR on oocyte quality in aging females were reproduced by deletion of the metabolic regulator, peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α). Thus, CR during adulthood or loss of PGC-1α function maintains female germline chromosomal stability and its proper segregation during meiosis, such that ovulated oocytes of aged female mice previously maintained on CR or lacking PGC-1α are comparable to those of young females during prime reproductive life.
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Cites
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160
Extending Healthy Life Span—From Yeast to Humans
Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023
Metabolic control through the PGC-1 family of transcription coactivators
Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130
Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice
Lin, J., Wu, P.-H., Tarr, P. T., Lindenberg, K. S., St-Pierre, J., Zhang, C.-Y., Mootha, V. K., Jäger, S., Vianna, C. R., Reznick, R. M., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.013 · Cited by 1,162
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
Nisoli, E., Tonello, C., Cardile, A., Cozzi, V., Bracale, R., Tedesco, L., Falcone, S., Valerio, A., Cantoni, O., Clementi, E., et al. (2005) · Science · doi:10.1126/science.1117728 · Cited by 1,107 · cited 2×
“On the basis of correlations drawn from gene expression studies (24, 45), we initially expected that the effects of CR might be minimized, rather than reproduced, by PGC-1α deficiency.”
BackgroundLeone, T. C., Lehman, J. J., Finck, B. N., Schaeffer, P. J., Wende, A. R., Boudina, S., Courtois, M., Wozniak, D. F., Sambandam, N., Bernal-Mizrachi, C., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030101 · Cited by 951
Maternal age-specific rates of numerical chromosome abnormalities with special reference to trisomy
Hassold, T., & Chiu, D. (1985) · Human Genetics · doi:10.1007/bf00389450 · Cited by 481
Pregnancy in the Sixth Decade of Life: Obstetric Outcomes in Women of Advanced Reproductive Age
Paulson, R. J., Boostanfar, R., Saadat, P., Mor, E., Tourgeman, D. E., Slater, C. C., Francis, M. M., & Jain, J. K. (2002) · JAMA · doi:10.1001/jama.288.18.2320 · Cited by 258
Cited by
Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women
White, Y. A. R., Woods, D. C., Takai, Y., Ishihara, O., Seki, H., & Tilly, J. L. (2012) · Nature Medicine · doi:10.1038/nm.2669 · Cited by 719
Self-citationMechanisms of oocyte aneuploidy associated with advanced maternal age
Mikwar, M., MacFarlane, A. J., & Marchetti, F. (2020) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2020.108320 · Cited by 308
Parenting from before conception
Lane, M., Robker, R. L., & Robertson, S. A. (2014) · Science · doi:10.1126/science.1254400 · Cited by 289
Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies
Igarashi, H., Takahashi, T., & Nagase, S. (2015) · Reproductive Medicine and Biology · doi:10.1007/s12522-015-0209-5 · Cited by 116
DNA damage in aging, the stem cell perspective
McNeely, T., Leone, M., Yanai, H., & Beerman, I. (2020) · Human Genetics · doi:10.1007/s00439-019-02047-z · Cited by 52
Metadata
- Authors
- Selesniemi, K., Lee, H.-J., Muhlhauser, A., & Tilly, J. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-07-05
- Volume
- 108
- Issue
- 30
- Pages
- 12319-12324
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1978691222
- Cited by
- 201
- References
- 8
- FWCI
- 19.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Selesniemi, K., Lee, H.-J., Muhlhauser, A., & Tilly, J. L. (2011). Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1018793108
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