The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron–glia interactions in Drosophila
Open accessAbstract
Extrinsic factors and the interactions of neurons with surrounding tissues are essential for almost every aspect of neuronal development. Here we describe a strategy of g ene e xpression with an independent e nhancer-driven cellular m arker (GEEM) for studying roles of cell–cell interactions and extrinsic factors in the development of the Drosophila nervous system. Key to this strategy is robust expression of enhancer-driven transgenic markers in specific neurons. To this end, we have created vectors to achieve bright and even labeling of neuronal processes, easy cloning of enhancer elements, and efficient and flexible generation of transgenic animals. We provide examples of enhancer-driven membrane markers for specific neurons in both the peripheral and central nervous systems and their applications in the study of neuronal projections and connections in the Drosophila brain. We further applied GEEM to examine the wrapping of sensory neuron somas by glia during embryonic and larval stages, and neuron–glia interaction during dendrite pruning in live animals, leading to the discovery that glia play critical roles in the severing and degradation of proximal dendrites. The GEEM paradigm should be applicable to the studies of both cell-autonomous and nonautonomous regulations of any cell type.
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Cites
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Self-citationCell-Surface Proteomic Profiling in the Fly Brain Uncovers Wiring Regulators
Li, J., Han, S., Li, H., Udeshi, N. D., Svinkina, T., Mani, D. R., Xu, C., Guajardo, R., Xie, Q., Li, T., et al. (2020) · Cell · doi:10.1016/j.cell.2019.12.029 · Cited by 204
Han, C., Wang, D., Soba, P., Zhu, S., Lin, X., Jan, L. Y., & Jan, Y.-N. (2012) · Neuron · doi:10.1016/j.neuron.2011.10.036 · Cited by 168
Self-citationLi, F., Sami, A., Noristani, H. N., Slattery, K., Qiu, J., Groves, T., Wang, S., Veerasammy, K., Chen, Y. X., Morales, J., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.08.015 · Cited by 147
Metadata
- Authors
- Han, C., Jan, L. Y., & Jan, Y.-N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-05-23
- Volume
- 108
- Issue
- 23
- Pages
- 9673-9678
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1990943845
- Cited by
- 278
- References
- 37
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- green
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