Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer
Open accessAbstract
p63 inhibits metastasis. Here, we show that p63 (both TAp63 and ΔNp63 isoforms) regulates expression of miR-205 in prostate cancer (PCa) cells, and miR-205 is essential for the inhibitory effects of p63 on markers of epithelial-mesenchymal transition (EMT), such as ZEB1 and vimentin. Correspondingly, the inhibitory effect of p63 on EMT markers and cell migration is reverted by anti-miR-205. p53 mutants inhibit expression of both p63 and miR-205, and the cell migration, in a cell line expressing endogenous mutated p53, can be abrogated by pre-miR-205 or silencing of mutated p53. In accordance with this in vitro data, ΔNp63 or miR-205 significantly inhibits the incidence of lung metastasis in vivo in a mouse tail vein model. Similarly, one or both components of the p63/miR-205 axis were absent in metastases or colonized lymph nodes in a set of 218 human prostate cancer samples. This was confirmed in an independent clinical data set of 281 patients. Loss of this axis was associated with higher Gleason scores, an increased likelihood of metastatic and infiltration events, and worse prognosis. These data suggest that p63/miR-205 may be a useful clinical predictor of metastatic behavior in prostate cancer.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
p63 and PTEN are tumor suppressors that play a key role in breast and prostate tissue development.
“we inhibited p63 and PTEN expression, two genes that are described as tumor-suppressors that play a key role in breast and prostate tissue development (32–35).”
From Direct transfection of clonal organoids in Matrigel microbeads: a promising approach toward organoid-based genetic screens (2018) · cites this paper as [34]
Cites
Gregory, P. A., Bert, A. G., Paterson, E. L., Barry, S. C., Tsykin, A., Farshid, G., Vadas, M. A., Khew‐Goodall, Y., & Goodall, G. J. (2008) · Nature Cell Biology · doi:10.1038/ncb1722 · Cited by 3,852 · see citing works
Integrative Genomic Profiling of Human Prostate Cancer
Taylor, B. S., Schultz, N. D., Hieronymus, H., Gopalan, A., Xiao, Y., Carver, B. S., Arora, V. K., Kaushik, P., Cerami, E. G., Reva, B. A., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.05.026 · Cited by 3,653 · see citing works
Yang, A., Kaghad, M., Wang, Y., Gillett, E. S., Fleming, M. D., Dötsch, V., Andrews, N. C., Caput, D., & McKeon, F. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80275-0 · Cited by 2,086 · see citing works
Self-citationGain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
Lang, G. A., Iwakuma, T., Suh, Y.-A., Liu, G., Rao, V. A., Parant, J. M., Valentin-Vega, Y. A., Terzian, T., Caldwell, L. C., Strong, L. C., et al. (2004) · Cell · doi:10.1016/j.cell.2004.11.006 · Cited by 1,069 · see citing works
Epithelial-Mesenchymal Transition in Breast Cancer Relates to the Basal-like Phenotype
Sarrió, D., Rodríguez-Pinilla, S. M., Hardisson, D., Cano, A., Moreno‐Bueno, G., & Palacios, J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2017 · Cited by 1,057 · see citing works
Mutant p53 drives invasion by promoting integrin recycling
Muller, P. A. J., Caswell, P. T., Doyle, B., Iwanicki, M. P., Tan, E. H., Karim, S., Lukashchuk, N., Gillespie, D. A., Ludwig, R. L., Gosselin, P., et al. (2009) · Cell · doi:10.1016/j.cell.2009.11.026 · Cited by 796 · see citing works
Self-citationA Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis
Adorno, M., Cordenonsi, M., Montagner, M., Dupont, S., Wong, C., Hann, B. C., Solari, A., Bobisse, S., Rondina, M. B., Guzzardo, V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.01.039 · Cited by 783 · see citing works
MicroRNAs as regulators of epithelial-mesenchymal transition
Gregory, P. A., Bracken, C. P., Bert, A. G., & Goodall, G. J. (2008) · Cell Cycle · doi:10.4161/cc.7.20.6851 · Cited by 506 · see citing works
Flores, E. R., Sengupta, S., Miller, J. B., Newman, J. J., Bronson, R. T., Crowley, D. G., Yang, A., McKeon, F., & Jacks, T. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.02.019 · Cited by 499 · see citing works
MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets
Baffa, R., Fassan, M., Volinia, S., O’Hara, B. J., Liu, C., Palazzo, J., Gardiman, M. P., Rugge, M., Gomella, L. G., Croce, C. M., et al. (2009) · The Journal of Pathology · doi:10.1002/path.2586 · Cited by 473 · see citing works
Gaiddon, C., Lokshin, M., Ahn, J., Zhang, T., & Prives, C. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.5.1874-1887.2001 · Cited by 464 · see citing works
TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs
Su, X., Chakravarti, D., Cho, M. S., Liu, L.-Z., Gi, Y. J., Lin, Y.-L., Leung, M. L., El‐Naggar, A. K., Creighton, C. J., Suraokar, M. B., et al. (2010) · Nature · doi:10.1038/nature09459 · Cited by 419 · see citing works
Kupfer, A., Louvard, D., & Singer, S. J. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.8.2603 · Cited by 400 · see citing works
Graham, T. R., Zhau, H. E., Odero-Marah, V., Osunkoya, A. O., Kimbro, K. S., Tighiouart, M., Liu, T., Simons, J. W., & O'Regan, R. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2559 · Cited by 385 · see citing works
Gandellini, P., Folini, M., Longoni, N., Pennati, M., Binda, M., Colecchia, M., Salvioni, R., Supino, R., Moretti, R. M., Limonta, P., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2894 · Cited by 358 · see citing works
Suppression of cell growth and invasion by miR-205 in breast cancer
Wu, H., Zhu, S., & Mo, Y. (2009) · Cell Research · doi:10.1038/cr.2009.18 · Cited by 354 · see citing works
MicroRNA‐205–directed transcriptional activation of tumor suppressor genes in prostate cancer
Majid, S., Dar, A. A., Saini, S., Yamamura, S., Hirata, H., Tanaka, Y., Deng, G., & Dahiya, R. (2010) · Cancer · doi:10.1002/cncr.25488 · Cited by 290 · see citing works
The p53 family: guardians of maternal reproduction
Levine, A. J., Tomasini, R., McKeon, F., Mak, T. W., & Melino, G. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3086 · Cited by 252 · see citing works
Self-citationp63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53
Melino, G. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.81 · Cited by 227 · see citing works
Self-citationPhysical Interaction with Human Tumor-derived p53 Mutants Inhibits p63 Activities
Strano, S., Fontemaggi, G., Costanzo, A., Rizzo, M. G., Monti, O., Baccarini, A., Sal, G. D., Levrero, M., Sacchi, A., Oren, M., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201405200 · Cited by 225 · see citing works
Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion
Muller, P. A. J., Trinidad, A. G., Timpson, P., Morton, J. P., Zanivan, S. R., van den Berghe, P. V. E., Nixon, C., Karim, S. A., Caswell, P. T., Noll, J. E., et al. (2012) · Oncogene · doi:10.1038/onc.2012.148 · Cited by 192 · see citing works
Self-citationp63–microRNA feedback in keratinocyte senescence
Cervo, P. R. D. V., Lena, A. M., Nicoloso, M. S., Rossi, S., Mancini, M., Zhou, H., Saintigny, G., Dellambra, E., Odorisio, T., Mahé, C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112257109 · Cited by 181 · see citing works
Self-citationCoppola, V., Maria, R. D., & Bonci, D. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0172 · Cited by 146 · see citing works
Antonini, D., Russo, M. T., Rosa, L. D., Gorrese, M., Vecchio, L. D., & Missero, C. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.438 · Cited by 123 · see citing works
Song, H., & Bu, G. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.08.020 · Cited by 69 · see citing works
Chiang, C., Chu, W., Chow, S., & Chen, J. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21656 · Cited by 31 · see citing works
Molecular sampling of prostate cancer: a dilemma for predicting disease progression
Sboner, A., Demichelis, F., Calza, S., Yudi Pawitan, Y., Setlur, S. R., Hoshida, Y., Perner, S., Adami, H., Fall, K., Mucci, L. A., et al. (2010) · BMC Medical Genomics · doi:10.1186/1755-8794-3-8 · Cited by 22 · see citing works
Flagged first, then by citations
1 of the 28 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Muller, P. A. J., & Vousden, K. H. (2013) · Nature Cell Biology · doi:10.1038/ncb2641 · Cited by 1,647 · see citing works
Self-citationMutant p53 in Cancer: New Functions and Therapeutic Opportunities
Muller, P. A. J., & Vousden, K. H. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.01.021 · Cited by 1,545 · see citing works
Self-citationSenescence and aging: the critical roles of p53
Rufini, A., Tucci, P., Celardo, I., & Melino, G. (2013) · Oncogene · doi:10.1038/onc.2012.640 · Cited by 798 · see citing works
Self-citationp53 signaling in cancer progression and therapy
Marei, H. E. S., Thani, A. A. A., Afifi, N. M., Hasan, A., Caceci, T., Pozzoli, G., Morrione, A., Giordano, A., & Cenciarelli, C. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02396-8 · Cited by 602 · see citing works
Formosa, A., Markert, E. K., Lena, A. M., Italiano, D., Agrò, E. F., Levine, A. J., Bernardini, S., Garabadgiu, A. V., Melino, G., & Candi, E. (2013) · Oncogene · doi:10.1038/onc.2013.451 · Cited by 314 · see citing works
Self-citationAgostini, M., & Knight, R. A. (2014) · Oncotarget · doi:10.18632/oncotarget.1825 · Cited by 255 · see citing works
Self-citationTRAIL-coated leukocytes that kill cancer cells in the circulation
Mitchell, M. J., Wayne, E. C., Rana, K., Schaffer, C. B., & King, M. R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316312111 · Cited by 213 · see citing works
Circulating tumor cells: from new biological insights to clinical practice
Gu, X., Wei, S., & Lv, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01938-6 · Cited by 196 · see citing works
miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13
Zhang, P., Wang, L., Rodriguez‐Aguayo, C., Yuan, Y., Debeb, B. G., Chen, D., Sun, Y., You, M. J., Liu, Y., Dean, D. C., et al. (2014) · Nature Communications · doi:10.1038/ncomms6671 · Cited by 188 · see citing works
Regulation of microRNAs in cancer metastasis
Bouyssou, J., Manier, S., Huynh, D., Issa, S., Roccaro, A. M., & Ghobrial, I. M. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.02.002 · Cited by 174 · see citing works
MicroRNA Profiling in Prostate Cancer - The Diagnostic Potential of Urinary miR-205 and miR-214
Srivastava, A., Goldberger, H., Dimtchev, A., Ramalinga, M., Chijioke, J., Marian, C., Oermann, E. K., Uhm, S., Kim, J. S., Chen, L. N., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076994 · Cited by 171 · see citing works
Tucci, P., Porta, G., Agostini, M., Dinsdale, D. D., Iavicoli, I., Cain, K., Finazzi‐Agrò, A., Melino, G., & Willis, A. E. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.76 · Cited by 167 · see citing works
Self-citationTranscription factor p63 bookmarks and regulates dynamic enhancers during epidermal differentiation
Kouwenhoven, E. N., Oti, M., Niehues, H., van Heeringen, S. J., Schalkwijk, J., Stunnenberg, H. G., van Bokhoven, H., & Zhou, H. (2015) · EMBO Reports · doi:10.15252/embr.201439941 · Cited by 165 · see citing works
Memmi, E. M., Sanarico, A. G., Giacobbe, A., Peschiaroli, A., Frezza, V., Cicalese, A., Pisati, F., Tosoni, D., Zhou, H., Tonon, G., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500762112 · Cited by 162 · see citing works
Self-citationMaintaining epithelial stemness with p63
Melino, G., Memmi, E. M., Pelicci, P. G., & Bernassola, F. (2015) · Science Signaling · doi:10.1126/scisignal.aaa1033 · Cited by 139 · see citing works
Self-citationLi, P., Yang, R., & Gao, W. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-55 · Cited by 143 · see citing works
Dysregulation of EMT Drives the Progression to Clinically Aggressive Sarcomatoid Bladder Cancer
Guo, C. C., Majewski, T., Zhang, L., Yao, H., Bondaruk, J. E., Wang, Y., Zhang, S., Wang, Z., Lee, J. G., Lee, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.048 · Cited by 145 · see citing works
How theTP53Family ProteinsTP63andTP73Contribute to Tumorigenesis: Regulators and Effectors
Candi, E., Agostini, M., Melino, G., & Bernassola, F. (2014) · Human Mutation · doi:10.1002/humu.22523 · Cited by 137 · see citing works
Self-citationGuo, F., Kerrigan, B. C. P., Yang, D., Hu, L., Ilya Shmulevich, C., Sood, A. K., Xue, F., & Zhang, W. (2014) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-7-19 · Cited by 134 · see citing works
Hagman, Z., Haflidadóttir, B. S., Ceder, J. A., Larne, O., Bjartell, A. S., Lilja, H. G., Edsjö, A., & Ceder, Y. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.131 · Cited by 128 · see citing works
Roles of microRNAs during prostatic tumorigenesis and tumor progression
Fang, Y.-X., & Gao, W.-Q. (2013) · Oncogene · doi:10.1038/onc.2013.54 · Cited by 123 · see citing works
Roles of Epithelial-Mesenchymal Transition in Cancer Drug Resistance
Shang, Y., Cai, X., & Fan, D. (2013) · Current Cancer Drug Targets · doi:10.2174/15680096113136660097 · Cited by 121 · see citing works
Molecular pathways and targets in prostate cancer
Shtivelman, E., Beer, T. M., & Evans, C. P. (2014) · Oncotarget · doi:10.18632/oncotarget.2406 · Cited by 115 · see citing works
Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer
Lin, S., Kao, C., Lee, H.-J., Creighton, C. J., Ittmann, M., Tsai, S., Tsai, M., & Tsai, M. (2016) · Nature Communications · doi:10.1038/ncomms11418 · Cited by 117 · see citing works
Bhowmick, S., Scharnweber, D., & Koul, V. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.02.034 · Cited by 111 · see citing works
p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer
Lodillinsky, C., Infante, E., Guichard, A., Chaligné, R., Fuhrmann, L., Cyrta, J., Irondelle, M., Lagoutte, E., Vacher, S., Bonsang‐Kitzis, H., et al. (2015) · Oncogene · doi:10.1038/onc.2015.87 · Cited by 109 · see citing works
Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer
Rachagani, S., Macha, M. A., Heimann, N., Seshacharyulu, P., Haridas, D., Chugh, S., & Batra, S. K. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.10.020 · Cited by 106 · see citing works
Screening for E3-Ubiquitin ligase inhibitors: challenges and opportunities
Landré, V., Rotblat, B., Melino, S., Bernassola, F., & Melino, G. (2014) · Oncotarget · doi:10.18632/oncotarget.2431 · Cited by 105 · see citing works
Self-citationVerdoodt, B., Neid, M., Vogt, M., KUHN, V., Liffers, S., Palisaar, R., Noldus, J., Tannapfel, A., & Mirmohammadsadegh, A. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1915 · Cited by 103 · see citing works
Noncoding RNAs as Novel Biomarkers in Prostate Cancer
Rönnau, C., Verhaegh, G. W. C. T., Velez, M. V. L., & Schalken, J. A. (2014) · BioMed Research International · doi:10.1155/2014/591703 · Cited by 99 · see citing works
Liu, Y., Zhang, P., Wu, Q., Fang, H., Wang, Y., Xiao, Y., Cong, M., Wang, T., He, Y., Ma, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25552-0 · Cited by 95 · see citing works
Regulation of Mutant p53 Protein Expression
Vijayakumaran, R., Tan, K. H., Miranda, P. J., Haupt, S., & Haupt, Y. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00284 · Cited by 87 · see citing works
Dang, T. T., Esparza, M. A., Maine, E. A., Westcott, J. M., & Pearson, G. W. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3363 · Cited by 85 · see citing works
Cola, A. D., Volpe, S., Budani, M. C., Ferracin, M., Lattanzio, R., Turdo, A., D'Agostino, D., Capone, E., Stassi, G., Todaro, M., et al. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.192 · Cited by 84 · see citing works
miR-205: A Potential Biomedicine for Cancer Therapy
Chauhan, N., Dhasmana, A., Jaggi, M., Chauhan, S. C., & Yallapu, M. M. (2020) · Cells · doi:10.3390/cells9091957 · Cited by 82 · see citing works
Leukocytes as carriers for targeted cancer drug delivery
Mitchell, M. J., & King, M. R. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2015.966684 · Cited by 81 · see citing works
Bioinformatics analysis of the serine and glycine pathway in cancer cells
Antonov, A. V., Agostini, M., Morello, M., Minieri, M., Melino, G., & Amelio, I. (2014) · Oncotarget · doi:10.18632/oncotarget.2668 · Cited by 80 · see citing works
Self-citationmiR-205 Hinders the Malignant Interplay Between Prostate Cancer Cells and Associated Fibroblasts
Gandellini, P., Giannoni, E., Casamichele, A., Taddei, M. L., Callari, M., Piovan, C., Valdagni, R., Pierotti, M. A., Zaffaroni, N., & Chiarugi, P. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5292 · Cited by 80 · see citing works
p63 regulates glutaminase 2 expression
Giacobbe, A., Bongiorno‐Borbone, L., Bernassola, F., Terrinoni, A., Markert, E. K., Levine, A. J., Fen, Z., Agostini, M., Zolla, L., Finazzi‐Agrò, A., et al. (2013) · Cell Cycle · doi:10.4161/cc.24478 · Cited by 79 · see citing works
Self-citationTranscriptional suppression of AMPKα1 promotes breast cancer metastasis upon oncogene activation
Yi, Y., Chen, D., Ao, J., Zhang, W., Yi, J., Ren, X., Fei, J., Li, F., Niu, M., Chen, H., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1914786117 · Cited by 76 · see citing works
Kalogirou, C., Linxweiler, J., Schmucker, P., Snaebjornsson, M. T., Schmitz, W., Wach, S., Krebs, M., Hartmann, E., Puhr, M., Müller, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25325-9 · Cited by 77 · see citing works
MicroRNAs and p63 in epithelial stemness
Candi, E., Amelio, I., Agostini, M., & Melino, G. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.113 · Cited by 75 · see citing works
Self-citationRepression of p63 and induction of EMT by mutant Ras in mammary epithelial cells
Yoh, K. E., Regunath, K., Guzman, A., Lee, S.-M., Pfister, N. T., Akanni, O., Kaufman, L. J., Prives, C., & Prywes, R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613417113 · Cited by 75 · see citing works
WANG, M., Ren, D., Guo, W., Wang, Z., Huang, S., Du, H., Song, L., & Peng, X. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2413 · Cited by 75 · see citing works
MiR‐301a regulates E‐cadherin expression and is predictive of prostate cancer recurrence
Nam, R. K., Benatar, T., Wallis, C. J. D., Amemiya, Y., Yang, W., Garbens, A., Naeim, M., Sherman, C., Sugar, L., & Seth, A. K. (2016) · The Prostate · doi:10.1002/pros.23177 · Cited by 75 · see citing works
MiR-205 and MiR-373 Are Associated with Aggressive Human Mucinous Colorectal Cancer
Eyking, A., Reis, H., Frank, M., Gerken, G., Schmid, K. W., & Cario, E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156871 · Cited by 75 · see citing works
Cancer Stemness: p53 at the Wheel
Ghatak, D., Ghosh, D. D., & Roychoudhury, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.604124 · Cited by 75 · see citing works
Noncoding RNAs in Prostate Cancer: The Long and the Short of It
Bolton, E. M., Tuzova, A. V., Walsh, A. L., Lynch, T. H., & Perry, A. S. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1989 · Cited by 74 · see citing works
Single Cell and Open Chromatin Analysis Reveals Molecular Origin of Epidermal Cells of the Skin
Fan, X., Wang, D., Burgmaier, J. E., Teng, Y., Romano, R., Sinha, S., & Yi, R. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.08.010 · Cited by 68 · see citing works
Muller, P. A. J., Trinidad, A. G., Caswell, P. T., Norman, J. C., & Vousden, K. H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.502138 · Cited by 71 · see citing works
Self-citationMcDade, S. S., Patel, D., Moran, M., Campbell, J., Fenwick, K., Kozarewa, I., Orr, N., Lord, C. J., Ashworth, A., & McCance, D. J. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku299 · Cited by 69 · see citing works
p63 at the Crossroads between Stemness and Metastasis in Breast Cancer
Gatti, V., Bongiorno‐Borbone, L., Fierro, C., Annicchiarico‐Petruzzelli, M., Melino, G., & Peschiaroli, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112683 · Cited by 68 · see citing works
Self-citationGameiro, S. R., Higgins, J. P., Dreher, M. R., Woods, D. L., Reddy, G., Wood, B. J., Guha, C., & Hodge, J. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070417 · Cited by 67 · see citing works
Yamada, Y., Nishikawa, R., Kato, M., Okato, A., Arai, T., Kojima, S., Yamazaki, K., Naya, Y., Ichikawa, T., & Seki, N. (2017) · Journal of Human Genetics · doi:10.1038/s10038-017-0371-1 · Cited by 66 · see citing works
The role of epithelial plasticity in prostate cancer dissemination and treatment resistance
Bitting, R. L., Schaeffer, D., Somarelli, J. A., García-Blanco, M. A., & Armstrong, A. J. (2014) · Cancer and Metastasis Reviews · doi:10.1007/s10555-013-9483-z · Cited by 65 · see citing works
Cheng, Q., Feng, F., Zhu, L., Zheng, Y., Luo, X., Liu, C., Yi, B., & Jiang, X. (2015) · Scientific Reports · doi:10.1038/srep16103 · Cited by 65 · see citing works
Pathway Regulation of p63, a Director of Epithelial Cell Fate
Yoh, K. E., & Prywes, R. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00051 · Cited by 63 · see citing works
Pan, F., Mao, H., Bu, F., Tong, X., Li, J., Zhang, S., Liu, X., Wang, L., Wu, L., Chen, R., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13902 · Cited by 64 · see citing works
A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases
Wang, Z., Liu, Z., Chen, X., Li, J., Yao, W., Huang, S., Gu, A., Lei, Q., Mao, Y. Q., & Wen, W. (2019) · Nature Communications · doi:10.1038/s41467-019-11224-7 · Cited by 64 · see citing works
ZNF750 represses breast cancer invasion via epigenetic control of prometastatic genes
Cassandri, M., Butera, A., Amelio, I., Lena, A. M., Montanaro, M., Mauriello, A., Anemona, L., Candi, E., Knight, R. A., Agostini, M., et al. (2020) · Oncogene · doi:10.1038/s41388-020-1277-5 · Cited by 62 · see citing works
Self-citationp63 the guardian of human reproduction
Amelio, I., Grespi, F., Annicchiarico‐Petruzzelli, M., & Melino, G. (2012) · Cell Cycle · doi:10.4161/cc.22819 · Cited by 61 · see citing works
Self-citationTamura, M., Sasaki, Y., Koyama, R., Takeda, K., Idogawa, M., & Tokino, T. (2013) · Oncogene · doi:10.1038/onc.2013.427 · Cited by 61 · see citing works
Hu, L., Liang, S., Chen, H., Lv, T., Wu, J., Chen, D., Wu, M. C., Sun, S., Zhang, H., You, H., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617816114 · Cited by 61 · see citing works
Ferrari, E., & Gandellini, P. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03192-4 · Cited by 60 · see citing works
Alterations of p63 and p73 in Human Cancers
Inoue, K., & Fry, E. A. (2014) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-017-9211-0_2 · Cited by 58 · see citing works
MicroRNAs and epithelial-mesenchymal transition in prostate cancer
Sekhon, K., Bucay, N., Majid, S., Dahiya, R., & Saini, S. (2016) · Oncotarget · doi:10.18632/oncotarget.11708 · Cited by 59 · see citing works
Novel genes associated with lymph node metastasis in triple negative breast cancer
Mathe, A., Wong‐Brown, M. W., Morten, B. C., Forbes, J., Braye, S. G., Avery‐Kiejda, K. A., & Scott, R. J. (2015) · Scientific Reports · doi:10.1038/srep15832 · Cited by 58 · see citing works
Zhang, P. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i34.12241 · Cited by 58 · see citing works
Zhang, H., Yang, W., Zheng, F., Wang, Y.-B., & Lu, J. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.03.104 · Cited by 56 · see citing works
The role of noncoding RNAs in epithelial cancer
Agostini, M., Ganini, C., Candi, E., & Melino, G. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-0247-6 · Cited by 55 · see citing works
Self-citationKehrloesser, S., Osterburg, C., Tuppi, M., Schäfer, B., Vousden, K. H., & Dötsch, V. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.75 · Cited by 56 · see citing works
Self-citationLaperrousaz, B., Porte, S., Gerbaud, S., Härmä, V., Kermarrec, F., Hourtane, V., Bottausci, F., Gidrol, X., & Picollet-D’hahan, N. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky030 · Cited by 54 · see citing works
LncRNAs and miRNAs: potential biomarkers and therapeutic targets for prostate cancer.
Ma, G., Tang, M., Wu, Y., Xu, X., Pan, F., & Xu, R. (2016) · PubMed Central · Cited by 54 · see citing works
Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition
Iwanicki, M., Chen, H., Iavarone, C., Zervantonakis, I. K., Muranen, T. E., Novak, M., Ince, T. A., Drapkin, R., & Brugge, J. S. (2016) · JCI Insight · doi:10.1172/jci.insight.86829 · Cited by 54 · see citing works
ΔNp63α induces the expression of FAT2 and Slug to promote tumor invasion
Dang, T. T., Westcott, J. M., Maine, E. A., Kanchwala, M., Xing, C., & Pearson, G. W. (2016) · Oncotarget · doi:10.18632/oncotarget.8696 · Cited by 52 · see citing works
Bhowmick, S., Thanusha, A. V., Kumar, A., Scharnweber, D., Rother, S., & Koul, V. (2018) · RSC Advances · doi:10.1039/c8ra01489b · Cited by 53 · see citing works
D’Abramo, M., Bešker, N., Desideri, A., Levine, A. J., Melino, G., & Chillemi, G. (2015) · Oncogene · doi:10.1038/onc.2015.388 · Cited by 52 · see citing works
Self-citationΔNp63α activates CD82 metastasis suppressor to inhibit cancer cell invasion
Wu, J., Liang, S., Bergholz, J. S., He, H., Walsh, E. M., Zhang, Y., & Xiao, Z.-X. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.239 · Cited by 52 · see citing works
Upregulation of MiR-205 under hypoxia promotes epithelial–mesenchymal transition by targeting ASPP2
Wang, X., Yu, M., Zhao, K., He, M., Ge, W., Sun, Y., Wang, Y., Sun, H., & Hu, Y. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.412 · Cited by 52 · see citing works
miRNA-205 Nanoformulation Sensitizes Prostate Cancer Cells to Chemotherapy
Nagesh, P. K. B., Chowdhury, P., Hatami, E., Boya, V. K. N., Kashyap, V. K., Khan, S., Hafeez, B. B., Chauhan, S. C., Jaggi, M., & Yallapu, M. M. (2018) · Cancers · doi:10.3390/cancers10090289 · Cited by 52 · see citing works
Caspase-1 is a novel target of p63 in tumor suppression
Celardo, I., Grespi, F., Antonov, A. V., Bernassola, F., Garabadgiu, A. V., Melino, G., & Amelio, I. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.175 · Cited by 51 · see citing works
Self-citationRole of Epithelial Mesenchymal Transition in Prostate Tumorigenesis
Khan, M. I., Hamid, A., Adhami, V. M., Lall, R. K., & Mukhtar, H. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666141211120326 · Cited by 50 · see citing works
Calleja, L. R., Jacques, C., Lamoureux, F., Baud’huin, M., Gabriel, M. T., Quillard, T., Sahay, D., Perrot, P., Amiaud, J., Charrier, C., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2317 · Cited by 50 · see citing works
Exploring and exploiting the fundamental role of microRNAs in tumor pathogenesis
Jiang, X., Cheng, Q., Yi, B., & Wang, A. (2013) · OncoTargets and Therapy · doi:10.2147/ott.s52730 · Cited by 48 · see citing works
Gonfloni, S., Caputo, V., & Iannizzotto, V. (2015) · The International Journal of Developmental Biology · doi:10.1387/ijdb.150045sg · Cited by 48 · see citing works
Flores‐Pérez, A., Marchat, L. A., Rodriguez-Cuevas, S. A., Bautista, V., Fuentes‐Mera, L., Romero‐Zamora, D., Maciel‐Dominguez, A., la Cruz, O. N. H.-D., Fonseca-Sánchez, M. A., Ruíz‐García, E., et al. (2016) · BMC Cancer · doi:10.1186/s12885-016-2470-3 · Cited by 46 · see citing works
Naeimzadeh, Y., Heidari, Z., Razban, V., & Khajeh, S. (2023) · Current Molecular Pharmacology · doi:10.2174/0118761429263841230926014118 · Cited by 45 · see citing works
Circulating Long Noncoding RNA as a Potential Target for Prostate Cancer
Su, Y., Yu, J., Huang, Y., & Yang, J. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160613322 · Cited by 45 · see citing works
TP53 Mutants in the Tower of Babel of Cancer Progression
Bisio, A., Ciribilli, Y., Fronza, G., Inga, A., & Monti, P. (2014) · Human Mutation · doi:10.1002/humu.22514 · Cited by 44 · see citing works
Kalogirou, C., Spahn, M., Krebs, M., Joniau, S., Lerut, E., Burger, M., Scholz, C. J., Kneitz, S., Riedmiller, H. N., & Kneitz, B. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141121414 · Cited by 44 · see citing works
Fujii, T., Shimada, K., Tatsumi, Y., Tanaka, N., Fujimoto, K., & Konishi, N. (2015) · Molecular Carcinogenesis · doi:10.1002/mc.22381 · Cited by 43 · see citing works
MicroRNAs as Key Effectors in the p53 Network
Goeman, F., Strano, S., & Blandino, G. (2017) · International review of cytology · doi:10.1016/bs.ircmb.2017.04.003 · Cited by 43 · see citing works
Activation of miR200 by c-Myb depends on ZEB1 expression and miR200 promoter methylation
Pieraccioli, M., Imbastari, F., Antonov, A. V., Melino, G., & Raschellà, G. (2013) · Cell Cycle · doi:10.4161/cc.25405 · Cited by 43 · see citing works
Self-citationTAp63 suppress metastasis via miR-133b in colon cancer cells
Lin, C., Li, X., Zhang, Y., Hu, G., Guo, Y., Zhou, J. Y., Du, J., Lv, L., Gao, K., Zhang, Y., et al. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.118 · Cited by 42 · see citing works
Cañueto, J., Cardeñoso‐Álvarez, E., García‐Hernández, J. L., Galindo‐Villardón, P., Vicente‐Galindo, P., Villardón, J. L. V., Alonso‐López, D., Rivas, J. D. L., Valero, J., Moyano‐Sanz, E., et al. (2016) · British Journal of Dermatology · doi:10.1111/bjd.15236 · Cited by 42 · see citing works
p63 controls cell migration and invasion by transcriptional regulation of MTSS1
Giacobbe, A., Compagnone, M., Bongiorno‐Borbone, L., Antonov, A. V., Markert, E. K., Zhou, H., Annicchiarico‐Petruzzelli, M., Melino, G., & Peschiaroli, A. (2015) · Oncogene · doi:10.1038/onc.2015.230 · Cited by 41 · see citing works
Self-citationThe Interactions of microRNA and Epigenetic Modifications in Prostate Cancer
Singh, P. K., & Campbell, M. J. (2013) · Cancers · doi:10.3390/cancers5030998 · Cited by 41 · see citing works
Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy
Salah, Z., Bar-Mag, T., Kohn, Y., Pichiorri, F., Palumbo, T., Melino, G., & Aqeilan, R. I. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.6 · Cited by 41 · see citing works
Self-citationDu, Q., Hoover, A. R., Dozmorov, I. M., Raj, P., Khan, S., Molina, E., Chang, T.-C., de la Morena, M. T., Cleaver, O. B., Mendell, J. T., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.03.012 · Cited by 41 · see citing works
Wang, F., Wang, W., Lu, L., Xie, Y., Yan, J., Chen, Y., Di, C., Gan, L., Si, J., Zhang, H., et al. (2020) · Oncology Reports · doi:10.3892/or.2020.7682 · Cited by 41 · see citing works
- Authors
- Tucci, P., Agostini, M., Grespi, F., Markert, E. K., Terrinoni, A., Vousden, K. H., Muller, P. A. J., Dötsch, V., Kehrloesser, S., Sayan, B. S., Giaccone, G., Lowe, S. W., Takahashi, N., Vandenabeele, P., Knight, R. A., Levine, A. J., & Melino, G.
- Affiliations
- University of Leicester (GB)
- Institute for Advanced Study (US)
- University of Rome Tor Vergata (IT)
- Cancer Research UK Scotland Institute (GB)
- Goethe University Frankfurt (DE)
- University of Southampton (GB)
- National Institutes of Health (US)
- Memorial Sloan Kettering Cancer Center (US)
- Vlaams Instituut voor Biotechnologie (BE)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2012-09-04
- Volume
- 109
- Issue
- 38
- Pages
- 15312-15317
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3458363
- OpenAlex
- W2113645544
- Cited by
- 286
- References
- 28
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 11 · 2023: 14 · 2022: 12 · 2021: 20 · 2020: 17 · 2019: 15 · 2018: 18 · 2017: 19 · 2016: 37 · 2015: 30 · 2014: 41 · 2013: 36 · 2012: 6
- FWCI
- 12.00
- Type
- journal article
- Language
- en
- Update notices
- correction (2014-01-17)
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Salford Institutional Repository (University of Salford) (submittedVersion, cc-by)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Durham Research Online (Durham University) (submittedVersion, cc-by)
- Archive of Doctoral Theses and Digital Collections (University of Calabria) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Ministero della Salute
- Vlaams Instituut voor Biotechnologie
- Associazione Italiana per la Ricerca sul Cancro (2008-2010_33-08)
- Vlaamse regering
- Alleanza Contro il Cancro
- Medical Research Council (ACC12)
- National Cancer Institute (P01CA087497, P01CA87497.)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- p63, miR-205, prostate cancer, metastasis, cell migration, epithelial-mesenchymal transition, ZEB1, vimentin, TP53 mutation, ΔNp63, TAp63, lung metastasis, lymph node metastasis, Gleason score, prognostic factors
- MeSH terms
- Animals, Cell Movement, Humans, Male, Mice, Inbred BALB C, Mutation, Neoplasm Metastasis, Neoplasm Transplantation, Phosphoproteins, Prostatic Neoplasms, Transcription Factors, Biomarkers, Tumor, Trans-Activators, Gene Expression Regulation, Neoplastic, Protein Isoforms, Gene Expression Profiling, Tumor Suppressor Proteins, MicroRNAs, Cell Line, Tumor, Cell Proliferation, Mice, Epithelial-Mesenchymal Transition
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review