Repression of p63 and induction of EMT by mutant Ras in mammary epithelial cells
Open accessAbstract
Significance: The oncogenes Harvey Rat Sarcoma Virus GTPase ( H-RAS ) and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ( PIK3CA ) are well known for altering cell growth and morphology. We show here that they are also able to modify the differentiation state of mammary epithelial cells by inducing an epithelial-to-mesenchymal transition (EMT). This transition leads to greater invasiveness, a hallmark of the progression of tumors toward metastasis. Expression of p63, a protein required for the development of mammary epithelial cells, is strongly repressed by these oncogenes. In turn, loss of p63, which occurs at the transcriptional level, causes a shift in microRNAs and transcription factors that control EMT. Targeting specific genes within this Ras-to-EMT axis may be useful as a therapy to block breast cancer progression.
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p63 and PTEN are tumor suppressors that play a key role in breast and prostate tissue development.
“we inhibited p63 and PTEN expression, two genes that are described as tumor-suppressors that play a key role in breast and prostate tissue development (32–35).”
From Direct transfection of clonal organoids in Matrigel microbeads: a promising approach toward organoid-based genetic screens (2018) · cites this paper as [35]
The paper’s introductory passage (page not provided) says p63 is a master regulator of epithelial cells and that mice lacking it have no mammary glands, supporting a role in breast development. It discusses p63’s cancer role as tissue-dependent and mentions PTEN loss in breast cancer, but does not establish that both genes are tumor suppressors with key roles in breast and prostate tissue development. (LLM, conf=0.86)
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Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548 · see citing works
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041 · see citing works
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890 · see citing works
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989 · see citing works
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
Li, B., & Dewey, C. N. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-323 · Cited by 22,179 · see citing works
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464 · see citing works
Differential expression analysis for sequence count data
Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581 · see citing works
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
Gao, J., Aksoy, B. A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S. O., Sun, Y., Jacobsen, A., Sinha, R., Larsson, E., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004088 · Cited by 15,160 · see citing works
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn923 · Cited by 14,108 · see citing works
Nishimura, R., Osako, T., Nishiyama, Y., Tashima, R., Nakano, M., Fujisue, M., Toyozumi, Y., & Arima, N. (2013) · Oncology · doi:10.1159/000353099 · Cited by 13,239 · see citing works
Comprehensive molecular portraits of human breast tumours
The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11412 · Cited by 12,129 · see citing works
Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A., & McGuire, W. L. (1987) · Science · doi:10.1126/science.3798106 · Cited by 11,760 · see citing works
TopHat: discovering splice junctions with RNA-Seq
Trapnell, C., Pachter, L. S., & Salzberg, S. L. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp120 · Cited by 11,477 · see citing works
The basics of epithelial-mesenchymal transition
Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196 · see citing works
Epithelial-Mesenchymal Transitions in Development and Disease
Thiery, J. P., Acloque, H., Huang, R. Y. J., & Nieto, M. A. (2009) · Cell · doi:10.1016/j.cell.2009.11.007 · Cited by 9,931 · see citing works
Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes
Parker, J. S., Mullins, M., Cheang, M. C. U., Leung, S. C. Y., Voduc, D. K., Vickery, T. L., Davies, S. R., Fauron, C. M. ‐., He, X., Hu, Z., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.1370 · Cited by 4,737 · see citing works
Gregory, P. A., Bert, A. G., Paterson, E. L., Barry, S. C., Tsykin, A., Farshid, G., Vadas, M. A., Khew‐Goodall, Y., & Goodall, G. J. (2008) · Nature Cell Biology · doi:10.1038/ncb1722 · Cited by 3,852 · see citing works
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
Samuels, Y., Wang, Z., Bardelli, A., Silliman, N., Ptak, J., Szabo, S., Yan, H., Gazdar, A. F., Powell, S. M., Riggins, G. J., et al. (2004) · Science · doi:10.1126/science.1096502 · Cited by 3,448 · see citing works
XSEDE: Accelerating Scientific Discovery
Towns, J. W., Cockerill, T. M., Dahan, M., Foster, I. T., Gaither, K., Grimshaw, A. S., Hazlewood, V., Lathrop, S. A., Lifka, D. A., Peterson, G. D., et al. (2014) · Computing in Science & Engineering · doi:10.1109/mcse.2014.80 · Cited by 3,114 · see citing works
More powerful procedures for multiple significance testing
Hochberg, Y., & Benjamini, Y. (1990) · Statistics in Medicine · doi:10.1002/sim.4780090710 · Cited by 2,715 · see citing works
Regulatory networks defining EMT during cancer initiation and progression
Craene, B. D., & Berx, G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3447 · Cited by 2,487 · see citing works
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
Forbes, S. A., Bindal, N., Bamford, S., Cole, C., Kok, C. Y., Beare, D., Jia, M., Shepherd, R., Leung, K., Menzies, A., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq929 · Cited by 2,278 · see citing works
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
Yang, A., Schweitzer, R., Sun, D., Kaghad, M., Walker, N., Bronson, R. T., Tabin, C. J., Sharpe, A. H., Caput, D., Crum, C. P., et al. (1999) · Nature · doi:10.1038/19539 · Cited by 2,224 · see citing works
Morgenstern, J. P., & Land, H. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.12.3587 · Cited by 2,099 · see citing works
Yang, A., Kaghad, M., Wang, Y., Gillett, E. S., Fleming, M. D., Dötsch, V., Andrews, N. C., Caput, D., & McKeon, F. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80275-0 · Cited by 2,086 · see citing works
A Comprehensive Survey of Ras Mutations in Cancer
Prior, I. A., Lewis, P. D., & Mattos, C. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-2612 · Cited by 2,063 · see citing works
Zheng, X., Carstens, J. L., Kim, J., Scheible, M., Kaye, J. A., Sugimoto, H., Wu, C.-C., LeBleu, V. S., & Kalluri, R. (2015) · Nature · doi:10.1038/nature16064 · Cited by 2,018 · see citing works
p63 is a p53 homologue required for limb and epidermal morphogenesis
Mills, A. A., Zheng, B., Wang, X., Vogel, H. S., Roop, D. R., & Bradley, A. (1999) · Nature · doi:10.1038/19531 · Cited by 1,974 · see citing works
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
Friedl, P., & Alexander, S. (2011) · Cell · doi:10.1016/j.cell.2011.11.016 · Cited by 1,940 · see citing works
Fischer, K. R., Durrans, A., Lee, S., Sheng, J., Li, F., Wong, S. T. C., Choi, H., El Rayes, T., Ryu, S., Troeger, J., et al. (2015) · Nature · doi:10.1038/nature15748 · Cited by 1,791 · see citing works
Self-citationHulsen, T., de Vlieg, J., & Alkema, W. B. L. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-488 · Cited by 1,675 · see citing works
Korpal, M., Lee, E. S., Hu, G., & Kang, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.c800074200 · Cited by 1,642 · see citing works
Soule, H. D., Maloney, T., Wolman, S. R., Peterson, W., Brenz, R., McGrath, C. M., Russo, J., Pauley, R. J., Jones, R. F., & Brooks, S. C. (1990) · PubMed · Cited by 1,527 · see citing works
kConFab, Lim, E., Vaillant, F., Wu, D., Forrest, N. C., Pal, B., Hart, A. H., Asselin-Labat, M.-L., Gyorki, D. E., Ward, T., et al. (2009) · Nature Medicine · doi:10.1038/nm.2000 · Cited by 1,492 · cited 1× · see citing works
“The cell of origin of basal-like breast cancers from BRCA1 mutation carriers may actually be a luminal progenitor cell; such cells have similar gene expression patterns to patient basal-like tumors (69,70).”
BackgroundThe two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion.
Comijn, J., Berx, G., Vermassen, P., Verschueren, K., van Grunsven, L. V., Bruyneel, E., Mareel, M., Huylebroeck, D., & van Roy, F. (2001) · Molecules and Cells · doi:10.1016/s1097-2765(01)00260-x · Cited by 1,464 · see citing works
Dynan, W. S., & Tjian, R. (1983) · Cell · doi:10.1016/0092-8674(83)90210-6 · Cited by 1,445 · see citing works
A causal role for E-cadherin in the transition from adenoma to carcinoma
Perl, A. T., Wilgenbus, P., Dahl, U., Semb, H., & Christofori, G. (1998) · Nature · doi:10.1038/32433 · Cited by 1,419 · see citing works
Plasticity of cell migration: a multiscale tuning model
Friedl, P., & Wolf, K. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200909003 · Cited by 1,356 · see citing works
Cheang, M. C. U., Voduc, D. K., Bajdik, C. D., Leung, S. C. Y., McKinney, S. E., Chia, S., Perou, C. M., & Nielsen, T. O. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1658 · Cited by 1,197 · see citing works
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
Kang, S., Bader, A. G., & Vogt, P. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408864102 · Cited by 827 · see citing works
Mutant p53 drives invasion by promoting integrin recycling
Muller, P. A. J., Caswell, P. T., Doyle, B., Iwanicki, M. P., Tan, E. H., Karim, S., Lukashchuk, N., Gillespie, D. A., Ludwig, R. L., Gosselin, P., et al. (2009) · Cell · doi:10.1016/j.cell.2009.11.026 · Cited by 796 · see citing works
Molyneux, G., Geyer, F. C., Magnay, F., McCarthy, A., Kendrick, H. D., Natrajan, R., Mackay, A. G., Grigoriadis, A. E., Tutt, A. N. J., Ashworth, A., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.07.010 · Cited by 795 · see citing works
A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis
Adorno, M., Cordenonsi, M., Montagner, M., Dupont, S., Wong, C., Hann, B. C., Solari, A., Bobisse, S., Rondina, M. B., Guzzardo, V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.01.039 · Cited by 783 · see citing works
Tumor metastasis: moving new biological insights into the clinic
Wan, L., Pantel, K., & Kang, Y. (2013) · Nature Medicine · doi:10.1038/nm.3391 · Cited by 746 · see citing works
Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis
Janda, E., Lehmann, K. E., Killisch, I., Jechlinger, M., Herzig, M., Downward, J., Beug, H., & Grünert, S. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200109037 · Cited by 702 · see citing works
A multiplicity of CCAAT box-binding proteins
Dorn, A., Bollekens, J. A., Staub, A., Benoist, C. O., & Mathis, D. J. (1987) · Cell · doi:10.1016/0092-8674(87)90513-7 · Cited by 688 · see citing works
Oft, M., Peli, J., Rudaz, C., Schwarz, H., Beug, H., & Ernst Reichmann, A. (1996) · Genes & Development · doi:10.1101/gad.10.19.2462 · Cited by 681 · see citing works
Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis
Grünert, S., Jechlinger, M., & Beug, H. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1175 · Cited by 677 · see citing works
The PIK3CA gene is mutated with high frequency in human breast cancers
Bachman, K. E., Argani, P., Samuels, Y., Silliman, N., Ptak, J., Szabo, S., Konishi, H., Karakas, B., Blair, B. G., Lin, C., et al. (2004) · Cancer Biology & Therapy · doi:10.4161/cbt.3.8.994 · Cited by 665 · see citing works
p63 is the molecular switch for initiation of an epithelial stratification programPreprint
Koster, M. I., Kim, S., Mills, A. A., DeMayo, F. J., & Roop, D. R. (2004) · Genes & Development · doi:10.1101/gad.1165104 · Cited by 622 · see citing works
Rapid Generation of Single-Tumor Spheroids for High-Throughput Cell Function and Toxicity Analysis
Ivascu, A., & Kubbies, M. (2006) · SLAS DISCOVERY · doi:10.1177/1087057106292763 · Cited by 598 · see citing works
Visualizing samples with box plots
Krzywinski, M., & Altman, N. (2014) · Nature Methods · doi:10.1038/nmeth.2813 · Cited by 576 · see citing works
SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions
Vandewalle, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki965 · Cited by 546 · see citing works
Guaita, S., Puig, I., Francı́, C., Garrido, M., Dominguez-Sola, D., Batlle, E., Sancho, E., Dedhar, S., de Herreros, A. G., & Baulida, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206400200 · Cited by 501 · see citing works
HER2-amplified breast cancer: mechanisms of trastuzumab resistance and novel targeted therapies
Gajria, D., & Chandarlapaty, S. (2011) · Expert Review of Anticancer Therapy · doi:10.1586/era.10.226 · Cited by 493 · see citing works
AIS is an oncogene amplified in squamous cell carcinoma
Hibi, K., Trink, B., Patturajan, M., Westra, W. H., Caballero, O. L., Hill, D. E., Ratovitski, E. A., Jen, J., & Sidransky, D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.10.5462 · Cited by 464 · see citing works
How basal are triple‐negative breast cancers?
Bertucci, F., Finetti, P., Cervera, N., Esterni, B., Hermitte, F., Viens, P., & Birnbaum, D. (2008) · International Journal of Cancer · doi:10.1002/ijc.23518 · Cited by 443 · see citing works
p63 regulates an adhesion programme and cell survival in epithelial cells
Carroll, D. K., Carroll, J. S., Leong, C., Cheng, F., Brown, M. A., Mills, A. A., Brugge, J. S., & Ellisen, L. W. (2006) · Nature Cell Biology · doi:10.1038/ncb1420 · Cited by 403 · see citing works
p63, a p53 Homologue, Is a Selective Nuclear Marker of Myoepithelial Cells of the Human Breast
Barbareschi, M., Pecciarini, L., Cangi, M. G., Macrì, E., Rizzo, A. G., Viale, G., & Doglioni, C. (2001) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200108000-00010 · Cited by 385 · see citing works
Integrin α2β1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells
Schiro, J. A., Chan, B. M. C., Roswit, W. T., Kassner, P. D., Pentland, A. P., Hemler, M. E., Eisen, A. Z., & Kupper, T. S. (1991) · Cell · doi:10.1016/0092-8674(91)90191-z · Cited by 376 · see citing works
Cancer Invasion: Patterns and Mechanisms
Krakhmal, N. V., Zavyalova, M. V., Denisov, E. V., Vtorushin, S. V., & Михайлович, П. В. (2015) · Acta Naturae · doi:10.32607/20758251-2015-7-2-17-28 · Cited by 373 · see citing works
The UCSC Cancer Genomics Browser: update 2015
Goldman, M. J., Craft, B., Swatloski, T., Cline, M., Morozova, O., Diekhans, M., Haussler, D. H., & Zhu, J. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1073 · Cited by 371 · see citing works
Varley, J. M., Swallow, J. E., Brammar, W. J., Whittaker, J. L., & Walker, R. A. (1987) · PubMed · Cited by 360 · see citing works
Multilayer control of the EMT master regulators
Zheng, H., & Kang, Y. (2013) · Oncogene · doi:10.1038/onc.2013.128 · Cited by 341 · see citing works
PAM50 Breast Cancer Subtyping by RT-qPCR and Concordance with Standard Clinical Molecular Markers
Bastien, R. R. L., Rodríguez-Lescure, Á., Ebbert, M., Prat, A., Munárriz, B., Rowe, L. R., Miller, P. A., Ruíz‐Borrego, M., Anderson, D., Lyons, B. W., et al. (2012) · BMC Medical Genomics · doi:10.1186/1755-8794-5-44 · Cited by 331 · see citing works
Zhao, J. J., Liu, Z., Wang, L., Shin, E., Loda, M. F., & Roberts, T. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508988102 · Cited by 324 · see citing works
DeFeo, D., Gonda, M. A., Young, H. A., Chang, E. H., Lowy, D. R., Scolnick, E. M., & Ellis, R. W. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.6.3328 · Cited by 301 · see citing works
Romano, R., Smalley, K., Magraw, C. B. L., Serna, V. A., Kurita, T., Raghavan, S., & Sinha, S. (2012) · Development · doi:10.1242/dev.071191 · Cited by 299 · see citing works
Sinha, S., Maity, S. N., Lü, J., & Crombrugghe, B. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1624 · Cited by 295 · see citing works
Tucci, P., Agostini, M., Grespi, F., Markert, E. K., Terrinoni, A., Vousden, K. H., Muller, P. A. J., Dötsch, V., Kehrloesser, S., Sayan, B. S., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110977109 · Cited by 286 · see citing works
Zuber, J., McJunkin, K., Fellmann, C., Dow, L. E., Taylor, M. J., Hannon, G., & Lowe, S. (2010) · Nature Biotechnology · doi:10.1038/nbt.1720 · Cited by 277 · see citing works
Differential expression of p63 isoforms in normal tissues and neoplastic cells
Nylander, K., Vojtesek, B., Nenutil, R., Lindgren, B., Roos, G., Zhanxiang, W., Sjöström, B., Dahlqvist, A. R., & Coates, P. J. (2002) · The Journal of Pathology · doi:10.1002/path.1231 · Cited by 276 · see citing works
Leong, C., Vidnovic, N., DeYoung, M. P., Sgroi, D. C., & Ellisen, L. W. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30866 · Cited by 270 · see citing works
Loss of p63 Expression Is Associated with Tumor Progression in Bladder Cancer
Urist, M. J., Como, C. J. D., Lu, M.-L., Charytonowicz, E., Verbel, D., Crum, C. P., Ince, T. A., McKeon, F., & Cordon‐Cardo, C. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64396-9 · Cited by 256 · see citing works
Trastuzumab-Induced HER Reprogramming in “Resistant” Breast Carcinoma Cells
Narayan, M., Wilken, J. A., Harris, L. N., Baron, A. T., Kimbler, K. D., & Maihle, N. J. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-1056 · Cited by 240 · see citing works
Mammary stem cells have myoepithelial cell properties
Prater, M. D., Petit, V., Russell, I. A., Giraddi, R. R., Shehata, M., Menon, S., Schulte, R., Kalajzić, I., Rath, N., Olson, M. F., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3025 · Cited by 237 · see citing works
Friedl, P., Maaser, K., Klein, C. E., Niggemann, B., Krohne, G., & Zänker, K. S. (1997) · PubMed · Cited by 237 · see citing works
G�rtner, F., Schmitt, F. C., Preto, A., Reis-Filho, J. S., Simpson, P. T., & Martins, A. M. (2003) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-003-0859-2 · Cited by 235 · see citing works
p63 induces key target genes required for epidermal morphogenesis
Koster, M. I., Dai, D., Marinari, B., Sano, Y., Costanzo, A., Karin, M., & Roop, D. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611376104 · Cited by 234 · see citing works
Xenograft Model of Progressive Human Proliferative Breast Disease
Miller, F. R., Soule, H. D., Tait, L. R., Pauley, R. J., Wolman, S. R., Dawson, P. J., & Heppner, G. H. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.21.1725 · Cited by 206 · see citing works
The UCSC Cancer Genomics Browser
Zhu, J., Sanborn, Z., Benz, S. C., Szeto, C. W., Hsu, F., Kuhn, R. M., Karolchik, D., Archie, J. G., Lenburg, M. E., Esserman, L. J., et al. (2009) · Nature Methods · doi:10.1038/nmeth0409-239 · Cited by 171 · see citing works
Jeanmougin, M., de Reyniès, A., Marisa, L., Paccard, C., Nuel, G., & Guedj, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012336 · Cited by 154 · see citing works
A Novel 3D In Vitro Culture Model to Study Stromal–Epithelial Interactions in the Mammary Gland
Krause, S., Maffini, M. V., Soto, A. M., & Sonnenschein, C. (2008) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2008.0030 · Cited by 148 · see citing works
Tran, M., Choi, W., Wszolek, M. F., Navai, N., Lee, I.-L. C., Nitti, G., Wen, S., Flores, E. R., Siefker-Radtke, A. O., Czerniak, B. A., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.408104 · Cited by 145 · see citing works
Barbieri, C. E., & Pietenpol, J. A. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.11.028 · Cited by 140 · see citing works
Farrell, A. S., Pelz, C., Wang, X., Daniel, C. J., Wang, Z., Su, Y., Janghorban, M., Zhang, X., Morgan, C. W., Impey, S., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01455-12 · Cited by 140 · see citing works
Li, H., Cherukuri, P., Li, N., Cowling, V. H., Spinella, M. J., Cole, M. D., Godwin, A. K., Wells, W. A., & DiRenzo, J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-05-4571 · Cited by 128 · see citing works
Elevated expression of p63 protein in human esophageal squamous cell carcinomas
Hu, H., Xia, S., Li, A., Xu, X., Cai, Y., Han, Y., Wei, F., Chen, B., Huang, X., Han, Y., et al. (2002) · International Journal of Cancer · doi:10.1002/ijc.10739 · Cited by 123 · see citing works
Wang, Y., & Prywes, R. (2000) · Oncogene · doi:10.1038/sj.onc.1203443 · Cited by 118 · see citing works
Self-citationMonoclonal antibody that defines human myoepithelium.
Dairkee, S. H., Blayney, C. B., Smith, H. S., & Hackett, A. J. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.21.7409 · Cited by 105 · see citing works
Streit, M., & Gehlenborg, N. (2014) · Nature Methods · doi:10.1038/nmeth.2807 · Cited by 100 · see citing works
Knouf, E. C., Garg, K. S., Arroyo, J. D., Correa, Y., Sarkar, D., Parkin, R. K., Wurz, K., O'Briant, K. C., Godwin, A. K., Urban, N. D., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr731 · Cited by 72 · see citing works
Utility of microwave-citrate antigen retrieval in diagnostic immunohistochemistry.
Brown, R. W., & Chirala, R. (1995) · PubMed · Cited by 69 · see citing works
p63 expression in benign and malignant breast lesions.
Stefanou, D., Batistatou, A., Nonni, A., Arkoumani, E., & Agnantis, N. J. (2004) · PubMed · doi:10.14670/hh-19.465 · Cited by 68 · see citing works
Pathway Regulation of p63, a Director of Epithelial Cell Fate
Yoh, K. E., & Prywes, R. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00051 · Cited by 63 · see citing works
Self-citationRole of ΔNp63γ in Epithelial to Mesenchymal Transition
Lindsay, J., McDade, S. S., Pickard, A., McCloskey, K. D., & McCance, D. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.162511 · Cited by 62 · see citing works
The Mammary Stem Cell Hierarchy
Fu, N. Y., Lindeman, G. J., & Visvader, J. E. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-416022-4.00005-6 · Cited by 59 · see citing works
Weiss, M. B., Vitolo, M. I., Mohseni, M., Rosen, D. M., Denmeade, S. R., Park, B. H., Weber, D. J., & Bachman, K. E. (2010) · Oncogene · doi:10.1038/onc.2010.220 · Cited by 56 · see citing works
Romano, R., Birkaya, B. G., & Sinha, S. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700297 · Cited by 55 · see citing works
Stxbp4 Regulates ΔNp63 Stability by Suppression of RACK1-Dependent Degradation
Li, Y., Peart, M. J., & Prives, C. L. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00449-09 · Cited by 52 · see citing works
Self-citationSobie, E. A. (2011) · Science Signaling · doi:10.1126/scisignal.2001984 · Cited by 52 · see citing works
Mazda, M., Nishi, K., Naito, Y., & Ui‐Tei, K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028688 · Cited by 40 · see citing works
Clinical relevance of the putative stem cell marker p63 in breast cancer
Hanker, L., Karn, T., Ruckhaeberle, E., Gaetje, R., Solbach, C., Schmidt, M., Engels, K., Holtrich, U., Kaufmann, M., & Rody, A. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0608-6 · Cited by 36 · see citing works
Lanza, M., Marinari, B., Papoutsaki, M., Giustizieri, M. L., D’Alessandra, Y., Chimenti, S., Guerrini, L., & Costanzo, A. (2006) · Cell Cycle · doi:10.4161/cc.5.17.3188 · Cited by 36 · see citing works
Sailer, V. W., Lüders, C., Kuhn, W. C., Pelzer, V., & Kristiansen, G. (2015) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-015-1766-z · Cited by 14 · see citing works
Flagged first, then by citations
1 of the 107 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
RAP2 mediates mechanoresponses of the Hippo pathway
Meng, Z., Qiu, Y., Lin, K. C., Kumar, A., Placone, J. K., Fang, C., Wang, K.-C., Lu, S., Pan, M., Hong, A. W., et al. (2018) · Nature · doi:10.1038/s41586-018-0444-0 · Cited by 377 · see citing works
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation
Haerinck, J., Goossens, S., & Berx, G. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-023-00601-0 · Cited by 138 · see citing works
Molecular Mechanisms of p63-Mediated Squamous Cancer Pathogenesis
Moses, M. A., George, A. L., Sakakibara, N., Mahmood, K., Ponnamperuma, R. M., King, K. E., & Weinberg, W. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143590 · Cited by 99 · see citing works
Yi, M., Tan, Y.-X., Wang, L., Cai, J., Li, X.-L., Zeng, Z.-Y., Xiong, W., Li, G.-Y., Li, X.-Y., Tan, P., et al. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03539-2 · Cited by 77 · see citing works
Concerted localization-resets precede YAP-dependent transcription
Franklin, J. M., Ghosh, R. P., Shi, Q., Reddick, M. P., & Liphardt, J. (2020) · Nature Communications · doi:10.1038/s41467-020-18368-x · Cited by 82 · see citing works
Transcriptional suppression of AMPKα1 promotes breast cancer metastasis upon oncogene activation
Yi, Y., Chen, D., Ao, J., Zhang, W., Yi, J., Ren, X., Fei, J., Li, F., Niu, M., Chen, H., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1914786117 · Cited by 76 · see citing works
p63 at the Crossroads between Stemness and Metastasis in Breast Cancer
Gatti, V., Bongiorno‐Borbone, L., Fierro, C., Annicchiarico‐Petruzzelli, M., Melino, G., & Peschiaroli, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112683 · Cited by 68 · see citing works
Liu, Z., Liu, J., Dong, X., Hu, X. Y., Jiang, Y., Li, L., Du, T., Yang, L., Wen, T., An, G., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14117 · Cited by 61 · see citing works
Hu, L., Liang, S., Chen, H., Lv, T., Wu, J., Chen, D., Wu, M. C., Sun, S., Zhang, H., You, H., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617816114 · Cited by 61 · see citing works
Laperrousaz, B., Porte, S., Gerbaud, S., Härmä, V., Kermarrec, F., Hourtane, V., Bottausci, F., Gidrol, X., & Picollet-D’hahan, N. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky030 · Cited by 54 · see citing works
Clonal Evolution and Epithelial Plasticity in the Emergence of AR-Independent Prostate Carcinoma
Laudato, S., Aparicio, A. M., & Giancotti, F. G. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.05.008 · Cited by 49 · see citing works
Devanny, A. J., Vancura, M. B., & Kaufman, L. J. (2021) · Molecular Biology of the Cell · doi:10.1091/mbc.e21-07-0357 · Cited by 48 · see citing works
Self-citationWatanabe, K., Liu, Y., Noguchi, S., Murray, M., Chang, J.-C., Kishima, M., Nishimura, H., Hashimoto, K., Minoda, A., & Suzuki, H. (2019) · Scientific Reports · doi:10.1038/s41598-019-43021-z · Cited by 47 · see citing works
Epithelial cells remove precancerous cells by cell competition via MHC class I–LILRB3 interaction
Ayukawa, S., Kamoshita, N., Nakayama, J., Teramoto, R., Pishesha, N., Ohba, K., Sato, N., Kozawa, K., Abe, H., Semba, K., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-01045-6 · Cited by 49 · see citing works
Role of p53 Family Proteins in Metformin Anti-Cancer Activities
Yi, Y., Zhang, W., Yi, J., & Xiao, Z. J. (2019) · Journal of Cancer · doi:10.7150/jca.30659 · Cited by 46 · see citing works
Chen, H., Yu, S., Ma, R., Deng, L., Yi, Y., Niu, M., Xu, C. S., & Xiao, Z. J. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01271-z · Cited by 34 · see citing works
ΔNp63α suppresses cells invasion by downregulating PKCγ/Rac1 signaling through miR-320a
Aljagthmi, A. A., Hill, N. T., Cooke, M., Kazanietz, M. G., Abba, M. C., Long, W., & Kadakia, M. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1921-6 · Cited by 31 · see citing works
The foggy world(s) of p63 isoform regulation in normal cells and cancer
Pokorná, Z., Vysloužil, J., Hrabal, V., Vojtĕsek, B., & Coates, P. J. (2021) · The Journal of Pathology · doi:10.1002/path.5656 · Cited by 31 · see citing works
Soares, E., Xu, Q., Li, Q., Qu, J., Zheng, Y., Raeven, H. H. M., Brandão, K. O., Petit, I., van den Akker, W. M. R., van Heeringen, S. J., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1908180116 · Cited by 29 · see citing works
Rodrigues, C., Pattabiraman, C., Vijaykumar, A., Arora, R., Narayana, S. M., Kumar, R. V., Notani, D., Varga‐Weisz, P., & Krishna, S. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.02.010 · Cited by 28 · see citing works
Coates, P. J., Nenutil, R., Holčáková, J., Nekulová, M., Podhorec, J., Svoboda, M., & Vojtěšek, B. (2018) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-018-2324-2 · Cited by 26 · see citing works
ΔNp63α in cancer: importance and therapeutic opportunities
Fisher, M. L., Balinth, S., & Mills, A. A. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.08.003 · Cited by 24 · see citing works
Fetiva, M. C., Liss, F., Gertzmann, D., Thomas, J., Gantert, B., Vogl, M., Sira, N., Weinstock, G., Kneitz, S., Ade, C. P., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad107 · Cited by 22 · see citing works
Westcott, J. M., Camacho, S., Nasir, A., Huysman, M. E., Rahhal, R., Dang, T. T., Riegel, A. T., Brekken, R. A., & Pearson, G. W. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-0014 · Cited by 22 · see citing works
Embryonic Programs in Cancer and Metastasis—Insights From the Mammary Gland
Lee, M. Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.938625 · Cited by 21 · see citing works
Sengupta, S., Ghufran, S. M., Khan, A. A., Biswas, S., & Roychoudhury, S. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02831-4 · Cited by 20 · see citing works
Ras Signaling in Breast Cancer
Moon, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9620-6_4 · Cited by 19 · see citing works
Bontemps, I., Lallemand, C., Biard, D. S. F., Déchamps, N., Kortulewski, T., Bourneuf, E., Siberchicot, C., Boussin, F. D., Chevillard, S., Campalans, A., et al. (2022) · Oncology Reports · doi:10.3892/or.2022.8441 · Cited by 18 · see citing works
Extracellular Matrix in Secondary Palate Development
Logan, S. M., Ruest, L. B., Benson, M. D., & Svoboda, K. K. H. (2019) · The Anatomical Record · doi:10.1002/ar.24263 · Cited by 16 · see citing works
Qian, L., Xu, F., Wang, X., Jiang, M., Wang, J., Song, W., Wu, D., Shen, Z., Feng, D., Ling, B., et al. (2017) · Cytokine · doi:10.1016/j.cyto.2017.04.001 · Cited by 16 · see citing works
RAS GTPase signalling to alternative effector pathways
Singh, S., & Smith, M. J. (2020) · Biochemical Society Transactions · doi:10.1042/bst20200506 · Cited by 15 · see citing works
Genest, M., Comunale, F., Planchon, D., Govindin, P., Noly, D., Vacher, S., Bièche, I., Robert, B., Malhotra, H., Schoenit, A., et al. (2022) · Journal of Cell Science · doi:10.1242/jcs.259178 · Cited by 14 · see citing works
Tanas, Ö., He, H., Grossmann, P., Alaghehbandan, R., Ulamec, M., Michalová, K., Pivovarčíková, K., Pérez‐Montiel, D., Ondič, O., Daum, O., et al. (2017) · Histopathology · doi:10.1111/his.13447 · Cited by 14 · see citing works
Transcriptional Factor Repertoire of Breast Cancer in 3D Cell Culture Models
Özkan, H., Öztürk, D. G., & Korkmaz, G. (2022) · Cancers · doi:10.3390/cancers14041023 · Cited by 14 · see citing works
Alshammari, E. S., Aljagthmi, A. A., Stacy, A. J., Bottomley, M., Shamma, H. N., Kadakia, M., & Long, W. (2021) · BMC Cancer · doi:10.1186/s12885-021-07866-w · Cited by 13 · see citing works
Emerging Roles of the Unique Molecular Chaperone Cosmc in the Regulation of Health and Disease
Xiang, T., Qiao, M., Xie, J., Li, Z., & Xie, H. (2022) · Biomolecules · doi:10.3390/biom12121732 · Cited by 12 · see citing works
Ras-mediated activation of mTORC2 promotes breast epithelial cell migration and invasion
Collins, S. E., Wiegand, M. E., Werner, A. N., Brown, I. N., Mundo, M. I., Swango, D. J., Mouneimne, G., & Charest, P. G. (2022) · Molecular Biology of the Cell · doi:10.1091/mbc.e22-06-0236 · Cited by 11 · see citing works
Pokorná, Z., Vysloužil, J., Vojtěšek, B., & Coates, P. J. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00323-x · Cited by 11 · see citing works
Werner, A. N., Kumar, A. I., & Charest, P. G. (2023) · Molecular Biology of the Cell · doi:10.1091/mbc.e23-05-0152 · Cited by 10 · see citing works
Garcia, D. D., Giri, S., Chatterjee, R., Nieves, A. S., Abedrabbo, M., Genna, A., Uribe, M. L., Lindzen, M., Sekar, A., Gupta, N., et al. (2025) · Science Signaling · doi:10.1126/scisignal.ado3473 · Cited by 9 · see citing works
Self-citationWang, H., Yang, X., Deng, L., Zhou, X., Jin, T., Wu, Z., & Chen, H. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07619-8 · Cited by 8 · see citing works
Демин, Д. Э., Afanasyeva, M. A., Uvarova, A. N., Prokofjeva, M. M., Gorbachova, A. M., Ustiugova, A. S., Klepikova, A. V., Putlyaeva, L. V., Tatosyan, K. A., Belousov, P. V., et al. (2019) · Biochemistry (Moscow) · doi:10.1134/s0006297919040096 · Cited by 7 · see citing works
Concerted localization-resets precede YAP-dependent transcriptionPreprint
Ghosh, R. P., Franklin, J. M., Shi, Q., Reddick, M. P., & Liphardt, J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/539049 · Cited by 8 · see citing works
Crosstalk between paralogs and isoforms influences p63-dependent regulatory element activity
Baniulyte, G., McCann, A. A., Woodstock, D. L., & Sammons, M. A. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae1143 · Cited by 6 · see citing works
The polycomb group proteins functions in epithelial to mesenchymal transition in lung cancer
Hou, J., & Wang, X. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.07.010 · Cited by 6 · see citing works
A Non-Canonical Hippo Pathway Represses the Expression of ΔNp63
Low-Calle, A. M., Ghoneima, H., Ortega, N., Cuibus, M. A., Katz, C., Tong, D., Prives, C., & Prywes, R. (2024) · Molecular and Cellular Biology · doi:10.1080/10985549.2023.2292037 · Cited by 5 · see citing works
Self-citationPokorná, Z., Tylichová, Z., Vojtěšek, B., & Coates, P. J. (2024) · Scientific Reports · doi:10.1038/s41598-024-57895-1 · Cited by 4 · see citing works
Epithelial recognition and elimination against aberrant cells
Ayukawa, S., Kamoshita, N., & Maruyama, T. (2024) · Seminars in Immunopathology · doi:10.1007/s00281-024-01001-0 · Cited by 2 · see citing works
Kamarlis, R. K., Lubis, M. N. D., Hernowo, B. S., Kar, A. S., & Gani, B. A. (2018) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2017.v11i1.22415 · Cited by 1 · see citing works
Cooperation between oncogenic NRF2 and wild-type HRAS promotes progression of breast cancer
Kim, S., Saeidi, S., Cho, N., Lee, H., Han, W., Kim, K. P., & Surh, Y. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111920 · Cited by 1 · see citing works
Faculty Opinions recommendation of RAP2 mediates mechanoresponses of the Hippo pathway.
Serini, G., & Valdembri, D. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733846171.793552360
Faculty Opinions recommendation of RAP2 mediates mechanoresponses of the Hippo pathway.
Cropper, E. C., & Zou, H. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733846171.793550054
Vuori, K., & Zhao, M. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737595225.793573384
BMAL1 and CLOCK control polarization and lumen formation during mammary alveologenesis in 3D culture
Larsen, J., Suárez-Trujillo, A., Teeple, K., Schoonmaker, J., Plaut, K. I., & Casey, T. (2023) · Journal of Student Research · doi:10.47611/jsr.v11i3.1719
Context dependent activity of p63-bound gene regulatory elementsPreprint
McCann, A. A., Baniulyte, G., Woodstock, D. L., & Sammons, M. A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.09.593326
Garcia, D. D., Giri, S., Chattaerjee, R., Nieves, A. S., Abedrabbo, M., Genna, A., Rios, M. L. U., Lindzen, M., Sekar, A., Gupta, N., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.09.636592
Self-citationTeramoto, R., Ayukawa, S., Kamoshita, N., Goda, N., & Maruyama, T. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.01.640938
Alshammari, E. S., Aljagthmi, A. A., Stacy, A. J., Bottomley, M., Shamma, H. N., Kadakia, M. P., & Long, W. (2021) · Figshare · doi:10.6084/m9.figshare.13978969
Alshammari, E. S., Aljagthmi, A. A., Stacy, A. J., Bottomley, M., Shamma, H. N., Kadakia, M. P., & Long, W. (2021) · Figshare · doi:10.6084/m9.figshare.13978984
Alshammari, E. S., Aljagthmi, A. A., Stacy, A. J., Bottomley, M., Shamma, H. N., Kadakia, M. P., & Long, W. (2021) · Figshare · doi:10.6084/m9.figshare.13978975
Alshammari, E. S., Aljagthmi, A. A., Stacy, A. J., Bottomley, M., Shamma, H. N., Kadakia, M. P., & Long, W. (2021) · Figshare · doi:10.6084/m9.figshare.13978987
Alshammari, E. S., Aljagthmi, A. A., Stacy, A. J., Bottomley, M., Shamma, H. N., Kadakia, M. P., & Long, W. (2021) · Figshare · doi:10.6084/m9.figshare.13978993
Pokorná, Z., Vysloužil, J., Vojtesek, B., & Coates, P. J. (2022) · Figshare · doi:10.6084/m9.figshare.19227004
Alshammari, E. S., Aljagthmi, A. A., Stacy, A. J., Bottomley, M., Shamma, H. N., Kadakia, M. P., & Long, W. (2021) · Figshare · doi:10.6084/m9.figshare.13978996
Pokorná, Z., Vysloužil, J., Vojtesek, B., & Coates, P. J. (2022) · Figshare · doi:10.6084/m9.figshare.19227001
Pokorná, Z., Vysloužil, J., Vojtesek, B., & Coates, P. J. (2022) · Figshare · doi:10.6084/m9.figshare.19227007
Pokorná, Z., Vysloužil, J., Vojtesek, B., & Coates, P. J. (2022) · Figshare · doi:10.6084/m9.figshare.19226995
Alshammari, E. S., Aljagthmi, A. A., Stacy, A. J., Bottomley, M., Shamma, H. N., Kadakia, M. P., & Long, W. (2021) · Figshare · doi:10.6084/m9.figshare.13978990
Alshammari, E. S., Aljagthmi, A. A., Stacy, A. J., Bottomley, M., Shamma, H. N., Kadakia, M. P., & Long, W. (2021) · Figshare · doi:10.6084/m9.figshare.13978981
Alshammari, E. S., Aljagthmi, A. A., Stacy, A. J., Bottomley, M., Shamma, H. N., Kadakia, M. P., & Long, W. (2021) · Figshare · doi:10.6084/m9.figshare.13978978
eTRex Reveals Oncogenic Transcriptional Regulatory Programs Across Human CancersPreprint
Lu, Z., Yang, Y., Zheng, Q., Gao, F., Xu, L., & Wang, X. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.16.699950
Robust identification of cell-cell communication heterogeneity in single cells
Bocci, F., Jia, Y. Y., Atwood, S. X., & Nie, Q. H. (2026) · Cell Systems · doi:10.1016/j.cels.2026.101703
Robust identification of cell-cell communication heterogeneity in single cellsPreprint
Bocci, F., Jia, Y. Y., Atwood, S. X., & Nie, Q. H. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.29.721691
- Authors
- Yoh, K. E., Regunath, K., Guzman, A., Lee, S.-M., Pfister, N. T., Akanni, O., Kaufman, L. J., Prives, C., & Prywes, R.
- Affiliations
- Columbia University (US)
- Yonsei University (KR)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-09-28
- Volume
- 113
- Issue
- 41
- Pages
- E6107-E6116
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5068336
- OpenAlex
- W2527245570
- Cited by
- 75
- References
- 107
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 13 · 2021: 15 · 2020: 6 · 2019: 13 · 2018: 7 · 2017: 3
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Cancer Institute (CA87497)
- National Science Foundation (ACI-1053575, PESO 1227297)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- p63, ΔNp63α, epithelial-mesenchymal transition, H-Ras, PIK3CA, mammary epithelial cells, transcriptional regulation, cell invasion, 3D collagen gel, epithelial differentiation
- MeSH terms
- Base Sequence, Binding Sites, Cell Transformation, Neoplastic, Epithelial Cells, Gene Expression Regulation, Humans, Models, Biological, Mutation, Promoter Regions, Genetic, Protein Binding, Transcription Factors, Signal Transduction, Tumor Suppressor Protein p53, Sequence Deletion, Genes, Reporter, ras Proteins, Phosphatidylinositol 3-Kinases, Tumor Suppressor Proteins, RNA Interference, RNA, Small Interfering, Cell Line, Tumor, Proto-Oncogene Proteins c-akt, Epithelial-Mesenchymal Transition
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