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Aberration-free three-dimensional multiphoton imaging of neuronal activity at kHz rates
Open accessAbstract
Multiphoton microscopy is a powerful tool in neuroscience, promising to deliver important data on the spatiotemporal activity within individual neurons as well as in networks of neurons. A major limitation of current technologies is the relatively slow scan rates along the z direction compared to the kHz rates obtainable in the x and y directions. Here, we describe a custom-built microscope system based on an architecture that allows kHz scan rates over hundreds of microns in all three dimensions without introducing aberration. We further demonstrate how this high-speed 3D multiphoton imaging system can be used to study neuronal activity at millisecond resolution at the subcellular as well as the population level.
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Cites
Principles of two-photon excitation microscopy and its applications to neuroscience
Svoboda, K., & Yasuda, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.019 · Cited by 1,027
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Metadata
- Authors
- Botcherby, E. J., Smith, C. W., Kohl, M. M., Débarre, D., Booth, M. J., Juškaitis, R., Paulsen, O., & Wilson, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2012-02-06
- Volume
- 109
- Issue
- 8
- Pages
- 2919-2924
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2147549961
- Cited by
- 187
- References
- 1
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Botcherby, E. J., Smith, C. W., Kohl, M. M., Débarre, D., Booth, M. J., Juškaitis, R., Paulsen, O., & Wilson, T. (2012). Aberration-free three-dimensional multiphoton imaging of neuronal activity at kHz rates. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1111662109
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