The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
p63–microRNA feedback in keratinocyte senescence
Open accessAbstract
We investigated the expression of microRNAs (miRNAs) associated with replicative senescence in human primary keratinocytes. A cohort of miRNAs up-regulated in senescence was identified by genome-wide miRNA profiling, and their change in expression was validated in proliferative versus senescent cells. Among these, miRNA (miR)-138, -181a, -181b, and -130b expression increased with serial passages. miR-138, -181a, and -181b, but not miR-130b, overexpression in proliferating cells was sufficient per se to induce senescence, as evaluated by inhibition of BrdU incorporation and quantification of senescence-activated β-galactosidase staining. We identified Sirt1 as a direct target of miR-138, -181a, and -181b, whereas ΔNp63 expression was inhibited by miR-130b. We also found that ΔNp63α inhibits miR-138, -181a, -181b, and -130b expression by binding directly to p63-responsive elements located in close proximity to the genomic loci of these miRNAs in primary keratinocytes. These findings suggest that changes in miRNA expression, by modulating the levels of regulatory proteins such as p63 and Sirt1, strongly contribute to induction of senescence in primary human keratinocytes, thus linking these two proteins. Our data also indicate that suppression of miR-138, -181a, -181b, and -130b expression is part of a growth-promoting strategy of ΔNp63α in epidermal proliferating cells.
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Cites
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
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BackgroundSenescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
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p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia
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“Nevertheless, all these in vitro and in vivo studies do not exclude a possible, and yet unexplored, role for ΔNp63α in cellular senescence and in the maintenance of keratinocyte stemness (20).”
BackgroundTelomeres and telomerase in cancer
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A skin microRNA promotes differentiation by repressing ‘stemness’
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miR-203 represses ‘stemness’ by repressing ΔNp63
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Self-citationDissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence
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Cited by
Senescence and aging: the critical roles of p53
Rufini, A., Tucci, P., Celardo, I., & Melino, G. (2013) · Oncogene · doi:10.1038/onc.2012.640 · Cited by 798
Self-citationTucci, P., Agostini, M., Grespi, F., Markert, E. K., Terrinoni, A., Vousden, K. H., Muller, P. A. J., Dötsch, V., Kehrloesser, S., Sayan, B. S., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110977109 · Cited by 286
Self-citationMicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration
Liu, C.-M., Wang, R.-Y., Saijilafu, Jiao, Z.-X., Zhang, B.-Y., & Zhou, F.-Q. (2013) · Genes & Development · doi:10.1101/gad.209619.112 · Cited by 148
DNA repair and aging: The impact of the p53 family
Nicolai, S., Rossi, A., Di Daniele, N., Melino, G., Annicchiarico-Petruzzelli, M., & Raschellà, G. (2015) · Aging · doi:10.18632/aging.100858 · Cited by 118
Self-citationMicroRNA-203 contributes to skin re-epithelialization
Viticchiè, G., Lena, A. M., Cianfarani, F., Odorisio, T., Annicchiarico-Petruzzelli, M., Melino, G., & Candi, E. (2012) · Cell Death & Disease · doi:10.1038/cddis.2012.174 · Cited by 105
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Metadata
- Authors
- Rivetti di Val Cervo, P., Lena, A. M., Nicoloso, M., Rossi, S., Mancini, M., Zhou, H., Saintigny, G., Dellambra, E., Odorisio, T., Mahé, C., Calin, G. A., Candi, E., & Melino, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2012-01-06
- Volume
- 109
- Issue
- 4
- Pages
- 1133-1138
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2085857119
- Cited by
- 182
- References
- 11
- FWCI
- 12.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rivetti di Val Cervo, P., Lena, A. M., Nicoloso, M., Rossi, S., Mancini, M., Zhou, H., Saintigny, G., Dellambra, E., Odorisio, T., Mahé, C., Calin, G. A., Candi, E., & Melino, G. (2012). p63–microRNA feedback in keratinocyte senescence. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1112257109
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