CoChat
Sign Up
Cited by 148

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration

Liu, Chang-Mei, Wang, Rui-Ying, Saijilafu, Jiao, Zhong-Xian, Zhang, Bo-Yin, Zhou, Feng-Quan·2013·Genes & Development
DOI 10.1101/gad.209619.112
Open this paper in CoChat — free account

Abstract

Regulated gene expression determines the intrinsic ability of neurons to extend axons, and loss of such ability is the major reason for the failed axon regeneration in the mature mammalian CNS. MicroRNAs and histone modifications are key epigenetic regulators of gene expression, but their roles in mammalian axon regeneration are not well explored. Here we report microRNA-138 (miR-138) as a novel suppressor of axon regeneration and show that SIRT1, the NAD-dependent histone deacetylase, is the functional target of miR-138. Importantly, we provide the first evidence that miR-138 and SIRT1 regulate mammalian axon regeneration in vivo. Moreover, we found that SIRT1 also acts as a transcriptional repressor to suppress the expression of miR-138 in adult sensory neurons in response to peripheral nerve injury. Therefore, miR-138 and SIRT1 form a mutual negative feedback regulatory loop, which provides a novel mechanism for controlling intrinsic axon regeneration ability.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1101/gad.209619.112

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 38

  1. 10.1038/nn.3082 · DOI
  2. 10.1016/j.cell.2012.04.005 · DOI · Paper page
  3. 10.1038/nmeth1079 · DOI · Paper page
  4. 10.1016/j.neuron.2009.10.020 · DOI
  5. 10.1038/emboj.2012.130 · DOI
  6. 10.1038/cdd.2009.216 · DOI
  7. 10.1093/brain/awr142 · DOI
  8. 10.1002/jnr.22725 · DOI
  9. 10.1101/gad.17015911 · DOI
  10. 10.1073/pnas.1011258108 · DOI
  11. 10.1111/j.1460-9568.2010.07493.x · DOI
  12. 10.1016/j.cell.2004.12.035 · DOI · Paper page
  13. 10.1038/nrn2739 · DOI · Paper page
  14. Li XH , Chen C , Tu Y , Sun HT , Zhao ML , Cheng SX , Qu Y , Zhang S . 2013. Sirt1 promotes axonogenesis by deacetylation of Akt and inactivation of GSK3. Mol Neurobiol doi: 10.1007/s12035-013-8437-3. · DOI
  15. 10.1007/s12017-009-8077-y · DOI
  16. 10.1016/j.stem.2010.02.017 · DOI
  17. 2012, Coordinating gene expression and axon assembly to control axon growth: Potential role of GSK3 signaling, Front Mol Neurosci, 5, 3
  18. 10.4161/cc.20898 · DOI
  19. 10.1006/meth.2001.1262 · DOI · Paper page
  20. 10.1126/science.1175737 · DOI · Paper page
  21. 10.1261/rna.2322506 · DOI · Paper page
  22. 10.1158/1535-7163.MCT-09-0971 · DOI
  23. 10.1073/pnas.1112257109 · DOI
  24. 2012, Genetic study of axon regeneration with cultured adult dorsal root ganglion neurons, J Vis Exp, 66, e4141
  25. 10.1038/ncomms1568 · DOI
  26. 10.1016/S0014-5793(03)01444-3 · DOI
  27. 10.1038/ncb1876 · DOI · Paper page
  28. 10.1016/j.gde.2011.04.008 · DOI
  29. 1997, A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth, J Neurosci, 17, 646, 10.1523/JNEUROSCI.17-02-00646.1997 · DOI
  30. 10.1371/journal.pone.0023423 · DOI
  31. 10.1016/j.febslet.2010.04.063 · DOI
  32. 10.1016/j.conb.2010.04.002 · DOI
  33. 10.1016/j.expneurol.2011.11.041 · DOI
  34. 2012, MicroRNA regulation of SIRT1, Front Physiol, 3, 68
  35. 10.1002/stem.1149 · DOI
  36. 10.1016/j.brainres.2011.01.067 · DOI
  37. 10.1242/jcs.03016 · DOI
  38. 10.1016/j.neulet.2011.02.064 · DOI

Cited by

Sorted by citations

Metadata

Authors
Liu, C.-M., Wang, R.-Y., Saijilafu, Jiao, Z.-X., Zhang, B.-Y., & Zhou, F.-Q.
Venue
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Published
2013-06-24
Volume
27
Issue
13
Pages
1473-1483
ISSN
  • 0890-9369
  • 1549-5477
DOI
10.1101/gad.209619.112
Cited by
148
References
5
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review