DNA repair and aging: The impact of the p53 family

Multiplex Genome Engineering Using CRISPR/Cas Systems

Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339 · see citing works

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

Oxidants, oxidative stress and the biology of ageing

Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works

RNA-Guided Human Genome Engineering via Cas9

Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210 · see citing works

Instability and decay of the primary structure of DNA

Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679 · see citing works

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649 · see citing works

Cellular senescence: when bad things happen to good cells

Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441 · see citing works

Genome maintenance mechanisms for preventing cancer

Hoeijmakers, J. H. J. (2001) · Nature · doi:10.1038/35077232 · Cited by 3,939 · see citing works

The DNA damage response: putting checkpoints in perspective

Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213 · see citing works

Live or let die: the cell's response to p53

Vousden, K. H., & Lü, X. (2002) · Nature reviews. Cancer · doi:10.1038/nrc864 · Cited by 3,177 · see citing works

Oxidative Stress, Caloric Restriction, and Aging

Sohal, R. S., & Weindruch, R. H. (1996) · Science · doi:10.1126/science.273.5271.59 · Cited by 3,133 · see citing works

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., & Vogelstein, B. (1998) · Science · doi:10.1126/science.282.5393.1497 · Cited by 2,803 · see citing works

DNA damage, aging, and Cancer

Hoeijmakers, J. H. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804615 · Cited by 2,239 · see citing works

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

Yang, A., Schweitzer, R., Sun, D., Kaghad, M., Walker, N., Bronson, R. T., Tabin, C. J., Sharpe, A. H., Caput, D., Crum, C. P., et al. (1999) · Nature · doi:10.1038/19539 · Cited by 2,224 · see citing works

TP53 mutations in human cancers: origins, consequences, and clinical use.

Olivier, M., Hollstein, M., & Hainaut, P. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001008 · Cited by 2,199 · see citing works

The essence of senescence: Figure 1.

Kuilman, T., Michaloglou, C., Mooi, W. J., & Peeper, D. S. (2010) · Genes & Development · doi:10.1101/gad.1971610 · Cited by 2,038 · see citing works

Understanding the odd science of aging

Kirkwood, T. B. L. (2005) · Cell · doi:10.1016/j.cell.2005.01.027 · Cited by 1,984 · see citing works

p63 is a p53 homologue required for limb and epidermal morphogenesis

Mills, A. A., Zheng, B., Wang, X., Vogel, H. S., Roop, D. R., & Bradley, A. (1999) · Nature · doi:10.1038/19531 · Cited by 1,974 · see citing works

The DNA Damage Response: Ten Years After

Harper, J. W., & Elledge, S. J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.11.015 · Cited by 1,705 · see citing works

The RB and p53 pathways in cancer

Sherr, C. J., & McCormick, F. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00102-2 · Cited by 1,690 · see citing works

Regulation of the G2/M transition by p53

Taylor, W. R., & Stark, G. R. (2001) · Oncogene · doi:10.1038/sj.onc.1204252 · Cited by 1,553 · see citing works

Base-excision repair of oxidative DNA damage

David, S. S., O'Shea, V. L., & Kundu, S. (2007) · Nature · doi:10.1038/nature05978 · Cited by 1,238 · see citing works

Sensing and repairing DNA double-strand breaks

Jackson, S. P. (2002) · Carcinogenesis · doi:10.1093/carcin/23.5.687 · Cited by 1,126 · see citing works

Molecular mechanism of nucleotide excision repair

de Laat, W. L., Jaspers, N. G. J., & Hoeijmakers, J. H. J. (1999) · Genes & Development · doi:10.1101/gad.13.7.768 · Cited by 1,122 · see citing works

Post‐translational modifications and activation of p53 by genotoxic stresses

Appella, E., & Anderson, C. W. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02225.x · Cited by 1,071 · see citing works

The signals and pathways activating cellular senescence

Ben-Porath, I., & Weinberg, R. A. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.10.013 · Cited by 1,046 · see citing works

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

Yang, A., Walker, N., Bronson, R. T., Kaghad, M., Oosterwegel, M. A., Bonnin, J., Vagner, C., Bonnet, H., Dikkes, P., Sharpe, A. H., et al. (2000) · Nature · doi:10.1038/35003607 · Cited by 989 · see citing works

MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings

McVey, M., & Lee, S. E. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.08.007 · Cited by 974 · see citing works

DNA Repair, Genome Stability, and Aging

Lombard, D. B., Chua, K. F., Mostoslavsky, R., Franco, S., Gostissa, M., & Alt, F. W. (2005) · Cell · doi:10.1016/j.cell.2005.01.028 · Cited by 944 · see citing works

The Free Radical Theory of Aging

Harman, D. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603770310202 · Cited by 926 · see citing works

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

Moynahan, M. E., & Jasin, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2851 · Cited by 923 · see citing works

p53 isoforms can regulate p53 transcriptional activity

Bourdon, J.-C., Fernandes, K., Murray-Zmijewski, F., Liu, G., Diot, A., Xirodimas, D. P., Saville, M. K., & Lane, D. P. (2005) · Genes & Development · doi:10.1101/gad.1339905 · Cited by 810 · see citing works

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

Flores, E. R., Tsai, K. Y., Crowley, D. G., Sengupta, S., Yang, A., McKeon, F., & Jacks, T. (2002) · Nature · doi:10.1038/416560a · Cited by 801 · see citing works

Senescence and aging: the critical roles of p53

Rufini, A., Tucci, P., Celardo, I., & Melino, G. (2013) · Oncogene · doi:10.1038/onc.2012.640 · Cited by 798 · see citing works

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

Sedelnikova, O. A., Horikawa, I., Zimonjic, D. B., Popescu, N. C., Bonner, W. M., & Barrett, J. C. (2004) · Nature Cell Biology · doi:10.1038/ncb1095 · Cited by 790 · see citing works

Does oxidative damage to DNA increase with age?

Hamilton, M. L., Van Remmen, H., Drake, J. A., Yang, H., Guo, Z. M., Kewitt, K., Walter, C. A., & Richardson, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171202698 · Cited by 768 · see citing works

The mechanism of human nonhomologous DNA end joining

Lieber, M. R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r700039200 · Cited by 720 · see citing works

Molecular Mechanisms of Mammalian Global Genome Nucleotide Excision Repair

Gillet, L. C. J., & Schärer, O. D. (2006) · Chemical Reviews · doi:10.1021/cr040483f · Cited by 642 · see citing works

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

Gao, Y., Ferguson, D., Xie, W., Manis, J., Sekiguchi, J., Frank, K., Chaudhuri, J., Horner, J., DePinho, R., & Alt, F. (2000) · Nature · doi:10.1038/35009138 · Cited by 608 · see citing works

The role of double-strand break repair — insights from human genetics

O’Driscoll, M., & Jeggo, P. A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1746 · Cited by 581 · see citing works

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

Yu, J., Wang, Z., Kinzler, K. W., Vogelstein, B., & Zhang, L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2627984100 · Cited by 565 · see citing works

p73: Friend or foe in tumorigenesis

Melino, G., Laurenzi, V. D., & Vousden, K. H. (2002) · Nature reviews. Cancer · doi:10.1038/nrc861 · Cited by 554 · see citing works

Aging and Genome Maintenance: Lessons from the Mouse?

Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H., & Vijg, J. (2003) · Science · doi:10.1126/science.1079161 · Cited by 553 · cited 1× · see citing works

p63 protects the female germ line during meiotic arrest

Suh, E.-K., Yang, A., Kettenbach, A. N., Bamberger, C., Michaelis, A. H., Zhu, Z., Elvin, J. A., Bronson, R. T., Crum, C. P., & McKeon, F. (2006) · Nature · doi:10.1038/nature05337 · Cited by 550 · see citing works

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

Difilippantonio, M. J., Zhu, J., Chen, H. T., Meffre, E., Nussenzweig, M. C., Max, E. E., Ried, T., & Nussenzweig, A. (2000) · Nature · doi:10.1038/35006670 · Cited by 546 · see citing works

Premature Aging in Mice Deficient in DNA Repair and Transcription

de Boer, J., Andressoo, J. O., de Wit, J., Huijmans, J., Beems, R. B., van Steeg, H., Weeda, G., van der Horst, G. T. J., van Leeuwen, W., Themmen, A. P. N., et al. (2002) · Science · doi:10.1126/science.1070174 · Cited by 545 · see citing works

Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts

Gems, D., & Partridge, L. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183712 · Cited by 545 · see citing works

Differential usage of non-homologous end-joining and homologous recombination in double strand break repair

Sonoda, E., Hochegger, H., Saberi, A., Taniguchi, Y., & Takeda, S. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.05.022 · Cited by 527 · see citing works

p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress

Murray-Zmijewski, F., Lane, D. P., & Bourdon, J. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401914 · Cited by 524 · see citing works

Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in Mice and Humans

Titus, S., Li, F., Stobezki, R., Akula, K., Ünsal, E., Jeong, K., Dickler, M. N., Robson, M. E., MOY, F. H., Goswami, S., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004925 · Cited by 523 · see citing works

DNA Ligase IV Deficiency in Mice Leads to Defective Neurogenesis and Embryonic Lethality via the p53 Pathway

Frank, K. M., Sharpless, N. E., Gao, Y., Sekiguchi, J., Ferguson, D. O., Zhu, C., Manis, J. P., Horner, J. W., DePinho, R. A., & Alt, F. W. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80264-6 · Cited by 492 · see citing works

Transcription-coupled nucleotide excision repair in mammalian cells: Molecular mechanisms and biological effects

Fousteri, M., & Mullenders, L. H. (2008) · Cell Research · doi:10.1038/cr.2008.6 · Cited by 487 · see citing works

p63 and p73: Roles in Development and Tumor Formation

Moll, U. M., & Slade, N. (2004) · Molecular Cancer Research · doi:10.1158/1541-7786.371.2.7 · Cited by 482 · see citing works

Subpathways of nucleotide excision repair and their regulation

Hanawalt, P. C. (2002) · Oncogene · doi:10.1038/sj.onc.1206096 · Cited by 447 · see citing works

Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: A complex genotype–phenotype relationship

Kraemer, K. H., Patronas, N. J., Schiffmann, R., Brooks, B. P., Tamura, D., & DiGiovanna, J. J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.020 · Cited by 443 · see citing works

A unified view of base excision repair: Lesion-dependent protein complexes regulated by post-translational modification

Almeida, K. H., & Sobol, R. W. (2007) · DNA Repair · doi:10.1016/j.dnarep.2007.01.009 · Cited by 437 · see citing works

Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis

Westphal, D., Kluck, R. M., & Dewson, G. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.139 · Cited by 437 · see citing works

Puzzles, promises and a cure for ageing

Vijg, J., & Campisi, J. (2008) · Nature · doi:10.1038/nature07216 · Cited by 407 · see citing works

Changes in DNA repair during aging

Gorbunova, V., Seluanov, A., Mao, Z., & Hine, C. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm756 · Cited by 405 · see citing works

Slug Antagonizes p53-Mediated Apoptosis of Hematopoietic Progenitors by Repressing puma

Wu, W.-S., Heinrichs, S., Xu, D., Garrison, S. P., Zambetti, G. P., Adams, J. M., & Look, A. T. (2005) · Cell · doi:10.1016/j.cell.2005.09.029 · Cited by 398 · see citing works

The role of DNA damage and repair in aging through the prism of Koch-like criteria

Moskalev, A. A., Shaposhnikov, M. V., Plyusnina, E. N., Zhavoronkov, A., Budovsky, A., Yanai, H., & Fraifeld, V. E. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.02.001 · Cited by 387 · see citing works

Two New p73 Splice Variants, γ and δ, with Different Transcriptional Activity

Laurenzi, V. D., Costanzo, A., Barcaroli, D., Terrinoni, A., Falco, M., Annicchiarico‐Petruzzelli, M., Levrero, M., & Melino, G. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.9.1763 · Cited by 366 · see citing works

The mechanics of base excision repair, and its relationship to aging and disease

WILSONIII, D., & Bohr, V. A. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.10.017 · Cited by 343 · see citing works

Requirement for theXrcc1DNA Base Excision Repair Gene during Early Mouse Development

Tebbs, R. S., Flannery, M. L., Meneses, J. J., Hartmann, A., Tucker, J. D., Thompson, L. H., Cleaver, J. E., & Pedersen, R. A. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9232 · Cited by 337 · see citing works

DNA double strand break repair and chromosomal translocation: Lessons from animal models

Ferguson, D. O., & Alt, F. W. (2001) · Oncogene · doi:10.1038/sj.onc.1204767 · Cited by 333 · see citing works

The p53 response to DNA damage

Meek, D. W. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.027 · Cited by 329 · see citing works

EVOLUTIONARY AND MECHANISTIC THEORIES OF AGING

Hughes, K. A., & Reynolds, R. M. (2004) · Annual Review of Entomology · doi:10.1146/annurev.ento.50.071803.130409 · Cited by 328 · see citing works

Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation

Ogrunc, M., Di Micco, R., Liontos, M., Bombardelli, L., Mione, M., Fumagalli, M., Gorgoulis, V. G., & d'Adda di Fagagna, F. (2014) · Cell Death & Differentiation · doi:10.1038/cdd.2014.16 · Cited by 328 · see citing works

Free radicals and senescence

Lu, T., & Finkel, T. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.01.011 · Cited by 327 · see citing works

PARP-3 and APLF Function Together to Accelerate Nonhomologous End-Joining

Rulten, S. L., Fisher, A. E. O., Robert, I., Zuma, M. C., Rouleau, M., Ju, L., Poirier, G. G., Reina‐San‐Martin, B., & Caldecott, K. W. (2011) · Molecular Cell · doi:10.1016/j.molcel.2010.12.006 · Cited by 326 · see citing works

A method for detecting abasic sites in living cells: Age-dependent changes in base excision repair

Atamna, H., Cheung, I., & Ames, B. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.686 · Cited by 323 · see citing works

PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair

Ochi, T., Blackford, A. N., Coates, J., Jhujh, S. S., Mehmood, S., Tamura, N., Travers, J., Wu, Q., Draviam, V. M., Robinson, C. V., et al. (2015) · Science · doi:10.1126/science.1261971 · Cited by 322 · see citing works

DNA Damage-Dependent Acetylation of p73 Dictates the Selective Activation of Apoptotic Target Genes

Costanzo, A., Merlo, P., Pediconi, N., Fulco, M., Sartorelli, V., Cole, P. A., Fontemaggi, G., Fanciulli, M., Schiltz, L., Blandino, G., et al. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00431-8 · Cited by 317 · see citing works

The cellular response to general and programmed DNA double strand breaks

Bassing, C. H., & Alt, F. W. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.06.001 · Cited by 301 · see citing works

p63 deficiency activates a program of cellular senescence and leads to accelerated agingPreprint

Keyes, W. M., Wu, Y., Vogel, H. S., Guo, X., Lowe, S. W., & Mills, A. A. (2005) · Genes & Development · doi:10.1101/gad.342305 · Cited by 296 · see citing works

Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

Cao, L., Li, W., Kim, S., Brodie, S. G., & Deng, C.-X. (2003) · Genes & Development · doi:10.1101/gad.1050003 · Cited by 293 · see citing works

DNA end joining becomes less efficient and more error-prone during cellular senescence

Seluanov, A., Mittelman, D., Pereira-Smith, O. M., Wilson, J. H., & Gorbunova, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400726101 · Cited by 278 · see citing works

Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations

Feng, Z., Hu, W., Teresky, A. K., Hernando, E., Cordon-Cardo, C., & Levine, A. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708043104 · Cited by 264 · see citing works

From cells to organisms: can we learn about aging from cells in culture?

Campisi, J. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00230-8 · Cited by 263 · see citing works

Lessons from human progeroid syndromes

Martin, G. M., & Oshima, J. (2000) · Nature · doi:10.1038/35041705 · Cited by 261 · see citing works

TAp63 induces senescence and suppresses tumorigenesis in vivo

Guo, X., Keyes, W. M., Papazoglu, C., Zuber, J. A., Li, W., Lowe, S. W., Vogel, H. S., & Mills, A. A. (2009) · Nature Cell Biology · doi:10.1038/ncb1988 · Cited by 252 · see citing works

TAp63 Prevents Premature Aging by Promoting Adult Stem Cell Maintenance

Su, X., Paris, M., Gi, Y. J., Tsai, K. Y., Cho, M. S., Lin, Y.-L., Biernaskie, J., Sinha, S., Prives, C. L., Pevny, L., et al. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.04.003 · Cited by 251 · see citing works

p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2Preprint

Urist, M. J., Tanaka, T., Poyurovsky, M. V., & Prives, C. L. (2004) · Genes & Development · doi:10.1101/gad.1221004 · Cited by 234 · see citing works

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis

Shi, Y., Nikulenkov, F., Zawacka‐Pankau, J., Li, H., Gabdoulline, R. R., Xu, J., Eriksson, S. E., Hedström, E., Issaeva, N., Kel, A. E., et al. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2013.186 · Cited by 232 · see citing works

p53, ROS and senescence in the control of aging

Vigneron, A., & Vousden, K. H. (2010) · Aging · doi:10.18632/aging.100189 · Cited by 221 · see citing works

Isoform-specific p73 knockout mice reveal a novel role for ΔNp73 in the DNA damage response pathwayPreprint

Wilhelm, M., Rufini, A., Wetzel, M. K., Tsuchihara, K., Inoue, S., Tomasini, R., Itie-YouTen, A., Wakeham, A. C., Arsenian‐Henriksson, M., Melino, G., et al. (2010) · Genes & Development · doi:10.1101/gad.1873910 · Cited by 203 · see citing works

Homologous recombination-mediated double-strand break repair

Wyman, C., Ristić, D., & Kanaar, R. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.037 · Cited by 195 · see citing works

Molecular bases of progeroid syndromes

Navarro, C. L., Cau, P., & Lévy, N. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl214 · Cited by 189 · see citing works

TAp63 and ΔNp63 in Cancer and Epidermal Development

Candi, E., Dinsdale, D. D., Rufini, A., Salomoni, P., Knight, R. A., Mueller, M., Krammer, P. H., & Melino, G. (2007) · Cell Cycle · doi:10.4161/cc.6.3.3797 · Cited by 188 · see citing works

Endogenous DNA damage and mutation

Marnett, L. J. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02239-9 · Cited by 183 · see citing works

Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner

Imam, S. Z., Karahalıl, B., Hogue, B. A., de Souza-Pinto, N. C., & Bohr, V. A. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.06.002 · Cited by 183 · see citing works

p63–microRNA feedback in keratinocyte senescence

Cervo, P. R. D. V., Lena, A. M., Nicoloso, M. S., Rossi, S., Mancini, M., Zhou, H., Saintigny, G., Dellambra, E., Odorisio, T., Mahé, C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112257109 · Cited by 181 · see citing works

Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway

Xing, M., Yang, M., Huo, W., Feng, F., Wei, L., Jiang, W., Ning, S., Yan, Z., Li, W., Wang, Q., et al. (2015) · Nature Communications · doi:10.1038/ncomms7233 · Cited by 180 · see citing works

No PUMA, no death

Yu, J., & Zhang, L. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00249-6 · Cited by 180 · see citing works

A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors

Izhar, L., Adamson, B., Ciccia, A., Lewis, J., Vaites, L. P., Leng, Y., Liang, A. C. T., Westbrook, T. F., Harper, J. W., & Elledge, S. J. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.053 · Cited by 178 · see citing works

The clinical impact of deficiency in DNA non-homologous end-joining

Woodbine, L. J., Gennery, A. R., & Jeggo, P. A. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.02.011 · Cited by 176 · see citing works

Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells

Venere, M., Hamerlik, P., Wu, Q., Rasmussen, R. D., Song, L. A., Vasanji, A., Tenley, N., Flavahan, W. A., Hjelmeland, A. B., Bártek, J., et al. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.136 · Cited by 172 · see citing works

Aging, tumor suppression and cancer: high wire-act!

Campisi, J. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.09.024 · Cited by 171 · see citing works

Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine

Toft, N. J., Winton, D. J., Kelly, J., Howard, L., Dekker, M., Riele, H. T., Arends, M. J., Wyllie, A. H., Margison, G. P., & Clarke, A. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3911 · Cited by 168 · see citing works

p63, a Story of Mice and Men

vanBokhoven, H., Melino, G., Candi, E., & Declercq, W. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.84 · Cited by 161 · see citing works

Divide and conquer: nucleotide excision repair battles cancer and ageing

Mitchell, J. R., Hoeijmakers, J. H., & Niedernhofer, L. J. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00018-8 · Cited by 160 · see citing works

p53 isoform Δ113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafishPreprint

Chen, J., Ng, S. M. E., Chang, C., Zhang, Z., Bourdon, J., Lane, D. P., & Peng, J. (2009) · Genes & Development · doi:10.1101/gad.1761609 · Cited by 155 · see citing works

Homeostatic functions of the p53 tumor suppressor: Regulation of energy metabolism and antioxidant defense

Olovnikov, I. A., Kravchenko, J. E., & Chumakov, P. M. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.11.005 · Cited by 154 · see citing works

Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging

Gambino, V., de Michele, G., Venezia, O., Migliaccio, P., Dall’Olio, V., Bernard, L., Minardi, S. P., Fazia, M. A. D., Bartoli, D., Servillo, G., et al. (2013) · Aging Cell · doi:10.1111/acel.12060 · Cited by 152 · see citing works

p73 Is Required for Survival and Maintenance of CNS Neurons

Pozniak, C. D., Barnabé‐Heider, F., Rymar, V. V., Lee, A. F., Sadikot, A. F., & Miller, F. D. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09800.2002 · Cited by 146 · see citing works

DNA Damage in Oocytes Induces a Switch of the Quality Control Factor TAp63α from Dimer to Tetramer

Deutsch, G. B., Zielonka, E. M., Coutandin, D., Weber, T. A., Schäfer, B., Hannewald, J., Luh, L. M., Durst, F. G., Ibrahim, M. F. M., Hoffmann, J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.01.013 · Cited by 140 · see citing works

E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis

Liu, J., Zhang, C., Wang, X. L., Ly, P., Белый, В. А., Xu-Monette, Z. Y., Young, K. H., Hu, W., & Feng, Z. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.121 · Cited by 137 · see citing works

p53 regulates a non-apoptotic death induced by ROS

Montero, J., Dutta, C., van Bodegom, D., Weinstock, D. M., & Letai, A. G. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.52 · Cited by 134 · see citing works

Nonhomologous end joining: A good solution for bad ends

Waters, C. A., Strande, N. T., Wyatt, D. W., Pryor, J. M., & Ramsden, D. A. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.02.008 · Cited by 133 · see citing works

TAp73 depletion accelerates aging through metabolic dysregulationPreprint

Rufini, A., Niklison-Chirou, M. V., Inoue, S., Tomasini, R., Harris, I. S., Marino, A., Federici, M., Dinsdale, D. D., Knight, R. A., Melino, G., et al. (2012) · Genes & Development · doi:10.1101/gad.197640.112 · Cited by 129 · see citing works

Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair

Goldstein, M., Derheimer, F. A., Tait-Mulder, J., & Kastan, M. B. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306160110 · Cited by 122 · see citing works

RNF4 is required for DNA double-strand break repair in vivo

Vyas, R., Kumar, R., Clermont, F. F., Helfricht, A., Kalev, P., Sotiropoulou, P., Hendriks, I. A., Radaelli, E., Hochepied, T., Blanpain, C., et al. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.145 · Cited by 115 · see citing works

DNA-PK, ATM and ATR collaboratively regulate p53–RPA interaction to facilitate homologous recombination DNA repair

Serrano, M. A., Li, Z., Dangeti, M., Musich, P. R., Patrick, S., Roginskaya, M., Cartwright, B., & Zou, Y. (2012) · Oncogene · doi:10.1038/onc.2012.257 · Cited by 112 · see citing works

Crucial role of calbindin-D28k in the pathogenesis of Alzheimer’s disease mouse model

Kook, S.-Y., Jeong, H., Kang, M. J., Park, R., Hj, S., Han, S.-H., Son, S. M., Song, H., Baik, S., Moon, M., et al. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.67 · Cited by 110 · see citing works

ΔNp73 Facilitates Cell Immortalization and Cooperates with Oncogenic Ras in Cellular Transformation In Vivo

Petrenko, O., Zaika, A. I., & Moll, U. M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5540-5555.2003 · Cited by 103 · see citing works

Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo

Phesse, T. J., Myant, K., Cole, A. M., Ridgway, R. A., Pearson, H. B., Muncan, V., BRINK, G. R. V. D., Vousden, K. H., Sears, R. C., Vassilev, L. T., et al. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.15 · Cited by 102 · see citing works

NHEJ and its backup pathways in chromosomal translocations

Lieber, M. R. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb0410-393 · Cited by 102 · see citing works

A new p38 MAP kinase‐regulated transcriptional coactivator that stimulates p53‐dependent apoptosis

Cuadrado, A., Lafarga, V., Cheung, P., Dolado, I., Llanos, S., Cohen, P., & Nebreda, Á. R. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601657 · Cited by 97 · see citing works

Modulation of p53β and p53γ expression by regulating the alternative splicing of TP53 gene modifies cellular response

Marcel, V., Fernandes, K., Terrier, O., Lane, D. P., & Bourdon, J. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.73 · Cited by 96 · see citing works

TAp73 is required for spermatogenesis and the maintenance of male fertility

Inoue, S., Tomasini, R., Rufini, A., Elia, A., Agostini, M., Amelio, I., Cescon, D. W., Dinsdale, D. D., Zhou, L., Harris, I. S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323416111 · Cited by 93 · see citing works

p73 Regulates Neurodegeneration and Phospho-Tau Accumulation during Aging and Alzheimer's Disease

Wetzel, M. K., Naska, S., Laliberté, C. L., Rymar, V. V., Fujitani, M., Biernaskie, J., Cole, C. J., Lerch, J. P., Spring, S., Wang, S., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.021 · Cited by 92 · see citing works

P73 functionally replaces p53 in Adriamycin‐treated, p53‐deficient breast cancer cells

Vayssade, M., Haddada, H., Faridoni‐Laurens, L., Tourpin, S., Valent, A., Bénard, J., & Ahomadegbe, J. (2005) · International Journal of Cancer · doi:10.1002/ijc.21033 · Cited by 90 · see citing works

TAp73 Acts via the bHLH Hey2 to Promote Long-Term Maintenance of Neural Precursors

Fujitani, M., Cancino, G. I., Dugani, S. B., Weaver, I. C. G., Gauthier-Fisher, A., Paquin, A., Mak, T. W., Wojtowicz, M. J., Miller, F. D., & Kaplan, D. R. (2010) · Current Biology · doi:10.1016/j.cub.2010.10.029 · Cited by 89 · see citing works

p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene

He, Z., Liu, H., Agostini, M., Yousefi, S., Perren, A. A., Tschan, M. P., Mak, T. W., Melino, G., & Simon, H. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.104 · Cited by 84 · see citing works

Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repairPreprint

Malewicz, M., Kadkhodaei, B., Kee, N., Volakakis, N., Hellman, U., Viktorsson, K., Leung, C. Y., Chen, B., Lewensohn, R., van Gent, D. C., et al. (2011) · Genes & Development · doi:10.1101/gad.16872411 · Cited by 84 · see citing works

Cellular senescence and DNA repair

Lou, Z., & Chen, J. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.06.009 · Cited by 82 · see citing works

Oxidative stress-induced p53 activity is enhanced by a redox-sensitive TP53INP1 SUMOylation

Peuget, S., Bonacci, T., Soubeyran, P., Iovanna, J., & Dusetti, N. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.28 · Cited by 80 · see citing works

p63 regulates glutaminase 2 expression

Giacobbe, A., Bongiorno‐Borbone, L., Bernassola, F., Terrinoni, A., Markert, E. K., Levine, A. J., Fen, Z., Agostini, M., Zolla, L., Finazzi‐Agrò, A., et al. (2013) · Cell Cycle · doi:10.4161/cc.24478 · Cited by 79 · see citing works

Modalities of Gene Action Predicted by the Classical Evolutionary Biological Theory of Aging

Martin, G. M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1395.002 · Cited by 78 · see citing works

Specificin VitroBinding of p53 to the Promoter Region of the Human Mismatch Repair Gene hMSH2

Scherer, S. J., Welter, C., Zang, K. D., & Dooley, S. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0663 · Cited by 76 · see citing works

XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair

Craxton, A., Somers, J., Munnur, D., Jukes‐Jones, R., Cain, K., & Malewicz, M. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.22 · Cited by 74 · see citing works

p73 regulates maintenance of neural stem cell

Agostini, M., Tucci, P., Chen, H., Knight, R. A., Bano, D., Nicotera, P., McKeon, F., & Melino, G. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.10.087 · Cited by 71 · see citing works

Role of Ku70 in deubiquitination of Mcl-1 and suppression of apoptosis

Wang, B., Xie, M., Li, R., Owonikoko, T. K., Ramalingam, S. S., Khuri, F. R., Curran, W. J., Wang, Y., & Deng, X. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.42 · Cited by 71 · see citing works

DNA damage and aging

Karanjawala, Z. E., & Lieber, M. R. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.04.003 · Cited by 71 · see citing works

Changes in the level and distribution of Ku proteins during cellular senescence

Seluanov, A., Danek, J., Hause, N., & Gorbunova, V. A. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.06.010 · Cited by 70 · see citing works

UV-induced ubiquitylation of XPC complex, the UV-DDB-ubiquitin ligase complex, and DNA repair

Sugasawa, K. (2006) · Journal of Molecular Histology · doi:10.1007/s10735-006-9044-7 · Cited by 69 · see citing works

A stress-induced cellular aging model with postnatal neural stem cells

Cm, D., Xl, W., Gm, W., Wj, Z., Zhu, L., Gao, S., Dj, Y., Qin, Y., Qj, L., Yl, C., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.82 · Cited by 68 · see citing works

The role of p63 in germ cell apoptosis in the developing testis

Petre‐Lazar, B., Livera, G., Moreno, S. G., Trautmann, E., Duquenne, C., Hanoux, V., Habert, R., & Coffigny, H. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20829 · Cited by 66 · see citing works

Integrated high-throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosis

Li, H., Zhang, Y., Ströse, A., Tedesco, D., Gurova, K. V., & Selivanova, G. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.69 · Cited by 65 · see citing works

Relationship between DNA Repair Capacity and Cellular Aging

Little, J. B. (2009) · Gerontology · doi:10.1159/000212123 · Cited by 64 · see citing works

p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells

Fatt, M. P., Cancino, G. I., Miller, F. D., & Kaplan, D. R. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.61 · Cited by 64 · see citing works

p63 the guardian of human reproduction

Amelio, I., Grespi, F., Annicchiarico‐Petruzzelli, M., & Melino, G. (2012) · Cell Cycle · doi:10.4161/cc.22819 · Cited by 61 · see citing works

p73 deficiency results in impaired self renewal and premature neuronal differentiation of mouse neural progenitors independently of p53

González-Cano, L., Herreros‐Villanueva, M., Fernández-Alonso, R., Ayuso‐Sacido, Á., Meyer, G., García‐Verdugo, J. M., Silva, A. D. N., Marqués, M. M., & Marín, M. C. (2010) · Cell Death and Disease · doi:10.1038/cddis.2010.87 · Cited by 60 · see citing works

NF-κB inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2

Busuttil, V., Droin, N. M., McCormick, L. L., Bernassola, F., Candi, E., Melino, G., & Green, D. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006163107 · Cited by 59 · see citing works

DNA damage induces the rapid and selective degradation of the ΔNp73 isoform, allowing apoptosis to occur

Maisse, C., Munarriz, E. R., Barcaroli, D., Melino, G., & Laurenzi, V. D. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401376 · Cited by 57 · see citing works

DNA damage, DNA repair, ageing and age-related disease

Wilson, D. M., Bohr, V. A., & McKinnon, P. J. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.02.013 · Cited by 56 · see citing works

p53 induces skin aging by depleting Blimp1+ sebaceous gland cells

Kim, J., Nakasaki, M., Todorova, D., Lake, B. B., Yuan, C.-Y., Jamora, C., & Xu, Y. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.87 · Cited by 56 · see citing works

p53-directed translational control can shape and expand the universe of p53 target genes

Zaccara, S., Tebaldi, T., Pederiva, C., Ciribilli, Y., Bisio, A., & Inga, A. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.79 · Cited by 56 · see citing works

The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover

Bohgaki, M., Hakem, A., Halaby, M. J., Bohgaki, T., Li, Q., Bissey, P.-A., Shloush, J., Kislinger, T., Sanchez, O., Sheng, Y., et al. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.7 · Cited by 55 · see citing works

Epidermal Snail expression drives skin cancer initiation and progression through enhanced cytoprotection, epidermal stem/progenitor cell expansion and enhanced metastatic potential

Craene, B. D., Denecker, G., Vermassen, P., Taminau, J., Mauch, C., Derore, A., Jonkers, J., Fuchs, E. V., & Berx, G. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.148 · Cited by 54 · see citing works

Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating KrasG12D-induced senescence

Grasso, D., Garcia, M. N., Hamidi, T., Cano, C. E., Calvo, E. L., Lomberk, G. A., Urrutia, R. A., & Iovanna, J. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.74 · Cited by 53 · see citing works

A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors

Tilgner, K., Neganova, I. E., Moreno, I., Al-Aama, J. Y., Burks, D. J., Yung, S., Singhapol, C., Saretzki, G. C., Evans, J., Gorbunova, V. A., et al. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.44 · Cited by 50 · see citing works

ATM kinase is a master switch for the ΔNp63α phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage

Huang, Y., Sen, T., Nagpal, J. K., Upadhyay, S. K., Trink, B., Ratovitski, E. A., & Sidransky, D. (2008) · Cell Cycle · doi:10.4161/cc.7.18.6627 · Cited by 49 · see citing works

Mapping the p53 transcriptome universe using p53 natural polymorphs

Wang, B., Niu, D., Lam, T. H., Xiao, Z., & Ren, E. C. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.132 · Cited by 49 · see citing works

Nemo-like kinase is critical for p53 stabilization and function in response to DNA damage

Zhang, H.-H., Li, S.-Z., Zhang, Z.-Y., Hu, X.-M., Hou, P.-N., Gao, L., Du, R.-L., & Zhang, X. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.78 · Cited by 48 · see citing works

DAPK2 is a novel modulator of TRAIL-induced apoptosis

Schlegel, C. R., Fonseca, A.-V., Stöcker, S., Georgiou, M. L., Misterek, M. B., Munro, C. E., do Carmo, C. R., Seckl, M. J., & Costa‐Pereira, A. P. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.93 · Cited by 47 · see citing works

Analysis of the oligomeric state and transactivation potential of TAp73α

Luh, L. M., Kehrloesser, S., Deutsch, G. B., Gebel, J., Coutandin, D., Schäfer, B., Agostini, M., Melino, G., & Dötsch, V. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.23 · Cited by 45 · see citing works

ZNF281 contributes to the DNA damage response by controlling the expression of XRCC2 and XRCC4

Pieraccioli, M., Nicolai, S., Antonov, A. V., Somers, J., Malewicz, M., Melino, G., & Raschellà, G. (2015) · Oncogene · doi:10.1038/onc.2015.320 · Cited by 44 · see citing works

p63 is a prosurvival factor in the adult mammary gland during post-lactational involution, affecting PI-MECs and ErbB2 tumorigenesis

Yallowitz, A. R., Alexandrova, E. M., Talos, F., Xu, S., Marchenko, N. D., & Moll, U. M. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2013.199 · Cited by 44 · see citing works

AMPK couples p73 with p53 in cell fate decision

Adamovich, Y., Adler, J., Meltser, V., Reuven, N. B., & Shaul, Y. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.60 · Cited by 44 · see citing works

Role of the p63-FoxN1 regulatory axis in thymic epithelial cell homeostasis during aging

Burnley, P., Rahman, M., Wang, H., Zhang, Z., Sun, X., Zhuge, Q. C., & Su, D.-M. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.460 · Cited by 42 · see citing works

DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals

Lans, H., Lindvall, J. M., Thijssen, K. L., Karambelas, A. E., Cupac, D., Fensgård, Ø., Jansen, G., Hoeijmakers, J. H. J., Nilsen, H. L., & Vermeulen, W. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.126 · Cited by 42 · see citing works

The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele

Shetzer, Y., Kagan, S., Koifman, G., Sarig, R., Kogan-Sakin, I., Charni, M., Kaufman, T., Zapatka, M., Molchadsky, A., Rivlin, N., et al. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.57 · Cited by 41 · see citing works

Faulty DNA Repair Linked to Ovarian Aging in Mice and Humans

Couzin-Frankel, J. (2013) · Science · doi:10.1126/science.339.6121.749 · Cited by 34 · see citing works

Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response

Nair, B. C., Krishnan, S. R., Sareddy, G. R., Mann, M., Xu, B., Natarajan, M., Hasty, P., Brann, D. W., TEKMAL, R. R., & Vadlamudi, R. K. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.55 · Cited by 34 · see citing works

Suppression of acetylpolyamine oxidase by selected AP-1 members regulates DNp73 abundance: mechanistic insights for overcoming DNp73-mediated resistance to chemotherapeutic drugs

Bunjobpol, W., Dulloo, I., Igarashi, K., Concin, N., Matsuo, K., & Sabapathy, K. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.41 · Cited by 34 · see citing works

Sprouty1 induces a senescence-associated secretory phenotype by regulating NFκB activity: implications for tumorigenesis

Macià, A., Vaquero, M., Gou-Fàbregas, M., Castelblanco, E., Valdivielso, J. M., Anerillas, C., Mauricio, D., Matías‐Guiu, X., Ribera, J., & Encinas, M. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.161 · Cited by 32 · see citing works

TAp73 is required for macrophage-mediated innate immunity and the resolution of inflammatory responses

Tomasini, R., Secq, V., Pouyet, L., Thakur, A. K., Wilhelm, M., Nigri, J., Vasseur, S., Berthézène, P., Calvo, E. L., Melino, G., et al. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.123 · Cited by 30 · see citing works

P53 Activates Fanconi Anemia Group C Gene Expression

Liebetrau, W., Budde, A., Savoia, A., Grummt, F., & Hoehn, H. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.2.277 · Cited by 27 · see citing works

Oocyte-specific inactivation of Omcg1 leads to DNA damage and c-Abl/TAp63-dependent oocyte death associated with dramatic remodeling of ovarian somatic cells

Vandormael‐Pournin, S., Guigon, C. J., Ishaq, M., Coudouel, N., Avé, P., Huerre, M., Magre, S., Cohen-Tannoudji, J., & Cohen‐Tannoudji, M. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.122 · Cited by 26 · see citing works

Reciprocally Regulated Chromatin Association of Cockayne Syndrome Protein B and p53 Protein

Lake, R. J., Basheer, A., & Fan, H.-Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.252643 · Cited by 25 · see citing works

ΔNp63 regulates select routes of reprogramming via multiple mechanisms

Alexandrova, E. M., Petrenko, O., Nemajerová, A., Romano, R.-A., Sinha, S., & Moll, U. M. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.122 · Cited by 23 · see citing works

Genotoxic stress-mediated cell cycle activities for the decision of cellular fate

Erol, A. (2011) · Cell Cycle · doi:10.4161/cc.10.19.17460 · Cited by 21 · see citing works

Causes and Consequences of the DNA Damage Response

Nussenzweig, A. (2007) · Cell Cycle · doi:10.4161/cc.6.19.4995 · Cited by 20 · see citing works

TAp73 promotes anti-senescence-anabolism not proliferation

Agostini, M., Niklison-Chirou, M. V., Catani, M. V., Knight, R. A., Melino, G., & Rufini, A. (2014) · Aging · doi:10.18632/aging.100701 · Cited by 19 · see citing works

Slug Antagonizes p53-Mediated Apoptosis of Hematopoietic Progenitors by Repressing Puma.

Wu, W., Heinrichs, S., Xu, D. M., Adams, J. M., & Look, A. T. (2005) · Blood · doi:10.1182/blood.v106.11.3624.3624 · Cited by 19 · see citing works

p73 is dispensable for commitment to neural stem cell fate, but is essential for neural stem cell maintenance and for blocking premature differentiation

Alexandrova, E. M., Talos, F., & Moll, U. M. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.134 · Cited by 16 · see citing works

ΔNp73β puts the brakes on DNA repair: Figure 1.Preprint

Vernersson-Lindahl, E., & Mills, A. A. (2010) · Genes & Development · doi:10.1101/gad.1914210 · Cited by 10 · see citing works

TAp63: The fountain of youth

Su, X., & Flores, E. R. (2009) · Aging · doi:10.18632/aging.100095 · Cited by 8 · see citing works

TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors

Fujitani, M., Miller, F. D., & Kaplan, D. R. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.07.277 · Cited by 6 · see citing works

p63-microRNA feedback in keratinocyte senescence

Melino, G., Saintigny, G., Mahé, C., & Candi, E. (2013) · Annales de Dermatologie et de Vénéréologie · doi:10.1016/j.annder.2013.09.645 · Cited by 6 · see citing works

Reprogramming and genome integrity: role of non-homologous end joining

Salomoni, P. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.95 · Cited by 4 · see citing works

282: p53-directed translational control can shape and expand the universe of p53 target genes

Zaccara, S., Bolado, C. M., Pederiva, C., Tebaldi, T., Ciribilli, Y., Bisio, A., & Inga, A. (2014) · European Journal of Cancer · doi:10.1016/s0959-8049(14)50250-x · Cited by 2 · see citing works

Zinc-finger proteins in health and disease

Cassandri, M., Smirnov, A., Novelli, F., Pitolli, C., Agostini, M., Malewicz, M., Melino, G., & Raschellà, G. (2017) · Cell Death Discovery · doi:10.1038/cddiscovery.2017.71 · Cited by 844 · see citing works

DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunities

Abuetabh, Y., Wu, H. H., Chai, C., Yousef, H. A., Persad, S., Sergi, C. M., & Leng, R. P. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00863-4 · Cited by 275 · see citing works

The path from mitochondrial <scp>ROS</scp> to aging runs through the mitochondrial permeability transition pore

Rottenberg, H., & Hoek, J. B. (2017) · Aging Cell · doi:10.1111/acel.12650 · Cited by 275 · see citing works

Therapeutic effects of EGCG: a patent review

Chakrawarti, L., Agrawal, R., Dang, S., Gupta, S., & Gabrani, R. (2016) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2016.1203419 · Cited by 222 · see citing works

Nrf2: Molecular and epigenetic regulation during aging

Silva‐Palacios, A., Ostolga-Chavarría, M., Zazueta, C., & Königsberg, M. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.06.003 · Cited by 195 · see citing works

DNA methylation dynamics in aging: how far are we from understanding the mechanisms?

Ciccarone, F., Tagliatesta, S., Caiafa, P., & Zampieri, M. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.12.002 · Cited by 184 · see citing works

The multiple mechanisms of MCL1 in the regulation of cell fate

Widden, H., & Placzek, W. J. (2021) · Communications Biology · doi:10.1038/s42003-021-02564-6 · Cited by 162 · see citing works

White shark genome reveals ancient elasmobranch adaptations associated with wound healing and the maintenance of genome stability

Marra, N. J., Stanhope, M. J., Jue, N. K., Wang, M., Sun, Q., Bitar, P. P., Richards, V. P., Komissarov, A. S., Rayko, M., Kliver, S. F., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1819778116 · Cited by 122 · see citing works

Exercise effects on physiological function during aging

Radak, Z. O., Torma, F., Berkes, I., Goto, S., Mimura, T., Pósa, A., Balogh, L., Boldogh, I. R., Suzuki, K., Higuchi, M., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.444 · Cited by 112 · see citing works

Targeting the Mitochondrial Permeability Transition Pore to Prevent Age‐Associated Cell Damage and Neurodegeneration

Kent, A. C., Baradie, K. B. Y. E., & Hamrick, M. W. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6626484 · Cited by 107 · see citing works

DNA Damage and Pulmonary Hypertension

Ranchoux, B., Meloche, J., Paulin, R., Boucherat, O., Provencher, S., & Bonnet, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060990 · Cited by 105 · see citing works

Pathophysiological Fundamentals of Diabetic Cardiomyopathy

Hu, X., Bai, T., Xu, Z., Liu, Q., Zheng, Y., & Cai, L. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160021 · Cited by 103 · see citing works

The mitochondrial permeability transition: Nexus of aging, disease and longevity

Rottenberg, H., & Hoek, J. B. (2021) · Cells · doi:10.3390/cells10010079 · Cited by 94 · see citing works

FOXM1 regulates proliferation, senescence and oxidative stress in keratinocytes and cancer cells

Smirnov, A., Panatta, E., Lena, A. M., Castiglia, D., Daniele, N. D., Melino, G., & Candi, E. (2016) · Aging · doi:10.18632/aging.100988 · Cited by 86 · see citing works

The impact of toxic metal bioaccumulation on colorectal cancer: Unravelling the unexplored connection

Bonfiglio, R., Sisto, R., Casciardi, S., Palumbo, V., Scioli, M. P., Palumbo, A., Trivigno, D., Giacobbi, E., Servadei, F., Melino, G., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.167667 · Cited by 71 · see citing works

hPMSCs-Derived Exosomal miRNA-21 Protects Against Aging-Related Oxidative Damage of CD4+ T Cells by Targeting the PTEN/PI3K-Nrf2 Axis

Xiong, Y., Xiong, Y., Zhang, H., Zhao, Y., Han, K., Zhang, J., Zhao, D., Yu, Z., Geng, Z., Wang, L., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.780897 · Cited by 69 · see citing works

Oncogenic Metabolism Acts as a Prerequisite Step for Induction of Cancer Metastasis and Cancer Stem Cell Phenotype

Lee, S. Y., Ju, M. K., Jeon, H. M., Lee, Y. J., Kim, C. H., Park, H. G., Han, S. I., & Kang, H. S. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1027453 · Cited by 67 · see citing works

Phenotyping of Drosophila Melanogaster—A Nutritional Perspective

Eickelberg, V., Lüersen, K., Staats, S., & Rimbach, G. H. (2022) · Biomolecules · doi:10.3390/biom12020221 · Cited by 51 · see citing works

The Rich World of p53 DNA Binding Targets: The Role of DNA Structure

Brázda, V., & Fojta, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225605 · Cited by 48 · see citing works

Ultraconserved long non-coding RNA uc.63 in breast cancer

Marini, A., Lena, A. M., Panatta, E., Ivan, C., Han, L., Liang, H., Annicchiarico‐Petruzzelli, M., Daniele, N. D., Calin, G. A., Candi, E., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10572 · Cited by 45 · see citing works

Sirtuins and their interactions with transcription factors and poly(ADP-ribose) polymerases

Jęśko, H. M., & Strosznajder, R. P. (2016) · Folia Neuropathologica · doi:10.5114/fn.2016.62531 · Cited by 44 · see citing works

ITGB 4 deficiency induces senescence of airway epithelial cells through p53 activation

Yuan, L., Du, X., Tang, S., Wu, S., Wang, L., Xiang, Y., Qu, X., Liu, H., Qin, X., & Liu, C. (2019) · FEBS Journal · doi:10.1111/febs.14749 · Cited by 44 · see citing works

A Comparative Review of the Effect of Microcystin-LR on the Proteome

Welten, R. D., Meneely, J. P., & Elliott, C. T. (2019) · Exposure and Health · doi:10.1007/s12403-019-00303-1 · Cited by 41 · see citing works

Cellular senescence in dental pulp stem cells

Morsczeck, C. O. (2019) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2019.01.012 · Cited by 40 · see citing works

Understanding the Multifaceted Role of Human Down Syndrome Kinase DYRK1A

Kay, L. J., Smulders-Srinivasan, T. K., & Soundararajan, M. (2016) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2016.07.001 · Cited by 38 · see citing works

Nutrigenomics at the Interface of Aging, Lifespan, and Cancer Prevention

Riscuta, G. (2016) · The Journal of Nutrition · doi:10.3945/jn.116.235119 · Cited by 37 · see citing works

Homeodomain-Interacting Protein Kinase-2: A Critical Regulator of the DNA Damage Response and the Epigenome

Kuwano, Y., Nishida, K., Akaike, Y., Kurokawa, K., Nishikawa, T., Masuda, K., & Rokutan, K. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101638 · Cited by 35 · see citing works

Helicobacter pylori-Mediated Genetic Instability and Gastric Carcinogenesis

Shimizu, T., Chiba, T., & Marusawa, H. (2017) · Current topics in microbiology and immunology · doi:10.1007/978-3-319-50520-6_13 · Cited by 35 · see citing works

Effects of caloric restriction on the antagonistic and integrative hallmarks of aging

Erbaba, B., Arslan-Ergül, A., & Adams, M. M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101228 · Cited by 33 · see citing works

Neurobiological mechanisms of mood disorders: Stress vulnerability and resilience

Pereira, C. M., Castro, F. C. D. A. Q., Barcelos, R. M., Chiepe, K. C. M. B., Rossoni, J. V., Ambrósio, R. P., Chiarelli-Neto, O., & Pesarico, A. P. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.1006836 · Cited by 32 · see citing works

Transcription factor p73 regulates Th1 differentiation

Ren, M., Kazemian, M., Zheng, M., He, J., Li, P., Oh, J., Liao, W., Li, J., Rajaseelan, J., Kelsall, B. L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15172-5 · Cited by 31 · see citing works

Expression Levels of Three Key Genes CCNB1, CDC20, and CENPF in HCC Are Associated With Antitumor Immunity

Si, T., Huang, Z., Jiang, Y., Walker-Jacobs, A., Gill, S., Hegarty, R., Hamza, M., Khorsandi, S. E., Jassem, W., Heaton, N. D., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.738841 · Cited by 31 · see citing works

TAp73 upregulates IL-1β in cancer cells: Potential biomarker in lung and breast cancer?

Вихрева, П. Н., Petrova, V., Gökbulut, T., Pestlikis, I., Mancini, M., Daniele, N. D., Knight, R. A., Melino, G., & Amelio, I. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.085 · Cited by 30 · see citing works

Aging promotes neoplastic disease through effects on the tissue microenvironment

Marongiu, F., Serra, M. P., Doratiotto, S., Sini, M., Fanti, M., Cadoni, E., Serra, M., & Laconi, E. (2016) · Aging · doi:10.18632/aging.101128 · Cited by 30 · see citing works

Exponential increase in mortality with age is a generic property of a simple model system of damage accumulation and death

Ledberg, A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233384 · Cited by 29 · see citing works

Skeletal Muscle Gene Expression in Long-Term Endurance and Resistance Trained Elderly

Bolotta, A., Filardo, G., Abruzzo, P. M., Astolfi, A., Sanctis, P. D., Martino, A. D., Höfer, C., Indio, V., Kern, H., Löfler, S., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113988 · Cited by 29 · see citing works

The role of truncated p53 isoforms in the DNA damage response

Reinhardt, L. S., Groen, K., Newton, C., & Avery‐Kiejda, K. A. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188882 · Cited by 30 · see citing works

Trypanosoma cruzi induces cellular proliferation in the trophoblastic cell line BeWo

Droguett, D., Carrillo, I., Castillo, C., Fresia, G., Miguel, N., Liempi, A. I., Muñoz, L., Galanti, N., Maya, J. D., & Kemmerling, U. (2016) · Experimental Parasitology · doi:10.1016/j.exppara.2016.12.005 · Cited by 27 · see citing works

Alternative Mechanisms of p53 Action During the Unfolded Protein Response

Fusée, L. T. S., Marı́n, M., Fåhræus, R., & López, I. (2020) · Cancers · doi:10.3390/cancers12020401 · Cited by 26 · see citing works

ZBED1/DREF: A transcription factor that regulates cell proliferation (Review)

Jin, Y., Li, R., Zhang, Z., Ren, J., Song, X., & Zhang, G. (2020) · Oncology Letters · doi:10.3892/ol.2020.11997 · Cited by 26 · see citing works

The Changes in the p53 Protein across the Animal Kingdom Point to Its Involvement in Longevity

Bartas, M., Brázda, V., Volná, A., Červeň, J., Pečínka, P., & Zawacka‐Pankau, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168512 · Cited by 26 · see citing works

Enhancement of UVB-induced DNA damage repair after a chronic low-dose UVB pre-stimulation

Drigeard Desgarnier, M.-C., & Rochette, P. J. (2018) · DNA Repair · doi:10.1016/j.dnarep.2018.01.008 · Cited by 24 · see citing works

Decline of regenerative potential of old muscle stem cells: contribution to muscle aging

Sahinyan, K., Lazure, F., Blackburn, D. M., & Soleimani, V. D. (2022) · FEBS Journal · doi:10.1111/febs.16352 · Cited by 25 · see citing works

Explaining Variation in Individual Aging, Its Sources, and Consequences: A Comprehensive Conceptual Model of Human Aging

Rothermund, K., Englert, C., & Gerstorf, D. (2023) · Gerontology · doi:10.1159/000534324 · Cited by 23 · see citing works

Metabolic pathways regulated by TAp73 in response to oxidative stress

Agostini, M., Annicchiarico‐Petruzzelli, M., Melino, G., & Rufini, A. (2016) · Oncotarget · doi:10.18632/oncotarget.8935 · Cited by 22 · see citing works

Tetraspanin family identified as the central genes detected in gastric cancer using bioinformatics analysis

Qi, W., Sun, L., Liu, N., Zhao, S., Lv, J., & Qiu, W. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9360 · Cited by 22 · see citing works

Corrupting the DNA damage response: a critical role for Rad52 in tumor cell survival

Lieberman, R., & You, M. (2017) · Aging · doi:10.18632/aging.101263 · Cited by 21 · see citing works

New factors in mammalian DNA repair—the chromatin connection

Raschellà, G., Melino, G., & Malewicz, M. (2017) · Oncogene · doi:10.1038/onc.2017.60 · Cited by 20 · see citing works

Transcriptomes of human primary skin fibroblasts of healthy individuals reveal age‐associated mRNAs and long noncoding RNAs

Tsitsipatis, D., Martindale, J. L., Mazan-Mamczarz, K., Herman, A. B., Piao, Y., Banskota, N., Yang, J., Cui, L., Anerillas, C., Chang, M., et al. (2023) · Aging Cell · doi:10.1111/acel.13915 · Cited by 19 · see citing works

ZNF185 is a p53 target gene following DNA damage

Smirnov, A., Cappello, A., Lena, A. M., Anemona, L., Mauriello, A., Daniele, N. D., Annicchiarico‐Petruzzelli, M., Melino, G., & Candi, E. (2018) · Aging · doi:10.18632/aging.101639 · Cited by 19 · see citing works

Saponin‐rich extracts fromHolothuria leucospilotamediate lifespan extension and stress resistance inCaenorhabditis elegansviadaf‐16

Kitisin, T., Suphamungmee, W., & Meemon, K. (2019) · Journal of Food Biochemistry · doi:10.1111/jfbc.13075 · Cited by 18 · see citing works

GSK-3β phosphorylation-dependent degradation of ZNF281 by β-TrCP2 suppresses colorectal cancer progression

Zhu, Y., Zhou, Q., Zhu, G., Xing, Y., Li, S., Ren, N., Liu, T., Zhu, A., Bai, Y., & Piao, D. (2017) · Oncotarget · doi:10.18632/oncotarget.20100 · Cited by 16 · see citing works

Does transcription-associated DNA damage limit lifespan?

Callegari, A. J. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.03.001 · Cited by 15 · see citing works

Zbp1 gene: a modulator of multiple aging hallmarks as potential therapeutic target for age-related diseases

Radak, M., & Fallahi, H. (2023) · Biogerontology · doi:10.1007/s10522-023-10039-w · Cited by 15 · see citing works

CD95 ligand induces senescence in mismatch repair-deficient human colon cancer via chronic caspase-mediated induction of DNA damage

Raats, D., Frenkel, N. C., van Schelven, S. J., Rinkes, I. H. M. B., Laoukili, J., & Kranenburg, O. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.87 · Cited by 14 · see citing works

Wogonin protects against bleomycin-induced mouse pulmonary fibrosis via the inhibition of CDK9/p53-mediated cell senescence

Wang, L., Lin, F., Liu, Y., Li, W., Ding, Q., Duan, X., Yang, L., Bai, Z., Zhang, M., & Guo, Y. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1407891 · Cited by 13 · see citing works

Sterigmatocystin-induced DNA damage triggers cell-cycle arrestviaMAPK in human neuroblastoma cells

Zingales, V., Fernández-Franzón, M., & Ruiz, M.-J. (2021) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2021.1916801 · Cited by 13 · see citing works

Immortalization Reversibility in the Context of Cell Therapy Biosafety

Sutyagina, O. I., Beilin, A. K., Vorotelyak, E. A., & Vasiliev, A. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097738 · Cited by 12 · see citing works

Programmed Cell Death Pathways in Cholangiocarcinoma: Opportunities for Targeted Therapy

Scimeca, M., Rovella, V., Palumbo, V., Scioli, M. P., Bonfiglio, R., Melino, G., Piacentini, M., Frati, L., Agostini, M., Candi, E., et al. (2023) · Cancers · doi:10.3390/cancers15143638 · Cited by 12 · see citing works

The Localization of p53 in the Crayfish Mechanoreceptor Neurons and Its Role in Axotomy-Induced Death of Satellite Glial Cells Remote from the Axon Transection Site

Rodkin, S., Khaitin, A. M., Pitinova, M., Dzreyan, V., Guzenko, V., Rudkovskii, M. V., Sharifulina, S., & Uzdensky, A. B. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01453-2 · Cited by 12 · see citing works

Retrotransposon‐derived p53 binding sites enhance telomere maintenance and genome protection

Lieberman, P. M. (2016) · BioEssays · doi:10.1002/bies.201600078 · Cited by 12 · see citing works

The Δ133p53 Isoform Reduces Wtp53-induced Stimulation of DNA Pol γ Activity in the Presence and Absence of D4T

Liu, K., Zang, Y., Guo, X., Wei, F., Yin, J., Pang, L., & Chen, D. (2017) · Aging and Disease · doi:10.14336/ad.2016.0910 · Cited by 12 · see citing works

Pathophysiological Fundamentals of Diabetic Cardiomyopathy

Hu, X., Bai, T., Xu, Z., Liu, Q., Zheng, Y., & Cai, L. (2017) · Comprehensive physiology · doi:10.1002/j.2040-4603.2017.tb00752.x · Cited by 11 · see citing works

The p75 neurotrophin receptor regulates cranial irradiation-induced hippocampus-dependent cognitive dysfunction

Ding, X., Wu, H., Ji, S., Cai, S., Dai, P.-W., Xu, M., Zhang, J., Zhang, Q.-X., Tian, Y., & Ma, Q. (2017) · Oncotarget · doi:10.18632/oncotarget.16492 · Cited by 11 · see citing works

A data mining framework based on boundary-points for gene selection from DNA-microarrays: Pancreatic Ductal Adenocarcinoma as a case study

Ramos, J., Castellanos-Garzón, J. A., Paz, J. F. D., & Corchado, J. M. (2018) · Engineering Applications of Artificial Intelligence · doi:10.1016/j.engappai.2018.01.007 · Cited by 11 · see citing works

Myoblasts rely on TAp63 to control basal mitochondria respiration

Ciuffoli, V., Lena, A. M., Gambacurta, A., Melino, G., & Candi, E. (2018) · Aging · doi:10.18632/aging.101668 · Cited by 11 · see citing works

Computational Drug Screening Identifies Compounds Targeting Renal Age-associated Molecular Profiles

Koppelstaetter, C., Leierer, J., Rudnicki, M., Kerschbaum, J., Kronbichler, A., Melk, A., Mayer, G. J., & Perco, P. (2019) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2019.06.019 · Cited by 11 · see citing works

Cell death in cancer in the era of precision medicine

Raschellà, G., Melino, G., & Gambacurta, A. (2018) · Genes and Immunity · doi:10.1038/s41435-018-0048-6 · Cited by 10 · see citing works

p73-regulated FER1L4 lncRNA sponges the oncogenic potential of miR-1273g-3p and aids in the suppression of colorectal cancer metastasis

Uboveja, A., Satija, Y. K., Siraj, F., & Saluja, D. (2022) · iScience · doi:10.1016/j.isci.2022.103811 · Cited by 10 · see citing works

Comparative analysis of markers for H2O2-induced senescence in renal tubular cells

Rattananinsruang, P., Noonin, C., Yoodee, S., & Thongboonkerd, V. (2022) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2022.104039 · Cited by 9 · see citing works

Distinct p63 and p73 Protein Interactions Predict Specific Functions in mRNA Splicing and Polyploidy Control in Epithelia

Rozenberg, J. M., Rogovaya, O. S., Melino, G., Barlev, N. A., & Kagansky, A. (2020) · Cells · doi:10.3390/cells10010025 · Cited by 9 · see citing works

p53 CRISPR Deletion Affects DNA Structure and Nuclear Architecture

Pozzo, A. R., Booth, S., Yu, P. L. I., Singh, M., Selivanova, G., & Mai, S. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020598 · Cited by 8 · see citing works

The cell cycle regulatory gene polymorphisms TP53 (rs1042522) and MDM2 (rs2279744) in lung cancer: a meta-analysis

Bulgakova, O., Kussainova, A., & Bersimbaev, R. I. (2020) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vj20.673 · Cited by 8 · see citing works

Identification and Mechanistic Studies of a Cell Cycle Regulator JP18 from a Library of Synthetic Indole Terpenoid Mimics

Pei, J., Zhou, S., Yang, F., Sun, Y., Li, A., Zhang, W., & He, W. (2016) · Chemistry - An Asian Journal · doi:10.1002/asia.201600714 · Cited by 7 · see citing works

Integrative p53, micro-RNA and Cathepsin Protease Co-Regulatory Expression Networks in Cancer

Soond, S. M., Kozhevnikova, M. V., Townsend, P. A., & Zamyatnin, A. A. (2020) · Cancers · doi:10.3390/cancers12113454 · Cited by 7 · see citing works

DNA Damage and Inflammatory Response of p53 Null H358 Non-Small Cell Lung Cancer Cells to X-Ray Exposure Under Chronic Hypoxia

Nisar, H., Brauny, M., Labonté, F. M., Schmitz, C., Konda, B., & Hellweg, C. E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312590 · Cited by 6 · see citing works

Multifunctional Proteins

Uzdensky, A. B. (2020) · BIOPHYSICS · doi:10.1134/s0006350920030227 · Cited by 6 · see citing works

Caloric restriction reinforces the stem cell pool in the aged brain without affecting overall proliferation status

Erbaba, B., Macaroglu, D., Ardic-Avci, N. I., Arslan-Ergül, A., & Adams, M. M. (2022) · Gene · doi:10.1016/j.gene.2022.147026 · Cited by 6 · see citing works

Genetic Risk Factors for Radiation Vasculopathy

Papakostas, T. D., Morrison, M. A., Lane, A. M., Awh, C. C., DeAngelis, M. M., Gragoudas, E. S., & Kim, I. K. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-22791 · Cited by 6 · see citing works

The G2 phase arrest induced by sterigmatocystin is dependent on hMLH1- ERK/p38-p53 pathway in human esophageal epithelium cells in vitro

Cui, J., Wang, J., Huang, S., Jiang, X., Li, Y., Wu, W., & Zhang, X. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.03.012 · Cited by 5 · see citing works

Age-dependent changes of p53 and p63 immunoreactivities in the mouse hippocampus

Lee, T.-K., Park, Y. E., Park, C. W., Kim, B., Lee, J., Park, J. H., Lee, H., Won, M., & Ahn, J. H. (2019) · Laboratory Animal Research · doi:10.1186/s42826-019-0022-0 · Cited by 5 · see citing works

TAp63γ influences mouse cartilage development

Wang, Q., Li, N., Chen, F., Hei, R., Gu, J., Lu, Y., Sun, L., & Zheng, Q. (2020) · Aging · doi:10.18632/aging.103190 · Cited by 4 · see citing works

Prenatal and pubertal exposure to 17α‐ethinylestradiol cause morphological changes in the prostate of old gerbils

Fleury, F. G., Guimarães, L. R. F., Rezende, E. B., Martins, T. M. M., Caires, C. R. S., dos Santos, F. C. A., Taboga, S. R., & Perez, A. P. D. S. (2021) · Cell Biology International · doi:10.1002/cbin.11656 · Cited by 4 · see citing works

Aging Cell Culture - Genetic and Metabolic Effects of Passage Number on Zebrafish Z3 Cells

Šrut, M., Peer, B. A., Fiechtner, B., Egg, M., Sandbichler, A. M., & Höckner, M. (2022) · Cellular Physiology and Biochemistry · doi:10.33594/000000494 · Cited by 4 · see citing works

Influence of UV-A irradiation on the selected nutrient composition and volatile profiling of whole milk: Safety and quality evaluation

Kurup, A. H., Patras, A., Bansode, R., Pendyala, B., Ravi, R., & Vergne, M. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.102029 · Cited by 2 · see citing works

The changes in the p53 protein across the animal kingdom pointing to its involvement in longevityPreprint

Bartas, M., Brázda, V., Volná, A., Červeň, J., Pečínka, P., & Zawacka‐Pankau, J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.06.080200 · Cited by 4 · see citing works

The role of HECT-type E3 ubiquitin ligases in DNA damage response and repair

Giovannini, S., Fiorilli, C., Moriconi, V., Shi, Y., Candi, E., Melino, G., & Bernassola, F. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02911-0 · Cited by 3 · see citing works

Genotoxicity and DNA repair indicative in blood cells after occupational exposure to ionizing radiation

Silva, R. G., de Alencar, M. V. O. B., Teixeira, J. S., Silva, R. R. E., Paz, M. F. C. J., Sousa, J. M. D. C. E., de Aguiar, R. P. S., de Carvalho, R. M., Júnior, A. L. G., da Mata, A. M. O. F., et al. (2016) · International Archives of Medicine · doi:10.3823/1992 · Cited by 3 · see citing works

Vimentin and p53 Immunoreactivity in Cases of Traumatic Brain Injury

Manetti, A. C., Matteis, A. D., Napoletano, G., Russa, R. L., Maiese, A., & Frati, P. (2025) · Journal of Personalized Medicine · doi:10.3390/jpm15040135 · Cited by 2 · see citing works

DOSE-RATE AS A CRITICAL ASPECT OF CELLULAR RESPONSE TO GAMMA-RADIATION

Vávrová, J., Řezáčová, M., Šinkorová, Z., & Tichý, A. (2018) · Military Medical Science Letters · doi:10.31482/mmsl.2018.016 · Cited by 2 · see citing works

Plasma Proteomics of Type 2 Diabetes, Hypertension, and Co-Existing Diabetes/Hypertension in Thai Adults

Fakfum, P., Chuljerm, H., Parklak, W., Roytrakul, S., Phaonakrop, N., Lerttrakarnnon, P., & Kulprachakarn, K. (2024) · Life · doi:10.3390/life14101269 · Cited by 2 · see citing works

Multicellular model of neuroblastoma proposes unconventional therapy based on multiple roles of p53

Wertheim, K. Y., Chisholm, R., Richmond, P., & Walker, D. (2024) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1012648 · Cited by 2 · see citing works

Hematopoietic Stem Cell Aging and Malignant Hemopathies

Goodhardt, M., Garrick, D., Dang, L., Salaroli, A., & Bron, D. (2017) · Springer eBooks · doi:10.1007/978-3-319-44870-1_71-1 · Cited by 2 · see citing works

Aging and Malignant Hemopathies: A Complex Multistep Process

Chi, V. L. D., Sibille, C., Willard-Gallo, K. E., & Bron, D. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_142-1 · Cited by 1 · see citing works

Aging and Malignant Hemopathies: A Complex Multistep Process

Chi, V. L. D., Sibille, C., Willard-Gallo, K. E., & Bron, D. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_142 · Cited by 1 · see citing works

p53-driven replication stress in nucleoli of malignant epithelial ovarian cancer

Guo, C. Y., Guo, L., Peng, C., Jia, Y., Yang, Y., Wang, X., Zeng, M., Wang, D., Liu, C., Zhao, M., et al. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2022.113225 · Cited by 1 · see citing works

Tension force causes cell cycle arrest at G2/M phase in osteocyte-like cell line MLO-Y4

Shimizu, N., Fujiwara, K., Mayahara, K., Motoyoshi, M., & Takahashi, T. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13236 · Cited by 1 · see citing works

Canagliflozin improves high-salt-induced aortic arteriosclerosis and premature aging in dahl salt-sensitive rats through the SIRT6/HIF-1 α signaling pathway

Wang, Q., Liang, Y., Zuo, Q., He, L., Zhang, T., Wang, Z., Zhai, J., Cao, B., Ma, S., Zhang, G., et al. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05321-z · Cited by 1 · see citing works

Assessment of the Role of Poly (ADP-Ribose) Polymerase in Drug-Induced Cardiomyopathy

Brinkerhoff, A. I. (2016) · Digital Commons - University of South Florida (University of South Florida)

Investigação de parceiros moleculares de Cdc42 em linhagens de células humanas submetidas a estresse genotóxico

de Souza, R. C. (2016) · doi:10.11606/d.46.2016.tde-15092016-090036

Crosstalk between P53 and DNA damage response in ageing

Mohammadzadeh, A., Mirza‐Aghazadeh‐Attari, M., Hallaj, S., Saei, A. A., Alivand, M. R., Valizadeh, A., Yousefi, B., & Majidinia, M. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.05.004 · Cited by 33 · see citing works

DNA damage responses and p53 in the aging process

Ou, H.-L., & Schumacher, B. (2018) · Blood · doi:10.1182/blood-2017-07-746396 · Cited by 377 · see citing works

The p53 network: cellular and systemic DNA damage responses in aging and Cancer

Reinhardt, H. C., & Schumacher, B. (2012) · Trends in Genetics · doi:10.1016/j.tig.2011.12.002 · Cited by 458 · see citing works

Senescence Regulation by the p53 Protein Family

Qian, Y., & Chen, X. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-239-1_3 · Cited by 170 · see citing works

doi:10.1093/nar/gkm744 SURVEY AND SUMMARY Two faces of p53: aging and tumor suppression

Rodier, F., Campisi, J., & Bhaumik, D. (2007)