The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
The genomic binding sites of a noncoding RNA
Open accessAbstract
Long noncoding RNAs (lncRNAs) have important regulatory roles and can function at the level of chromatin. To determine where lncRNAs bind to chromatin, we developed capture hybridization analysis of RNA targets (CHART), a hybridization-based technique that specifically enriches endogenous RNAs along with their targets from reversibly cross-linked chromatin extracts. CHART was used to enrich the DNA and protein targets of endogenous lncRNAs from flies and humans. This analysis was extended to genome-wide mapping of roX2 , a well-studied ncRNA involved in dosage compensation in Drosophila . CHART revealed that roX2 binds at specific genomic sites that coincide with the binding sites of proteins from the male-specific lethal complex that affects dosage compensation. These results reveal the genomic targets of roX2 and demonstrate how CHART can be used to study RNAs in a manner analogous to chromatin immunoprecipitation for proteins.
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Cites
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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
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Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
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Long Noncoding RNAs with Enhancer-like Function in Human Cells
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CLIP Identifies Nova-Regulated RNA Networks in the Brain
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Cited by
The emerging role of lncRNAs in cancer
Huarte, M. (2015) · Nature Medicine · doi:10.1038/nm.3981 · Cited by 2,702
Long Noncoding RNAs: Cellular Address Codes in Development and Disease
Batista, P. J., & Chang, H. Y. (2013) · Cell · doi:10.1016/j.cell.2013.02.012 · Cited by 2,531
Long noncoding RNAs: past, present, and future
Kung, J. T. Y., Colognori, D., & Lee, J. T. (2013) · Genetics · doi:10.1534/genetics.112.146704 · Cited by 1,874
the 4D Nucleome Network, Dekker, J., Belmont, A. S., Guttman, M., Leshyk, V. O., Lis, J. T., Lomvardas, S., Mirny, L. A., O’Shea, C. C., Park, P. J., et al. (2017) · Nature · doi:10.1038/nature23884 · Cited by 732
The Long Noncoding RNAs NEAT1 and MALAT1 Bind Active Chromatin Sites
West, J. A., Davis, C. P., Sunwoo, H., Simon, M. D., Sadreyev, R. I., Wang, P. I., Tolstorukov, M. Y., & Kingston, R. E. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.07.012 · Cited by 709
Self-citation
Metadata
- Authors
- Simon, M. D., Wang, C. I., Kharchenko, P. V., West, J. A., Chapman, B. A., Alekseyenko, A. A., Borowsky, M. L., Kuroda, M. I., & Kingston, R. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-12-05
- Volume
- 108
- Issue
- 51
- Pages
- 20497-20502
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1992212213
- Cited by
- 446
- References
- 10
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Open access
- green
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