The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Self-amplifying autocrine actions of BDNF in axon development
Open accessAbstract
A critical step in neuronal development is the formation of axon/dendrite polarity, a process involving symmetry breaking in the newborn neuron. Local self-amplifying processes could enhance and stabilize the initial asymmetry in the distribution of axon/dendrite determinants, but the identity of these processes remains elusive. We here report that BDNF, a secreted neurotrophin essential for the survival and differentiation of many neuronal populations, serves as a self-amplifying autocrine factor in promoting axon formation in embryonic hippocampal neurons by triggering two nested positive-feedback mechanisms. First, BDNF elevates cytoplasmic cAMP and protein kinase A activity, which triggers further secretion of BDNF and membrane insertion of its receptor TrkB. Second, BDNF/TrkB signaling activates PI3-kinase that promotes anterograde transport of TrkB in the putative axon, further enhancing local BDNF/TrkB signaling. Together, these self-amplifying BDNF actions ensure stable elevation of local cAMP/protein kinase A activity that is critical for axon differentiation and growth.
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Cites
Trk Receptors: Roles in Neuronal Signal Transduction
Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537 · cited 1×
“Because PI3K is a major downstream effector of BDNF (8), the highly localized PI3K at the axonal tip could initially be triggered by the localized autocrine action of BDNF, and the PI3K/PIP3/ RhoGTPase feedback loop thus represents another positivefeedback loop in promoting PI3K-dependent TrkB anterograde transport sh…”
ResultThe establishment of polarity by hippocampal neurons in culture.
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Neurotrophins as synaptic modulators
Poo, M.-M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35049004 · Cited by 1,775
Self-citationCa2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J., & Greenberg, M. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81010-7 · Cited by 1,561
Requirement for BDNF in activity-dependent survival of cortical neurons
Ghosh, A., Carnahan, J., & Greenberg, M. E. (1994) · Science · doi:10.1126/science.7907431 · Cited by 989
A BDNF autocrine loop in adult sensory neurons prevents cell death
Acheson, A., Conover, J. C., Fandl, J. P., DeChiara, T. M., Russell, M., Thadani, A., Squinto, S. P., Yancopoulos, G. D., & Lindsay, R. M. (1995) · Nature · doi:10.1038/374450a0 · Cited by 765
Identification of a Signaling Pathway Involved in Calcium Regulation of BDNF Expression
Shieh, P. B., Hu, S.-C., Bobb, K., Timmusk, T., & Ghosh, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)81011-9 · Cited by 693
Neuronal polarity: from extracellular signals to intracellular mechanisms.
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Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines
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“Localized action of secreted BDNF at the synapse plays a critical role in synapse-specific long-term modification (46).”
BackgroundHippocampal Neuronal Polarity Specified by Spatially Localized mPar3/mPar6 and PI 3-Kinase Activity
Shi, S.-H., Jan, L. Y., & Jan, Y.-N. (2003) · Cell · doi:10.1016/s0092-8674(02)01249-7 · Cited by 600
Cited by
Neurotrophin regulation of neural circuit development and function
Park, H., & Poo, M.-M. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3379 · Cited by 2,060
Self-citationNeuroinflammation and depression: A review
Troubat, R., Barone, P., Leman, S., Desmidt, T., Cressant, A., Atanasova, B., Brizard, B., El Hage, W., Surget, A., Belzung, C., et al. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14720 · Cited by 1,107
BDNF mechanisms in late LTP formation: A synthesis and breakdown
Panja, D., & Bramham, C. R. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.024 · Cited by 336
Neurobiology of local and intercellular BDNF signaling
Sasi, M., Vignoli, B., Canossa, M., & Blum, R. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1964-4 · Cited by 324
Regulation of Memory Formation by the Transcription Factor XBP1
Martínez, G., Vidal, R. L., Mardones, P., Serrano, F. G., Ardiles, A. O., Wirth, C., Valdés, P., Thielen, P., Schneider, B. L., Kerr, B., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.028 · Cited by 163
Metadata
- Authors
- Cheng, P.-L., Song, A.-H., Wong, Y.-H., Wang, S., Zhang, X., & Poo, M.-M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-10-24
- Volume
- 108
- Issue
- 45
- Pages
- 18430-18435
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2063252423
- Cited by
- 250
- References
- 12
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- green
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- Cheng, P.-L., Song, A.-H., Wong, Y.-H., Wang, S., Zhang, X., & Poo, M.-M. (2011). Self-amplifying autocrine actions of BDNF in axon development. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1115907108
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