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Cited by 311

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8 + T-cell immunity

Open access
Lang, Philipp A., Lang, Karl S., Xu, Haifeng C., Grusdat, Melanie, Parish, Ian A., Recher, Mike, Elford, Alisha R., Dhanji, Salim, Shaabani, Namir, Tran, Charles W., Dissanayake, Dilan, Rahbar, Ramtin, Ghazarian, Magar, Brüstle, Anne, Fine, Jason, Chen, Peter, Weaver, Casey T., Klose, Christoph, Diefenbach, Andreas, Häussinger, Dieter, Carlyle, James R., Kaech, Susan M., Mak, Tak W., Ohashi, Pamela S.·2012·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1118834109
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Abstract

Infections with HIV, hepatitis B virus, and hepatitis C virus can turn into chronic infections, which currently affect more than 500 million patients worldwide. It is generally thought that virus-mediated T-cell exhaustion limits T-cell function, thus promoting chronic disease. Here we demonstrate that natural killer (NK) cells have a negative impact on the development of T-cell immunity by using the murine lymphocytic choriomeningitis virus. NK cell-deficient (Nfil3 −/− , E4BP4 −/− ) mice exhibited a higher virus-specific T-cell response. In addition, NK cell depletion caused enhanced T-cell immunity in WT mice, which led to rapid virus control and prevented chronic infection in lymphocytic choriomeningitis virus clone 13- and reduced viral load in DOCILE-infected animals. Further experiments showed that NKG2D triggered regulatory NK cell functions, which were mediated by perforin, and limited T-cell responses. Therefore, we identified an important role of regulatory NK cells in limiting T-cell immunity during virus infection.

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Metadata

Authors
Lang, P. A., Lang, K. S., Xu, H. C., Grusdat, M., Parish, I. A., Recher, M., Elford, A. R., Dhanji, S., Shaabani, N., Tran, C. W., Dissanayake, D., Rahbar, R., Ghazarian, M., Brüstle, A., Fine, J., Chen, P., Weaver, C. T., Klose, C., Diefenbach, A., Häussinger, D., Carlyle, J. R., Kaech, S. M., Mak, T. W., & Ohashi, P. S.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2011-12-13
Volume
109
Issue
4
Pages
1210-1215
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1118834109
OpenAlex
W2011647218
Cited by
311
References
47
FWCI
11.04
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8 + T-cell immunity. https://app.cochat.ai/papers/10.1073/pnas.1118834109
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Lang, P. A., Lang, K. S., Xu, H. C., Grusdat, M., Parish, I. A., Recher, M., Elford, A. R., Dhanji, S., Shaabani, N., Tran, C. W., Dissanayake, D., Rahbar, R., Ghazarian, M., Brüstle, A., Fine, J., Chen, P., Weaver, C. T., Klose, C., Diefenbach, A., . . . Ohashi, P. S. (2012). Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8 + T-cell immunity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1118834109

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.