The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Evidence for neurogenesis in the adult mammalian substantia nigra
Open accessAbstract
New neurons are generated from stem cells in a few regions of the adult mammalian brain. Here we provide evidence for the generation of dopaminergic projection neurons of the type that are lost in Parkinson's disease from stem cells in the adult rodent brain and show that the rate of neurogenesis is increased after a lesion. The number of new neurons generated under physiological conditions in substantia nigra pars compacta was found to be several orders of magnitude smaller than in the granular cell layer of the dentate gyrus of the hippocampus. However, if the rate of neuronal turnover is constant, the entire population of dopaminergic neurons in substantia nigra could be replaced during the lifespan of a mouse. These data indicate that neurogenesis in the adult brain is more widespread than previously thought and may have implications for our understanding of the pathogenesis and treatment of neurodegenerative disorders such as Parkinson's disease.
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Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Functional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853
Neuronal replacement from endogenous precursors in the adult brain after stroke
Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O. (2002) · Nature Medicine · doi:10.1038/nm747 · Cited by 2,799
The efficiency of systematic sampling in stereology—reconsidered
GUNDERSEN, H. J. G., JENSEN, E. B. V., KIÊU, K., & NIELSEN, J. (1999) · Journal of Microscopy · doi:10.1046/j.1365-2818.1999.00457.x · Cited by 1,317
Cited by
Inflammation is detrimental for neurogenesis in adult brain
Ekdahl, C. T., Claasen, J.-H., Bonde, S., Kokaia, Z., & Lindvall, O. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2234031100 · Cited by 1,559
PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
Rivers, L. E., Young, K. M., Rizzi, M., Jamen, F., Psachoulia, K., Wade, A., Kessaris, N., & Richardson, W. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2220 · Cited by 961
Stem cell therapy for human neurodegenerative disorders–how to make it work
Lindvall, O., Kokaia, Z., & Martinez-Serrano, A. (2004) · Nature Medicine · doi:10.1038/nm1064 · Cited by 915
Taupin, P. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.08.002 · Cited by 645
Whitney, N. P., Eidem, T. M., Peng, H., Huang, Y., & Zheng, J. C. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05886.x · Cited by 373
Metadata
- Authors
- Zhao, M., Momma, S., Delfani, K., Carlén, M., Cassidy, R. M., Johansson, C. B., Brismar, H., Shupliakov, O., Frisén, J., & Janson, A. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-06-05
- Volume
- 100
- Issue
- 13
- Pages
- 7925-7930
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1983488393
- Cited by
- 590
- References
- 5
- FWCI
- 12.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhao, M., Momma, S., Delfani, K., Carlén, M., Cassidy, R. M., Johansson, C. B., Brismar, H., Shupliakov, O., Frisén, J., & Janson, A. M. (2003). Evidence for neurogenesis in the adult mammalian substantia nigra. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1131955100
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
