The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.
A role for ephrin-A5 in axonal sprouting, recovery, and activity-dependent plasticity after stroke
Open accessAbstract
Stroke causes loss of neurological function. Recovery after stroke is facilitated by forced use of the affected limb and is associated with sprouting of new connections, a process that is sharply confined in the adult brain. We show that ephrin-A5 is induced in reactive astrocytes in periinfarct cortex and is an inhibitor of axonal sprouting and motor recovery in stroke. Blockade of ephrin-A5 signaling using a unique tissue delivery system induces the formation of a new pattern of axonal projections in motor, premotor, and prefrontal circuits and mediates recovery after stroke in the mouse through these new projections. Combined blockade of ephrin-A5 and forced use of the affected limb promote new and surprisingly widespread axonal projections within the entire cortical hemisphere ipsilateral to the stroke. These data indicate that stroke activates a newly described membrane-bound astrocyte growth inhibitor to limit neuroplasticity, activity-dependent axonal sprouting, and recovery in the adult.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These new connections are causally associated with functional recovery4.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [4]
In the citing paper
“Stroke induces axonal sprouting and the formation of new connections in peri-infarct cortex that link premotor, motor, somatosensory and association areas1–4.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [4]
In the citing paper
“In rodent and primate models of stroke, axonal sprouting and the formation of new connections occurs in motor, somatosensory and premotor areas1–4.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [4]
In the citing paper
“To test this hypothesis, GDF10 gain and loss of function was produced directly from the stroke through sustained release via biopolymer hydrogel, which produces release over 2–3 weeks from the stroke site3,4,28 without altering local inflammation, gliosis, neuronal or vascular structure4.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [4]
In the citing paper
“As reported previously3,4,28,29, stroke alone modestly but significantly induces axonal sprouting in the motor cortex adjacent to the stroke site compared to normal motor system connections (Supplementary Fig. 6b).”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [4]
In the citing paper
“As previously reported4, stroke alone produced increased levels of GFAP, CD31/PECAM and IBA-1, makers for astrocytes, endothelial cells and microglia/macrophages, respectively (Fig. 5).”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [4]
In the citing paper
“As previously shown in other gene systems3,4, nucleotide-modified siRNA delivered directly into the infarct core produces protein knockdown over at least 2 weeks after stroke with GDF10 (Supplementary Fig. 3a).”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [4]
In the citing paper
“After stroke, axonal sprouting has been demonstrated in mice, rats and non-human primates1–4,10,38.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [4]
In the citing paper
“Stroke normally produces a limited pattern of axonal sprouting from motor or somatosensory cortex posteriorly to areas adjacent to or caudal to the stroke2–4,28,29.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [4]
In the citing paper
“The magnitude of post-stroke axonal sprouting induced by GDF10 exceeds that seen with the blockade of several axonal growth inhibitory systems, such as ephrin-A54 and Nogo/NgR13.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [4]
In the citing paper
“This anterior projection from motor cortex to premotor cortex is causally associated with functional recovery in this model of stroke4.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [4]
In the citing paper
“Animal number in in vivo quantitative cortical mapping studies utilizes spatial correlation statistics, so sample size was estimated from previous publications with similar mechanistic studies3,4,28,29.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [4]
In the citing paper
“This experimental design has been validated by other groups conducting similar behavioral4 or tissue outcomes experiments3,4,28,29.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [4]
In the citing paper
“This biopolymer hydrogel releases both small and large molecules over a 3 week period from the infarct core3,4,29.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [4]
Citations
Cites
Effect of Constraint-Induced Movement Therapy on Upper Extremity Function 3 to 9 Months After Stroke
Wolf, S. L., Winstein, C. J., Miller, J. P., Taub, E., Uswatte, G., Morris, D. M., Giuliani, C., Light, K. E., Nichols‐Larsen, D. S., & for the EXCITE Investigators (2006) · JAMA · doi:10.1001/jama.296.17.2095 · Cited by 1,891
Wong‐Riley, M. T. T. (1979) · Brain Research · doi:10.1016/0006-8993(79)90728-5 · Cited by 1,853
Glial inhibition of CNS axon regeneration
Yiu, G. C., & He, Z. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1956 · Cited by 1,525
Neeper, S. A., Gómez‐Pinilla, F., Choi, J., & Cotman, C. W. (1996) · Brain Research · doi:10.1016/0006-8993(96)00273-9 · Cited by 1,022
Eph receptor signalling casts a wide net on cell behaviour
Pasquale, E. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1662 · Cited by 1,013
A Neurovascular Niche for Neurogenesis after Stroke
Ohab, J. J., Fleming, S., Blesch, A., & Carmichael, S. T. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4323-06.2006 · Cited by 878 · cited 2×
“To measure the function of these somatosensory, motor, and premotor circuits, we used a photothrombotic stroke model because the small barrel field strokes produced by branch vessel MCAo occlusion do not produce a consistent behavioral deficit (22).”
BackgroundMethodSelf-citationReducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke
Clarkson, A. N., Huang, B. S., MacIsaac, S. E., Mody, I., & Carmichael, S. T. (2010) · Nature · doi:10.1038/nature09511 · Cited by 869
Self-citationWang, L., Zhang, Z., Wang, Y., Zhang, R., & Chopp, M. (2004) · Stroke · doi:10.1161/01.str.0000132196.49028.a4 · Cited by 760
Davis, S. H., Gale, N. W., Aldrich, T. H., Maisonpierre, P. C., Lhotak, V., Pawson, T. J., Goldfarb, M. P., & Yancopoulos, G. D. (1994) · Science · doi:10.1126/science.7973638 · Cited by 710
Extensive Cortical Rewiring after Brain Injury
Dancause, N., Barbay, S., Frost, S. B., Plautz, E. J., Chen, D., Zoubina, E. V., Stowe, A. M., & Nudo, R. J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3256-05.2005 · Cited by 704
Research works printed but not linked: 6
- 10.1038/nn.2674 · DOI · Paper page
- 10.1016/j.nbd.2006.03.011 · DOI
- 10.1016/j.expneurol.2005.01.004 · DOI · Paper page
- 10.1038/sj.jcbfm.9600158 · DOI
- 10.1001/jama.296.17.2095 · DOI
- 10.1097/01.WCB.0000084252.20114.BE · DOI · Paper page
Cited by
Sorted by citations
Reactive Gliosis and the Multicellular Response to CNS Damage and Disease
Burda, J. E., & Sofroniew, M. V. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.034 · Cited by 1,500
Neuroinflammation: friend and foe for ischemic stroke
Jayaraj, R. L., Azimullah, S., Beiram, R., Jalal, F. Y., & Rosenberg, G. A. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1516-2 · Cited by 1,479
Astrocyte reactivity and reactive astrogliosis: costs and benefits
Pekny, M., & Pekna, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00041.2013 · Cited by 934
Astrocytes: a central element in neurological diseases
Pekny, M., Pekna, M., Messing, A., Steinhäuser, C., Lee, J., Parpura, V., Hol, E. M., Sofroniew, M. V., & Verkhratsky, A. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1513-1 · Cited by 793
The dual role of astrocyte activation and reactive gliosis
Pekny, M., Wilhelmsson, U., & Pekna, M. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2013.12.071 · Cited by 693
Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke
Liu, Z., & Chopp, M. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.008 · Cited by 610
Maida, C. D., Norrito, R. L., Daidone, M., Tuttolomondo, A., & Pinto, A. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186454 · Cited by 594
Current and Novel Polymeric Biomaterials for Neural Tissue Engineering
Boni, R., Ali, A., Shavandi, A., & Clarkson, A. N. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0491-8 · Cited by 439
Self-citationReactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway
Morizawa, Y. M., Hirayama, Y., Ohno, N., Shibata, S., Shigetomi, E., Sui, Y., Nabekura, J., Sato, K., Okajima, F., Takebayashi, H., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00037-1 · Cited by 424
The interaction between training and plasticity in the poststroke brain
Zeiler, S. R., & Krakauer, J. W. (2013) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000025 · Cited by 436
CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury
Joy, M. T., Ben Assayag, E., Shabashov-Stone, D., Liraz-Zaltsman, S., Mazzitelli, J., Arenas, M., Abduljawad, N., Kliper, E., Korczyn, A. D., Thareja, N. S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.044 · Cited by 389
Self-citationMotor compensation and its effects on neural reorganization after stroke
Jones, T. A. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.26 · Cited by 388
Central nervous system regeneration
Varadarajan, S. G., Hunyara, J. L., Hamilton, N. R., Kolodkin, A. L., & Huberman, A. D. (2022) · Cell · doi:10.1016/j.cell.2021.10.029 · Cited by 323
Eph Receptors and Ephrins: Therapeutic Opportunities
Barquilla, A., & Pasquale, E. B. (2014) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140226 · Cited by 295
Encouraging an excitable brain state: mechanisms of brain repair in stroke
Joy, M. T., & Carmichael, S. T. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-00396-7 · Cited by 300
Self-citationReactive gliosis in the pathogenesis of CNS diseases
Pekny, M., & Pekna, M. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.11.014 · Cited by 289
Human astrocytes in the diseased brain
Dossi, E., Vasile, F., & Rouach, N. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.02.001 · Cited by 250
Restoring brain function after stroke — bridging the gap between animals and humans
Ward, N. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.34 · Cited by 247
Astrocyte activation and reactive gliosis—A new target in stroke?
Pekny, M., Wilhelmsson, U., Tatlisumak, T., & Pekna, M. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.07.021 · Cited by 240
Understanding upper limb recovery after stroke
Buma, F. E., Kwakkel, G., & Ramsey, N. F. (2013) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-130332 · Cited by 230
Astrocytes: Integrative Regulators of Neuroinflammation in Stroke and Other Neurological Diseases
Cekanaviciute, E., & Buckwalter, M. S. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0477-8 · Cited by 229
Stroke and the Connectome: How Connectivity Guides Therapeutic Intervention
Silasi, G., & Murphy, T. H. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.052 · Cited by 223
Recent progress of drug nanoformulations targeting to brain
Khan, A. R., Yang, X., Fu, M., & Zhai, G. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.10.004 · Cited by 216
Activity-dependent neural plasticity from bench to bedside
Ganguly, K., & Poo, M.-M. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.028 · Cited by 202
Cook, D. J., Nguyen, C., Chun, H. N., Llorente, I. L., Chiu, A. S., Machnicki, M., Zarembinski, T. I., & Carmichael, S. T. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16649964 · Cited by 204
Self-citationMolecular, cellular and functional events in axonal sprouting after stroke
Carmichael, S. T., Kathirvelu, B., Schweppe, C. A., & Nie, E. H. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.02.007 · Cited by 206
Self-citationJin, D., Liu, Y., Sun, F., Wang, X., Liu, X., & He, Z. (2015) · Nature Communications · doi:10.1038/ncomms9074 · Cited by 182
GDF10 is a signal for axonal sprouting and functional recovery after stroke
Li, S., Nie, E. H., Yin, Y., Benowitz, L. I., Tung, S., Vinters, H. V., Bahjat, F. R., Stenzel-Poore, M. P., Kawaguchi, R., Coppola, G., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4146 · Cited by 181
Self-citationLam, J. G. T., Lowry, W. E., Carmichael, S. T., & Segura, T. (2014) · Advanced Functional Materials · doi:10.1002/adfm.201401483 · Cited by 176
Self-citationAdvances in stroke pharmacology
Zhou, Z., Lu, J., Liu, W.-W., Manaenko, A., Hou, X., Mei, Q., Huang, J., Tang, J., Zhang, J. H., Yao, H., et al. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.05.012 · Cited by 164
CREB controls cortical circuit plasticity and functional recovery after stroke
Caracciolo, L., Marosi, M., Mazzitelli, J. A., Latifi, S., Sano, Y., Galvan, L., Kawaguchi, R., Holley, S. M., Levine, M. S., Coppola, G., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04445-9 · Cited by 159
Self-citationStem Cells as an Emerging Paradigm in Stroke 3
Savitz, S. I., Cramer, S. C., Wechsler, L. R., Aronowski, J. A., Boltze, J., Borlongan, C. V., Case, C., Chase, T. N., Chopp, M., Carmichael, S. T., et al. (2013) · Stroke · doi:10.1161/strokeaha.113.003379 · Cited by 157
Self-citationChristie, K. J., & Turnley, A. M. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2012.00070 · Cited by 152
Emergent properties of neural repair: elemental biology to therapeutic concepts
Carmichael, S. T. (2016) · Annals of Neurology · doi:10.1002/ana.24653 · Cited by 147
Self-citationReactive astrogliosis in stroke: Contributions of astrocytes to recovery of neurological function
Sims, N. R., & Yew, W. P. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2016.12.016 · Cited by 149
Houlton, J., Abumaria, N., Hinkley, S. F. R., & Clarkson, A. N. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00790 · Cited by 138
Self-citationInflammation in Neurological Disorders: The Thin Boundary Between Brain and Periphery
Cervellati, C., Trentini, A., Pecorelli, A., & Valacchi, G. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8076 · Cited by 140
Motor System Reorganization After Stroke: Stimulating and Training Toward Perfection
Jones, T. A., & Adkins, D. L. (2015) · Physiology · doi:10.1152/physiol.00014.2015 · Cited by 142
Hydrogels for brain repair after stroke: an emerging treatment option
Nih, L. R., Carmichael, S. T., & Segura, T. (2016) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2016.04.021 · Cited by 123
Self-citationNeuroinflammation in Post-Ischemic Neurodegeneration of the Brain: Friend, Foe, or Both?
Pluta, R. M., Januszewski, S., & Czuczwar, S. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094405 · Cited by 122
Stroke target identification guided by astrocyte transcriptome analysis
Rakers, C., Schleif, M., Blank-Stein, N., Matušková, H., Ulas, T., Händler, K., Torres, S. V., Schumacher, T., Taï, K., Schultze, J. L., et al. (2018) · Glia · doi:10.1002/glia.23544 · Cited by 116
The Specific Requirements of Neural Repair Trials for Stroke
Dobkin, B. H., & Carmichael, S. T. (2015) · Neurorehabilitation and neural repair · doi:10.1177/1545968315604400 · Cited by 127
Self-citationSözmen, E. G., Rosenzweig, S., Llorente, I. L., DiTullio, D. J., Machnicki, M., Vinters, H. V., Havton, L. A., Giger, R. J., Hinman, J. D., & Carmichael, S. T. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615322113 · Cited by 114
Self-citationRobust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS
Omura, T., Omura, K., Tedeschi, A., Riva, P., Painter, M. W., Rojas, L., Martin, J., Lisi, V., Huebner, E. A., Latrémolière, A., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.005 · Cited by 108
Self-citationRemodeling of the Axon Initial Segment After Focal Cortical and White Matter Stroke
Hinman, J. D., Rasband, M. N., & Carmichael, S. T. (2012) · Stroke · doi:10.1161/strokeaha.112.668749 · Cited by 110
Self-citationLim, D. H., LeDue, J. M., Mohajerani, M. H., & Murphy, T. H. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3384-14.2014 · Cited by 105
Corbett, D., Carmichael, S. T., Murphy, T. H., Jones, T. A., Schwab, M. E., Jolkkonen, J., Clarkson, A. N., Dancause, N., Weiloch, T., Johansen‐Berg, H., et al. (2017) · International Journal of Stroke · doi:10.1177/1747493017711814 · Cited by 110
Self-citationPlasticity in the Injured Brain
Overman, J. J., & Carmichael, S. T. (2013) · The Neuroscientist · doi:10.1177/1073858413491146 · Cited by 113
Self-citationGlial Cells as Therapeutic Approaches in Brain Ischemia-Reperfusion Injury
Hernández, I. H., Villa-González, M., Martín-López, G., Soto, M. S., & Pérez-Álvarez, M. J. (2021) · Cells · doi:10.3390/cells10071639 · Cited by 98
Clarkson, A. N., López-Valdés, H. E., Overman, J. J., Charles, A. C., Brennan, K., & Carmichael, S. T. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.7 · Cited by 103
Self-citationAge-Dependent Exacerbation of White Matter Stroke Outcomes
Rosenzweig, S., & Carmichael, S. T. (2013) · Stroke · doi:10.1161/strokeaha.113.001796 · Cited by 98
Self-citationRehabilitation and plasticity following stroke: Insights from rodent models
Caleo, M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.10.029 · Cited by 101
Molecular Pathogenesis of Ischemic and Hemorrhagic Strokes: Background and Therapeutic Approaches
Maida, C. D., Norrito, R. L., Rizzica, S., Mazzola, M., Scarantino, E. R., & Tuttolomondo, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126297 · Cited by 114
The 3 Rs of Stroke Biology: Radial, Relayed, and Regenerative
Carmichael, S. T. (2015) · Neurotherapeutics · doi:10.1007/s13311-015-0408-0 · Cited by 99
Self-citationRegion-specific and activity-dependent regulation of SVZ neurogenesis and recovery after stroke
Liang, H., Zhao, H., Gleichman, A. J., Machnicki, M., Telang, S. S., Tang, S., Rshtouni, M., Ruddell, J., & Carmichael, S. T. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811825116 · Cited by 89
Self-citationCorbett, D., Carmichael, S. T., Murphy, T. H., Jones, T. A., Schwab, M. E., Jolkkonen, J., Clarkson, A. N., Dancause, N., Weiloch, T., Johansen‐Berg, H., et al. (2017) · Neurorehabilitation and neural repair · doi:10.1177/1545968317724285 · Cited by 86
Self-citationNoninvasive Strategies to Promote Functional Recovery after Stroke
Faralli, A., Bigoni, M., Mauro, A., Rossi, F., & Carulli, D. (2013) · Neural Plasticity · doi:10.1155/2013/854597 · Cited by 91
Astrocytic therapies for neuronal repair in stroke
Gleichman, A. J., & Carmichael, S. T. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.10.055 · Cited by 84
Self-citationClinical Pathways in Stroke Rehabilitation
Platz, T. (2021) · Springer eBooks · doi:10.1007/978-3-030-58505-1 · Cited by 80
Translating concepts of neural repair after stroke: Structural and functional targets for recovery
Regenhardt, R. W., Takase, H., Lo, E. H., & Lin, D. J. (2020) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-190978 · Cited by 75
Bhuiyan, M. H., Clarkson, A. N., & Ali, M. A. (2023) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2023.113193 · Cited by 75
Self-citationGlial function (and dysfunction) in the normal & ischemic brain
Magaki, S., Williams, C. K., & Vinters, H. V. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.009 · Cited by 78
Clarkson, A. N., Parker, K., Nilsson, M., Walker, F. R., & Gowing, E. K. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.33 · Cited by 72
Self-citationXuan, W., Huang, L., & Hamblin, M. R. (2016) · Journal of Biophotonics · doi:10.1002/jbio.201500336 · Cited by 72
Inflammation Mediated Epileptogenesis as Possible Mechanism Underlying Ischemic Post-stroke Epilepsy
Tröscher, A. R., Gruber, J., Wagner, J. N., Böhm, V., Wahl, A.-S., & von Oertzen, T. J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.781174 · Cited by 66
The Specific Role of Reactive Astrocytes in Stroke
Li, L., Zhou, J., Han, L., Wu, X., Shi, Y., Cui, W., Zhang, S., Hu, Q., Wang, J., Bai, H., et al. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.850866 · Cited by 71
Astrocytic Ephrin-B1 Regulates Synapse Remodeling Following Traumatic Brain Injury
Nikolakopoulou, A. M., Koeppen, J., Garcia, M. L., Leish, J., Obenaus, A., & Ethell, I. M. (2016) · ASN NEURO · doi:10.1177/1759091416630220 · Cited by 72
Alamri, F. F., Shoyaib, A. A., Biggers, A., Jayaraman, S., Guindon, J., & Karamyan, V. T. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.09.008 · Cited by 68
Inflammation and neural repair after ischemic brain injury
Sakai, S., & Shichita, T. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.10.013 · Cited by 67
Stokowska, A., Aswendt, M., Žucha, D., Lohmann, S., Wieters, F., Suarez, J. M., Atkins, A. L., Li, Y., Miteva, M., Lewin, J., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci162253 · Cited by 68
Zarembinski, T. I., Doty, N. J., Erickson, I. E., Srinivas, R., Wirostko, B. M., & Tew, W. P. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.09.029 · Cited by 66
Astrocytes in functional recovery following central nervous system injuries
Alhadidi, Q., Bahader, G. A., Arvola, O., Kitchen, P., Shah, Z. A., & Salman, M. M. (2023) · The Journal of Physiology · doi:10.1113/jp284197 · Cited by 67
Crosstalk of Astrocytes and Other Cells during Ischemic Stroke
He, T., Yang, G., & Zhang, Z. (2022) · Life · doi:10.3390/life12060910 · Cited by 63
The neurorehabilitation of post‐stroke dysphagia: Physiology and pathophysiology
Sasegbon, A., Cheng, I., & Hamdy, S. (2024) · The Journal of Physiology · doi:10.1113/jp285564 · Cited by 69
Saxena, S., & Hillis, A. E. (2017) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1373020 · Cited by 60
Neuroimmune and Inflammatory Signals in Complex Disorders of the Central Nervous System
Liberman, A. C., Trías, E., Chagas, L. D. S., Trindade, P., Pereira, M. D. S., Refojo, D., Hedin‐Pereira, C., & Serfaty, C. A. (2018) · NeuroImmunoModulation · doi:10.1159/000494761 · Cited by 62
Shu, Y., Xiao, B., Wu, Q., Liu, T., Du, Y., Tang, H., Chen, S., Feng, L., Long, L., & Li, Y. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-9020-2 · Cited by 57
Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease
Wang, L., Xia, J., Li, J., Hagemann, T. L., Jones, J. R., Fraenkel, E., Weitz, D. A., Zhang, S., Messing, A., & Feany, M. Β. (2018) · Nature Communications · doi:10.1038/s41467-018-04269-7 · Cited by 62
Use it and/or lose it—experience effects on brain remodeling across time after stroke
Allred, R. P., Kim, S. Y., & Jones, T. A. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00379 · Cited by 55
Okoreeh, A. K., Bake, S., & Sohrabji, F. (2017) · Glia · doi:10.1002/glia.23142 · Cited by 56
Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) Disorders
Liddelow, S. A., Olsen, M. L., & Sofroniew, M. V. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041356 · Cited by 55
Biomaterials to Neuroprotect the Stroke Brain: A Large Opportunity for Narrow Time Windows
González‐Nieto, D., Fernández-Serra, R., Pérez‐Rigueiro, J., Panetsos, F., Martínez‐Murillo, R., & Guinea, G. V. (2020) · Cells · doi:10.3390/cells9051074 · Cited by 54
Brunkhorst, R., Kanaan, N., Koch, A. H., Ferreirós, N., Mirceska, A., Zeiner, P. S., Mittelbronn, M. G. A., Derouiche, A., Steinmetz, H., Foerch, C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070124 · Cited by 53
Fernández-García, L., Pérez‐Rigueiro, J., Martínez‐Murillo, R., Panetsos, F., Ramos, M., Guinea, G. V., & González‐Nieto, D. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00296 · Cited by 54
Martínez‐Coria, H., Arrieta-Cruz, I., Arrieta‐Cruz, I., & López-Valdés, H. E. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.293129 · Cited by 55
The Implications of Microglial Regulation in Neuroplasticity-Dependent Stroke Recovery
Qiao, C., Liu, Z., & Qie, S. (2023) · Biomolecules · doi:10.3390/biom13030571 · Cited by 55
Xerri, C., Zennou‐Azogui, Y., Sadlaoud, K., & Sauvajon, D. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.06.066 · Cited by 58
Reactive astrocytes prevent maladaptive plasticity after ischemic stroke
Aswendt, M., Wilhelmsson, U., Wieters, F., Stokowska, A., Schmitt, F. J., Pallast, N., de Pablo, Y., Mohammed, L., Hoehn, M., Pekna, M., et al. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102199 · Cited by 50
Barratt, H. E., Lanman, T. A., & Carmichael, S. T. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.107 · Cited by 49
Self-citationm6A methylation: Critical roles in aging and neurological diseases
Fan, Y., Lv, X., Chen, Z., Peng, Y., & Zhang, M. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1102147 · Cited by 50
Modifying expression of EphA4 and its downstream targets improves functional recovery after stroke
Lemmens, R., Jaspers, T., Robberecht, W., & Thijs, V. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt073 · Cited by 48
Neuronal Restoration Following Ischemic Stroke
Kahle, M., & Bix, G. J. (2013) · Neurorehabilitation and neural repair · doi:10.1177/1545968312474119 · Cited by 47
Kim, S. Y., Hsu, J. E., Husbands, L. C., Kleim, J. A., & Jones, T. A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1295-17.2017 · Cited by 48
Cerebral ischemia in the developing brain
Dietz, R. M., Dingman, A., & Herson, P. S. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221111600 · Cited by 45
Ghori, A., Freimann, F. B., Nieminen-Kelhä, M., Kremenetskaia, I., Gertz, K. R., Endres, M., & Vajkoczy, P. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308620 · Cited by 47
Aswendt, M., Pallast, N., Wieters, F., Baues, M., Hoehn, M., & Fink, G. R. (2020) · Translational Stroke Research · doi:10.1007/s12975-020-00802-3 · Cited by 44
Phosphorylation and Assembly of Glutamate Receptors After Brain Ischemia
Zhang, F., Guo, A., Liu, C., Comb, M., & Hu, B. (2012) · Stroke · doi:10.1161/strokeaha.112.667253 · Cited by 44
Optogenetic Approaches to Target Specific Neural Circuits in Post-stroke Recovery
Cheng, M., Aswendt, M., & Steinberg, G. K. (2015) · Neurotherapeutics · doi:10.1007/s13311-015-0411-5 · Cited by 43
White Matter Stroke Induces a Unique Oligo-Astrocyte Niche That Inhibits Recovery
Sözmen, E. G., DiTullio, D. J., Rosenzweig, S., Hinman, J. D., Bridges, S. P., Marin, M. A., Kawaguchi, R., Coppola, G., & Carmichael, S. T. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0103-19.2019 · Cited by 45
Self-citationHydrogels for neuroprotection and functional rewiring: a new era for brain engineering
González‐Nieto, D., Fernández-Serra, R., Gallego-Ruiz, R., & Lozano-Picazo, P. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.268891 · Cited by 46
Metadata
- Authors
- Overman, J. J., Clarkson, A. N., Wanner, I. B., Overman, W. T., Eckstein, I., Maguire, J. L., Dinov, I. D., Toga, A. W., & Carmichael, S. T.
- Affiliations
- Department of Neurology, David Geffen School of Medicine, and
- University of Otago (NZ)
- University of California, Los Angeles (US)
- Tufts University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2012-07-25
- Volume
- 109
- Issue
- 33
- Pages
- E2230-9
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3421211
- OpenAlex
- W2134115573
- Cited by
- 245
- References
- 51
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 11 · 2023: 24 · 2022: 17 · 2021: 22 · 2020: 23 · 2019: 23 · 2018: 17 · 2017: 19 · 2016: 17 · 2015: 19 · 2014: 17 · 2013: 18 · 2012: 3
- FWCI
- 7.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1f31ns061530-01)
- National Institute of Nursing Research (K99NR010797)
- National Institute of Neurological Disorders and Stroke (NS049041, R01NS045729, NS045729, NS061530-02, R01NS049041)
- National Center for Research Resources (RR021813, U54RR021813)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- ephrin-A5, axonal sprouting, stroke recovery, motor recovery, reactive astrocytes, activity-dependent plasticity, neuroplasticity, prefrontal cortex, premotor cortex
- MeSH terms
- Animals, Astrocytes, Axons, Behavior, Animal, Cerebral Cortex, Mice, Inbred C57BL, Motor Activity, Nerve Net, Neuronal Plasticity, Phosphorylation, Staining and Labeling, Signal Transduction, Recovery of Function, Stroke, Ephrin-A5, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
