Cited by 236Hearing, Cochlea, Tinnitus, GeneticsBarrier Structure and Function StudiesVestibular and auditory disorders

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Perivascular-resident macrophage-like melanocytes in the inner ear are essential for the integrity of the intrastrial fluid–blood barrier

Open access

Zhang, Wenjing, Dai, Min, Fridberger, Anders, Hassan, Ahmed, DeGagne, Jacqueline, Neng, Lingling, Zhang, Fei, He, Wenxuan, Ren, Tianying, Trune, Dennis, Auer, Manfred, Shi, Xiaorui·2012·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1205210109PMC PMC3387119

Open this paper in CoChat — free account Open PDF

Abstract

The microenvironment of the cochlea is maintained by the barrier between the systemic circulation and the fluids inside the stria vascularis. However, the mechanisms that control the permeability of the intrastrial fluid–blood barrier remain largely unknown. The barrier comprises endothelial cells connected to each other by tight junctions and an underlying basement membrane. In a recent study, we found that the intrastrial fluid–blood barrier also includes a large number of perivascular cells with both macrophage and melanocyte characteristics. The perivascular-resident macrophage-like melanocytes (PVM/Ms) are in close contact with vessels through cytoplasmic processes. Here we demonstrate that PVM/Ms have an important role in maintaining the integrity of the intrastrial fluid–blood barrier and hearing function. Using a cell culture-based in vitro model and a genetically induced PVM/M-depleted animal model, we show that absence of PVM/Ms increases the permeability of the intrastrial fluid–blood barrier to both low- and high-molecular-weight tracers. The increased permeability is caused by decreased expression of pigment epithelial-derived factor, which regulates expression of several tight junction-associated proteins instrumental to barrier integrity. When tested for endocochlear potential and auditory brainstem response, PVM/M-depleted animals show substantial drop in endocochlear potential with accompanying hearing loss. Our results demonstrate a critical role for PVM/Ms in regulating the permeability of the intrastrial fluid–blood barrier for establishing a normal endocochlear potential hearing threshold.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.1205210109

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Astrocyte-endothelial interactions at the blood-brain barrier
Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
Duffield, J. S., Forbes, S. J., Constandinou, C. M., Clay, S., Partolina, M., Vuthoori, S., Wu, S., Lang, R., & Iredale, J. P. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200522675 · Cited by 1,649
Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences
Redzic, Z. B. (2011) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-8-3 · Cited by 455
Another role for melanocytes: their importance for normal stria vascularis development in the mammalian inner ear
Steel, K. P., & Barkway, C. (1989) · Development · doi:10.1242/dev.107.3.453 · Cited by 419
Glial cell influence on the human blood‐brain barrier
Prat, A., Biernacki, K., Wosik, K., & Antel, J. P. (2001) · Glia · doi:10.1002/glia.1104 · Cited by 334
Mechanisms of endocochlear potential generation by stria vascularis
Salt, A. N., Mleichar, I., & Thalmann, R. (1987) · The Laryngoscope · doi:10.1288/00005537-198708000-00020 · Cited by 301
A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells
Hochweller, K., Striegler, J., Hämmerling, G. J., & Garbi, N. (2008) · European Journal of Immunology · doi:10.1002/eji.200838659 · Cited by 179
Expression patterns of claudins, tight junction adhesion molecules, in the inner ear
Kitajiri, S.-I., Furuse, M., Morita, K., Saishin-Kiuchi, Y., Kido, H., Ito, J., & Tsukita, S. (2003) · Hearing Research · doi:10.1016/s0378-5955(03)00338-1 · Cited by 167
Connexin30 deficiency causes instrastrial fluid–blood barrier disruption within the cochlear stria vascularis
Cohen‐Salmon, M., Regnault, B., Cayet, N., Caille, D., Demuth, K., Hardelin, J., Janel, N., Meda, P., & Petit, C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605108104 · Cited by 163
An ATP-Dependent Inwardly Rectifying Potassium Channel, KAB-2 (Kir4.1), in Cochlear Stria Vascularis of Inner Ear: Its Specific Subcellular Localization and Correlation with the Formation of Endocochlear Potential
Hibino, H., Horio, Y., Inanobe, A., Doi, K., Ito, M., Yamada, M., Gotow, T., Uchiyama, Y., Kawamura, M., Kubo, T., et al. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04711.1997 · Cited by 162

Show all 35 references

Sorted by citations

Macrophages in health and disease
Park, M. D., Silvin, A., Ginhoux, F., & Merad, M. (2022) · Cell · doi:10.1016/j.cell.2022.10.007 · Cited by 644
The melanocyte lineage in development and disease
Mort, R. L., Jackson, I. J., & Patton, E. E. (2015) · Development · doi:10.1242/dev.106567 · Cited by 416
Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier
Nyberg, S., Abbott, N. J., Shi, X., Steyger, P. S., & Dabdoub, A. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aao0935 · Cited by 352
Self-citation
Aminoglycoside-Induced Cochleotoxicity: A Review
Jiang, M., Karasawa, T., & Steyger, P. S. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00308 · Cited by 264
Perivascular macrophages in health and disease
Lapenna, A., Palma, M. D., & Lewis, C. E. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0056-9 · Cited by 268
Pathophysiology of the cochlear intrastrial fluid-blood barrier (review)
Shi, X. (2016) · Hearing Research · doi:10.1016/j.heares.2016.01.010 · Cited by 254
Self-citation
Chronic inflammation – inflammaging – in the ageing cochlea: A novel target for future presbycusis therapy
Watson, N. W., Ding, B., Zhu, X., & Frisina, R. D. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.10.002 · Cited by 215
NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy
Nakanishi, H., Kawashima, Y., Kurima, K., Chae, J. J., Ross, A. M., Pinto-Patarroyo, G. P., Patel, S. K., Muskett, J. A., Ratay, J. S., Chattaraj, P., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1702946114 · Cited by 153
Inflammatory and immune responses in the cochlea: potential therapeutic targets for sensorineural hearing loss
Fujioka, M., Okano, H., & Ogawa, K. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00287 · Cited by 134
Inflammation associated with noise-induced hearing loss
Frye, M. D., Ryan, A. F., & Kurabi, A. (2019) · The Journal of the Acoustical Society of America · doi:10.1121/1.5132545 · Cited by 138
DNA Variations in Oculocutaneous Albinism: An Updated Mutation List and Current Outstanding Issues in Molecular Diagnostics
Simeonov, D. R., Wang, X., Wang, C., Sergeev, Y. V., Dolinska, M. B., Bower, M., Fischer, R. E., Winer, D., Dubrovsky, G., Balog, J. Z., et al. (2013) · Human Mutation · doi:10.1002/humu.22315 · Cited by 133
Molecular Characteristics of Cisplatin-Induced Ototoxicity and Therapeutic Interventions
Tan, W. J. T., & Vlajkovic, S. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216545 · Cited by 134
Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss
Kalinec, G. M., Lomberk, G. A., Urrutia, R. A., & Kalinec, F. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00192 · Cited by 117
The melanocyte lineage in development and disease
Mort, R. L., Jackson, I. J., & Patton, E. E. (2015) · Development · doi:10.1242/dev.123729 · Cited by 132
Endothelial Cell, Pericyte, and Perivascular Resident Macrophage-Type Melanocyte Interactions Regulate Cochlear Intrastrial Fluid–Blood Barrier Permeability
Neng, L., Zhang, F., Kachelmeier, A., & Shi, X. (2012) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-012-0365-9 · Cited by 112
Self-citation
Anti CD163+, Iba1+, and CD68+ Cells in the Adult Human Inner Ear
O’Malley, J. T., Nadol, J. B., & McKenna, M. J. (2015) · Otology & Neurotology · doi:10.1097/mao.0000000000000879 · Cited by 109
Immune cells and non-immune cells with immune function in mammalian cochleae
Hu, B., Zhang, C., & Frye, M. D. (2017) · Hearing Research · doi:10.1016/j.heares.2017.12.009 · Cited by 104
Exosomes mediate sensory hair cell protection in the inner ear
Breglio, A. M., May, L. A., Barzik, M., Welsh, N. C., Francis, S. P., Costain, T., Wang, L., Anderson, D. E., Petralia, R. S., Wang, Y., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci128867 · Cited by 104
Macrophages in the Human Cochlea: Saviors or Predators—A Study Using Super-Resolution Immunohistochemistry
Liu, W., Molnár, M., Garnham, C., Benav, H., & Rask‐Andersen, H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00223 · Cited by 103
Brain perivascular macrophages: current understanding and future prospects
Wen, W., Cheng, J., & Tang, Y. (2023) · Brain · doi:10.1093/brain/awad304 · Cited by 107
Brain perivascular macrophages: Recent advances and implications in health and diseases
Yang, T., Guo, R., & Zhang, F. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13263 · Cited by 97
Self-citation
Systemic Lipopolysaccharide Compromises the Blood-Labyrinth Barrier and Increases Entry of Serum Fluorescein into the Perilymph
Hirose, K., Hartsock, J. J., Johnson, S. B., Santi, P. A., & Salt, A. N. (2014) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-014-0476-6 · Cited by 92
The blood labyrinthine barrier in the human normal and Meniere’s disease macula utricle
Ishiyama, G. P., López, I. A., Ishiyama, P., Vinters, H. V., & Ishiyama, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-00330-5 · Cited by 91
Biology and therapeutic targeting of tumour‐associated macrophages
Beltraminelli, T., & Palma, M. D. (2020) · The Journal of Pathology · doi:10.1002/path.5403 · Cited by 87
Tissue-Resident Macrophages in the Control of Infection and Resolution of Inflammation
Mu, X., Li, Y., & Fan, G. (2020) · Shock · doi:10.1097/shk.0000000000001601 · Cited by 93
Two cell populations participate in clearance of damaged hair cells from the sensory epithelia of the inner ear
Hirose, K., Rutherford, M. A., & Warchol, M. E. (2017) · Hearing Research · doi:10.1016/j.heares.2017.04.006 · Cited by 85
Anatomical basis of drug delivery to the inner ear
Glueckert, R., Chacko, L. J., Rask‐Andersen, H., Liu, W., Handschuh, S., & Schrott‐Fischer, A. (2018) · Hearing Research · doi:10.1016/j.heares.2018.06.017 · Cited by 83
Macrophages in the cochlea; an immunological link between risk factors and progressive hearing loss
Hough, K., Verschuur, C. A., Cunningham, C. M., & Newman, T. A. (2021) · Glia · doi:10.1002/glia.24095 · Cited by 76
Macrophage depletion protects against cisplatin-induced ototoxicity and nephrotoxicity
Sung, C. Y. W., Hayase, N., Yuen, P. S. T., Lee, J., Fernandez, K. A., Hu, X., Cheng, H., Star, R. A., Warchol, M. E., & Cunningham, L. L. (2024) · Science Advances · doi:10.1126/sciadv.adk9878 · Cited by 79
Lipopolysaccharide-Induced Middle Ear Inflammation Disrupts the cochlear Intra-Strial Fluid–Blood Barrier through Down-Regulation of Tight Junction Proteins
Zhang, J., Chen, S., Hou, Z., Cai, J., Mingmin, D., & Shi, X. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122572 · Cited by 73
Self-citation
The complex TIE between macrophages and angiogenesis
Cheyne, C. D., Tay, H., & Spiegelaere, W. D. (2019) · Anatomia, Histologia, Embryologia. Journal of Veterinary Medicine Series C · doi:10.1111/ahe.12518 · Cited by 63
Structural changes in thestrial blood–labyrinth barrier of aged C57BL/6 mice
Neng, L., Zhang, J., Yang, J., Zhang, F., López, I. A., Mingmin, D., & Shi, X. (2015) · Cell and Tissue Research · doi:10.1007/s00441-015-2147-2 · Cited by 71
Self-citation
Immune system of the inner ear as a novel therapeutic target for sensorineural hearing loss
Okano, T. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00205 · Cited by 69
Spinster Homolog 2 (Spns2) Deficiency Causes Early Onset Progressive Hearing Loss
Chen, J., Ingham, N. J., Kelly, J. J., Jadeja, S., Goulding, D., Pass, J. C., Mahajan, V. B., Tsang, S. H., Nijnik, A., Jackson, I. J., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004688 · Cited by 71
Isolation and culture of endothelial cells, pericytes and perivascular resident macrophage-like melanocytes from the young mouse ear
Neng, L., Zhang, W., Hassan, A. M., Zemla, M., Kachelmeier, A., Fridberger, A., Auer, M., & Shi, X. (2013) · Nature Protocols · doi:10.1038/nprot.2013.033 · Cited by 69
Self-citation
Perivascular macrophage‐like melanocyte responsiveness to acoustic trauma—a salient feature of strial barrier associated hearing loss
Zhang, F., Dai, M., Neng, L., Zhang, J. H., Zhi, Z., Fridberger, A., & Shi, X. (2013) · The FASEB Journal · doi:10.1096/fj.13-232892 · Cited by 64
Self-citation
Update on Findings about Sudden Sensorineural Hearing Loss and Insight into Its Pathogenesis
Yamada, S., Kita, J., Shinmura, D., Nakamura, Y., Sahara, S., Misawa, K., & Nakanishi, H. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11216387 · Cited by 72
Gene therapy for the inner ear
Fukui, H., & Raphael, Y. (2012) · Hearing Research · doi:10.1016/j.heares.2012.11.017 · Cited by 68
ROS-Responsive Nanoparticle as a Berberine Carrier for OHC-Targeted Therapy of Noise-Induced Hearing Loss
Zhao, Z., Han, Z., Konduru, N., Lei, G., Qiu, S., Li, X., Li, T., Shi, X., Zhuang, W., Li, Y., et al. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c21151 · Cited by 67
Self-citation
Age-Related Changes in Immune Cells of the Human Cochlea
Noble, K. V., Liu, T., Matthews, L. J., Schulte, B. A., & Lang, H. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00895 · Cited by 64
Intrinsic mechanism and pharmacologic treatments of noise-induced hearing loss
Xu, K., Xu, B., Gu, J., Wang, X., Chen, Y., & Chen, Y. (2023) · Theranostics · doi:10.7150/thno.83383 · Cited by 64
Gfi1Cre mice have early onset progressive hearing loss and induce recombination in numerous inner ear non-hair cells
Matern, M. S., Vijayakumar, S., Margulies, Z., Milon, B. C., Song, Y., Elkon, R., Zhang, X., Jones, S. M., & Hertzano, R. P. (2017) · Scientific Reports · doi:10.1038/srep42079 · Cited by 64
Hearing Function, Degeneration, and Disease: Spotlight on the Stria Vascularis
Thulasiram, M. R., Ogier, J. M., & Dabdoub, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.841708 · Cited by 63
Macrophages in Noise-Exposed Cochlea: Changes, Regulation and the Potential Role
Weiwei, H., Jintao, Y., Sun, Y., & Weijia, K. (2020) · Aging and Disease · doi:10.14336/ad.2019.0723 · Cited by 62
Deletion of Tricellulin Causes Progressive Hearing Loss Associated with Degeneration of Cochlear Hair Cells
Kamitani, T., Sakaguchi, H., Tamura, A., Miyashita, T., Yamazaki, Y., Tokumasu, R., Inamoto, R., Matsubara, A., Mori, N., Hisa, Y., et al. (2015) · Scientific Reports · doi:10.1038/srep18402 · Cited by 60
An atypical role for the myeloid receptor Mincle in central nervous system injury
Arumugam, T. V., Manzanero, S., Furtado, M. B., Biggins, P. J., Hsieh, Y.-H., Gelderblom, M., MacDonald, K. P. A., Salimova, E., Li, Y., Korn, O., et al. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16661201 · Cited by 56
CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier
Lund, H., Hunt, M. A., Kurtović, Z., Sándor, K., Kägy, P. B., Fereydouni, N., Julien, A., Göritz, C., Vázquez-Liébanas, E., Mäe, M. A., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20230675 · Cited by 62
Losartan prevents tumor-induced hearing loss and augments radiation efficacy in NF2 schwannoma rodent models
Wu, L., Vasilijić, S., Sun, Y., Chen, J., Landegger, L. D., Zhang, Y., Zhou, W., Ren, J. P., Early, S., Yin, Z., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abd4816 · Cited by 53
Characterization and Inflammatory Response of Perivascular-Resident Macrophage-Like Melanocytes in the Vestibular System
Zhang, F., Zhang, J., Neng, L., & Shi, X. (2013) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-013-0403-2 · Cited by 52
Self-citation
Slc26a4-insufficiency causes fluctuating hearing loss and stria vascularis dysfunction
Ito, T., Li, X., Kurima, K., Choi, B. Y., Wangemann, P., & Griffith, A. J. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.02.002 · Cited by 51
Inner ear immunity
Keithley, E. M. (2022) · Hearing Research · doi:10.1016/j.heares.2022.108518 · Cited by 50
The role of monocytes and macrophages in the dynamic permeability of the blood-perilymph barrier
Hirose, K., & Li, S.-Z. (2019) · Hearing Research · doi:10.1016/j.heares.2019.01.006 · Cited by 50
Cisplatin-Induced Stria Vascularis Damage Is Associated with Inflammation and Fibrosis
Zhang, N., Cai, J., Xu, L., Wang, H., & Liu, W. (2020) · Neural Plasticity · doi:10.1155/2020/8851525 · Cited by 50
VEGFA165 gene therapy ameliorates blood-labyrinth barrier breakdown and hearing loss
Zhang, J., Hou, Z., Wang, X., Jiang, H., Neng, L., Zhang, Y., Yu, Q. T., Burwood, G., Song, J., Auer, M., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.143285 · Cited by 53
Self-citation
Genetic Hearing Loss Associated With Autoinflammation
Nakanishi, H., Prakash, P., Ito, T., Kim, H. J., Brewer, C. C., Harrow, D., Roux, I., Hosokawa, S., & Griffith, A. J. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00141 · Cited by 48
Vascular Associations and Dynamic Process Motility in Perivascular Myeloid Cells of the Mouse Choroid: Implications for Function and Senescent Change
Kumar, A., Zhao, L., Fariss, R. N., McMenamin, P. G., & Wong, W. T. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-13522 · Cited by 45
The Detrimental and Beneficial Functions of Macrophages After Cochlear Injury
Zhang, Y., Li, Y., Fu, X., Wang, P., Wang, Q., Meng, W., Wang, T., Yang, J., & Chai, R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.631904 · Cited by 46
LDL receptor-related protein 1 (LRP1), a novel target for opening the blood-labyrinth barrier (BLB)
Shi, X., Wang, Z., Ren, W., Chen, L., Xu, C., Li, M., Fan, S., Xu, Y., Chen, M., Zheng, F., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00995-z · Cited by 45
Self-citation
Biology of melanocytes in mammals
Cui, Y.-Z., & Man, X. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1309557 · Cited by 47
Interactions between Macrophages and the Sensory Cells of the Inner EarPreprint
Warchol, M. E. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a033555 · Cited by 46
Chronic suppurative otitis media causes macrophage-associated sensorineural hearing loss
Xia, A., Thai, A., Cao, Z., Chen, X., Chen, J., Bacacao, B., Bekale, L. A., Schiel, V., Bollyky, P. L., & Maria, P. L. S. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02585-w · Cited by 43
Mechanisms of radiation-induced sensorineural hearing loss and radioprotection
Mujica‐Mota, M. A., Lehnert, S., Dević, S., Gasbarrino, K., & Daniel, S. J. (2014) · Hearing Research · doi:10.1016/j.heares.2014.03.003 · Cited by 43
Defining the Inflammatory Microenvironment in the Human Cochlea by Perilymph Analysis: Toward Liquid Biopsy of the Cochlea
Warnecke, A., Prenzler, N., Schmitt, H., Daemen, K., Keil, J., Dursin, M., Lenarz, T., & Falk, C. S. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00665 · Cited by 42
The Distribution and Prevalence of Macrophages in the Cochlea Following Cochlear Implantation in the Human: An Immunohistochemical Study Using Anti-Iba1 Antibody
Okayasu, T., Quesnel, A. M., O’Malley, J. T., Kamakura, T., & Nadol, J. B. (2019) · Otology & Neurotology · doi:10.1097/mao.0000000000002495 · Cited by 40
On the Role of Fibrocytes and the Extracellular Matrix in the Physiology and Pathophysiology of the Spiral Ligament
Peeleman, N., Verdoodt, D., Ponsaerts, P., & Rompaey, V. V. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.580639 · Cited by 41
Macrophage-Mediated Glial Cell Elimination in the Postnatal Mouse Cochlea
Brown, L. N., Xing, Y., Noble, K. V., Barth, J. L., Panganiban, C. H., Smythe, N. M., Bridges, C., Zhu, J., & Lang, H. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00407 · Cited by 40
Perivascular macrophages in high-fat diet-induced hypothalamic inflammation
Mendes, N. F., & Velloso, L. A. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02519-6 · Cited by 41
Chemiexcitation and Its Implications for Disease
Brash, D. E., Gonçalves, L. C. P., & Bechara, E. J. H. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.04.004 · Cited by 37
Complete Restoration of Hearing Loss and Cochlear Synaptopathy via Minimally Invasive, Single-Dose, and Controllable Middle Ear Delivery of Brain-Derived Neurotrophic Factor–Poly( dl -lactic acid- co -glycolic acid)-Loaded Hydrogel
Yu, Q., Liu, S., Guo, R., Chen, K., Li, Y., Jiang, D., Gong, S., Yin, L., & Liu, K. (2024) · ACS Nano · doi:10.1021/acsnano.3c11049 · Cited by 40
Human blood-labyrinth barrier model to study the effects of cytokines and inflammation
Sekulic‐Jablanovic, M., Puche, R., Bodmer, D., & Petkovic, V. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1243370 · Cited by 36
The disruption and hyperpermeability of blood-labyrinth barrier mediates cisplatin-induced ototoxicity
Gu, J., Tong, L., Lin, X., Chen, Y., Wu, H., Wang, X., & Yu, D. (2021) · Toxicology Letters · doi:10.1016/j.toxlet.2021.10.015 · Cited by 36
Noise-induced cochlear inflammation
Tan, W. J. T. (2013) · World Journal of Otorhinolaryngology · doi:10.5319/wjo.v3.i3.89 · Cited by 34
Cochlear Immune Response in Presbyacusis: a Focus on Dysregulation of Macrophage Activity
Noble, K. V., Brown, L. N., Elvis, P. R., & Lang, H. (2021) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-021-00819-x · Cited by 37
Hyperpigmentation Results in Aberrant Immune Development in Silky Fowl (Gallus gallus domesticus Brisson)
Han, D., Wang, S., Hu, Y., Zhang, Y., Dong, X., Yang, Z., Wang, J., Li, J., & Deng, X. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125686 · Cited by 35
Advances in research on labyrinth membranous barriers
Sun, W., & Wang, W. (2015) · Journal of Otology · doi:10.1016/j.joto.2015.11.003 · Cited by 34
Blood–Labyrinth Barrier in Health and Diseases: Effect of Hormetic Nutrients
Cosentino, A., Agafonova, A., Modafferi, S., Salinaro, A. T., Scuto, M. C., Maiolino, L., Fritsch, T., Calabrese, E. J., Lupo, G., Anfuso, C. D., et al. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0251 · Cited by 35
Noncoding Microdeletion in Mouse Hgf Disrupts Neural Crest Migration into the Stria Vascularis, Reduces the Endocochlear Potential, and Suggests the Neuropathology for Human Nonsyndromic Deafness DFNB39
Morell, R. J., Olszewski, R. T., Tona, R., Leitess, S., Wafa, T. T., Taukulis, I., Schultz, J. M., Thomason, E. J., Richards, K., Whitley, B. N., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2278-19.2020 · Cited by 33
Human induced pluripotent stem cells and CRISPR/Cas-mediated targeted genome editing: Platforms to tackle sensorineural hearing loss
Stojković, M., Han, D., Jeong, M., Stojković, P., & Stanković, K. M. (2021) · Stem Cells · doi:10.1002/stem.3353 · Cited by 34
MRI With Gadolinium as a Measure of Blood-Labyrinth Barrier Integrity in Patients With Inner Ear Symptoms: A Scoping Review
Song, C. I., Pogson, J. M., Andresen, N. S., & Ward, B. K. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.662264 · Cited by 33
Developments in delivery of medications for inner ear disease
Staecker, H., & Rodgers, B. D. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.766167 · Cited by 33
Progressive irreversible hearing loss is caused by stria vascularis degeneration in an Slc26a4-insufficient mouse model of large vestibular aqueduct syndrome
Ito, T., Nishio, A., Wangemann, P., & Griffith, A. J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.016 · Cited by 32
Lipopolysaccharide disrupts the cochlear blood-labyrinth barrier by activating perivascular resident macrophages and up-regulating MMP-9
Jiang, Y., Zhang, J., Rao, Y., Chen, J., Chen, K., & Tang, Y. (2019) · International Journal of Pediatric Otorhinolaryngology · doi:10.1016/j.ijporl.2019.109656 · Cited by 32
Mechanism and Protection of Radiotherapy Induced Sensorineural Hearing Loss for Head and Neck Cancer
Shi, W., Hou, X., Bao, X., Hou, W., Jiang, X., Ma, L., Jiang, X. M., & Dong, L. (2021) · BioMed Research International · doi:10.1155/2021/3548706 · Cited by 32
Recognition of Melanocytes in Immuno-Neuroendocrinology and Circadian Rhythms: Beyond the Conventional Melanin Synthesis
Chen, Y.-Y., Liu, L., Zhou, H., Zheng, Y., & Li, Y. (2022) · Cells · doi:10.3390/cells11132082 · Cited by 33
Activated tissue-resident macrophages contribute to hair cell insults in noise-induced hearing loss in mice
Pan, J., Wang, K., Qu, J., Chen, D., Chen, A., You, Y., Tang, J., & Zhang, H. (2024) · Communications Biology · doi:10.1038/s42003-024-06768-4 · Cited by 36
Resilience of dermis resident macrophages to inflammatory challenges
Lee, S. H., & Sacks, D. L. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01313-z · Cited by 34
Allicin Protects against Cisplatin-Induced Stria Vascularis Damage: Possible Relation to Inhibition of Caspase-3 and PARP-1-AIF-Mediated Apoptotic Pathways
Cai, J., Wu, X., Li, X., Ma, C., Xu, L., Guo, X., Li, J., Wang, H., & Han, Y. (2019) · ORL · doi:10.1159/000500557 · Cited by 31
Tissue-Resident Macrophages in the Stria Vascularis
Ito, T., Kurata, N., & Fukunaga, Y. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.818395 · Cited by 32
Morphology, localization, and postnatal development of dural macrophages
Sato, T., Konishi, H., Tamada, H., Nishiwaki, K., & Kiyama, H. (2021) · Cell and Tissue Research · doi:10.1007/s00441-020-03346-y · Cited by 30
Human Inner Ear Immune Activity: A Super-Resolution Immunohistochemistry Study
Liu, W., Nordström, C. K., Danckwardt-Lillieström, N., & Rask‐Andersen, H. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00728 · Cited by 31
Neutrophils infiltrate into the spiral ligament but not the stria vascularis in the cochlea during lipopolysaccharide-induced inflammation
Bae, S. H., Yoo, J. E., Choe, Y. H., Kwak, S. H., Choi, J. Y., Jung, J., & Hyun, Y. (2021) · Theranostics · doi:10.7150/thno.49121 · Cited by 29
Macrophage-related immune responses in inner ear: a potential therapeutic target for sensorineural hearing loss
Liu, Y., & Xu, K. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1339134 · Cited by 28
Non-autonomous Cellular Responses to Ototoxic Drug-Induced Stress and Death
Francis, S. P., & Cunningham, L. L. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00252 · Cited by 27
Role of Inner Ear Macrophages and Autoimmune/Autoinflammatory Mechanisms in the Pathophysiology of Inner Ear Disease
Miwa, T., & Okano, T. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.861992 · Cited by 28
The redox protein p66shc mediates cochlear vascular dysfunction and transient noise-induced hearing loss
Fetoni, A. R., Eramo, S. L. M., Paciello, F., Rolesi, R., Samengo, D., Paludetti, G., Troiani, D., & Pani, G. (2016) · Scientific Reports · doi:10.1038/srep25450 · Cited by 28
The Stria Vascularis: Renewed Attention on a Key Player in Age-Related Hearing Loss
Bovee, S., Klump, G. M., Köppl, C., & Pyott, S. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105391 · Cited by 29
Transcriptome analyses of differential gene expression in the bursa of Fabricius between Silky Fowl and White Leghorn
Han, D., Zhang, Y., Chen, J., Hua, G., Li, J., Deng, X., & Deng, X. (2017) · Scientific Reports · doi:10.1038/srep45959 · Cited by 25
Migration and fate of vestibular melanocytes during the development of the human inner ear
van Beelen, E. S. A., van der Valk, W. H., de Groot, J. C. M. J., Hensen, E. F., Locher, H., & van Benthem, P. P. G. (2020) · Developmental Neurobiology · doi:10.1002/dneu.22786 · Cited by 27
GM‐CSF ameliorates microvascular barrier integrity via pericyte‐derived Ang‐1 in wound healing
Yan, M., Hu, Y., Yao, M., Bao, S., & Fang, Y. (2017) · Wound Repair and Regeneration · doi:10.1111/wrr.12608 · Cited by 26
Potential Mechanisms Underlying Inflammation-Enhanced Aminoglycoside-Induced Cochleotoxicity
Jiang, M., Taghizadeh, F., & Steyger, P. S. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00362 · Cited by 27

Authors: Zhang, W., Dai, M., Fridberger, A., Hassan, A., DeGagne, J., Neng, L., Zhang, F., He, W., Ren, T., Trune, D., Auer, M., & Shi, X.
Affiliations: Oregon Health & Science University (US)
Karolinska Institutet (SE)
Lawrence Berkeley National Laboratory (US)
ORCID: Zhang, Wenjing
Dai, Min
Fridberger, Anders
Hassan, Ahmed
Neng, Lingling
Zhang, Fei
He, Wenxuan
Ren, Tianying
Trune, Dennis
Auer, Manfred
Shi, Xiaorui
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2012-06-11
Volume: 109
Issue: 26
Pages: 10388-10393
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1205210109
PMC: PMC3387119
OpenAlex: W1988390197
Cited by: 236
References: 35
Citations by year: 2026: 14 · 2025: 19 · 2024: 22 · 2023: 24 · 2022: 22 · 2021: 20 · 2020: 21 · 2019: 16 · 2018: 13 · 2017: 24 · 2016: 7 · 2015: 14 · 2014: 12 · 2013: 6 · 2012: 2
FWCI: 6.03
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Israel National Institute for Health Policy Research
National Institutes of Health (DC005983)
National Institute on Deafness and Other Communication Disorders (R01DC004554, NIH P30 DC005983, DC005983, R01DC010844, R03DC008888, DC008888-02A1, P30DC005983, DC 008888-02S1)
Topics: Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
Keywords: inner ear, stria vascularis, pigment epithelium-derived factor, tight junctions, endocochlear potential, hearing loss, cochlea, pericytes, basement membrane
MeSH terms: Animals, Humans, Ear, Inner, Macrophages, Melanocytes, Mice, Transgenic, Stria Vascularis, Tight Junctions, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Perivascular-resident macrophage-like melanocytes in the inner ear are essential for the integrity of the intrastrial fluid–blood barrier

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks