The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Brain conditioning is instrumental for successful microglia reconstitution following hematopoietic stem cell transplantation
Abstract
The recent hypothesis that postnatal microglia are maintained independently of circulating monocytes by local precursors that colonize the brain before birth has relevant implications for the treatment of various neurological diseases, including lysosomal storage disorders (LSDs), for which hematopoietic cell transplantation (HCT) is applied to repopulate the recipient myeloid compartment, including microglia, with cells expressing the defective functional hydrolase. By studying wild-type and LSD mice at diverse time-points after HCT, we showed the occurrence of a short-term wave of brain infiltration by a fraction of the transplanted hematopoietic progenitors, independently from the administration of a preparatory regimen and from the presence of a disease state in the brain. However, only the use of a conditioning regimen capable of ablating functionally defined brain-resident myeloid precursors allowed turnover of microglia with the donor, mediated by local proliferation of early immigrants rather than entrance of mature cells from the circulation.
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“Host microglia are relatively radio-resistant”
From Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge (2018) · cites this paper as [31]
In the citing paper
“unless combined with conditioning, engraftment of the brain macrophage pool was therefore reported to be limited27,29–31.”
From Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge (2018) · cites this paper as [31]
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“Likewise, other studies suggested that a transient wave of early hematopoietic progenitors infiltrates the host CNS during transplantation and following local proliferation, establishing the graft31.”
From Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge (2018) · cites this paper as [31]
In the citing paper
“The reported efficiencies of microglia replacement following BMT in mice vary greatly (18–23).”
From Treatment of a genetic brain disease by CNS-wide microglia replacement (2022) · cites this paper as [18]
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Cites
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Self-citation
Metadata
- Authors
- Capotondo, A., Milazzo, R., Politi, L. S., Quattrini, A., Palini, A., Plati, T., Merella, S., Nonis, A., di Serio, C., Montini, E., Naldini, L., & Biffi, A.
- Affiliations
- San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells and Gene Therapy,
- Imaging Core,
- Division of Neuroscience,
- Flow Cytometry Resource Analytical Cytology Technical Applications Laboratory, and
- Center of Biostatistics, Vita-Salute San Raffaele University, San Raffaele Scientific Institute, 20132 Milan, Italy
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2012-08-23
- Volume
- 109
- Issue
- 37
- Pages
- 15018-15023
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 200
- References
- 5
- Language
- en
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- Capotondo, A., Milazzo, R., Politi, L. S., Quattrini, A., Palini, A., Plati, T., Merella, S., Nonis, A., di Serio, C., Montini, E., Naldini, L., & Biffi, A. (2012). Brain conditioning is instrumental for successful microglia reconstitution following hematopoietic stem cell transplantation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1205858109
