The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Protein-coding genes are epigenetically regulated in Arabidopsis polyploids
Open accessAbstract
The fate of redundant genes resulting from genome duplication is poorly understood. Previous studies indicated that ribosomal RNA genes from one parental origin are epigenetically silenced during interspecific hybridization or polyploidization. Regulatory mechanisms for protein-coding genes in polyploid genomes are unknown, partly because of difficulty in studying expression patterns of homologous genes. Here we apply amplified fragment length polymorphism (AFLP)–cDNA display to perform a genome-wide screen for orthologous genes silenced in Arabidopsis suecica , an allotetraploid derived from Arabidopsis thaliana and Cardaminopsis arenosa . We identified ten genes that are silenced from either A. thaliana or C. arenosa origin in A. suecica and located in four of the five A. thaliana chromosomes. These genes represent a variety of RNA and predicted proteins including four transcription factors such as TCP3. The silenced genes in the vicinity of TCP3 are hypermethylated and reactivated by blocking DNA methylation, suggesting epigenetic regulation is involved in the expression of orthologous genes in polyploid genomes. Compared with classic genetic mutations, epigenetic regulation may be advantageous for selection and adaptation of polyploid species during evolution and development.
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Cited by
Understanding mechanisms of novel gene expression in polyploids
Osborn, T. C., Chris Pires, J., Birchler, J. A., Auger, D. L., Jeffery Chen, Z., Lee, H.-S., Comai, L., Madlung, A., Doerge, R. W., Colot, V., et al. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00015-5 · Cited by 910
Self-citationAdvances in the study of polyploidy since Plant speciation
Soltis, D. E., Soltis, P. S., & Tate, J. A. (2004) · New Phytologist · doi:10.1046/j.1469-8137.2003.00948.x · Cited by 720
Differentiation of the maize subgenomes by genome dominance and both ancient and ongoing gene loss
Schnable, J. C., Springer, N. M., & Freeling, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101368108 · Cited by 708
Genomic Changes in Resynthesized Brassica napus and Their Effect on Gene Expression and Phenotype
Gaeta, R. T., Pires, J. C., Iniguez-Luy, F., Leon, E., & Osborn, T. C. (2007) · The Plant Cell · doi:10.1105/tpc.107.054346 · Cited by 629
Genomewide Nonadditive Gene Regulation in Arabidopsis Allotetraploids
Wang, J., Tian, L., Lee, H.-S., Wei, N. E., Jiang, H., Watson, B., Madlung, A., Osborn, T. C., Doerge, R. W., Comai, L., et al. (2006) · Genetics · doi:10.1534/genetics.105.047894 · Cited by 599
Self-citation
Metadata
- Authors
- Lee, H.-S., & Chen, Z. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-05-22
- Volume
- 98
- Issue
- 12
- Pages
- 6753-6758
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1975404287
- Cited by
- 311
- References
- 36
- FWCI
- 32.23
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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