The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Cyanobacterial conversion of carbon dioxide to 2,3-butanediol
Open accessAbstract
Conversion of CO 2 for the synthesis of chemicals by photosynthetic organisms is an attractive target for establishing independence from fossil reserves. However, synthetic pathway construction in cyanobacteria is still in its infancy compared with model fermentative organisms. Here we systematically developed the 2,3-butanediol (23BD) biosynthetic pathway in Synechococcus elongatus PCC7942 as a model system to establish design methods for efficient exogenous chemical production in cyanobacteria. We identified 23BD as a target chemical with low host toxicity, and designed an oxygen-insensitive, cofactor-matched biosynthetic pathway coupled with irreversible enzymatic steps to create a driving force toward the target. Production of 23BD from CO 2 reached 2.38 g/L, which is a significant increase for chemical production from exogenous pathways in cyanobacteria. This work demonstrates that developing strong design methods can continue to increase chemical production in cyanobacteria.
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Cites
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Self-citationDirect photosynthetic recycling of carbon dioxide to isobutyraldehyde
Atsumi, S., Higashide, W., & Liao, J. C. (2009) · Nature Biotechnology · doi:10.1038/nbt.1586 · Cited by 870
Self-citationLindberg, P., Park, S., & Melis, A. (2010) · Metabolic Engineering · doi:10.1016/j.ymben.2009.10.001 · Cited by 596
BRENDA, the enzyme information system in 2011
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Cited by
Synthetic biology of cyanobacteria: unique challenges and opportunities
Berla, B. M., Saha, R., Immethun, C. M., Maranas, C. D., Moon, T. S., & Pakrasi, H. B. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00246 · Cited by 305
Metabolic engineering of cyanobacteria for the synthesis of commodity products
Angermayr, S. A., Gorchs Rovira, A., & Hellingwerf, K. J. (2015) · Trends in Biotechnology · doi:10.1016/j.tibtech.2015.03.009 · Cited by 273
New applications of synthetic biology tools for cyanobacterial metabolic engineering
Santos-Merino, M., Singh, A. K., & Ducat, D. C. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00033 · Cited by 222
Cyanobacteria: Review of Current Potentials and Applications.
Zahra, Z., Choo, D. H., Lee, H., & Parveen, A. (2020) · Environments · doi:10.3390/environments7020013 · Cited by 228
Cyanobacteria as a Platform for Biofuel Production.
Nozzi, N. E., Oliver, J. W. K., & Atsumi, S. (2013) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2013.00007 · Cited by 227
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Metadata
- Authors
- Oliver, J. W. K., Machado, I. M. P., Yoneda, H., & Atsumi, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-01-07
- Volume
- 110
- Issue
- 4
- Pages
- 1249-1254
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2057911693
- Cited by
- 380
- References
- 7
- FWCI
- 18.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Oliver, J. W. K., Machado, I. M. P., Yoneda, H., & Atsumi, S. (2013). Cyanobacterial conversion of carbon dioxide to 2,3-butanediol. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1213024110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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