The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile
Open accessAbstract
Patients with type 2 diabetes (T2D) have disease-associated changes in B-cell function, but the role these changes play in disease pathogenesis is not well established. Data herein show B cells from obese mice produce a proinflammatory cytokine profile compared with B cells from lean mice. Complementary in vivo studies show that obese B cell–null mice have decreased systemic inflammation, inflammatory B- and T-cell cytokines, adipose tissue inflammation, and insulin resistance (IR) compared with obese WT mice. Reduced inflammation in obese/insulin resistant B cell–null mice associates with an increased percentage of anti-inflammatory regulatory T cells (Tregs). This increase contrasts with the sharply decreased percentage of Tregs in obese compared with lean WT mice and suggests that B cells may be critical regulators of T-cell functions previously shown to play important roles in IR. We demonstrate that B cells from T2D (but not non-T2D) subjects support proinflammatory T-cell function in obesity/T2D through contact-dependent mechanisms. In contrast, human monocytes increase proinflammatory T-cell cytokines in both T2D and non-T2D analyses. These data support the conclusion that B cells are critical regulators of inflammation in T2D due to their direct ability to promote proinflammatory T-cell function and secrete a proinflammatory cytokine profile. Thus, B cells are potential therapeutic targets for T2D.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Adipose tissue‐resident B cells, which are localized around macrophage clusters, have also been shown to have a predominant pathogenic role in obesity‐related IR in mice.[ 68 ]”
From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [68]
In the citing paper
“These pathogenic B cells activate IFNγ‐producing CD4+ and CD8 + T cells and/or IL‐17‐secreting Th1 cells within the visceral adipose tissues, presumably through LTB4/leukotriene‐B4 receptor 1 (LTB4R1) signalling.”
From Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review (2022) · cites this paper as [68]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655
Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230
Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145
Stein, M., Keshav, S., Harris, N., & Gordon, S. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.1.287 · Cited by 1,960
Kitamura, D., Roes, J., Kühn, R., & Rajewsky, K. (1991) · Nature · doi:10.1038/350423a0 · Cited by 1,783
Blair, P. A., Noreña, L. Y., Flores-Borja, F., Rawlings, D. J., Isenberg, D. A., Ehrenstein, M. R., & Mauri, C. (2010) · Immunity · doi:10.1016/j.immuni.2009.11.009 · Cited by 1,574
Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis
Wu, D., Molofsky, A. B., Liang, H.-E., Ricardo-González, R. R., Jouihan, H. A., Bando, J. K., Chawla, A., & Locksley, R. M. (2011) · Science · doi:10.1126/science.1201475 · Cited by 1,411
Normalization of obesity-associated insulin resistance through immunotherapy
Winer, S., Chan, Y., Paltser, G., Truong, D., Tsui, H., Bahrami, J., Dorfman, R., Wang, Y., Zielenski, J., Mastronardi, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2001 · Cited by 1,370
Obesity-associated improvements in metabolic profile through expansion of adipose tissue
Kim, J.-Y., van de Wall, E., Laplante, M., Azzara, A., Trujillo, M. E., Hofmann, S. M., Schraw, T., Durand, J. L., Li, H., Li, G., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31021 · Cited by 1,310 · cited 1×
“B cells can also promote hypertrophic obesity, which, in contrast to hyperplastic obesity (due to increased adipocyte number), promotes AT and systemic inflammation and deleterious changes in glucose– insulin homeostasis (30).”
BackgroundYanaba, K., Bouaziz, J., Haas, K. M., Poe, J. C., Fujimoto, M., & Tedder, T. F. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.017 · Cited by 1,233
Winer, D. A., Winer, S., Shen, L., Wadia, P. P., Yantha, J., Paltser, G., Tsui, H., Wu, P., Davidson, M. G., Alonso, M. N., et al. (2011) · Nature Medicine · doi:10.1038/nm.2353 · Cited by 1,050
Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications
Strissel, K. J., Stancheva, Z., Miyoshi, H., Perfield, J. W., DeFuria, J., Jick, Z., Greenberg, A. S., & Obin, M. S. (2007) · Diabetes · doi:10.2337/db07-0767 · Cited by 1,007
Self-citationRegulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression
Matsushita, T., Yanaba, K., Bouaziz, J., Fujimoto, M., & Tedder, T. F. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36030 · Cited by 940
Prevention of Arthritis by Interleukin 10–producing B Cells
Mauri, C., Gray, D., Mushtaq, N., & Londei, M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021293 · Cited by 858
Fain, J. N. (2006) · Vitamins and hormones · doi:10.1016/s0083-6729(06)74018-3 · Cited by 702
Spectral compensation for flow cytometry: Visualization artifacts, limitations, and caveats
Roederer, M. (2001) · Cytometry · doi:10.1002/1097-0320(20011101)45:3 · Cited by 561
Carter, N. A., Vasconcellos, R., Rosser, E. C., Tulone, C., Muñoz-Suano, A., Kamanaka, M., Ehrenstein, M. R., Flavell, R. A., & Mauri, C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100284 · Cited by 476
Yang, H., Youm, Y., Vandanmagsar, B., Ravussin, A., Gimble, J. M., Greenway, F. L., Stephens, J. M., Mynatt, R. L., & Dixit, V. D. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000021 · Cited by 455
Bertola, A., Ciucci, T., Rousseau, D., Bourlier, V., Duffaut, C., Bonnafous, S., Blin‐Wakkach, C., Anty, R., Iannelli, A., Gugenheim, J., et al. (2012) · Diabetes · doi:10.2337/db11-1274 · Cited by 429
Jagannathan‐Bogdan, M., McDonnell, M. E., Shin, H., Rehman, Q., Hastürk, H., Apovian, C. M., & Nikolajczyk, B. S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002615 · Cited by 422
Self-citationIL-17 regulates adipogenesis, glucose homeostasis, and obesity
Zúñiga, L. A., Shen, W.-J., Joyce-Shaikh, B., Pyatnova, E. A., Richards, A. G., Thom, C., Andrade, S. M., Cua, D. J., Kraemer, F. B., & Butcher, E. C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001269 · Cited by 394
Fernandez-Botrán, R., Sanders, V. M., Mosmann, T. R., & Vitetta, E. S. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.168.2.543 · Cited by 379
Shulzhenko, N., Morgun, A., Hsiao, W., Battle, M., Yao, M., Gavrilova, O., Orandle, M., Mayer, L., Macpherson, A. J., McCoy, K. D., et al. (2011) · Nature Medicine · doi:10.1038/nm.2505 · Cited by 349
Therapeutic B cell depletion impairs adaptive and autoreactive CD4 + T cell activation in mice
Bouaziz, J., Yanaba, K., Venturi, G. M., Wang, Y., Tisch, R., Poe, J. C., & Tedder, T. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709205105 · Cited by 315
Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity
Duffaut, C., Galitzky, J., Lafontan, M., & Bouloumié, A. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.05.002 · Cited by 305
Ray, A., Basu, S., Williams, C. B., Salzman, N. H., & Dittel, B. N. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103354 · Cited by 258
The anti-CD20 antibody rituximab reduces the Th17 cell response
van de Veerdonk, F. L., Lauwerys, B., Marijnissen, R. J., Timmermans, K., Padova, F. D., Koenders, M. I., Gutierrez-Roelens, I., Durez, P., Netea, M. G., van der Meer, J. W. M., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30314 · Cited by 184
Increased Toll-Like Receptor Activity in Patients With Metabolic Syndrome
Jialal, I., Huet, B., Kaur, H., Chien, A., & Devaraj, S. (2012) · Diabetes Care · doi:10.2337/dc11-2375 · Cited by 171
Toll-like receptors regulate B cell cytokine production in patients with diabetes
Jagannathan, M., McDonnell, M., Liang, Y., Hasturk, H., Hetzel, J., Rubin, D., Kantarci, A., Van Dyke, T. E., Ganley-Leal, L. M., & Nikolajczyk, B. S. (2010) · Diabetologia · doi:10.1007/s00125-010-1730-z · Cited by 156
Self-citationGoossens, G. H., Blaak, E. E., Theunissen, R. O. M. F. I. H., Duijvestijn, A. M., Clément, K., Tervaert, J.-W. C., & Thewissen, M. M. (2012) · Molecular Immunology · doi:10.1016/j.molimm.2012.01.005 · Cited by 112
Gotoh, K., Inoue, M., Masaki, T., Chiba, S., Shimasaki, T., Ando, H., Fujiwara, K., Katsuragi, I., Kakuma, T., Seike, M., et al. (2012) · Diabetes · doi:10.2337/db11-1688 · Cited by 86
Resting B cells expand a CD4+CD25+Foxp3+ Treg population via TGF‐β3
Shah, S., & Qiao, L. (2008) · European Journal of Immunology · doi:10.1002/eji.200838201 · Cited by 81
Chen, Y., Shen, S., Gorentla, B. K., Gao, J., & Zhong, X. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102448 · Cited by 71
Iwata, S., Saito, K., Tokunaga, M., Yamaoka, K., Nawata, M., Yukawa, S., Hanami, K., Fukuyo, S., Miyagawa, I., Kubo, S., et al. (2010) · The Journal of Rheumatology · doi:10.3899/jrheum.100729 · Cited by 71
B Lymphocytes in Human Subcutaneous Adipose Crown‐Like Structures
McDonnell, M. E., Ganley-Leal, L. M., Mehta, A., Bigornia, S., Mott, M. M., Rehman, Q., Farb, M. G., Hess, D. T., Joseph, L., Gokce, N., et al. (2012) · Obesity · doi:10.1038/oby.2012.54 · Cited by 69
Self-citationThe outliers become a stampede as immunometabolism reaches a tipping point
Nikolajczyk, B. S., Jagannathan‐Bogdan, M., & Denis, G. V. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01142.x · Cited by 55
Self-citationHaskell, B. D., Flurkey, K., Duffy, T. M., Sargent, E. E., & Leiter, E. H. (2002) · Laboratory Investigation · doi:10.1097/01.lab.0000018915.53257.00 · Cited by 47 · cited 2×
“Obesity (Silver Spring) 20(7):1372–1378.”
Result
Cited by
Sorted by citations
Inflammation, metaflammation and immunometabolic disorders
Hotamisligil, G. S. (2017) · Nature · doi:10.1038/nature21363 · Cited by 2,570
From NASH to HCC: current concepts and future challenges
Anstee, Q. M., Reeves, H. L., Kotsiliti, E., Govaere, O., & Heikenwalder, M. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0145-7 · Cited by 1,392
Adapting to obesity with adipose tissue inflammation
Reilly, S. M., & Saltiel, A. R. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.90 · Cited by 1,204
Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
Zatterale, F., Longo, M., Naderi, J., Raciti, G. A., Desiderio, A., Miele, C., & Beguinot, F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01607 · Cited by 1,180
Metabolic Inflammation and Insulin Resistance in Obesity
Wu, H., & Ballantyne, C. M. (2020) · Circulation Research · doi:10.1161/circresaha.119.315896 · Cited by 1,059
Metadata
- Authors
- DeFuria, J., Belkina, A. C., Jagannathan-Bogdan, M., Snyder-Cappione, J., Carr, J. D., Nersesova, Y. R., Markham, D., Strissel, K. J., Watkins, A. A., Zhu, M., Allen, J., Bouchard, J., Toraldo, G., Jasuja, R., Obin, M. S., McDonnell, M. E., Apovian, C., Denis, G. V., & Nikolajczyk, B. S.
- Affiliations
- Boston University (US)
- Cancer Research Center (US)
- Department of Pathology, Boston University School of Medicine, Boston, MA 02118;
- Department of Microbiology,
- Boston Medical Center (US)
- Tufts University (US)
- Renal Section and
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-03-11
- Volume
- 110
- Issue
- 13
- Pages
- 5133-5138
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3612635
- OpenAlex
- W2144821774
- Cited by
- 521
- References
- 39
- Citations by year
- 2026: 17 · 2025: 36 · 2024: 31 · 2023: 32 · 2022: 50 · 2021: 50 · 2020: 43 · 2019: 37 · 2018: 42 · 2017: 51 · 2016: 36 · 2015: 41 · 2014: 31 · 2013: 23
- FWCI
- 32.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Boston Area Diabetes Endocrinology Research Center (DK046200)
- National Institutes of Health (DK046200, AI007309)
- Boston Nutrition Obesity Research Center, Boston University
- National Heart, Lung, and Blood Institute (T32HL007501, HL007501)
- National Cancer Institute (U01CA182898)
- National Institute of Allergy and Infectious Diseases (T32AI007309, AI007309)
- National Institute of Diabetes and Digestive and Kidney Diseases (R56DK090455, P30DK046200, DK046200, R21DK089270, R56DK096525)
- National Institute of Dental and Craniofacial Research (R21DE021154)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- B cells, type 2 diabetes, obesity, inflammation, insulin resistance, regulatory T cells, T cell function, inflammatory cytokines, adipose tissue inflammation, monocytes, contact-dependent signaling, therapeutic target
- MeSH terms
- Animals, B-Lymphocytes, Diabetes Mellitus, Type 2, Female, Humans, Inflammation, Male, Mice, Obese, Obesity, Cytokines, T-Lymphocytes, Regulatory, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
