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Cadherin-based intercellular adhesions organize epithelial cell–matrix traction forces
Open accessAbstract
Cell–cell and cell–matrix adhesions play essential roles in the function of tissues. There is growing evidence for the importance of cross talk between these two adhesion types, yet little is known about the impact of these interactions on the mechanical coupling of cells to the extracellular matrix (ECM). Here, we combine experiment and theory to reveal how intercellular adhesions modulate forces transmitted to the ECM. In the absence of cadherin-based adhesions, primary mouse keratinocytes within a colony appear to act independently, with significant traction forces extending throughout the colony. In contrast, with strong cadherin-based adhesions, keratinocytes in a cohesive colony localize traction forces to the colony periphery. Through genetic or antibody-mediated loss of cadherin expression or function, we show that cadherin-based adhesions are essential for this mechanical cooperativity. A minimal physical model in which cell–cell adhesions modulate the physical cohesion between contractile cells is sufficient to recreate the spatial rearrangement of traction forces observed experimentally with varying strength of cadherin-based adhesions. This work defines the importance of cadherin-based cell–cell adhesions in coordinating mechanical activity of epithelial cells and has implications for the mechanical regulation of epithelial tissues during development, homeostasis, and disease.
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“Moreover, loss of E-cadherin interfered with coordinated transfer of force across multiple cells to cell–matrix adhesion sites at edges of multicellular colonies (Fig. 5e, f)24.”
From E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning (2017) · cites this paper as [24]
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Citations
Cites
Methods of Digital Video Microscopy for Colloidal Studies
Crocker, J. C., & Grier, D. G. (1996) · Journal of Colloid and Interface Science · doi:10.1006/jcis.1996.0217 · Cited by 3,895
Flow-mediated endothelial mechanotransduction
Davies, P. F. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.519 · Cited by 2,802
Balaban, N. Q., Schwarz, U. S., Riveline, D., Goichberg, P., Tzur, G., Sabanay, I., Mahalu, D., Safran, S. A., Bershadsky, A. D., Addadi, L., et al. (2001) · Nature Cell Biology · doi:10.1038/35074532 · Cited by 2,137
Myotubes differentiate optimally on substrates with tissue-like stiffness
Engler, A. J., Griffin, M. A., Sen, S., Bönnemann, C. G., Sweeney, H. L., & Discher, D. E. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200405004 · Cited by 1,743
Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways
Önder, T. T., Gupta, P. B., Mani, S. A., Yang, J., Lander, E. S., & Weinberg, R. A. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2938 · Cited by 1,557
Stresses at the Cell-to-Substrate Interface during Locomotion of Fibroblasts
Dembo, M., & Wang, Y. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77386-8 · Cited by 1,319
The Influence of Cell Mechanics, Cell-Cell Interactions, and Proliferation on Epithelial Packing
Farhadifar, R., Röper, J.-C., Aigouy, B., Eaton, S., & Jülicher, F. (2007) · Current Biology · doi:10.1016/j.cub.2007.11.049 · Cited by 1,254
Directed Actin Polymerization Is the Driving Force for Epithelial Cell–Cell Adhesion
Vasioukhin, V., Bauer, C., Yin, M., & Fuchs, E. (2000) · Cell · doi:10.1016/s0092-8674(00)81559-7 · Cited by 1,205
Physical forces during collective cell migration
Trepat, X., Wasserman, M. R., Angelini, T. E., Millet, E. J., Weitz, D. A., Butler, J. P., & Fredberg, J. J. (2009) · Nature Physics · doi:10.1038/nphys1269 · Cited by 1,198
Reconstruction of Tissues by Dissociated Cells
Steinberg, M. S. (1963) · Science · doi:10.1126/science.141.3579.401 · Cited by 1,127
Traction fields, moments, and strain energy that cells exert on their surroundings
Butler, J. P., Tolić, I. M., Fabry, B., & Fredberg, J. J. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00270.2001 · Cited by 1,048
α-Catenin as a tension transducer that induces adherens junction development
Yonemura, S., Wada, Y., Watanabe, T., Nagafuchi, A., & Shibata, M. (2010) · Nature Cell Biology · doi:10.1038/ncb2055 · Cited by 972
Collective cell guidance by cooperative intercellular forces
Tambe, D. T., Hardin, C., Angelini, T. E., Rajendran, K., Park, C. Y., Serra‐Picamal, X., Zhou, E. H., Zaman, M. H., Butler, J. P., Weitz, D. A., et al. (2010) · Nature Materials · doi:10.1038/nmat3025 · Cited by 942
The differential adhesion hypothesis: a direct evaluation
Foty, R. A., & Steinberg, M. S. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2004.11.012 · Cited by 908 · cited 1×
“Cadherin-based adhesions can alter physical aspects of cells such as the surface tension of cellular aggregates (20) and the spreading (21) and migration (22) of single cells adherent to cadherin-patterned substrates.”
BackgroundMechanical control of tissue and organ development
Mammoto, T., & Ingber, D. E. (2010) · Development · doi:10.1242/dev.024166 · Cited by 874
Mechanical tugging force regulates the size of cell–cell junctions
Liu, Z., Tan, J. L., Cohen, D. M., Yang, M. T., Sniadecki, N. J., Ruiz, S. A., Nelson, C. M., & Chen, C. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914547107 · Cited by 704
le Duc, Q., Shi, Q., Blonk, I., Sonnenberg, A., Wang, N., Leckband, D., & de Rooij, J. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201001149 · Cited by 652
Borghi, N., Sorokina, M., Shcherbakova, O. G., Weis, W. I., Pruitt, B. L., Nelson, W. J., & Dunn, A. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1204390109 · Cited by 616
Spatial organization of the extracellular matrix regulates cell–cell junction positioning
Tseng, Q., Duchemin-Pelletier, E., Deshière, A., Balland, M., Guillou, H., Filhol, O., & Théry, M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106377109 · Cited by 611
High Resolution Traction Force Microscopy Based on Experimental and Computational Advances
Sabass, B., Gardel, M. L., Waterman, C. M., & Schwarz, U. S. (2007) · Biophysical Journal · doi:10.1529/biophysj.107.113670 · Cited by 590
Integration of contractile forces during tissue invagination
Martin, A. C., Gelbart, M., Fernandez-Gonzalez, R., Kaschube, M., & Wieschaus, E. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200910099 · Cited by 545
Cell-ECM traction force modulates endogenous tension at cell–cell contacts
Maruthamuthu, V., Sabass, B., Schwarz, U. S., & Gardel, M. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011123108 · Cited by 520
E‐cadherin is essential for in vivo epidermal barrier function by regulating tight junctions
Tunggal, J. A., Helfrich, I., Schmitz, A., Schwarz, H., Günzel, D., Fromm, M., Kemler, R., Krieg, T., & Niessen, C. M. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600605 · Cited by 491 · cited 1×
“We further investigated the role of classical cadherins using primary keratinocytes from an epidermal-E-cadherin–knockout (KO) mouse (46).”
BackgroundSelf-citationTNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2
Pasparakis, M., Courtois, G., Hafner, M., Schmidt‐Supprian, M., Nenci, A., Toksoy, A., Krampert, M., Goebeler, M., Gillitzer, R., Israël, A., et al. (2002) · Nature · doi:10.1038/nature00820 · Cited by 471
Yamada, S., & Nelson, W. J. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200701058 · Cited by 468
Planar Polarity and Tissue Morphogenesis
Zallen, J. A. (2007) · Cell · doi:10.1016/j.cell.2007.05.050 · Cited by 459
Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling
Hordijk, P. L., ten Klooster, J. P., van der Kammen, R. A., Michiels, F., Oomen, L. C. J. M., & Collard, J. G. (1997) · Science · doi:10.1126/science.278.5342.1464 · Cited by 441
Niessen, C. M., Leckband, D., & Yap, A. S. (2011) · Physiological Reviews · doi:10.1152/physrev.00004.2010 · Cited by 427
Self-citationVascular Adaptation and Mechanical Homeostasis at Tissue, Cellular, and Sub-cellular Levels
Humphrey, J. D. (2007) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-007-9002-3 · Cited by 426
Fibroblast–collagen-matrix contraction: growth-factor signalling and mechanical loading
Grinnell, F. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01802-x · Cited by 405
Differential adhesion in morphogenesis: a modern view
Steinberg, M. S. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2007.05.002 · Cited by 393
Conditional Ablation of β1 Integrin in Skin
Raghavan, S., Bauer, C. R., Mundschau, G., Li, Q. S., & Fuchs, E. V. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.5.1149 · Cited by 386
Weber, G. F., Bjerke, M. A., & DeSimone, D. W. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.10.013 · Cited by 373
Integrins and cadherins join forces to form adhesive networks
Weber, G. F., Bjerke, M. A., & DeSimone, D. W. (2011) · Journal of Cell Science · doi:10.1242/jcs.064618 · Cited by 367
Vaezi, A., Bauer, C., Vasioukhin, V., & Fuchs, E. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00259-9 · Cited by 349
Integrin-dependent actomyosin contraction regulates epithelial cell scattering
de Rooij, J., Kerstens, A., Danuser, G. M., Schwartz, M. A., & Waterman, C. M. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200506152 · Cited by 324
Polarization of PAR Proteins by Advective Triggering of a Pattern-Forming System
Goehring, N. W., Trong, P. K., Bois, J. S., Chowdhury, D., Nicola, E. M., Hyman, A. A., & Grill, S. W. (2011) · Science · doi:10.1126/science.1208619 · Cited by 309
Liquid properties of embryonic tissues: Measurement of interfacial tensions
Foty, R. A., Forgács, G., Pfleger, C. M., & Steinberg, M. S. (1994) · Physical Review Letters · doi:10.1103/physrevlett.72.2298 · Cited by 306
Signaling pathways and cell mechanics involved in wound closure by epithelial cell sheets
Fenteany, G., Janmey, P. A., & Stossel, T. P. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00579-0 · Cited by 305
Ng, M. R., Besser, A., Danuser, G. M., & Brugge, J. S. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201207148 · Cited by 300
Cell traction force and measurement methods
Wang, J. H., & Lin, J. (2007) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-006-0068-4 · Cited by 275
Strength Dependence of Cadherin-Mediated Adhesions
Ladoux, B., Anon, E., Lambert, M., Rabodzey, A., Hersen, P., Buguin, A., Silberzan, P., & Mège, R. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2009.10.044 · Cited by 243
Pillai, S. G., Bikle, D. D., Mancianti, M., Cline, P. R., & Hincenbergs, M. (1990) · Journal of Cellular Physiology · doi:10.1002/jcp.1041430213 · Cited by 243
Determinants of leader cells in collective cell migration
Khalil, A. A., & Friedl, P. (2010) · Integrative Biology · doi:10.1039/c0ib00052c · Cited by 240
Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces
Krishnan, R., Klumpers, D. D., Park, C. Y., Rajendran, K., Trepat, X., van Bezu, J. S. M., van Hinsbergh, V. W. M., Carman, C. V., Brain, J. D., Fredberg, J. J., et al. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00195.2010 · Cited by 229
Spatio-temporal analysis of eukaryotic cell motility by improved force cytometry
del Álamo, J. C., Meili, R., Alonso‐Latorre, B., Rodríguez‐Rodríguez, J., Aliseda, A., Firtel, R., & Lasheras, J. C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705815104 · Cited by 216
Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions
Borghi, N., Lowndes, M., Maruthamuthu, V., Gardel, M. L., & Nelson, W. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002662107 · Cited by 212
Isolation and Culture of Epithelial Stem Cells
Nowak, J. A., & Fuchs, E. V. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-060-7_14 · Cited by 197
Mutations inhalf baked/E-cadherin block cell behaviors that are necessary for teleost epiboly
Kane, D. A., McFarland, K. N., & Warga, R. M. (2005) · Development · doi:10.1242/dev.01668 · Cited by 191
Scaling of Traction Forces with the Size of Cohesive Cell Colonies
Mertz, A. F., Banerjee, S., Che, Y., German, G. K., Xu, Y., Hyland, C., Marchetti, M. C., Horsley, V., & Dufresne, E. R. (2012) · Physical Review Letters · doi:10.1103/physrevlett.108.198101 · Cited by 190
Self-citationCooperative coupling of cell-matrix and cell–cell adhesions in cardiac muscle
McCain, M. L., Lee, H., Aratyn-Schaus, Y., Kléber, A. G., & Parker, K. K. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203007109 · Cited by 187
Dzamba, B. J., Jakab, K., Marsden, M., Schwartz, M. A., & DeSimone, D. W. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.008 · Cited by 186
Nelson, C. M., Pirone, D. M., Tan, J. L., & Chen, C. S. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-10-0745 · Cited by 184
Micallef, L., Belaubre, F., Pinon, A., Jayat‐Vignoles, C., Delage, C., Charvéron, M., & Simon, A. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00775.x · Cited by 172
Calcium-induced assembly of adherens junctions in keratinocytes.
O’Keefe, E. J., Briggaman, R. A., & Herman, B. A. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.105.2.807 · Cited by 163
A Molecular Clutch between the Actin Flow and N-Cadherin Adhesions Drives Growth Cone Migration
Bard, L., Boscher, C., Lambert, M., Mège, R., Choquet, D., & Thoumine, O. R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5331-07.2008 · Cited by 156
Martinez-Rico, C., Pincet, F., Thiery, J. P., & Dufour, S. (2010) · Journal of Cell Science · doi:10.1242/jcs.047878 · Cited by 143
Mechanical control of global cell behaviour during dorsal closure inDrosophila
Gorfinkiel, N., Blanchard, G. B., Adams, R. J., & Arias, A. M. (2009) · Development · doi:10.1242/dev.030866 · Cited by 138
Estimation of fracture toughness of liver tissue: Experiments and validation
Gökgöl, C., Başdoğan, Ç., & Canadinç, D. (2011) · Medical Engineering & Physics · doi:10.1016/j.medengphy.2011.09.030 · Cited by 90
Cytoskeletal mechanics in confluent epithelial cells probed through integrins and E-cadherins
Potard, U. S., Butler, J. P., & Wang, N. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.272.5.c1654 · Cited by 83
Force Localization in Contracting Cell Layers
Dunlop, C. M., & Schwarz, U. S. (2011) · Physical Review Letters · doi:10.1103/physrevlett.107.128101 · Cited by 80
Imaging in-plane and normal stresses near an interface crack using traction force microscopy
Xu, Y., Engl, W., Jerison, E. R., Wallenstein, K. J., Hyland, C., Wilen, L. A., & Dufresne, E. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005537107 · Cited by 73
Self-citationContractile Stresses in Cohesive Cell Layers on Finite-Thickness Substrates
Banerjee, S., & Marchetti, M. C. (2012) · Physical Review Letters · doi:10.1103/physrevlett.109.108101 · Cited by 72
Self-citationRigidity-Dependent Cross Talk between Integrin and Cadherin Signaling
Tsai, J., & Kam, L. C. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2009.01.005 · Cited by 63
Jasaitis, A., Estévez, M., Heysch, J., Ladoux, B., & Dufour, S. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2012.06.009 · Cited by 56
Classical Cadherins Regulate Desmosome Formation
Michels, C., Buchta, T., Bloch, W., Krieg, T., & Niessen, C. M. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.17 · Cited by 56
Self-citationSubstrate Rigidity Deforms and Polarizes Active Gels
Banerjee, S., Marchetti, M. C., Banerjee, S., & Marchetti, M. C. (2011) · Cited by 45
Self-citationSubstrate rigidity deforms and polarizes active gels
Banerjee, S., & Marchetti, M. C. (2011) · Europhysics Letters (EPL) · doi:10.1209/0295-5075/96/28003 · Cited by 43
Self-citationNotbohm, J., Kim, J., Asthagiri, A. R., & Ravichandran, G. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2012.02.016 · Cited by 32
Heterogeneous Drying Stresses in Stratum Corneum
German, G. K., Engl, W., Pashkovski, E. E., Banerjee, S., Xu, Y., Mertz, A. F., Hyland, C., & Dufresne, E. R. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2012.04.045 · Cited by 28
Self-citationInfluence of Ionic Strength on the Actomyosin Reaction Steps in Contracting Skeletal Muscle Fibers
Iwamoto, H. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76850-0 · Cited by 26
Thornton, D. J. A., Harrison, C. A., Heaton, M. J., Bullock, A. J., & MacNeil, S. (2008) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e318166da8c · Cited by 12
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Metadata
- Authors
- Mertz, A. F., Che, Y., Banerjee, S., Goldstein, J. M., Rosowski, K. A., Revilla, S. F., Niessen, C. M., Marchetti, M. C., Dufresne, E. R., & Horsley, V.
- Affiliations
- Departments of aPhysics,
- Department of Physics, and
- Molecular, Cellular, and Developmental Biology,
- Maryville College (US)
- University of Cologne (DE)
- Syracuse University (US)
- Yale University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2012-12-31
- Volume
- 110
- Issue
- 3
- Pages
- 842-847
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3549115
- OpenAlex
- W2162198931
- Cited by
- 243
- References
- 72
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 11 · 2023: 14 · 2022: 17 · 2021: 20 · 2020: 18 · 2019: 17 · 2018: 20 · 2017: 21 · 2016: 26 · 2015: 25 · 2014: 18 · 2013: 9
- FWCI
- 7.87
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- arXiv (Cornell University) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- arXiv (Cornell University)
- Funders
- Yale University
- National Institute of General Medical Sciences (T32GM007223)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR060295, AR060295)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Keywords
- cell-cell adhesion, cell-matrix adhesion, traction force, epithelial mechanics, keratinocytes, mechanical coupling, extracellular matrix, cell contractility, physical model, force localization, tissue mechanics
- MeSH terms
- Animals, Calcium, Cell Adhesion, Cells, Cultured, Culture Media, Intercellular Junctions, Models, Biological, Keratinocytes, Cadherins, RNA, Small Interfering, Mechanotransduction, Cellular, Mice, Biophysical Phenomena, Gene Knockdown Techniques, Gene Knockout Techniques
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