The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress
Open accessAbstract
Impairment of ribosomal biogenesis can activate the p53 protein independently of DNA damage. The ability of ribosomal proteins L5, L11, L23, L26, or S7 to bind Mdm2 and inhibit its ubiquitin ligase activity has been suggested as a critical step in p53 activation under these conditions. Here, we report that L5 and L11 are particularly important for this response. Whereas several other newly synthesized ribosomal proteins are degraded by proteasomes upon inhibition of Pol I activity by actinomycin D, L5 and L11 accumulate in the ribosome-free fraction where they bind to Mdm2. This selective accumulation of free L5 and L11 is due to their mutual protection from proteasomal degradation. Furthermore, the endogenous, newly synthesized L5 and L11 continue to be imported into nucleoli even after nucleolar disruption and colocalize with Mdm2, p53, and promyelocytic leukemia protein. This suggests that the disrupted nucleoli may provide a platform for L5- and L11-dependent p53 activation, implying a role for the nucleolus in p53 activation by ribosomal biogenesis stress. These findings may have important implications with respect to understanding the pathogenesis of diseases caused by impaired ribosome biogenesis.
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Citations
Cites
Blinded by the Light: The Growing Complexity of p53
Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163
Self-citationAnalysis of Nucleolar Protein Dynamics Reveals the Nuclear Degradation of Ribosomal Proteins
Lam, Y. W., Lamond, A. I., Mann, M., & Andersen, J. S. (2007) · Current Biology · doi:10.1016/j.cub.2007.03.064 · Cited by 369
Importin 7 and Exportin 1 Link c-Myc and p53 to Regulation of Ribosomal Biogenesis
Golomb, L., Bublik, D. R., Wilder, S., Nevo, R., Kiss, V., Grabusic, K., Volarevic, S., & Oren, M. (2012) · Molecular Cell · doi:10.1016/j.molcel.2011.11.022 · Cited by 137
Self-citationRegulation of nucleolar signalling to p53 through NEDDylation of L11
Sundqvist, A., Liu, G., Mirsaliotis, A., & Xirodimas, D. P. (2009) · The EMBO Reports · doi:10.1038/embor.2009.178 · Cited by 132
Cited by
Sloan, K. E., Warda, A. S., Sharma, S., Entian, K.-D., Lafontaine, D. L. J., & Bohnsack, M. T. (2017) · RNA Biology · doi:10.1080/15476286.2016.1259781 · Cited by 707
The Ribosome Biogenesis—Cancer Connection
Penzo, M., Montanaro, L., Treré, D., & Derenzini, M. (2019) · Cells · doi:10.3390/cells8010055 · Cited by 242
The role of ubiquitin modification in the regulation of p53
Hock, A. K., & Vousden, K. H. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.05.022 · Cited by 168
Hubackova, S., Davidova, E., Boukalova, S., Kovarova, J., Bajzikova, M., Coelho, A., Terp, M. G., Ditzel, H. J., Rohlena, J., & Neuzil, J. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2224-7 · Cited by 58
Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis
Garbarino, O., Lambroia, L., Basso, G., Marrella, V., Franceschini, B., Soldani, C., Pasqualini, F., Giuliano, D., Costa, G., Peano, C., et al. (2023) · Aging Cell · doi:10.1111/acel.13853 · Cited by 43
“…the nucleoplasm; however, RPL11 and HDM2 were tightly co- localized within the nucleus in >72% of inspected cells; in contrast, 50% of cytoplasmic RPL11 co- localized with HDM2 (Figure 3i), supporting the role of RPL11 as a shuttle for HDM2- mediated proteasomal degradation (Bursać et al., 2012).”
Background
Metadata
- Authors
- Bursać, S., Brdovčak, M. C., Pfannkuchen, M., Orsolić, I., Golomb, L., Zhu, Y., Katz, C., Daftuar, L., Grabušić, K., Vukelić, I., Filić, V., Oren, M., Prives, C., & Volarević, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2012-11-20
- Volume
- 109
- Issue
- 50
- Pages
- 20467-20472
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2048642489
- Cited by
- 227
- References
- 4
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Bursać, S., Brdovčak, M. C., Pfannkuchen, M., Orsolić, I., Golomb, L., Zhu, Y., Katz, C., Daftuar, L., Grabušić, K., Vukelić, I., Filić, V., Oren, M., Prives, C., & Volarević, S. (2012). Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1218535109
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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