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Dendritic K + channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons
Open accessAbstract
We investigated the role of A-type K + channels for the induction of long-term potentiation (LTP) of Schaffer collateral inputs to hippocampal CA1 pyramidal neurons. When low-amplitude excitatory postsynaptic potentials (EPSPs) were paired with two postsynaptic action potentials in a theta-burst pattern, N -methyl- d -aspartate (NMDA)-receptor-dependent LTP was induced. The amplitudes of the back-propagating action potentials were boosted in the dendrites only when they were coincident with the EPSPs. Mitogen-activated protein kinase (MAPK) inhibitors PD 098059 or U0126 shifted the activation of dendritic K + channels to more hyperpolarized potentials, reduced the boosting of dendritic action potentials by EPSPs, and suppressed the induction of LTP. These results support the hypothesis that dendritic K + channels and the boosting of back-propagating action potentials contribute to the induction of LTP in CA1 neurons.
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Cites
The MAPK cascade is required for mammalian associative learning
Atkins, C. M., Selcher, J. C., Petraitis, J. J., Trzaskos, J. M., & Sweatt, J. D. (1998) · Nature Neuroscience · doi:10.1038/2836 · Cited by 1,083
Two components of long-term potentiation induced by different patterns of afferent activation
Grover, L. M., & Teyler, T. J. (1990) · Nature · doi:10.1038/347477a0 · Cited by 708
Cited by
Spike Timing–Dependent Plasticity: A Hebbian Learning Rule
Caporale, N., & Dan, Y. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125639 · Cited by 1,997
Pyramidal neurons: dendritic structure and synaptic integration
Spruston, N. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2286 · Cited by 1,688
The Spike-Timing Dependence of Plasticity
Feldman, D. E. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.001 · Cited by 1,071
Spike Timing-Dependent Plasticity: From Synapse to Perception
Dan, Y., & Poo, M.-M. (2006) · Physiological Reviews · doi:10.1152/physrev.00030.2005 · Cited by 675
Häusser, M., & Mel, B. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00075-8 · Cited by 392
Metadata
- Authors
- Watanabe, S., Hoffman, D. A., Migliore, M., & Johnston, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-06-04
- Volume
- 99
- Issue
- 12
- Pages
- 8366-8371
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2061008935
- Cited by
- 283
- References
- 2
- FWCI
- 6.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Watanabe, S., Hoffman, D. A., Migliore, M., & Johnston, D. (2002). Dendritic K + channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.122210599
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