Two components of long-term potentiation induced by different patterns of afferent activation
Abstract
Long-term potentiation (LTP) of excitatory synaptic transmission could be a mechanism underlying memory. Induction of LTP requires Ca2+ influx into postsynaptic neurons through ion channels gated by NMDA (N-methyl-D-aspartate) receptors in hippocampus (area CA1 and dentate gyrus) and neocortex. Here we report that a component of LTP not requiring the activation of NMDA receptors can be induced in area CA1. The component is dependent on tetanus frequency, requires increases in postsynaptic intracellular Ca2+ concentrations, and is suppressed by an antagonist of voltage-dependent Ca2+ channels.
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At CA1 excitatory synapses, both NMDAR-dependent and NMDAR-independent forms of LTP can coexist under certain conditions.
“There is even evidence that at CA1 excitatory synapses both NMDAR-dependent and NMDAR-independent forms of LTP can coexist under certain conditions (49–51).”
From Synaptic memory and CaMKII (2023) · cites this paper as [49]
With intense induction protocols for LTP, a component of LTP requires the activation of VDCCs.
“with intense induction protocols for LTP a component of LTP requires the activation of VDCCs (49–51, 193, 196).”
From Synaptic memory and CaMKII (2023) · cites this paper as [49]
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- Authors
- Grover, L. M., & Teyler, T. J.
- Affiliations
- Northeast Ohio Medical University (US)
- ORCID
- Grover, Lawrence M.
- Venue
- Nature
- Published
- 1990-10
- Volume
- 347
- Issue
- 6292
- Pages
- 477-479
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2080700455
- Cited by
- 708
- References
- 2
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 8 · 2023: 10 · 2022: 11 · 2021: 10 · 2020: 13 · 2019: 6 · 2018: 10 · 2017: 29 · 2016: 14 · 2015: 10 · 2014: 16 · 2013: 15 · 2012: 22
- FWCI
- 11.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- long-term potentiation, tetanic stimulation, calcium influx, voltage-gated calcium channels, hippocampal CA1, synaptic plasticity, memory
- MeSH terms
- Afferent Pathways, Animals, Calcium, Hippocampus, Membrane Potentials, Memory, Synaptic Transmission, Neuronal Plasticity, Time Factors, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, In Vitro Techniques
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