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Reconciling migration models to the Americas with the variation of North American native mitogenomes

Achilli, Alessandro, Perego, Ugo A., Lancioni, Hovirag, Olivieri, Anna, Gandini, Francesca, Hooshiar Kashani, Baharak, Battaglia, Vincenza, Grugni, Viola, Angerhofer, Norman, Rogers, Mary P., Herrera, Rene J., Woodward, Scott R., Labuda, Damian, Smith, David Glenn, Cybulski, Jerome S., Semino, Ornella, Malhi, Ripan S., Torroni, Antonio·2013·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1306290110
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Abstract

In this study we evaluated migration models to the Americas by using the information contained in native mitochondrial genomes (mitogenomes) from North America. Molecular and phylogeographic analyses of B2a mitogenomes, which are absent in Eskimo–Aleut and northern Na-Dene speakers, revealed that this haplogroup arose in North America ∼11–13 ka from one of the founder Paleo-Indian B2 mitogenomes. In contrast, haplogroup A2a, which is typical of Eskimo–Aleuts and Na-Dene, but also present in the easternmost Siberian groups, originated only 4–7 ka in Alaska, led to the first Paleo-Eskimo settlement of northern Canada and Greenland, and contributed to the formation of the Na-Dene gene pool. However, mitogenomes also show that Amerindians from northern North America, without any distinction between Na-Dene and non–Na-Dene, were heavily affected by an additional and distinctive Beringian genetic input. In conclusion, most mtDNA variation (along the double-continent) stems from the first wave from Beringia, which followed the Pacific coastal route. This was accompanied or followed by a second inland migratory event, marked by haplogroups X2a and C4c, which affected all Amerindian groups of Northern North America. Much later, the ancestral A2a carriers spread from Alaska, undertaking both a westward migration to Asia and an eastward expansion into the circumpolar regions of Canada. Thus, the first American founders left the greatest genetic mark but the original maternal makeup of North American Natives was subsequently reshaped by additional streams of gene flow and local population dynamics, making a three-wave view too simplistic.

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Research works printed but not linked: 85

  1. A Curry, Ancient migration: Coming to America. Nature 485, 30–32 (2012). · DOI
  2. T Goebel, MR Waters, DH O’Rourke, The late Pleistocene dispersal of modern humans in the Americas. Science 319, 1497–1502 (2008). · DOI · Paper page
  3. S Mazières, Towards a reconciling model about the initial peopling of America. C R Biol 334, 497–504 (2011). · DOI
  4. TG Schurr, ST Sherry, Mitochondrial DNA and Y chromosome diversity and the peopling of the Americas: Evolutionary and demographic evidence. Am J Hum Biol 16, 420–439 (2004). · DOI
  5. A Torroni, et al., Asian affinities and continental radiation of the four founding Native American mtDNAs. Am J Hum Genet 53, 563–590 (1993).
  6. DH O’Rourke, JA Raff, The human genetic history of the Americas: The final frontier. Curr Biol 20, R202–R207 (2010). · DOI
  7. E Tamm, et al., Beringian standstill and spread of Native American founders. PLoS ONE 2, e829 (2007). · DOI · Paper page
  8. N Ray, et al., A statistical evaluation of models for the initial settlement of the american continent emphasizes the importance of gene flow with Asia. Mol Biol Evol 27, 337–345 (2010). · DOI
  9. S Bourgeois, et al., X-chromosome lineages and the settlement of the Americas. Am J Phys Anthropol 140, 417–428 (2009). · DOI
  10. A Arnaiz-Villena, et al., The origin of Amerindians and the peopling of the Americas according to HLA genes: Admixture with Asian and Pacific people. Curr Genomics 11, 103–114 (2010). · DOI
  11. S Wang, G Bedoya, D Labuda, A Ruiz-Linares, Brief communication: Patterns of linkage disequilibrium and haplotype diversity at Xq13 in six Native American populations. Am J Phys Anthropol 142, 476–480 (2010). · DOI
  12. NJ Fagundes, et al., Mitochondrial population genomics supports a single pre-Clovis origin with a coastal route for the peopling of the Americas. Am J Hum Genet 82, 583–592 (2008). · DOI · Paper page
  13. DA Merriwether, F Rothhammer, RE Ferrell, Distribution of the four founding lineage haplotypes in Native Americans suggests a single wave of migration for the New World. Am J Phys Anthropol 98, 411–430 (1995). · DOI
  14. SL Bonatto, FM Salzano, A single and early migration for the peopling of the Americas supported by mitochondrial DNA sequence data. Proc Natl Acad Sci USA 94, 1866–1871 (1997). · DOI
  15. M Hubbe, K Harvati, W Neves, Paleoamerican morphology in the context of European and East Asian late Pleistocene variation: Implications for human dispersion into the New World. Am J Phys Anthropol 144, 442–453 (2011). · DOI
  16. A Torroni, et al., Native American mitochondrial DNA analysis indicates that the Amerind and the Nadene populations were founded by two independent migrations. Genetics 130, 153–162 (1992). · DOI
  17. JH Greenberg, et al., The settlement of the Americas: A comparison of the linguistic, dental, and genetic evidence. Curr Anthropol 27, 477–497 (1986). · DOI
  18. MC Dulik, et al., Y-chromosome analysis reveals genetic divergence and new founding native lineages in Athapaskan- and Eskimoan-speaking populations. Proc Natl Acad Sci USA; Genographic Consortium 109, 8471–8476 (2012). · DOI
  19. NV Volodko, et al., Mitochondrial genome diversity in arctic Siberians, with particular reference to the evolutionary history of Beringia and Pleistocenic peopling of the Americas. Am J Hum Genet 82, 1084–1100 (2008). · DOI
  20. JA Raff, DA Bolnick, J Tackney, DH O’Rourke, Ancient DNA perspectives on American colonization and population history. Am J Phys Anthropol 146, 503–514 (2011). · DOI
  21. KB Schroeder, et al., Haplotypic background of a private allele at high frequency in the Americas. Mol Biol Evol 26, 995–1016 (2009). · DOI
  22. M Balter, Archaeology. Do island sites suggest a coastal route to the Americas? Science 331, 1122 (2011). · DOI
  23. M Balter, Human evolution. Tracing the paths of the first Americans. Science 333, 1692 (2011). · DOI
  24. D Reich, et al., Reconstructing Native American population history. Nature 488, 370–374 (2012). · DOI · Paper page
  25. R González-José, MC Bortolini, FR Santos, SL Bonatto, The peopling of America: Craniofacial shape variation on a continental scale and its interpretation from an interdisciplinary view. Am J Phys Anthropol 137, 175–187 (2008). · DOI
  26. RC Williams, et al., GM allotypes in Native Americans: Evidence for three distinct migrations across the Bering land bridge. Am J Phys Anthropol 66, 1–19 (1985). · DOI
  27. JH Greenberg Language in the Americas (Stanford Univ Press, Stanford, CA), pp. 438 (1987).
  28. DC Wallace, A Torroni, American Indian prehistory as written in the mitochondrial DNA: A review. Hum Biol 64, 403–416 (1992).
  29. A Torroni, et al., mtDNA variation of aboriginal Siberians reveals distinct genetic affinities with Native Americans. Am J Hum Genet 53, 591–608 (1993).
  30. UA Perego, et al., The initial peopling of the Americas: A growing number of founding mitochondrial genomes from Beringia. Genome Res 20, 1174–1179 (2010). · DOI
  31. UA Perego, et al., Decrypting the mitochondrial gene pool of modern Panamanians. PLoS ONE 7, e38337 (2012). · DOI
  32. A Salas, et al., Mitochondrial echoes of first settlement and genetic continuity in El Salvador. PLoS ONE 4, e6882 (2009). · DOI
  33. YB Starikovskaya, RI Sukernik, TG Schurr, AM Kogelnik, DC Wallace, mtDNA diversity in Chukchi and Siberian Eskimos: Implications for the genetic history of Ancient Beringia and the peopling of the New World. Am J Hum Genet 63, 1473–1491 (1998). · DOI
  34. R Rubicz, TG Schurr, PL Babb, MH Crawford, Mitochondrial DNA variation and the origins of the Aleuts. Hum Biol 75, 809–835 (2003). · DOI
  35. GF Shields, et al., mtDNA sequences suggest a recent evolutionary divergence for Beringian and northern North American populations. Am J Hum Genet 53, 549–562 (1993).
  36. A Helgason, et al., mtDNA variation in Inuit populations of Greenland and Canada: Migration history and population structure. Am J Phys Anthropol 130, 123–134 (2006). · DOI
  37. TG Schurr, et al., Clan, language, and migration history has shaped genetic diversity in Haida and Tlingit populations from Southeast Alaska. Am J Phys Anthropol; Genographic Consortium 148, 422–435 (2012). · DOI
  38. RS Malhi, et al., Native American mtDNA prehistory in the American Southwest. Am J Phys Anthropol 120, 108–124 (2003). · DOI
  39. B Budowle, et al., HVI and HVII mitochondrial DNA data in Apaches and Navajos. Int J Legal Med 116, 212–215 (2002). · DOI
  40. BM Kemp, et al., Evaluating the Farming/Language Dispersal Hypothesis with genetic variation exhibited by populations in the Southwest and Mesoamerica. Proc Natl Acad Sci USA 107, 6759–6764 (2010). · DOI
  41. RS Malhi, BA Schultz, DG Smith, Distribution of mitochondrial DNA lineages among Native American tribes of Northeastern North America. Hum Biol 73, 17–55 (2001). · DOI
  42. RS Malhi, et al., Patterns of mtDNA diversity in northwestern North America. Hum Biol 76, 33–54 (2004). · DOI
  43. MD Brown, et al., mtDNA haplogroup X: An ancient link between Europe/Western Asia and North America? Am J Hum Genet 63, 1852–1861 (1998). · DOI
  44. PS Bellwood, C Renfrew Examining the Farming/Language Dispersal Hypothesis (McDonald Institute for Archaeological Research, Cambridge, UK, 2002).
  45. P Soares, et al., Correcting for purifying selection: An improved human mitochondrial molecular clock. Am J Hum Genet 84, 740–759 (2009). · DOI
  46. J Raff, J Tackney, DH O’Rourke, South from Alaska: A pilot aDNA study of genetic history on the Alaska Peninsula and the eastern Aleutians. Hum Biol 82, 677–693 (2010). · DOI
  47. M de Saint Pierre, et al., Arrival of Paleo-Indians to the southern cone of South America: New clues from mitogenomes. PLoS ONE 7, e51311 (2012). · DOI
  48. P Taboada-Echalar, et al., The genetic legacy of the pre-colonial period in contemporary Bolivians. PLoS ONE 8, e58980 (2013). · DOI
  49. B Hooshiar Kashani, et al., Mitochondrial haplogroup C4c: A rare lineage entering America through the ice-free corridor? Am J Phys Anthropol 147, 35–39 (2012). · DOI
  50. UA Perego, et al., Distinctive Paleo-Indian migration routes from Beringia marked by two rare mtDNA haplogroups. Curr Biol 19, 1–8 (2009). · DOI · Paper page
  51. WL Merrill, et al., The diffusion of maize to the southwestern United States and its impact. Proc Natl Acad Sci USA 106, 21019–21026 (2009). · DOI
  52. JH Hill, Proto-Uto-Aztecan: A community of cultivators in Central Mexico? Am Anthropol 103, 913–934 (2001). · DOI
  53. DA Gregory, DR Wilcox Zuni Origins: Toward a New Synthesis of Southwestern Archaeology (Univ of Arizona Press, Tucson, AZ, 2007).
  54. CH Brown, Lack of linguistic support for Proto-Uto-Aztecan at 8900 BP. Proc Natl Acad Sci USA 107, E34–author reply E35–E36 (2010). · DOI
  55. B Pritzker A Native American Encyclopedia: History, Culture, and Peoples (Oxford Univ Press, New York, 2000). · DOI
  56. WC Sturtevant Handbook of North American Indians: Southeast (Smithsonian Institution, Washington, D.C, 2004).
  57. DG Smith, et al., Implications of the distribution of Albumin Naskapi and Albumin Mexico for new world prehistory. Am J Phys Anthropol 111, 557–572 (2000). · DOI
  58. RK Harritt, Paleo-Eskimo beginnings in North America: A new discovery at Kuzitrin Lake, Seward Peninsula, Alaska. Etudes Inuit Stud 22, 61–81 (1998).
  59. MTP Gilbert, et al., Paleo-Eskimo mtDNA genome reveals matrilineal discontinuity in Greenland. Science 320, 1787–1789 (2008). · DOI
  60. M Regueiro, J Alvarez, D Rowold, RJ Herrera, On the origins, rapid expansion and genetic diversity of Native Americans from hunting-gatherers to agriculturalists. Am J Phys Anthropol 150, 333–348 (2013). · DOI
  61. B Malyarchuk, et al., Ancient links between Siberians and Native Americans revealed by subtyping the Y chromosome haplogroup Q1a. J Hum Genet 56, 583–588 (2011). · DOI
  62. M Derenko, et al., Phylogeographic analysis of mitochondrial DNA in northern Asian populations. Am J Hum Genet 81, 1025–1041 (2007). · DOI
  63. RS Malhi, et al., Distribution of Y chromosomes among native North Americans: a study of Athapaskan population history. Am J Phys Anthropol 137, 412–424 (2008). · DOI
  64. A Achilli, et al., The phylogeny of the four pan-American mtDNA haplogroups: Implications for evolutionary and disease studies. PLoS ONE 3, e1764 (2008). · DOI
  65. M Bodner, et al., Rapid coastal spread of First Americans: Novel insights from South America’s Southern Cone mitochondrial genomes. Genome Res 22, 811–820 (2012). · DOI
  66. LL Cavalli-Sforza, P Menozzi, A Piazza, Demic expansions and human evolution. Science 259, 639–646 (1993). · DOI
  67. FM Salzano, SM Callegari-Jacques South American Indians: A Case Study in Evolution (Oxford Univ Press, Cambridge, New York, 1988).
  68. MH Crawford The Origins of Native Americans: Evidence from Anthropological Genetics (Cambridge Univ Press, Cambridge, New York, 1998). · DOI
  69. FM Salzano, MC Bortolini The Evolution and Genetics of Latin American Populations (Cambridge Univ Press, Cambridge, New York, 2002).
  70. RS Malhi, et al., Brief communication: Mitochondrial haplotype C4c confirmed as a founding genome in the Americas. Am J Phys Anthropol 141, 494–497 (2010). · DOI
  71. R Scozzari, et al., mtDNA and Y chromosome-specific polymorphisms in modern Ojibwa: Implications about the origin of their gene pool. Am J Hum Genet 60, 241–244 (1997).
  72. P Soares, et al., The archaeogenetics of Europe. Curr Biol 20, R174–R183 (2010). · DOI
  73. M Pala, et al., Mitochondrial DNA signals of late glacial recolonization of Europe from near eastern refugia. Am J Hum Genet 90, 915–924 (2012). · DOI
  74. R Bisso-Machado, et al., Distribution of Y-chromosome Q lineages in Native Americans. Am J Hum Biol 23, 563–566 (2011). · DOI
  75. DA Bolnick, DI Bolnick, DG Smith, Asymmetric male and female genetic histories among Native Americans from Eastern North America. Mol Biol Evol 23, 2161–2174 (2006). · DOI
  76. MC Bortolini, et al., Y-chromosome evidence for differing ancient demographic histories in the Americas. Am J Hum Genet 73, 524–539 (2003). · DOI
  77. G Hellenthal, A Auton, D Falush, Inferring human colonization history using a copying model. PLoS Genet 4, e1000078 (2008). · DOI
  78. DF Conrad, et al., A worldwide survey of haplotype variation and linkage disequilibrium in the human genome. Nat Genet 38, 1251–1260 (2006). · DOI
  79. C Moreau, et al., Deep human genealogies reveal a selective advantage to be on an expanding wave front. Science 334, 1148–1150 (2011). · DOI
  80. RM Andrews, et al., Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA. Nat Genet 23, 147 (1999). · DOI · Paper page
  81. DM Behar, et al., A “Copernican” reassessment of the human mitochondrial DNA tree from its root. Am J Hum Genet 90, 675–684 (2012). · DOI
  82. AJ Drummond, A Rambaut, B Shapiro, OG Pybus, Bayesian coalescent inference of past population dynamics from molecular sequences. Mol Biol Evol 22, 1185–1192 (2005). · DOI
  83. AJ Drummond, A Rambaut, BEAST: Bayesian evolutionary analysis by sampling trees. BMC Evol Biol 7, 214 (2007). · DOI
  84. A Torroni, A Achilli, V Macaulay, M Richards, H-J Bandelt, Harvesting the fruit of the human mtDNA tree. Trends Genet 22, 339–345 (2006). · DOI
  85. P Soares, et al., The Expansion of mtDNA Haplogroup L3 within and out of Africa. Mol Biol Evol 29, 915–927 (2012). · DOI

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Metadata

Authors
Achilli, A., Perego, U. A., Lancioni, H., Olivieri, A., Gandini, F., Hooshiar Kashani, B., Battaglia, V., Grugni, V., Angerhofer, N., Rogers, M. P., Herrera, R. J., Woodward, S. R., Labuda, D., Smith, D. G., Cybulski, J. S., Semino, O., Malhi, R. S., & Torroni, A.
Affiliations
  • Dipartimento di Chimica, Biologia e Biotecnologie, Università di Perugia, 06123 Perugia, Italy;
  • Dipartimento di Biologia e Biotecnologie “Lazzaro Spallanzani”, Università di Pavia, 27100 Pavia, Italy;
  • Sorenson Molecular Genealogy Foundation, Salt Lake City, UT 84115;
  • Department of Anthropology and
  • Department of Biological Sciences, Florida International University, Miami, FL 33199;
  • Département de Pédiatrie, Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, QC, Canada H3T 1C5;
  • Department of Anthropology, University of California, Davis, CA 95616; and
  • Canadian Museum of Civilization, Gatineau, QC, Canada K1A 0M8
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2013-08-12
Volume
110
Issue
35
Pages
14308-14313
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.1306290110
Cited by
109
References
2
Language
en

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