The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Reactivation of stalled polyribosomes in synaptic plasticity
Open accessAbstract
Significance: In neurons, many mRNAs are transported to synapses in a translationally repressed state, allowing for the spatial and temporal regulation of protein synthesis required for synaptic plasticity. It has been assumed that these mRNAs are repressed at the initiation step of translation. Here we provide evidence for a second mechanism whereby these mRNAs are instead repressed at elongation/termination awaiting translational reactivation upon appropriate synaptic signals. Our results establish that a form of translation-dependent synaptic plasticity, which is dysregulated in neurodevelopmental and psychiatric pathologies, occurs independently of translation initiation. Elucidating the upstream pathways that lead to repression and reactivation of elongation/termination on these mRNAs may provide new avenues for the design of therapies targeting neurodevelopmental disorders.
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Cites
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FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism
Darnell, J. C., Van Driesche, S. J., Zhang, C., Hung, K. Y. S., Mele, A., Fraser, C. E., Stone, E. F., Chen, C., Fak, J. J., Chi, S. W., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.013 · Cited by 2,072
RNA regulons: coordination of post-transcriptional events
Keene, J. D. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2111 · Cited by 1,321
The Autistic Neuron: Troubled Translation?
Kelleher, R. J., & Bear, M. F. (2008) · Cell · doi:10.1016/j.cell.2008.10.017 · Cited by 598
The Pathophysiology of Fragile X (and What It Teaches Us about Synapses)
Bhakar, A. L., Dölen, G., & Bear, M. F. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153138 · Cited by 370
Characterization of an RNA Granule from Developing Brain
Elvira, G., Wasiak, S., Blandford, V., Tong, X.-K., Serrano, A., Fan, X., del Rayo Sánchez-Carbente, M., Servant, F., Bell, A. W., Boismenu, D., et al. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500255-mcp200 · Cited by 287
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Cited by
Dynamic Axonal Translation in Developing and Mature Visual Circuits
Shigeoka, T., Jung, H., Jung, J., Turner-Bridger, B., Ohk, J., Lin, J. Q., Amieux, P. S., & Holt, C. E. (2016) · Cell · doi:10.1016/j.cell.2016.05.029 · Cited by 455
Monosomes actively translate synaptic mRNAs in neuronal processes
Biever, A., Glock, C., Tushev, G., Ciirdaeva, E., Dalmay, T., Langer, J. D., & Schuman, E. M. (2020) · Science · doi:10.1126/science.aay4991 · Cited by 267
Gkogkas, C. G., Khoutorsky, A., Cao, R., Jafarnejad, S. M., Prager-Khoutorsky, M., Giannakas, N., Kaminari, A., Fragkouli, A., Nader, K., Price, T. J., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.064 · Cited by 201
“To assess the effect of the genetic reduction of eIF4E phosphorylation on protein synthesis, we measured de novo protein synthesis in hippocampal slices using puromycin labeling, to tag nascent polypeptide chains (Bhattacharya et al., 2012; Graber et al., 2013; Schmidt et al., 2009).”
MethodSelf-citationNeuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy
Harbauer, A. B., Hees, J. T., Wanderoy, S., Segura, I., Gibbs, W., Cheng, Y., Ordonez, M., Cai, Z., Cartoni, R., Ashrafi, G., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.035 · Cited by 156
Translational Control in the Brain in Health and Disease
Sossin, W. S., & Costa-Mattioli, M. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a032912 · Cited by 138
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Metadata
- Authors
- Graber, T. E., Hébert-Seropian, S., Khoutorsky, A., David, A., Yewdell, J. W., Lacaille, J.-C., & Sossin, W. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-09-16
- Volume
- 110
- Issue
- 40
- Pages
- 16205-16210
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2052359428
- Cited by
- 182
- References
- 6
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Graber, T. E., Hébert-Seropian, S., Khoutorsky, A., David, A., Yewdell, J. W., Lacaille, J.-C., & Sossin, W. S. (2013). Reactivation of stalled polyribosomes in synaptic plasticity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1307747110
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