Translational Control in the Brain in Health and Disease

mTOR Signaling in Growth Control and Disease

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TOR signaling in growth and metabolism

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LTP and LTD

Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

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FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

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Protein synthesis and memory: A review.

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A unifying model for mTORC1-mediated regulation of mRNA translation

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The translational landscape of mTOR signalling steers cancer initiation and metastasis

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Synaptic plasticity, memory and the hippocampus: a neural network approach to causality

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Rapid formation and selective stabilization of synapses for enduring motor memories

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Stably maintained dendritic spines are associated with lifelong memories

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A translational profiling approach for the molecular characterization of CNS cell types

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Translational control by 5′-untranslated regions of eukaryotic mRNAs

Hinnebusch, A. G., Ivanov, I. P., & Sonenberg, N. (2016) · Science · doi:10.1126/science.aad9868 · Cited by 1,079 · see citing works

Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.

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A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity

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Translational control of long-lasting synaptic plasticity and memory

Costa-Mattioli, M., Sossin, W. S., Klann, E., & Sonenberg, N. (2009) · Neuron · doi:10.1016/j.neuron.2008.10.055 · Cited by 944 · see citing works

Dendritic Protein Synthesis, Synaptic Plasticity, and Memory

Sutton, M. A., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.09.014 · Cited by 894 · see citing works

Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis

Ehninger, D., Han, S., Shilyansky, C., Zhou, Y., Li, W., Kwiatkowski, D. J., Ramesh, V., & Silva, A. J. (2008) · Nature Medicine · doi:10.1038/nm1788 · Cited by 879 · see citing works

Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase

Wang, X.-M., Li, W., Williams, M. R., Terada, N., Alessi, D., & Proud, C. G. (2001) · EMBO Journal · doi:10.1093/emboj/20.16.4370 · Cited by 862 · see citing works

Translational Control by MAPK Signaling in Long-Term Synaptic Plasticity and Memory

Kelleher, R. J., Govindarajan, A., Jung, H.-Y., Kang, H., & Tonegawa, S. (2004) · Cell · doi:10.1016/s0092-8674(04)00115-1 · Cited by 845 · see citing works

Engram cells retain memory under retrograde amnesia

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A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

Tang, S. J., Reis, G., Kang, H., Gingras, A.-C., Sonenberg, N., & Schuman, E. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012605299 · Cited by 734 · see citing works

Pharmacological brake-release of mRNA translation enhances cognitive memory

Sidrauski, C., Acosta‐Alvear, D., Khoutorsky, A., Vedantham, P., Hearn, B. R., Li, H., Gamache, K., Gallagher, C. M., Ang, K. K. H., Wilson, C. G. M., et al. (2013) · eLife · doi:10.7554/elife.00498 · Cited by 732 · see citing works

The local transcriptome in the synaptic neuropil revealed by deep sequencing and high-resolution imaging

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Memory Consolidation

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Finding the engram

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Sustained translational repression by eIF2α-P mediates prion neurodegeneration

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Synaptic tagging: implications for late maintenance of hippocampal long-term potentiation

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Memory Engram Cells Have Come of Age

Tonegawa, S., Liu, X., Ramirez, S., & Redondo, R. L. (2015) · Neuron · doi:10.1016/j.neuron.2015.08.002 · Cited by 613 · see citing works

Dynamic visualization of local protein synthesis in hippocampal neurons

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The Autistic Neuron: Troubled Translation?

Kelleher, R. J., & Bear, M. F. (2008) · Cell · doi:10.1016/j.cell.2008.10.017 · Cited by 598 · see citing works

Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits

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Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G.

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The unfolded protein response is activated in Alzheimer’s disease

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Role of eIF2α Kinases in Translational Control and Adaptation to Cellular StressPreprint

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Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors

Ju, W. H., Morishita, W., Tsui, J., Gaietta, G. M., Deerinck, T. J., Adams, S., Garner, C. C., Tsien, R. Y., Ellisman, M. H., & Malenka, R. C. (2004) · Nature Neuroscience · doi:10.1038/nn1189 · Cited by 524 · see citing works

Autism-related deficits via dysregulated eIF4E-dependent translational control

Gkogkas, C. G., Khoutorsky, A., Ran, I., Rampakakis, E., Nevarko, T., Weatherill, D. B., Vasuta, C., Yee, S., Truitt, M., Dallaire, P., et al. (2013) · Nature · doi:10.1038/nature11628 · Cited by 522 · see citing works

Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD

Park, S., Park, J. M., Kim, S., Kim, J.-A., Shepherd, J. D., Smith-Hicks, C. L., Chowdhury, S., Kaufmann, W., Kuhl, D., Ryazanov, A. G., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.023 · Cited by 516 · see citing works

eIF2α Phosphorylation Bidirectionally Regulates the Switch from Short- to Long-Term Synaptic Plasticity and Memory

Costa‐Mattioli, M., Gobert, D., Stern, E., Gamache, K., Colina, R., Cuello, A. C., Sossin, W. S., Kaufman, R. J., Pelletier, J., Rosenblum, K., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.050 · Cited by 510 · see citing works

Disruption of Dendritic Translation of CaMKIIα Impairs Stabilization of Synaptic Plasticity and Memory Consolidation

Miller, S., Yasuda, M., Coats, J., Jones, Y., Martone, M. E., & Mayford, M. R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00978-9 · Cited by 507 · see citing works

Synapses and Memory Storage

Mayford, M., Siegelbaum, S. A., & Kandel, E. R. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005751 · Cited by 500 · see citing works

Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair

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Dynamic Translational and Proteasomal Regulation of Fragile X Mental Retardation Protein Controls mGluR-Dependent Long-Term Depression

Hou, L., Antion, M. D., Hu, D., Spencer, C. M., Paylor, R., & Klann, E. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.005 · Cited by 469 · see citing works

Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration

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Translational control of hippocampal synaptic plasticity and memory by the eIF2α kinase GCN2

Costa-Mattioli, M., Gobert, D., Harding, H., Herdy, B., Azzi, M., Bruno, M., Bidinosti, M., Mamou, C. B., Marcinkiewicz, E., Yoshida, M., et al. (2005) · Nature · doi:10.1038/nature03897 · Cited by 421 · see citing works

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

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Insights into immediate-early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches

Guzowski, J. F. (2002) · Hippocampus · doi:10.1002/hipo.10010 · Cited by 392 · see citing works

NMDA receptor-mediated control of protein synthesis at developing synapses

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Exaggerated translation causes synaptic and behavioural aberrations associated with autism

Santini, E., Huynh, T. N., MacAskill, A. F., Carter, A. G., Pierre, P., Ruggero, D., Kaphzan, H., & Klann, E. (2012) · Nature · doi:10.1038/nature11782 · Cited by 376 · see citing works

Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression

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mTOR complexes in neurodevelopmental and neuropsychiatric disorders

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Translational control in synaptic plasticity and cognitive dysfunction

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Protein Synthesis Initiation in Eukaryotic CellsPreprint

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Identification of the major Mr 100,000 substrate for calmodulin-dependent protein kinase III in mammalian cells as elongation factor-2.

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The Pharmacology of Memory: A Neurobiological Perspective

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The Translation Repressor 4E-BP2 Is Critical for eIF4F Complex Formation, Synaptic Plasticity, and Memory in the Hippocampus

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LTP requires a reserve pool of glutamate receptors independent of subunit type

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Tetanic Stimulation Leads to Increased Accumulation of Ca2+/Calmodulin-Dependent Protein Kinase II via Dendritic Protein Synthesis in Hippocampal Neurons

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mTORC2 controls actin polymerization required for consolidation of long-term memory

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The many roles of the eukaryotic elongation factor 1 complex

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Metabotropic Receptor-Dependent Long-Term Depression Persists in the Absence of Protein Synthesis in the Mouse Model of Fragile X Syndrome

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Phosphorylation of eukaryotic initiation factor-2α (eIF2α) is associated with neuronal degeneration in Alzheimerʼs disease

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Ribosome Profiling: Global Views of TranslationPreprint

Ingolia, N. T., Hussmann, J. A., & Weissman, J. S. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a032698 · Cited by 285 · see citing works

Single β-Actin mRNA Detection in Neurons Reveals a Mechanism for Regulating Its Translatability

Buxbaum, A. R., Wu, B., & Singer, R. H. (2014) · Science · doi:10.1126/science.1242939 · Cited by 280 · see citing works

Local Protein Synthesis Mediates a Rapid Increase in Dendritic Elongation Factor 1A after Induction of Late Long-Term Potentiation

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Local protein synthesis and its role in synapse-specific plasticity

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Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury

Chou, A., Krukowski, K., Jopson, T. D., Zhu, P., Costa‐Mattioli, M., Walter, P., & Rosi, S. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707661114 · Cited by 253 · see citing works

Translation Elongation and Recoding in EukaryotesPreprint

Dever, T. E., Dinman, J. D., & Green, R. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a032649 · Cited by 250 · see citing works

Targeting the endocannabinoid system in the treatment of fragile X syndrome

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Fragile X Mental Retardation Protein Regulates Translation by Binding Directly to the Ribosome

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Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

Stoica, L., Zhu, P. J., Huang, W., Zhou, H., Kozma, S. C., & Costa-Mattioli, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014715108 · Cited by 232 · see citing works

Metformin ameliorates core deficits in a mouse model of fragile X syndrome

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Synapse- and Stimulus-Specific Local Translation During Long-Term Neuronal Plasticity

Wang, D. O., Kim, S. M., Zhao, Y., Hwang, H., Miura, S. K., Sossin, W. S., & Martin, K. C. (2009) · Science · doi:10.1126/science.1173205 · Cited by 226 · see citing works

Synaptic tagging — who's it?

Martin, K. C., & Kosik, K. S. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn942 · Cited by 219 · see citing works

Eukaryotic elongation factor‐2 (eEF2): its regulation and peptide chain elongation

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Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition

Zhu, P. J., Huang, W., Kalikulov, D., Yoo, J. W., Placzek, A. N., Stoica, L., Zhou, H., Bell, J. C., Friedlander, M. J., Krnjević, K., et al. (2011) · Cell · doi:10.1016/j.cell.2011.11.029 · Cited by 215 · see citing works

β-Adrenergic Receptor Activation Facilitates Induction of a Protein Synthesis-Dependent Late Phase of Long-Term Potentiation

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Pausing on Polyribosomes: Make Way for Elongation in Translational Control

Richter, J. D., & Coller, J. M. (2015) · Cell · doi:10.1016/j.cell.2015.09.041 · Cited by 204 · see citing works

Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α

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Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes

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Regulation of mRNA Translation in Neurons—A Matter of Life and Death

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Synaptic Tagging and Cross-Tagging: The Role of Protein Kinase M in Maintaining Long-Term Potentiation But Not Long-Term Depression

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Local translation in neuronal compartments: how local is local?

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Identification of Compartment- and Process-Specific Molecules Required for “Synaptic Tagging” during Long-Term Potentiation and Long-Term Depression in Hippocampal CA1

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Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid β

Ma, T., Chen, Y., Vingtdeux, V., Zhao, H., Viollet, B., Marambaud, P., & Klann, E. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1694-14.2014 · Cited by 191 · see citing works

Ribosome pausing, arrest and rescue in bacteria and eukaryotes

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Reactivation of stalled polyribosomes in synaptic plasticity

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Involvement of double‐stranded RNA‐dependent protein kinase and phosphorylation of eukaryotic initiation factor‐2α in neuronal degeneration

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Presynaptic protein synthesis is required for long-term plasticity of GABA release

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mTOR signaling in the hippocampus is necessary for memory formation

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Memory in Mice Analyzed with Antibiotics

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Mitogen-Activated Protein Kinase Upregulates the Dendritic Translation Machinery in Long-Term Potentiation by Controlling the Mammalian Target of Rapamycin Pathway

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Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism

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The CaMKII/NMDAR complex as a molecular memory

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