The DOI matches its Crossref record; 56 of the 57 references it cites were found in a registry or an index.
Dynamics of dendritic spines in the mouse auditory cortex during memory formation and memory recall.
Open accessAbstract
Long-lasting changes in synaptic connections induced by relevant experiences are believed to represent the physical correlate of memories. Here, we combined chronic in vivo two-photon imaging of dendritic spines with auditory-cued classical conditioning to test if the formation of a fear memory is associated with structural changes of synapses in the mouse auditory cortex. We find that paired conditioning and unpaired conditioning induce a transient increase in spine formation or spine elimination, respectively. A fraction of spines formed during paired conditioning persists and leaves a long-lasting trace in the network. Memory recall triggered by the reexposure of mice to the sound cue did not lead to changes in spine dynamics. Our findings provide a synaptic mechanism for plasticity in sound responses of auditory cortex neurons induced by auditory-cued fear conditioning; they also show that retrieval of an auditory fear memory does not lead to a recapitulation of structural plasticity in the auditory cortex as observed during initial memory consolidation.
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“In the auditory cortex, it was found that increased spine formation was correlated with paired fear conditioning, while unpaired conditioning was associated with increased elimination of spines (Moczulska et al., 2013).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Moczulska et al., 2013
In the citing paper
“In the auditory cortex, it was found that increased spine formation was correlated with paired fear conditioning, while unpaired conditioning was associated with increased elimination of spines (Moczulska et al., 2013).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Moczulska et al., 2013
In the citing paper
“For example, a fear conditioning paradigm that pairs auditory cues with foot shocks has demonstrated opposite effects in auditory and frontal cortex.”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Moczulska et al., 2013
Citations
Cites
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Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP
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Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Nader, K., Schafe, G. E., & Le Doux, J. E. (2000) · Nature · doi:10.1038/35021052 · Cited by 2,706
Experience-dependent structural synaptic plasticity in the mammalian brain
Holtmaat, A., & Svoboda, K. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2699 · Cited by 1,934
Neurons in medial prefrontal cortex signal memory for fear extinction
Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836 · cited 1×
“Interestingly, the frontal associative cortex showed increased spine elimination during initial classical conditioning to sound cues but an increase in spine formation during extinction training (10), paralleling earlier studies in which the specific role of higher-order cortical areas has been demonstrated in extinct…”
BackgroundThe Emotional Brain, Fear, and the Amygdala
LeDoux, J. (2003) · Cellular and Molecular Neurobiology · doi:10.1023/a:1025048802629 · Cited by 1,818
Cortical Map Reorganization Enabled by Nucleus Basalis Activity
Kilgard, M. P., & Merzenich, M. M. (1998) · Science · doi:10.1126/science.279.5357.1714 · Cited by 1,197
Rapid formation and selective stabilization of synapses for enduring motor memories
Xu, T., Yu, X., Perlik, A. J., Tobin, W. F., Zweig, J. A., Tennant, K., Jones, T., & Zuo, Y. (2009) · Nature · doi:10.1038/nature08389 · Cited by 1,193
Stably maintained dendritic spines are associated with lifelong memories
Yang, G., Pan, F., & Gan, W.-B. (2009) · Nature · doi:10.1038/nature08577 · Cited by 1,182
Research works printed but not linked: 1
- KS Lashley, In search of the engram. Symp Soc Exp Biol 4, 454–482 (1950).
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What is memory? The present state of the engram
Poo, M.-M., Pignatelli, M., Ryan, T. J., Tonegawa, S., Bonhoeffer, T., Martin, K. C., Rudenko, A., Tsai, L., Tsien, R. W., Fishell, G., et al. (2016) · BMC Biology · doi:10.1186/s12915-016-0261-6 · Cited by 409
Functional and structural underpinnings of neuronal assembly formation in learning
Holtmaat, A., & Caroni, P. (2016) · Nature Neuroscience · doi:10.1038/nn.4418 · Cited by 239
Keck, T., Toyoizumi, T., Chen, L., Doiron, B., Feldman, D. E., Fox, K. D., Wulfram Gerstner, B., Haydon, P. G., Hübener, M., Lee, H., et al. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0158 · Cited by 217
Biochemical Computation for Spine Structural Plasticity
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Metadata
- Authors
- Moczulska, K. E., Tinter-Thiede, J., Peter, M., Ushakova, L., Wernle, T., Bathellier, B., & Rumpel, S.
- Affiliations
- Research Institute of Molecular Pathology (AT)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-10-22
- Volume
- 110
- Issue
- 45
- Pages
- 18315-18320
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3831433
- OpenAlex
- W1963639605
- Cited by
- 127
- References
- 57
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 1 · 2023: 7 · 2022: 7 · 2021: 14 · 2020: 5 · 2019: 22 · 2018: 12 · 2017: 13 · 2016: 17 · 2015: 6 · 2014: 9
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- dendritic spines, auditory cortex, fear memory, memory consolidation, memory retrieval, synaptic plasticity, spine dynamics, two-photon imaging, acoustic response
- MeSH terms
- Analysis of Variance, Animals, Auditory Cortex, Conditioning, Psychological, Fear, Male, Memory, Microscopy, Fluorescence, Mental Recall, Synapses, Polymerase Chain Reaction, Dendritic Spines, Mice
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