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Dynamics of dendritic spines in the mouse auditory cortex during memory formation and memory recall.
Open accessAbstract
Long-lasting changes in synaptic connections induced by relevant experiences are believed to represent the physical correlate of memories. Here, we combined chronic in vivo two-photon imaging of dendritic spines with auditory-cued classical conditioning to test if the formation of a fear memory is associated with structural changes of synapses in the mouse auditory cortex. We find that paired conditioning and unpaired conditioning induce a transient increase in spine formation or spine elimination, respectively. A fraction of spines formed during paired conditioning persists and leaves a long-lasting trace in the network. Memory recall triggered by the reexposure of mice to the sound cue did not lead to changes in spine dynamics. Our findings provide a synaptic mechanism for plasticity in sound responses of auditory cortex neurons induced by auditory-cued fear conditioning; they also show that retrieval of an auditory fear memory does not lead to a recapitulation of structural plasticity in the auditory cortex as observed during initial memory consolidation.
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“In the auditory cortex, it was found that increased spine formation was correlated with paired fear conditioning, while unpaired conditioning was associated with increased elimination of spines (Moczulska et al., 2013).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Moczulska et al., 2013
In the citing paper
“In the auditory cortex, it was found that increased spine formation was correlated with paired fear conditioning, while unpaired conditioning was associated with increased elimination of spines (Moczulska et al., 2013).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Moczulska et al., 2013
In the citing paper
“For example, a fear conditioning paradigm that pairs auditory cues with foot shocks has demonstrated opposite effects in auditory and frontal cortex.”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Moczulska et al., 2013
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Metadata
- Authors
- Moczulska, K. E., Tinter-Thiede, J., Peter, M., Ushakova, L., Wernle, T., Bathellier, B., & Rumpel, S.
- Affiliations
- Research Institute of Molecular Pathology (AT)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-10-22
- Volume
- 110
- Issue
- 45
- Pages
- 18315-18320
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3831433
- OpenAlex
- W1963639605
- Cited by
- 127
- References
- 57
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 1 · 2023: 7 · 2022: 7 · 2021: 14 · 2020: 5 · 2019: 22 · 2018: 12 · 2017: 13 · 2016: 17 · 2015: 6 · 2014: 9
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- dendritic spines, auditory cortex, fear memory, memory consolidation, memory retrieval, synaptic plasticity, spine dynamics, two-photon imaging, acoustic response
- MeSH terms
- Analysis of Variance, Animals, Auditory Cortex, Conditioning, Psychological, Fear, Male, Memory, Microscopy, Fluorescence, Mental Recall, Synapses, Polymerase Chain Reaction, Dendritic Spines, Mice
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