Cited by 127Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

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Dynamics of dendritic spines in the mouse auditory cortex during memory formation and memory recall.

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Moczulska, Kaja Ewa, Tinter-Thiede, Juliane, Peter, Manuel, Ushakova, Lyubov, Wernle, Tanja, Bathellier, Brice, Rumpel, Simon·2013·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1312508110PMC PMC3831433

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Abstract

Long-lasting changes in synaptic connections induced by relevant experiences are believed to represent the physical correlate of memories. Here, we combined chronic in vivo two-photon imaging of dendritic spines with auditory-cued classical conditioning to test if the formation of a fear memory is associated with structural changes of synapses in the mouse auditory cortex. We find that paired conditioning and unpaired conditioning induce a transient increase in spine formation or spine elimination, respectively. A fraction of spines formed during paired conditioning persists and leaves a long-lasting trace in the network. Memory recall triggered by the reexposure of mice to the sound cue did not lead to changes in spine dynamics. Our findings provide a synaptic mechanism for plasticity in sound responses of auditory cortex neurons induced by auditory-cued fear conditioning; they also show that retrieval of an auditory fear memory does not lead to a recapitulation of structural plasticity in the auditory cortex as observed during initial memory consolidation.

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The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
A theory of Pavlovian conditioning : Variations in the effectiveness of reinforcement and nonreinforcement
Rescorla, R. A. (1972) · Medical Entomology and Zoology · Cited by 7,268
Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP
Feng, G., Mellor, R. H., Bernstein, M., Keller-Peck, C., Nguyen, Q. T., Wallace, M., Nerbonne, J. M., Lichtman, J. W., & Sanes, J. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00084-2 · Cited by 3,042
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Nader, K., Schafe, G. E., & Le Doux, J. E. (2000) · Nature · doi:10.1038/35021052 · Cited by 2,706
Experience-dependent structural synaptic plasticity in the mammalian brain
Holtmaat, A., & Svoboda, K. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2699 · Cited by 1,934
Neurons in medial prefrontal cortex signal memory for fear extinction
Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836 · cited 1×
“Interestingly, the frontal associative cortex showed increased spine elimination during initial classical conditioning to sound cues but an increase in spine formation during extinction training (10), paralleling earlier studies in which the specific role of higher-order cortical areas has been demonstrated in extinct…”
Background
The Emotional Brain, Fear, and the Amygdala
LeDoux, J. (2003) · Cellular and Molecular Neurobiology · doi:10.1023/a:1025048802629 · Cited by 1,818
Cortical Map Reorganization Enabled by Nucleus Basalis Activity
Kilgard, M. P., & Merzenich, M. M. (1998) · Science · doi:10.1126/science.279.5357.1714 · Cited by 1,197
Rapid formation and selective stabilization of synapses for enduring motor memories
Xu, T., Yu, X., Perlik, A. J., Tobin, W. F., Zweig, J. A., Tennant, K., Jones, T., & Zuo, Y. (2009) · Nature · doi:10.1038/nature08389 · Cited by 1,193
Stably maintained dendritic spines are associated with lifelong memories
Yang, G., Pan, F., & Gan, W.-B. (2009) · Nature · doi:10.1038/nature08577 · Cited by 1,182

Show all 57 references

Research works printed but not linked: 1

KS Lashley, In search of the engram. Symp Soc Exp Biol 4, 454–482 (1950).

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Authors: Moczulska, K. E., Tinter-Thiede, J., Peter, M., Ushakova, L., Wernle, T., Bathellier, B., & Rumpel, S.
Affiliations: Research Institute of Molecular Pathology (AT)
ORCID: Moczulska, Kaja Ewa
Peter, Manuel
Wernle, Tanja
Bathellier, Brice
Rumpel, Simon
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2013-10-22
Volume: 110
Issue: 45
Pages: 18315-18320
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1312508110
PMC: PMC3831433
OpenAlex: W1963639605
Cited by: 127
References: 57
Citations by year: 2026: 6 · 2025: 8 · 2024: 1 · 2023: 7 · 2022: 7 · 2021: 14 · 2020: 5 · 2019: 22 · 2018: 12 · 2017: 13 · 2016: 17 · 2015: 6 · 2014: 9
FWCI: 5.83
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: dendritic spines, auditory cortex, fear memory, memory consolidation, memory retrieval, synaptic plasticity, spine dynamics, two-photon imaging, acoustic response
MeSH terms: Analysis of Variance, Animals, Auditory Cortex, Conditioning, Psychological, Fear, Male, Memory, Microscopy, Fluorescence, Mental Recall, Synapses, Polymerase Chain Reaction, Dendritic Spines, Mice

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Dynamics of dendritic spines in the mouse auditory cortex during memory formation and memory recall.

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