Cited by 126DNA Repair MechanismsFungal and yeast genetics researchEvolution and Genetic Dynamics

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Mutational landscape of yeast mutator strains

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Serero, Alexandre, Jubin, Claire, Loeillet, Sophie, Legoix-Né, Patricia, Nicolas, Alain G.·2014·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1314423111PMC PMC3918763

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Abstract

Significance: Deficiencies in genome maintenance genes (so-called mutator genes) result in increased mutagenesis that impacts cell evolvability. How the mutational processes drive the evolution of genome structure is not well understood. Here, we used high-throughput sequencing to characterize the mutation events (from punctual mutations to large chromosomal rearrangements) that occurred in mutation accumulation lines derived from a broad set of yeast mutator strains. Establishing genome-wide mutation profiles revealed that each mutator exhibits a unique and sometimes complex mutational signature. Our results also show how the dynamics of mutation accumulation can generate different genomes.

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Authors: Serero, A., Jubin, C., Loeillet, S., Legoix-Né, P., & Nicolas, A. G.
Affiliations: Centre National de la Recherche Scientifique (FR)
Institut Curie (FR)
ORCID: Loeillet, Sophie
Nicolas, Alain G.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2014-01-21
Volume: 111
Issue: 5
Pages: 1897-1902
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1314423111
PMC: PMC3918763
OpenAlex: W2053903416
Cited by: 126
References: 48
Citations by year: 2026: 6 · 2025: 7 · 2024: 7 · 2023: 10 · 2022: 6 · 2021: 15 · 2020: 15 · 2019: 11 · 2018: 9 · 2017: 19 · 2016: 6 · 2015: 9 · 2014: 6
FWCI: 5.47
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Agence Nationale de la Recherche (ANR-10-EQPX-0003, 10-EQPX-03, ANR10EQPX03, ANR 10-INBS-09-08, ANR-10, ANR-09-BLAN-0278, ANR-10-EQPX)
Fondation ARC pour la Recherche sur le Cancer
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords: mutator strains, Saccharomyces cerevisiae, mutation spectrum, genome maintenance, genomic instability, FEN1, ATR, ATM, chromosome structural variation, aneuploidy, clonal evolution, tumor evolution, DNA mismatch repair, DNA damage checkpoint, telomere maintenance, mitochondrial DNA maintenance
MeSH terms: Aneuploidy, Genes, Fungal, Haploidy, Mutation, Saccharomyces cerevisiae, Gene Rearrangement, Chromosomes, Fungal, Sequence Analysis, DNA

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