The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.
Mutational landscape of yeast mutator strains
Open accessAbstract
Significance: Deficiencies in genome maintenance genes (so-called mutator genes) result in increased mutagenesis that impacts cell evolvability. How the mutational processes drive the evolution of genome structure is not well understood. Here, we used high-throughput sequencing to characterize the mutation events (from punctual mutations to large chromosomal rearrangements) that occurred in mutation accumulation lines derived from a broad set of yeast mutator strains. Establishing genome-wide mutation profiles revealed that each mutator exhibits a unique and sometimes complex mutational signature. Our results also show how the dynamics of mutation accumulation can generate different genomes.
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“Furthermore, the mutational profile of the C23 genome resembles that of a S. cerevisiae MSH2 mutant (24, 25).”
From Mismatch Repair of DNA Replication Errors Contributes to Microevolution in the Pathogenic Fungus Cryptococcus neoformans (2017) · cites this paper as [25]
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Metadata
- Authors
- Serero, A., Jubin, C., Loeillet, S., Legoix-Né, P., & Nicolas, A. G.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Institut Curie (FR)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-01-21
- Volume
- 111
- Issue
- 5
- Pages
- 1897-1902
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3918763
- OpenAlex
- W2053903416
- Cited by
- 126
- References
- 48
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 7 · 2023: 10 · 2022: 6 · 2021: 15 · 2020: 15 · 2019: 11 · 2018: 9 · 2017: 19 · 2016: 6 · 2015: 9 · 2014: 6
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-10-EQPX-0003, 10-EQPX-03, ANR10EQPX03, ANR 10-INBS-09-08, ANR-10, ANR-09-BLAN-0278, ANR-10-EQPX)
- Fondation ARC pour la Recherche sur le Cancer
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- mutator strains, Saccharomyces cerevisiae, mutation spectrum, genome maintenance, genomic instability, FEN1, ATR, ATM, chromosome structural variation, aneuploidy, clonal evolution, tumor evolution, DNA mismatch repair, DNA damage checkpoint, telomere maintenance, mitochondrial DNA maintenance
- MeSH terms
- Aneuploidy, Genes, Fungal, Haploidy, Mutation, Saccharomyces cerevisiae, Gene Rearrangement, Chromosomes, Fungal, Sequence Analysis, DNA
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