Increased Circulating Levels of Betatrophin in Newly Diagnosed Type 2 Diabetic Patients

Diagnosis and Classification of Diabetes Mellitus

American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc11-s062 · Cited by 14,019 · see citing works

Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp

Matsuda, M., & DeFronzo, R. A. (1999) · Diabetes Care · doi:10.2337/diacare.22.9.1462 · Cited by 5,621 · see citing works

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235 · see citing works

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.

Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., & Kahn, C. R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00015-8 · Cited by 1,296 · see citing works

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

Brüning, J. C., Michael, M. D., Winnay, J. N., Hayashi, T., Hörsch, D., Accili, D., Goodyear, L. J., & Kahn, C. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80155-0 · Cited by 1,183 · see citing works

Adipose Tissue Selective Insulin Receptor Knockout Protects against Obesity and Obesity-Related Glucose Intolerance

Blüher, M., Michael, M. D., Peroni, O. D., Ueki, K., Carter, N., Kahn, B. B., & Kahn, C. R. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00199-5 · Cited by 806 · see citing works

Insulin Secretion and Action in Subjects With Impaired Fasting Glucose and Impaired Glucose Tolerance

Abdul-Ghani, M. A., Jenkinson, C. P., Richardson, D. K., Tripathy, D., & DeFronzo, R. A. (2006) · Diabetes · doi:10.2337/db05-1200 · Cited by 500 · see citing works

β-Cell Mass and Turnover in Humans

Saisho, Y., Butler, A. E., Manesso, E., Elashoff, D. A., Rizza, R. A., & Butler, P. C. (2012) · Diabetes Care · doi:10.2337/dc12-0421 · Cited by 406 · see citing works

Hyperbolic Relationship Between Insulin Secretion and Sensitivity on Oral Glucose Tolerance Test

Retnakaran, R. R., Shen, S., Hanley, A. J., Vuksan, V. V. V., Hamilton, J. K., & Zinman, B. (2008) · Obesity · doi:10.1038/oby.2008.307 · Cited by 364 · see citing works

Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men

Stančáková, A., Javorský, M., Kuulasmaa, T., Haffner, S. M., Kuusisto, J., & Laakso, M. (2009) · Diabetes · doi:10.2337/db08-1607 · Cited by 348 · see citing works

Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels

Zhang, R. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.07.038 · Cited by 345 · see citing works

Evaluation of proposed oral disposition index measures in relation to the actual disposition index

Retnakaran, R. R., Qi, Y., Goran, M. I., & Hamilton, J. K. (2009) · Diabetic Medicine · doi:10.1111/j.1464-5491.2009.02841.x · Cited by 322 · see citing works

Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis

Wang, Y., Quagliarini, F., Gusarova, V., Gromada, J., Valenzuela, D. M., Cohen, J. C., & Hobbs, H. H. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315292110 · Cited by 317 · see citing works

Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation

Zaret, K. S. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2318 · Cited by 285 · see citing works

Contribution of Insulin-Stimulated Glucose Uptake and Basal Hepatic Insulin Sensitivity to Surrogate Measures of Insulin Sensitivity

Tripathy, D., Almgren, P., Tuomi, T., & Groop, L. (2004) · Diabetes Care · doi:10.2337/diacare.27.9.2204 · Cited by 205 · see citing works

Circulating betatrophin correlates with atherogenic lipid profiles but not with glucose and insulin levels in insulin-resistant individuals

Fenzl, A., Itariu, B. K., Kosi, L., Fritzer‐Szekeres, M., Kautzky‐Willer, A., Stulnig, T. M., & Kiefer, F. W. (2014) · Diabetologia · doi:10.1007/s00125-014-3208-x · Cited by 165 · see citing works

The role of aging upon β cell turnover

Kushner, J. A. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64095 · Cited by 156 · see citing works

Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states

El Ouaamari, A., Kawamori, D., Dirice, E., Liew, C. W., Shadrach, J. L., Hu, J., Katsuta, H., Hollister-Lock, J., Qian, W.-J., Wagers, A. J., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.007 · Cited by 136 · see citing works

Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes

Espes, D., Lau, J., & Carlsson, P. (2013) · Diabetologia · doi:10.1007/s00125-013-3071-1 · Cited by 128 · see citing works

Association of Hematological Parameters with Insulin Resistance and β-Cell Dysfunction in Nondiabetic Subjects

Hanley, A. J., Retnakaran, R. R., Qi, Y., Gerstein, H. C., Perkins, B. A., Raboud, J., Harris, S. B., & Zinman, B. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0719 · Cited by 90 · see citing works

Indices of insulin action calculated from fasting glucose and insulin reflect hepatic, not peripheral, insulin sensitivity in African-American and Caucasian adolescents

Hoffman, R. P. (2008) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2007.00350.x · Cited by 68 · see citing works

Microphthalmia Transcription Factor Regulates Pancreatic β-Cell Function

Mazur, M. A., Winkler, M., Ganić, E., Colberg, J. K., Johansson, J. K., Bennet, H., Fex, M., Nuber, U. A., & Artner, I. (2013) · Diabetes · doi:10.2337/db12-1464 · Cited by 27 · see citing works

Pancreatic regulation of glucose homeostasis.

Röder, P. V., Wu, B., Liu, Y., & Han, W. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.6 · Cited by 985 · see citing works

Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power

Atkinson, E. G., Maihofer, A. X., Kanai, M., Martin, A. R., Karczewski, K. J., Santoro, M. L., Ulirsch, J. C., Kamatani, Y., Okada, Y., Finucane, H. K., et al. (2021) · Nature Genetics · doi:10.1038/s41588-020-00766-y · Cited by 230 · see citing works

Diabetes mellitus in patients with cirrhosis: clinical implications and management

Elkrief, L., Rautou, P., Sarin, S. K., Valla, D. C., Paradis, V., & Moreau, R. (2016) · Liver International · doi:10.1111/liv.13115 · Cited by 222 · see citing works

The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking

Zhang, R. (2016) · Open Biology · doi:10.1098/rsob.150272 · Cited by 222 · see citing works

Circulating angiopoietin-like protein 8 (ANGPTL8) and ANGPTL3 concentrations in relation to anthropometric and metabolic profiles in Korean children: a prospective cohort study

Chung, H. S., Lee, M. J., Hwang, S. Y., Lee, H. J., Yoo, H. J., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., Choi, D. S., et al. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0324-y · Cited by 129 · see citing works

Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance

Abu‐Farha, M., Abubaker, J. A., Al‐Khairi, I., Cherian, P., Noronha, F., Hu, F. B., Behbehani, K., & Elkum, N. B. (2015) · Scientific Reports · doi:10.1038/srep10949 · Cited by 126 · see citing works

Association between betatrophin/ANGPTL8 and non-alcoholic fatty liver disease: animal and human studies

Lee, Y., Lee, S., Lee, C. J., Kim, S. H., Song, Y.-M., Yoon, M. R., Jeon, B. H., Lee, J. H., Lee, B., Kang, E. S., et al. (2016) · Scientific Reports · doi:10.1038/srep24013 · Cited by 111 · see citing works

A dual role of lipasin (betatrophin) in lipid metabolism and glucose homeostasis: consensus and controversy

Zhang, R., & Abou‐Samra, A. (2014) · Cardiovascular Diabetology · doi:10.1186/s12933-014-0133-8 · Cited by 107 · see citing works

Circulating betatrophin is elevated in patients with type 1 and type 2 diabetes

Yamada, H., Saito, T., Aoki, A., Asano, T., Yoshida, M., Ikoma, A., Kusaka, I., Toyoshima, H., Kakei, M., & Ishikawa, S. (2015) · Endocrine Journal · doi:10.1507/endocrj.ej14-0525 · Cited by 93 · see citing works

Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin

Haridas, P. A. N., Soronen, J., Sädevirta, S., Mysore, R., Quagliarini, F., Pasternack, A. H., Metso, J., Perttilä, J., Leivonen, M., Smas, C. M., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1254 · Cited by 83 · see citing works

A lipasin/Angptl8 monoclonal antibody lowers mouse serum triglycerides involving increased postprandial activity of the cardiac lipoprotein lipase

Fu, Z., Abou‐Samra, A., & Zhang, R. (2015) · Scientific Reports · doi:10.1038/srep18502 · Cited by 82 · see citing works

Circulating angiopoietin-like protein 8 (betatrophin) association with HsCRP and metabolic syndrome

Abu‐Farha, M., Abubaker, J. A., Al‐Khairi, I., Cherian, P., Noronha, F., Kavalakatt, S., Khadir, A., Behbehani, K., Alarouj, M., Bennakhi, A., et al. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0346-0 · Cited by 76 · see citing works

Serum Meteorin-like protein levels decreased in patients newly diagnosed with type 2 diabetes

Lee, J. H., Kang, Y. E., Kim, J. M., Choung, S., Joung, K. H., Kim, H. J., & Ku, B. J. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.10.005 · Cited by 75 · see citing works

Serum betatrophin concentrations are significantly increased in overweight but not in obese or type 2 diabetic individuals

Guo, K., Lu, J., Yu, H., Zhao, F., Pan, P., Zhang, L., Chen, H., Bao, Y., & Jia, W. (2015) · Obesity · doi:10.1002/oby.21038 · Cited by 74 · see citing works

Hepatogenous diabetes: Is it time to separate it from type 2 diabetes?

Orsi, E., Grancini, V., Menini, S., Aghemo, A., & Pugliese, G. (2016) · Liver International · doi:10.1111/liv.13337 · Cited by 73 · see citing works

ANGPTL8 (betatrophin) role in diabetes and metabolic diseases

Abu‐Farha, M., Abubaker, J. A., & Tuomilehto, J. O. (2017) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2919 · Cited by 72 · see citing works

Emerging Regulation and Function of Betatrophin

Tseng, Y., Yeh, Y., Chen, W.-J., & Lin, K. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151223640 · Cited by 68 · see citing works

The characteristics of newly diagnosed adult early-onset diabetes: a population-based cross-sectional study

Zou, X., Zhou, X., Ji, L., Yang, W., Lu, J., Weng, J., Jia, W., Shan, Z., Liu, J., Tian, H., et al. (2017) · Scientific Reports · doi:10.1038/srep46534 · Cited by 68 · see citing works

ANGPTL8/betatrophin alleviates insulin resistance via the Akt-GSK3β or Akt-FoxO1 pathway in HepG2 cells

Guo, X., Wang, X. L., Chen, Y., Yuan, Y., Chen, Y. M., Ding, Y., Fang, J., Bian, L. J., & Li, D. S. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.09.012 · Cited by 67 · see citing works

Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice

Cox, A. R., Lam, C. J., Bonnyman, C. W., Chavez, J., Rios, J. S., & Kushner, J. A. (2015) · Diabetologia · doi:10.1007/s00125-015-3590-z · Cited by 66 · see citing works

AMP-activated protein kinase suppresses the expression of LXR/SREBP-1 signaling-induced ANGPTL8 in HepG2 cells

Lee, J., Hong, S., Park, S. E., Rhee, E., Park, C., Oh, K.-W., Park, S., & Lee, W. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.07.031 · Cited by 64 · see citing works

Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function

Chen, C.-C., Susanto, H., Chuang, W.-H., Liu, T.-Y., & Wang, C.-H. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0326-9 · Cited by 57 · see citing works

Circulating Betatrophin Correlates with Triglycerides and Postprandial Glucose among Different Glucose Tolerance Statuses—A Case-Control Study

Gao, T., Jin, K., Chen, P., Jin, H., Yang, L., Xie, X., Yang, M., Hu, C., & Yu, X. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133640 · Cited by 54 · see citing works

Circulating Betatrophin Is Strongly Increased in Pregnancy and Gestational Diabetes Mellitus

Trebotic, L. K., Klimek, P., Thomas, A., Fenzl, A., Leitner, K., Springer, S., Kiefer, F. W., & Kautzky‐Willer, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136701 · Cited by 52 · see citing works

Interplay of atherogenic factors, protein intake and betatrophin levels in obese–metabolic syndrome patients treated with hypocaloric diets

Crujeiras, A. B., Zulet, M. Á., Abete, I., Amil, M., Carreira, M. C., Martínez, J. A., & Casanueva, F. F. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.206 · Cited by 51 · see citing works

Elevated circulating levels of betatrophin are associated with polycystic ovary syndrome

Çalan, M., Yılmaz, Ö., Küme, T., Kocabaş, G. Ü., Senses, P. Y., Senses, Y. M., Temür, M., & Çalan, Ö. G. (2016) · Endocrine · doi:10.1007/s12020-016-0875-z · Cited by 50 · see citing works

The Effects of Serum ANGPTL8/betatrophin on the Risk of Developing the Metabolic Syndrome – A Prospective Study

Wang, H., Lai, Y., Han, C., Liu, A., Fan, C., Wang, H., Zhang, H., Ding, S., Teng, W., & Shan, Z. (2016) · Scientific Reports · doi:10.1038/srep28431 · Cited by 50 · see citing works

Circulating Betatrophin Levels Are Increased in Anorexia and Decreased in Morbidly Obese Women

Barja-Fernández, S., Folgueira, C., Seoane, L. M., Casanueva, F. F., Diéguez, C., Castelao, C., Agüera, Z., Baños, R., Botella, C., de la Torre, R., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1595 · Cited by 50 · see citing works

WISP1 is a novel adipokine linked to metabolic parameters in gestational diabetes mellitus

Ersoy, G. Ş., Ensarı, T. A., Subaş, S., Giray, B., Şimşek, E. E., & Çevik, Ö. D. (2016) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2016.1192118 · Cited by 46 · see citing works

Omics-based biomarkers in the diagnosis of diabetes

Gan, W., Ramachandran, V., Lim, C. S. Y., & Koh, R. Y. (2019) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2019-0120 · Cited by 47 · see citing works

Evaluation of circulating betatrophin levels in gestational diabetes mellitus

Erol, O. Ö., Elli̇dağ, H. Y., Ayık, H., Özel, M. K., Derbent, A. U., & Yılmaz, N. (2015) · Gynecological Endocrinology · doi:10.3109/09513590.2015.1056142 · Cited by 40 · see citing works

Insulin upregulates betatrophin expression via PI3K/Akt pathway

Lu, P., Chen, X., Zhang, Z., Zhang, J., Yang, Y., Liu, Z., Xie, J., Shao, S., Zhou, X., Hu, S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06052-y · Cited by 41 · see citing works

Characterisation of betatrophin concentrations in childhood and adolescent obesity and insulin resistance

Wu, S., Gao, H., Ma, Y., Fu, L., Zhang, C., & Luo, X. (2014) · Pediatric Diabetes · doi:10.1111/pedi.12233 · Cited by 40 · see citing works

Lack of associations between betatrophin/ANGPTL8 level and C-peptide in type 2 diabetic subjects

Abu‐Farha, M., Abubaker, J. A., Noronha, F., Al‐Khairi, I., Cherian, P., Alarouj, M., Bennakhi, A., & Elkum, N. B. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0277-1 · Cited by 39 · see citing works

Associations of betatrophin levels with irisin in Chinese women with normal glucose tolerance

Xie, X., Gao, T., Yang, M., Chen, P., Jin, H., Yang, L., & Yu, X. (2015) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-015-0019-2 · Cited by 40 · see citing works

Circulating Levels of Betatrophin and Irisin Are Not Associated with Pancreaticβ-Cell Function in Previously Diagnosed Type 2 Diabetes Mellitus Patients

Wang, L., Song, J., Wang, C., Lin, P., Liang, K., Sun, Y. S., He, T., Li, W., Zhao, R., Qin, J., et al. (2015) · Journal of Diabetes Research · doi:10.1155/2016/2616539 · Cited by 39 · see citing works

Circulating Betatrophin in Patients with Type 2 Diabetes: A Meta-Analysis

Li, S., Liu, D., Li, L., Li, Y., Li, Q., An, Z., Sun, X., & Tian, H. (2015) · Journal of Diabetes Research · doi:10.1155/2016/6194750 · Cited by 39 · see citing works

Increased Maternal and Cord Blood Betatrophin in Gestational Diabetes

Wawrusiewicz‐Kurylonek, N., Telejko, B., Kuźmicki, M., Sobota, A., Lipińska, D., Pliszka, J., Raczkowska, B. A., Kuć, P., Urban, R., Szamatowicz, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131171 · Cited by 39 · see citing works

Angiopoietin-like protein 8 (ANGPTL8) in pregnancy: a brown adipose tissue–derived endocrine factor with a potential role in fetal growth

Martinez-Perez, B., Ejarque, M., Gutiérrez, C., Núñez‐Roa, C., Roche, K., Vila‐Bedmar, R., Ballesteros, M., Redondo‐Angulo, I., Planavila, A., Villarroya, F., et al. (2016) · Translational research · doi:10.1016/j.trsl.2016.06.012 · Cited by 36 · see citing works

ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives

von Loeffelholz, C., Pfeiffer, A. F. H., Lock, J. F., Lieske, S., Döcke, S., Murahovschi, V., Kriebel, J., Gala, T. D. L. H., Grallert, H., Rudovich, N. N., et al. (2017) · Hormone and Metabolic Research · doi:10.1055/s-0043-102950 · Cited by 34 · see citing works

Triglyceride-mediated influence of serum angiopoietin-like protein 8 on subclinical atherosclerosis in type 2 diabetic patients: results from the GDMD study in China

Zheng, T., Ge, B., Liu, H., Chen, B., Qin, L., Xiao, L., & Song, J. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0687-y · Cited by 34 · see citing works

Vitamin D modifies the associations between circulating betatrophin and cardiometabolic risk factors among youths at risk for metabolic syndrome

Fu, J., Hou, C., Li, L., Feng, D., Li, G., Li, M., Li, C., Gao, S., & Li, M. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0461-y · Cited by 33 · see citing works

Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin-like protein 8 rs2278426 gene variants highly elevates the risk of type 2 diabetes mellitus and cardiovascular disease

El-Lebedy, D. H. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0742-8 · Cited by 32 · see citing works

Relationship of betatrophin with youth onset type 2 diabetes among Asian Indians

Gokulakrishnan, K., Manokaran, K., Pandey, G. K., Amutha, A., Ranjani, H., Anjana, R. M., & Mohan, V. (2015) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2015.04.028 · Cited by 31 · see citing works

Betatrophin Acts as a Diagnostic Biomarker in Type 2 Diabetes Mellitus and Is Negatively Associated with HDL-Cholesterol

Yi, M., Chen, R., Yang, R., Guo, X., Zhang, J.-C., & Chen, H. (2015) · International Journal of Endocrinology · doi:10.1155/2015/479157 · Cited by 31 · see citing works

Circulating betatrophin concentration is negatively correlated with insulin resistance in obese children and adolescents

Tuhan, H., Abacı, A., Anık, A., Çatlı, G., Küme, T., Çalan, Ö. G., Acar, S., & Böber, E. (2016) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2016.02.008 · Cited by 31 · see citing works

Circulating Betatrophin Is Increased in Patients with Overt and Subclinical Hypothyroidism

Han, C., Xia, X., Liu, A., Zhang, X., Zhou, M., Xiong, C., Liu, X., Sun, J., Shi, X., Shan, Z., et al. (2016) · BioMed Research International · doi:10.1155/2016/5090852 · Cited by 31 · see citing works

ANGPTL8 in metabolic homeostasis: more friend than foe?

Guo, C. Y., Wang, C., Deng, X., He, J., Yang, L., & Yuan, G. (2021) · Open Biology · doi:10.1098/rsob.210106 · Cited by 31 · see citing works

Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 Diabetes

Yin, Y., Ding, X., Peng, L., Hou, Y., Ling, Y., Gu, M., Wang, Y., Peng, Y., & Sun, H. (2017) · Journal of Diabetes Research · doi:10.1155/2017/8293207 · Cited by 30 · see citing works

MicroRNA-221-3p Regulates Angiopoietin-Like 8 (ANGPTL8) Expression in Adipocytes

Mysore, R., Ortega, F. J., Latorre, J., Ahonen, M. A., Savolainen-Peltonen, H. M., Fischer‐Posovszky, P., Wabitsch, M., Olkkonen, V. M., Fernández‐Real, J. M., & Haridas, P. A. N. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00453 · Cited by 29 · see citing works

Angiopoietin‐like protein 8/betatrophin correlates with hepatocellular lipid content independent of insulin resistance in non‐alcoholic fatty liver disease patients

Hong, B. S., Liu, J., Zheng, J., Ke, W., Huang, Z., Wan, X., He, X., Xiao, H., & Li, Y. (2017) · Journal of Diabetes Investigation · doi:10.1111/jdi.12792 · Cited by 29 · see citing works

Associations between circulating full-length angiopoietin-like protein 8 levels and severity of coronary artery disease in Chinese non-diabetic patients: a case–control study

Jiao, X., He, J., Yang, Y., Yang, S., Li, J., & Qin, Y. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0736-6 · Cited by 28 · see citing works

Serum CCN3 levels are increased in type 2 diabetes mellitus and associated with obesity, insulin resistance and inflammation

Li, J.-Y., Wang, Y., Qi, X.-Y., Li, R., Hong, T., Yang, J., Yan, B., Liao, Z., Liu, J., & Xiao, X. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.03.006 · Cited by 28 · see citing works

Regulation of ANGPTL8 in liver and adipose tissue by nutritional and hormonal signals and its effect on glucose homeostasis in mice

Zhang, L., Shannon, C. E., Bakewell, T. M., Abdul‐Ghani, M. A., Fourcaudot, M. J., & Norton, L. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00339.2019 · Cited by 27 · see citing works

ANGPTL8 enhances insulin sensitivity by directly activating insulin-mediated AKT phosphorylation

Zhang, Z., Wu, H., Dai, L., Yuan, Y., Zhu, Y., Ma, Z., Ruan, X., & Guo, X. (2020) · Gene · doi:10.1016/j.gene.2020.144707 · Cited by 26 · see citing works

Angiopoietin-like protein 8 (betatrophin) inhibits hepatic gluconeogenesis through PI3K/Akt signaling pathway in diabetic mice

Zhao, Z., Deng, X., Jia, J., Zhao, L., Wang, C., Cai, Z., Guo, C. Y., Yang, L., Wang, D., Ma, S., et al. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154921 · Cited by 26 · see citing works

Renal function is independently associated with circulating betatrophin

Maurer, L., Schwarz, F., Fischer‐Rosinsky, A., Schlueter, N., Brachs, S., Möhlig, M., Pfeiffer, A. F. H., Mai, K., Spranger, J., & Bobbert, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173197 · Cited by 26 · see citing works

The Relationship between Betatrophin Levels in Blood and T2DM: A Systematic Review and Meta-Analysis

Yue, S., Wu, J., Zhang, J., Liu, L., & Chen, L. (2016) · Disease Markers · doi:10.1155/2016/9391837 · Cited by 25 · see citing works

Circulating betatrophin is associated with insulin resistance in humans: cross-sectional and interventional studiesin vivoandin vitro

Wang, H., Wu, T., Wu, T., Yang, G., Hu, W., Yang, M., Yang, M., Liu, D., Gu, H. F., Zhu, Z., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21852 · Cited by 25 · see citing works

Increased Level of Angiopoietin Like Proteins 4 and 8 in People With Sleep Apnea

Alterki, A., Abu‐Farha, M., Al‐Khairi, I., Cherian, P., Devarajan, S., Shyamsundar, A., Ali, S., Al‐Mulla, F., Tuomilehto, J., & Abubaker, J. A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00651 · Cited by 25 · see citing works

Evidences for Expression and Location of ANGPTL8 in Human Adipose Tissue

Catalano-Iniesta, L. A., Sánchez‐Robledo, V., Osma, M. D. C. I., Albiñana, A. G., Carrero, S., Blanco, E. J., Carretero‐Hernández, M., Carretero, J., & García‐Barrado, M. J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020512 · Cited by 25 · see citing works

Serum betatrophin levels are increased and associated with insulin resistance in patients with polycystic ovary syndrome

Qu, Q., Zhao, D., Zhang, F., Bao, H., & Yang, Q. (2017) · Journal of International Medical Research · doi:10.1177/0300060516680441 · Cited by 23 · see citing works

Higher circulating levels of ANGPTL8 are associated with body mass index, triglycerides, and endothelial dysfunction in patients with coronary artery disease

Fadaei, R., Shateri, H., DiStefano, J. K., Moradi, N., Mohammadi, M. R., Emami, F., Aghajani, H., & Ziamajidi, N. (2020) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-03725-7 · Cited by 23 · see citing works

Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus

Cannon, M. E., Duan, Q., Wu, Y., Zeynalzadeh, M., Xu, Z. Q., Kangas, A. J., Soininen, P., Ala‐Korpela, M., Civelek, M., Lusis, A. J., et al. (2017) · G3 Genes Genomes Genetics · doi:10.1534/g3.117.300088 · Cited by 22 · see citing works

Effects of a diet with or without physical activity on angiopoietin-like protein 8 concentrations in overweight/obese patients with newly diagnosed type 2 diabetes: a randomized controlled trial

Hu, H., Yuan, G., Wang, X., Jin, S. Y., Gao, Z., Zhou, T., Yin, W., Cai, R., Ye, X., & Wang, Z. (2018) · Endocrine Journal · doi:10.1507/endocrj.ej18-0191 · Cited by 22 · see citing works

Adipose Insulin Resistance and Circulating Betatrophin Levels in Women with PCOS

He, Y., Hu, W., Yang, G., Guo, H., Liu, H., & Li, L. (2020) · BioMed Research International · doi:10.1155/2020/1253164 · Cited by 21 · see citing works

Correlation of circulating betatrophin concentrations with insulin secretion capacity, evaluated by glucagon stimulation tests

Tokumoto, S., Hamamoto, Y., Fujimoto, K., Yamaguchi, E., Okamura, E., Honjo, S., Ikeda, H., Wada, Y., Hamasaki, A., & Koshiyama, H. (2015) · Diabetic Medicine · doi:10.1111/dme.12696 · Cited by 21 · see citing works

High betatrophin in coronary patients protects from cardiovascular events

Leiherer, A., Ebner, J., Muendlein, A., Brandtner, E. M., Zach, C., Geiger, K. D., Fraunberger, P., & Drexel, H. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.11.011 · Cited by 21 · see citing works

The Rise and the Fall of Betatrophin/ANGPTL8 as an Inducer ofβ-Cell Proliferation

Abu‐Farha, M., Madhoun, A. S. A., & Abubaker, J. A. (2016) · Journal of Diabetes Research · doi:10.1155/2016/4860595 · Cited by 21 · see citing works

Circulating Betatrophin Levels Are Associated with the Lipid Profile in Type 2 Diabetes

Ghasemi, H., Tavilani, H., Khodadadi, I., Saidijam, M., & Karimi, J. (2015) · Chonnam Medical Journal · doi:10.4068/cmj.2015.51.3.115 · Cited by 20 · see citing works

High frequency of type 2 diabetes and impaired glucose tolerance in Japanese subjects with the angiopoietin-like protein 8 R59W variant

Liu, J., Yagi, K., Nohara, A., Chujo, D., Ohbatake, A., Fujimoto, A., Miyamoto, Y., Kobayashi, J., & Yamagishi, M. (2017) · Journal of clinical lipidology · doi:10.1016/j.jacl.2017.12.011 · Cited by 19 · see citing works

GLP-1 receptor agonists stimulate ANGPTL8 production through the PI3K/Akt pathway in a GLP-1 receptor-dependent manner

Liu, J., Yang, K., Xiao, W., Le, Y., Lang, S., Zhang, J., Wei, R., Yang, J., & Hong, T. (2018) · Peptides · doi:10.1016/j.peptides.2018.07.001 · Cited by 20 · see citing works

Betatrophin for diagnosis and prognosis of mothers with gestational diabetes mellitus

Pan, R., Zhang, H., Yu, S., Deng, J., Ma, S., Li, Y., Yuan, G., & Wang, J. (2018) · Journal of International Medical Research · doi:10.1177/0300060518808683 · Cited by 20 · see citing works

Predictive values of ANGPTL8 on risk of all-cause mortality in diabetic patients: results from the REACTION Study

Zou, H., Xu, Y., Chen, X., Yin, P., Li, D., Li, W., Xie, J., Shao, S., Liu, L., & Yu, X. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-020-01103-7 · Cited by 21 · see citing works

Regulation of angiopoietin-like protein 8 expression under different nutritional and metabolic status

Guo, C. Y., Zhao, Z., Deng, X., Chen, Z., Tu, Z., & Yuan, G. (2019) · Endocrine Journal · doi:10.1507/endocrj.ej19-0263 · Cited by 20 · see citing works

ANGPTL8/Betatrophin R59W variant is associated with higher glucose level in non-diabetic Arabs living in Kuwaits

Abu‐Farha, M., Melhem, M., Abubaker, J. A., Behbehani, K., Alsmadi, O. A., & Elkum, N. B. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0195-6 · Cited by 19 · see citing works

Moderate-Intensity Exercise and Musical Co-Treatment Decreased the Circulating Level of Betatrophin

Susanto, H., Taufiq, A., Sugiharto, Merawati, D., Badu, K. M., Purnomo, J. D. T., & Handaya, A. Y. (2020) · International Journal of Endocrinology · doi:10.1155/2020/3098261 · Cited by 18 · see citing works

Betatrophin in Diabetes Mellitus: the Epidemiological Evidence in Humans

Espes, D., Martinell, M., Liljebäck, H., & Carlsson, P. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0676-4 · Cited by 18 · see citing works

Decreased serum betatrophin levels correlate with improved fasting plasma glucose and insulin secretion capacity after Roux-en-Y gastric bypass in obese Chinese patients with type 2 diabetes: a 1-year follow-up

Guo, K., Yu, H., Lu, J., Bao, Y., Chen, H., & Jia, W. (2016) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2016.01.024 · Cited by 18 · see citing works

Plasma betatrophin levels in patients with liver cirrhosis

Arias, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i37.10662 · Cited by 18 · see citing works

The circulating ANGPTL8 levels show differences among novel subgroups of adult patients with diabetes and are associated with mortality in the subsequent 5 years

Zou, H., Wu, D., Zhang, Z., Chen, X., Lu, P., & Yu, X. (2020) · Scientific Reports · doi:10.1038/s41598-020-69091-y · Cited by 18 · see citing works

Betatrophin Levels were Increased in Pregnant Women with or without Gestational Diabetes Mellitus and Associated with Beta Cell Function

Huang, Y., Fang, C., Ma, Z., Guo, H., Wang, R., & Hu, J. (2016) · Revista Brasileira Ginecologia e Obstetrícia · doi:10.1055/s-0036-1584566 · Cited by 17 · see citing works

Association of serum betatrophin with fibroblast growth factor-21 in women with polycystic ovary syndrome

Kahraman, S., Altınova, A. E., Yalçın, M. M., Gülbahar, Ö., Arslan, B., Aktürk, M., Cakir, N., & Törüner, F. B. (2018) · Journal of Endocrinological Investigation · doi:10.1007/s40618-018-0831-2 · Cited by 17 · see citing works

Circulating Angiopoietin-like 8 protein (ANGPTL8/Betatrophin) in patients with polycystic ovary syndrome: a systematic review and multi effect size meta-analysis

Varikasuvu, S. R., Panga, J. R., & Satyanarayana, M. V. (2019) · Gynecological Endocrinology · doi:10.1080/09513590.2018.1536736 · Cited by 17 · see citing works

Circulating ANGPTL8 Is Associated with the Presence of Metabolic Syndrome and Insulin Resistance in Polycystic Ovary Syndrome Young Women

Pu, D., Li, L., Jingxia, Y., Liu, R., Yang, G., Liao, Y., & Wu, Q. (2019) · Mediators of Inflammation · doi:10.1155/2019/6321427 · Cited by 17 · see citing works

Association of ANGPTL8 and Resistin With Diabetic Nephropathy in Type 2 Diabetes Mellitus

Li, M., Fan, R., Peng, X., Huang, J., Zou, H., Yu, X., Yang, Y., Shi, X., & Ma, D. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.695750 · Cited by 17 · see citing works

Increased Cord Blood Betatrophin Levels in the Offspring of Mothers with Gestational Diabetes

Xie, X., Gao, H., Wu, S., Zhao, Y., Du, C., Yuan, G., Ning, Q., McCormick, K. L., & Luo, X. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155646 · Cited by 17 · see citing works

Angiopoietin-like protein 8: An attractive biomarker for the evaluation of subjects with insulin resistance and related disorders

Wang, S., Hong, X., Tu, Z., & Yuan, G. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.08.025 · Cited by 16 · see citing works

Associations Between Plasma Betatrophin Levels and Coronary and Peripheral Artery Disease

Niki, H., Kishimoto, Y., Ibe, S., Saita, E., Sasaki, K., Miura, K., Ikegami, Y., Ohmori, R., Kondo, K. N., & Momiyama, Y. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.46508 · Cited by 16 · see citing works

The potential role of angiopoietin-like protein-8 in type 2 diabetes mellitus: a possibility for predictive diagnosis and targeted preventive measures?

Issa, Y. A., ElHafeez, S. A., & Amin, N. G. (2019) · The EPMA Journal · doi:10.1007/s13167-019-00180-3 · Cited by 16 · see citing works

Expression of angiopoietin-like protein 8 correlates with VEGF in patients with proliferative diabetic retinopathy

Lu, Q., Li, L., Chen, W., & Lu, P. (2017) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-017-3676-z · Cited by 16 · see citing works

Circulating betatrophin in healthy control and type 2 diabetic subjects and its association with metabolic parameters

Al‐Daghri, N. M., Rahman, S., Sabico, S., Amer, O. E., Wani, K., Ansari, M. G. A., Al-Attas, O. S., Kumar, S., & Alokail, M. S. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.05.023 · Cited by 15 · see citing works

Association of Serum Angiopoietin-Like Protein 8 With Albuminuria in Type 2 Diabetic Patients: Results From the GDMD Study in China

Yang, L., Song, J., Zhang, X., Xiao, L., Hu, X., Pan, H., Qin, L., Liu, H., Ge, B., & Zheng, T. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00414 · Cited by 15 · see citing works

Dynamic alteration of plasma levels of betatrophin in younger female onset obesity post acute moderate-intensity exercise training

Susanto, H., Sugiharto, S., Taufiq, A., Pranoto, A., & Purnomo, J. D. T. (2022) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2022.103546 · Cited by 15 · see citing works

Circulating 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) levels are associated with hyperglycemia and β cell dysfunction in a Chinese population

Zhang, S., Chen, P., Jin, H., Yi, J., Xie, X., Yang, M., Gao, T., Yang, L., Hu, C., Zhang, X., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03271-1 · Cited by 15 · see citing works

Investigation of Blood Betatrophin Levels in Obese Children with Non-Alcoholic Fatty Liver Disease

Battal, F., Türkön, H., Aylanç, N., Aylanç, H., Yıldırım, Ş., Kaymaz, N., & Uysal, S. (2018) · Pediatric Gastroenterology Hepatology & Nutrition · doi:10.5223/pghn.2018.21.2.111 · Cited by 15 · see citing works

Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary Syndrome

Adamska, A., Łebkowska, A., Jacewicz‐Święcka, M., Krentowska, A., Hryniewicka, J., Wołczyński, S., Górska, M., & Kowalska, I. (2017) · International Journal of Endocrinology · doi:10.1155/2017/2316986 · Cited by 14 · see citing works

Betatrophin: no relation to glucose metabolism or weight status in obese children before and after lifestyle intervention

Roth, C. L., Elfers, C., Lass, N., & Reinehr, T. (2016) · Pediatric Diabetes · doi:10.1111/pedi.12412 · Cited by 14 · see citing works

Transcriptional Regulation of the Angptl8 Gene by Hepatocyte Nuclear Factor-1 in the Murine Liver

Watanabe, T., Ozawa, A., Masuda, S., Yoshino, S., Ishida, E., Kondo, Y., Matsumoto, S., Katano-Toki, A., Horiguchi, K., Nakajima, Y., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-66570-0 · Cited by 13 · see citing works

Relationship between serum betatrophin levels and the first-phase of glucose-stimulated insulin secretion

Liu, D., Qu, H., Wang, H., Duan, Y., Liu, F., Feng, Z., & Deng, H. (2016) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2016.08.004 · Cited by 13 · see citing works

Study of serum betatrophin level as a biochemical marker in patients with type 2 diabetes mellitus

Abbas, N., ABOUELMAGD, M. M., Marzouk, H. F. A., & Elghaba, M. (2022) · International Journal of Medical Arts · doi:10.21608/ijma.2022.99440.1377

Circulating betatrophin in healthy control and type 2 diabetic subjects and its association with metabolic parameters

Al‐Daghri, N. M., Rahman, S., Sabico, S., Amer, O. E., Wani, K., Ansari, M. G. A., Al-Attas, O. S., Kumar, S., & Alokail, M. S. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.05.023 · Cited by 15 · see citing works

Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes

Espes, D., Martinell, M., & Carlsson, P. (2014) · International Journal of Endocrinology · doi:10.1155/2014/323407 · Cited by 116 · see citing works

Research Article Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes

Espes, D., Martinell, M., & Carlsson, P.-O. (2016)

Circulating Betatrophin Levels Are Increased in Patients With Type 2 Diabetes and Associated With Insulin Resistance

Chen, X., Lu, P., He, W., Zhang, J., Liu, L., Yang, Y., Liu, Z., Xie, J., Shao, S., Du, T., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2300 · Cited by 129 · see citing works